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The map label for this gene is hpt [H]

Identifier: 50841749

GI number: 50841749

Start: 312708

End: 313262

Strand: Direct

Name: hpt [H]

Synonym: PPA0259

Alternate gene names: 50841749

Gene position: 312708-313262 (Clockwise)

Preceding gene: 50841748

Following gene: 50841750

Centisome position: 12.21

GC content: 55.68

Gene sequence:

>555_bases
GTGCGAGCTTCTGACATTCCTGGAGATTTCGACCACGTTCTGTACACCGAGGAGCAGGTGGCCTCCCGTATTCGCGAGGT
TGCTGCCCAAATTGACGCTGACTACGCCGGGCGAGAGATCCTTATGGTTGGCGTGCTCAATGGGGCCGTGATGACGATGG
CGGATCTATGTCGCGCGATGACCTCCCATATGTCCATGGACTGGATGGCTGTGTCGTCCTATGGGGCTGGGACAAAGTCC
AGCGGCGTGGTGCGCATCCTCAAGGACCTCACCAAGGACATCGATGGTCGTGACATTCTCATTGTTGAGGACATCATTGA
CACCGGGTTGACGCTGAGCTATTTGGTGCAGAACTTGCGTAGCCGCAACCCAAACTCGATTGAGATCATGGCGATGTTCC
GCAAGCCCGAGGTTGTTACCTGCCCGCTGGATGTCAAATATGTCGGTTTCGACATCCCAAACGAGTTTGTCGTCGGATAT
GGCCTTGACTACGCCGATAAGTACCGCAACCTCACGGATGTGGCGACGCTGGCACCGCACGTCTACAAATCCTGA

Upstream 100 bases:

>100_bases
TGCAGGGGTGGACGTCCCGGGCGGACGCGTCGAGATGAGACAGGGGACTCTGTATCTAGCCCGGCGCCTGTGATGGGACA
TAAGTCGGTAGGCTGATGGT

Downstream 100 bases:

>100_bases
GGATGCGATCCCAAGTCGTGACGCCGTGCCAGTGAACTATTTCTGTTCTGAGCTGTCCGCGGAACGTAGCAAGGGCCGGT
TGTTGTCATGCGCTGGTATC

Product: putative hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAMTSHMSMDWMAVSSYGAGTKS
SGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLRSRNPNSIEIMAMFRKPEVVTCPLDVKYVGFDIPNEFVVGY
GLDYADKYRNLTDVATLAPHVYKS

Sequences:

>Translated_184_residues
MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAMTSHMSMDWMAVSSYGAGTKS
SGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLRSRNPNSIEIMAMFRKPEVVTCPLDVKYVGFDIPNEFVVGY
GLDYADKYRNLTDVATLAPHVYKS
>Mature_184_residues
MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAMTSHMSMDWMAVSSYGAGTKS
SGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLRSRNPNSIEIMAMFRKPEVVTCPLDVKYVGFDIPNEFVVGY
GLDYADKYRNLTDVATLAPHVYKS

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI9910262, Length=183, Percent_Identity=30.6010928961749, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI4504483, Length=182, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI87081689, Length=162, Percent_Identity=45.679012345679, Blast_Score=148, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17510817, Length=200, Percent_Identity=33, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20422; Mature: 20422

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAM
CCCCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHH
TSHMSMDWMAVSSYGAGTKSSGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLR
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHH
SRNPNSIEIMAMFRKPEVVTCPLDVKYVGFDIPNEFVVGYGLDYADKYRNLTDVATLAPH
CCCCCCEEEEEEECCCCEEECCCCEEEEECCCCCCEEEECCCCHHHHHCCHHHHHHHHHH
VYKS
HHCC
>Mature Secondary Structure
MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAM
CCCCCCCCCCHHHEECHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHH
TSHMSMDWMAVSSYGAGTKSSGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLR
HHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHH
SRNPNSIEIMAMFRKPEVVTCPLDVKYVGFDIPNEFVVGYGLDYADKYRNLTDVATLAPH
CCCCCCEEEEEEECCCCEEECCCCEEEEECCCCCCEEEECCCCHHHHHCCHHHHHHHHHH
VYKS
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]