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The map label for this gene is rnc

Identifier: 161621795

GI number: 161621795

Start: 1567852

End: 1568592

Strand: Reverse

Name: rnc

Synonym: PPA1452

Alternate gene names: 161621795

Gene position: 1568592-1567852 (Counterclockwise)

Preceding gene: 50842932

Following gene: 50842930

Centisome position: 61.27

GC content: 59.24

Gene sequence:

>741_bases
GTGCACGCAAGCAGGGATCAGAATATCGGCCGCCCCGACGTCGAGGATTGGCCTTTTCTCGCCCTTCTCGAGGAGTTGGG
AATCCGGTGTGATCCCCAGCTCCTCGATCTTGCGCTGACGCACCGCTCGTATGCGTTCGAAAACGGTGGTATTCCCACCA
ACGAGAGGCTGGAGTTTTTAGGTGACGCCATCCTTGAAGTTGGTGTTACCGACTATTTGTACCGGGCGTTCCCGGATAAA
CCCGAAGGCCAGCTAGCCAAGTTACGGTCGGCTGTTGTGAGTACCGTCTCGCTAGGACGGCTGGCACGTCAACTCGGCAT
TGGTCCTCGGATCAAATTGGGCAAGGGAGAGGAACGTACTGGCGGCCACGACAAGACGTCGATCCTGGCCGACACTACCG
AGGCACTGCTGGGCGCGGTCGAGCTGTCAGCTGGGCTTCCGAACGTACTGCGTTTAGTCCACCACCTTTTCGATCCTCTC
GTTGATGAGGCAGACCGCTCTGGGGCGGGCACAGACTGGAAGACTGTCCTGCAAGAGTACTGCGCTGAGCATGGCTTCGA
TGCCCCCCGATACGAAATCGTCGGGTCTGGCCCAGATCACAATCGTCGGTACTGTGCCAGAGCGAATGTGGACGGCAGGC
TACATGCCGCCTACACCGGCCACAACAAGAAAGAAGCGGAGCAAGGTGCGGCCCGCCGTGCTGTCTCCGCGCTGATACCA
AGCTCTCACACAGGTGCCTGA

Upstream 100 bases:

>100_bases
TGCGGTGAGAAGCACCTGCCCCACACCGCCTGCCCGTCTTGCGGTGGGTACGGGCCGCGCGGCGACCGTCGTCAGGTTGT
CGAGGCCTGAGATCGACACT

Downstream 100 bases:

>100_bases
GCTCCCCGAGGTCGAGACCGTTCGAGCCGGACTCGAACATTTCGTTGTTCCGGCTGTCGTCGACAGCGTCGACGTCGTCG
ATACTCGCGGGCTTCGCCCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEFLGDAILEVGVTDYLYRAFPDK
PEGQLAKLRSAVVSTVSLGRLARQLGIGPRIKLGKGEERTGGHDKTSILADTTEALLGAVELSAGLPNVLRLVHHLFDPL
VDEADRSGAGTDWKTVLQEYCAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALIP
SSHTGA

Sequences:

>Translated_246_residues
MHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEFLGDAILEVGVTDYLYRAFPDK
PEGQLAKLRSAVVSTVSLGRLARQLGIGPRIKLGKGEERTGGHDKTSILADTTEALLGAVELSAGLPNVLRLVHHLFDPL
VDEADRSGAGTDWKTVLQEYCAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALIP
SSHTGA
>Mature_246_residues
MHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEFLGDAILEVGVTDYLYRAFPDK
PEGQLAKLRSAVVSTVSLGRLARQLGIGPRIKLGKGEERTGGHDKTSILADTTEALLGAVELSAGLPNVLRLVHHLFDPL
VDEADRSGAGTDWKTVLQEYCAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALIP
SSHTGA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=242, Percent_Identity=29.3388429752066, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI155030236, Length=242, Percent_Identity=29.3388429752066, Blast_Score=85, Evalue=6e-17,
Organism=Escherichia coli, GI1788920, Length=181, Percent_Identity=37.5690607734807, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323895, Length=162, Percent_Identity=29.6296296296296, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137682, Length=210, Percent_Identity=31.4285714285714, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26795; Mature: 26795

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00039 DEAD_ATP_HELICASE ; PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEFL
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GDAILEVGVTDYLYRAFPDKPEGQLAKLRSAVVSTVSLGRLARQLGIGPRIKLGKGEERT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
GGHDKTSILADTTEALLGAVELSAGLPNVLRLVHHLFDPLVDEADRSGAGTDWKTVLQEY
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALIP
HHHCCCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
SSHTGA
CCCCCC
>Mature Secondary Structure
MHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEFL
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
GDAILEVGVTDYLYRAFPDKPEGQLAKLRSAVVSTVSLGRLARQLGIGPRIKLGKGEERT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCC
GGHDKTSILADTTEALLGAVELSAGLPNVLRLVHHLFDPLVDEADRSGAGTDWKTVLQEY
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
CAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALIP
HHHCCCCCCCEEEECCCCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
SSHTGA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA