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The map label for this gene is folP1 [H]

Identifier: 50841760

GI number: 50841760

Start: 321592

End: 322437

Strand: Direct

Name: folP1 [H]

Synonym: PPA0271

Alternate gene names: 50841760

Gene position: 321592-322437 (Clockwise)

Preceding gene: 50841759

Following gene: 50841761

Centisome position: 12.56

GC content: 61.35

Gene sequence:

>846_bases
ATGATCAATGTCGGCTCGGCTACCAACTCGCATCCCGCCCGCACCCTCGTCATGGGGGTCGTCAACGTCACTCCTAACTC
GTTCTCTGACGGAGGCATGTGGGCCGATCCTGAGGTGGCCATCCGCCACGCTCGCGACCTCGTTGTCGAAGGAGCTGACA
TCATCGACGTCGGTGGTGAATCGACCCGTCCGGGCACCGAACGCACCCCCGAGCACGAAGAATTGCGCCGCGTCCTGCCC
GTCGTCAAAGCTTTGGTGGCCGACGGGGTAGCCGTCTCCGTCGACACTATGCGCGCCTCAGTGGCCAAGGCTGTTGTCGA
GGCAGGAGCCACCATCGTCAACGACGTCTCTGGGGGCAAGGCTGAACCGGAAATCCTTGATGTCGTTGCCGACGCTGGCG
TCGATTACGTTCTCATGCACTGGCGCGGTCAATCCGCCACTATGCAGAACCTTGTCGACTATGACGACGTGGTAGCCGAC
GTCATTTCTGAGACCTCCCAGCAGGTCGACGCAGCTATTGCCGCTGGAATCGACCGTAGGCGCATCATCGTCGACCCGGG
CATTGGTTTCTCCAAGACTTCCGAGCACAACTGGCAGCTCATGAACGCCGTTGACGCCTTCCAAGAAGGATTTGCCGACC
TTCGTGTCCTGTGGGGAGTTAGTCGCAAGCGCTTCCTTGGTGAACTTCTCGCCCAGAACGGGGAGGACCGTCCGGCCCTC
GAACGCGATGCGAGCACCATGGCCCTGTCGACTTATTTCGCCCTTCATCACGCCTGGTGTGTGCGCACCCACGAAGTTCG
GGCCAACCGCGACGCCGTGGAGACTGTTGCCCGCCTTCTCGCCTGA

Upstream 100 bases:

>100_bases
GAGAACGGCAAACGTGTCCCCAAGATTAGTGAGGGGTGCAAGTAAGTGACTCCCCGCAGACCTCGATGAGTGCCTGCGAG
GCAGTCCTAGACTCCACTGC

Downstream 100 bases:

>100_bases
CGCGGTAATCTGCGCACTTGTCGGTAAAGTCCGATTGTGGCGAACAGGTAACCTTCCGCCATGACCTACGGACAGATCAC
CCTGACGGGCATCCGTGCCC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MINVGSATNSHPARTLVMGVVNVTPNSFSDGGMWADPEVAIRHARDLVVEGADIIDVGGESTRPGTERTPEHEELRRVLP
VVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGKAEPEILDVVADAGVDYVLMHWRGQSATMQNLVDYDDVVAD
VISETSQQVDAAIAAGIDRRRIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPAL
ERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA

Sequences:

>Translated_281_residues
MINVGSATNSHPARTLVMGVVNVTPNSFSDGGMWADPEVAIRHARDLVVEGADIIDVGGESTRPGTERTPEHEELRRVLP
VVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGKAEPEILDVVADAGVDYVLMHWRGQSATMQNLVDYDDVVAD
VISETSQQVDAAIAAGIDRRRIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPAL
ERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA
>Mature_281_residues
MINVGSATNSHPARTLVMGVVNVTPNSFSDGGMWADPEVAIRHARDLVVEGADIIDVGGESTRPGTERTPEHEELRRVLP
VVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGKAEPEILDVVADAGVDYVLMHWRGQSATMQNLVDYDDVVAD
VISETSQQVDAAIAAGIDRRRIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPAL
ERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=273, Percent_Identity=38.8278388278388, Blast_Score=175, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6324073, Length=308, Percent_Identity=32.1428571428571, Blast_Score=139, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30317; Mature: 30317

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVGSATNSHPARTLVMGVVNVTPNSFSDGGMWADPEVAIRHARDLVVEGADIIDVGGE
CCCCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGTERTPEHEELRRVLPVVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCHHEECCCCCC
AEPEILDVVADAGVDYVLMHWRGQSATMQNLVDYDDVVADVISETSQQVDAAIAAGIDRR
CCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPAL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCH
ERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
>Mature Secondary Structure
MINVGSATNSHPARTLVMGVVNVTPNSFSDGGMWADPEVAIRHARDLVVEGADIIDVGGE
CCCCCCCCCCCCHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCC
STRPGTERTPEHEELRRVLPVVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGK
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCHHEECCCCCC
AEPEILDVVADAGVDYVLMHWRGQSATMQNLVDYDDVVADVISETSQQVDAAIAAGIDRR
CCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPAL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCH
ERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]