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The map label for this gene is mutM [H]

Identifier: 50842930

GI number: 50842930

Start: 1567089

End: 1567859

Strand: Reverse

Name: mutM [H]

Synonym: PPA1451

Alternate gene names: 50842930

Gene position: 1567859-1567089 (Counterclockwise)

Preceding gene: 161621795

Following gene: 50842927

Centisome position: 61.24

GC content: 59.01

Gene sequence:

>771_bases
GTGCCTGAGCTCCCCGAGGTCGAGACCGTTCGAGCCGGACTCGAACATTTCGTTGTTCCGGCTGTCGTCGACAGCGTCGA
CGTCGTCGATACTCGCGGGCTTCGCCCCAGCGGTGGACTCGAGGACGCTGCGCTTTTCGAGACGACCTTGTCGGGTCGTC
AATTTACTGCCGTGAATCGCCGGGGTAAGTACCTGTGGTTCATCCTTGACGATGGCACCGCGATGTTGGCTCATCTAGGT
ATGAGCGGACAATTCCGTGTTAGCCCCCAACATGCCCCGCAGCATCGCCATACCCGTATAGTCATCACCCTCGACGATGG
TCGTGACCTGCGCTTCCTCGACCAGCGCACCTTCGGCGGATTGACCCTAGCCCCGCTCGTTGACGGTATTCCCGGTCCGG
TGACCCACATCGCCCCTGATCCGTTCGAGGAGTGTTTCGACGTTGACGAGGTAGCGCGACGGTTGTGCGCACGCAGGTCC
GCCATTAAGAGGAGTTTGCTCGATCAGACCCTTGTTTCCGGGATTGGCAATATCTATGCCGACGAAACTCTTTGGCGGGT
CCGTCGTCACCCCGAGACACCATGCTCTCGCCTGAGTCAATCTGAAGCGGTGGAATTGTTACAGACGGCCCGCGATGTTA
TGGCAGAGGCCATGTCTCAGGGCGGTACCTCTTTCGACTCCCTTTATGTCAACGTTAACGGGGAATCGGGGTGGTTTTTC
CGCGTTGTGGATGCCTATGGCCGTGAGGATGAGCCCCTGCCACCGATGTGA

Upstream 100 bases:

>100_bases
GGCAGGCTACATGCCGCCTACACCGGCCACAACAAGAAAGAAGCGGAGCAAGGTGCGGCCCGCCGTGCTGTCTCCGCGCT
GATACCAAGCTCTCACACAG

Downstream 100 bases:

>100_bases
GACGCCGATCATACGCGAGTCTTTCATGAACCGGAGCTCGTTCCGATGCCCGAAGTGTCAGAGACCACGGTGATCCTGCC
GTCATCTGGCATGGCTAGCG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MPELPEVETVRAGLEHFVVPAVVDSVDVVDTRGLRPSGGLEDAALFETTLSGRQFTAVNRRGKYLWFILDDGTAMLAHLG
MSGQFRVSPQHAPQHRHTRIVITLDDGRDLRFLDQRTFGGLTLAPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRS
AIKRSLLDQTLVSGIGNIYADETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFF
RVVDAYGREDEPLPPM

Sequences:

>Translated_256_residues
MPELPEVETVRAGLEHFVVPAVVDSVDVVDTRGLRPSGGLEDAALFETTLSGRQFTAVNRRGKYLWFILDDGTAMLAHLG
MSGQFRVSPQHAPQHRHTRIVITLDDGRDLRFLDQRTFGGLTLAPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRS
AIKRSLLDQTLVSGIGNIYADETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFF
RVVDAYGREDEPLPPM
>Mature_255_residues
PELPEVETVRAGLEHFVVPAVVDSVDVVDTRGLRPSGGLEDAALFETTLSGRQFTAVNRRGKYLWFILDDGTAMLAHLGM
SGQFRVSPQHAPQHRHTRIVITLDDGRDLRFLDQRTFGGLTLAPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRSA
IKRSLLDQTLVSGIGNIYADETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFFR
VVDAYGREDEPLPPM

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=252, Percent_Identity=33.7301587301587, Blast_Score=144, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 28416; Mature: 28285

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRAGLEHFVVPAVVDSVDVVDTRGLRPSGGLEDAALFETTLSGRQFTAVNR
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECC
RGKYLWFILDDGTAMLAHLGMSGQFRVSPQHAPQHRHTRIVITLDDGRDLRFLDQRTFGG
CCCEEEEEEECCHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCEEEHHHHCCCC
LTLAPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRSAIKRSLLDQTLVSGIGNIYA
EEHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFF
HHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEE
RVVDAYGREDEPLPPM
EEEECCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRAGLEHFVVPAVVDSVDVVDTRGLRPSGGLEDAALFETTLSGRQFTAVNR
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEEECC
RGKYLWFILDDGTAMLAHLGMSGQFRVSPQHAPQHRHTRIVITLDDGRDLRFLDQRTFGG
CCCEEEEEEECCHHHHHHCCCCCEEEECCCCCCCCCCEEEEEEECCCCCEEEHHHHCCCC
LTLAPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRSAIKRSLLDQTLVSGIGNIYA
EEHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFF
HHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEE
RVVDAYGREDEPLPPM
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA