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The map label for this gene is ribH

Identifier: 50086524

GI number: 50086524

Start: 3494441

End: 3494911

Strand: Direct

Name: ribH

Synonym: ACIAD3571

Alternate gene names: 50086524

Gene position: 3494441-3494911 (Clockwise)

Preceding gene: 50086523

Following gene: 50086525

Centisome position: 97.11

GC content: 45.01

Gene sequence:

>471_bases
ATGGCAATTCGCCGAATTGAAGGTTTATTACATCTCGCGAGCGAAGGCCGTTACGCGATTTTGGTCGGTCGTTTTAACAG
TTTTGTCGTTGAGCATTTGCTCGAAGGTGCAATTGACACCTTGAAACGTCATGGTGTTAGCGAGGATAATATCACTGTTG
CTTACGCACCAGGTGCATGGGAACTCCCAATCGTTGCTAAAAAACTGGCAGCGTCGGATAAGTTTGATGCCATTATCGCT
TTGGGCGCAGTTATTCGTGGTAGCACCCCGCATTTCGACTTTGTTGCAGGTGAATGTGCCAAAGGTCTGGGTGTTGTTGC
ACTTGAAAGTAGTCTTCCAGTGATCAATGGTGTATTGACCACTGACAGTATCGAACAAGCCATTGAGCGTTCAGGTACAA
AAGCAGGAAATAAAGGTTCTGAAGCAGCCTTAACTGCAATTGAAATGGTTAATCTGTTAAAGGCAATCTAA

Upstream 100 bases:

>100_bases
TCAGTTCGCCTTTACGTTTCAATGCATTATCTGGATTTAACTTGGAAGTGGTGGAATATATCACCGCAGATCAAACTATA
GAGAACTAATCGAGGTTGTT

Downstream 100 bases:

>100_bases
AGCATGTCGCAAACACTCCAAGCCGCTTATGCAGCGAAACGCAAAGCACGTCGTTTTGCTGTACAAGGCATTTATGAATG
GCAAATGAGCCGTAACCCAG

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVSEDNITVAYAPGAWELPIVAKKLAASDKFDAIIA
LGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI

Sequences:

>Translated_156_residues
MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVSEDNITVAYAPGAWELPIVAKKLAASDKFDAIIA
LGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI
>Mature_155_residues
AIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVSEDNITVAYAPGAWELPIVAKKLAASDKFDAIIAL
GAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLTTDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=143, Percent_Identity=62.9370629370629, Blast_Score=179, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324429, Length=145, Percent_Identity=31.7241379310345, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_ACIAD (Q6F6V3)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_048034.1
- HSSP:   P11998
- ProteinModelPortal:   Q6F6V3
- SMR:   Q6F6V3
- STRING:   Q6F6V3
- GeneID:   2879524
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3571
- NMPDR:   fig|62977.3.peg.3227
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   Q6F6V3
- ProtClustDB:   PRK00061
- BioCyc:   ASP62977:ACIAD3571-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16421; Mature: 16290

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVSEDNITVAYAPGAW
CCHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
ELPIVAKKLAASDKFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLT
CCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHEEC
TDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIRRIEGLLHLASEGRYAILVGRFNSFVVEHLLEGAIDTLKRHGVSEDNITVAYAPGAW
CHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCC
ELPIVAKKLAASDKFDAIIALGAVIRGSTPHFDFVAGECAKGLGVVALESSLPVINGVLT
CCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEECCCCCHHHHEEC
TDSIEQAIERSGTKAGNKGSEAALTAIEMVNLLKAI
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA