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The map label for this gene is pncB

Identifier: 50086516

GI number: 50086516

Start: 3487171

End: 3488394

Strand: Reverse

Name: pncB

Synonym: ACIAD3562

Alternate gene names: 50086516

Gene position: 3488394-3487171 (Counterclockwise)

Preceding gene: 50086518

Following gene: 50086515

Centisome position: 96.94

GC content: 40.6

Gene sequence:

>1224_bases
TTGTTGTCTATGTCTCCAATCATTCATTCATTACTTGATACCGATCTTTATAAATTCACCATGTTGCAAGTGGTGTTACA
CCAGTTTCCACAAACGCATAGTGTCTATCATTTTCGCTGTCGTAATCTGGATGAAACTCAATATCCTTTAACCGATATTC
TGGATGATTTGAATGAACAACTCGATCATTTATGTACGCTGAAATTTAAGGACGACGAACTACAATATCTGCGTTCTTTT
CGGTTTATTAAAAGTGATTTTGTCGATTACTTGGAACTGTTCCAGCTTAAACGTCGTTTTATCACTGCGGGTATTGATGA
AGAAGGCCGCCTGGATATCTGGGTTGAAGGACCGATGGTTCAGGCCATGATGTTTGAAATATTTGTACTGGCGATTGTGA
ATGAGCTTTATTTTCGTCGTATACGAAGTGATGCTGTACTTGAAGAGGGTGAGCGTCGCTTACAGGCTAAGCTGGCTTTA
CTTGAGCAGTATCAGACCCAGCATCAGTCAGATGAGCCACCATTTTTAGTTTCTGATTTTGGTACACGTCGCCGTTATAG
TTTTGAATGGCAAAAACATGTCATTGCAGCATTTCATCATCATTTCCCAAATATCTTTAGGGGAACCAGTAATGTGCTGT
TGGCAAAAGAACTCAACATTACACCAATTGGTACGATGGCACATGAGTTTTTGCAAGCCTTTCAGGCACTTGATGTACGT
TTGCGTGATTTTCAGAAAGCTGCACTTGAAACGTGGGTACAAGAGTATCGTGGAGATTTAGGGATTGCATTAACGGATGT
CGTCGGAATGGATGCATTTCTACGCGACTTCGATTTGTATTTTGCCAAGTTGTTTGATGGTTTGCGTCATGACAGTGGTG
ACCCTTATGAATGGGGAGATAAAGCCTATGCACATTATCGTAAATTAAAGATAGACACCAAGACCAAGATGCTCACGTTT
AGTGATGGCTTAAATCTGGAAAAGGCATGGGAATTGCATCAATATTTTAAGGGCCGTTTTAAGGTGAGTTTTGGAATTGG
GACTAATCTCACCAACGATATGGGGCAAACGCCGCTCAATATTGTGTTGAAACTGGTAGAATGTAATGGGCAATCTGTGG
CTAAAATTTCAGATAGTCCAGGCAAAACCATGACTGATAACGATACCTTTCTGGCTTATTTAAGACAGGTATTTCAAATT
GCTGAAGAAGAGCCTGTCGCCTAA

Upstream 100 bases:

>100_bases
TGAGAGCAGTAAACCTACGATCAGCGACAAAGGTCTTATACAAATCACTGTGATTCTTGCTAAAAAAATATGGTTTAATG
CATAAAGCTTACTCGCATGT

Downstream 100 bases:

>100_bases
TCAATTTCTATTTTTCTGCTAAGGATGCATGAAAAATCAGAAAGAGAGTGAAAAGGCTTATGATAAAATCGTAGGTGCTA
AAAATTGAATGTGATTGGAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLSMSPIIHSLLDTDLYKFTMLQVVLHQFPQTHSVYHFRCRNLDETQYPLTDILDDLNEQLDHLCTLKFKDDELQYLRSF
RFIKSDFVDYLELFQLKRRFITAGIDEEGRLDIWVEGPMVQAMMFEIFVLAIVNELYFRRIRSDAVLEEGERRLQAKLAL
LEQYQTQHQSDEPPFLVSDFGTRRRYSFEWQKHVIAAFHHHFPNIFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVR
LRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGDKAYAHYRKLKIDTKTKMLTF
SDGLNLEKAWELHQYFKGRFKVSFGIGTNLTNDMGQTPLNIVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQI
AEEEPVA

Sequences:

>Translated_407_residues
MLSMSPIIHSLLDTDLYKFTMLQVVLHQFPQTHSVYHFRCRNLDETQYPLTDILDDLNEQLDHLCTLKFKDDELQYLRSF
RFIKSDFVDYLELFQLKRRFITAGIDEEGRLDIWVEGPMVQAMMFEIFVLAIVNELYFRRIRSDAVLEEGERRLQAKLAL
LEQYQTQHQSDEPPFLVSDFGTRRRYSFEWQKHVIAAFHHHFPNIFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVR
LRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGDKAYAHYRKLKIDTKTKMLTF
SDGLNLEKAWELHQYFKGRFKVSFGIGTNLTNDMGQTPLNIVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQI
AEEEPVA
>Mature_407_residues
MLSMSPIIHSLLDTDLYKFTMLQVVLHQFPQTHSVYHFRCRNLDETQYPLTDILDDLNEQLDHLCTLKFKDDELQYLRSF
RFIKSDFVDYLELFQLKRRFITAGIDEEGRLDIWVEGPMVQAMMFEIFVLAIVNELYFRRIRSDAVLEEGERRLQAKLAL
LEQYQTQHQSDEPPFLVSDFGTRRRYSFEWQKHVIAAFHHHFPNIFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVR
LRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGDKAYAHYRKLKIDTKTKMLTF
SDGLNLEKAWELHQYFKGRFKVSFGIGTNLTNDMGQTPLNIVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQI
AEEEPVA

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=397, Percent_Identity=44.8362720403023, Blast_Score=330, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324783, Length=416, Percent_Identity=31.7307692307692, Blast_Score=194, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_ACIAD (Q6F6W1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_048026.1
- ProteinModelPortal:   Q6F6W1
- SMR:   Q6F6W1
- STRING:   Q6F6W1
- GeneID:   2879798
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3562
- NMPDR:   fig|62977.3.peg.3219
- eggNOG:   COG1488
- HOGENOM:   HBG325503
- OMA:   LYKFTML
- PhylomeDB:   Q6F6W1
- ProtClustDB:   PRK05321
- BioCyc:   ASP62977:ACIAD3562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 47577; Mature: 47577

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSMSPIIHSLLDTDLYKFTMLQVVLHQFPQTHSVYHFRCRNLDETQYPLTDILDDLNEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LDHLCTLKFKDDELQYLRSFRFIKSDFVDYLELFQLKRRFITAGIDEEGRLDIWVEGPMV
HHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHH
QAMMFEIFVLAIVNELYFRRIRSDAVLEEGERRLQAKLALLEQYQTQHQSDEPPFLVSDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
GTRRRYSFEWQKHVIAAFHHHFPNIFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVR
CCCCCCCHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KAYAHYRKLKIDTKTKMLTFSDGLNLEKAWELHQYFKGRFKVSFGIGTNLTNDMGQTPLN
HHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHH
IVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQIAEEEPVA
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLSMSPIIHSLLDTDLYKFTMLQVVLHQFPQTHSVYHFRCRNLDETQYPLTDILDDLNEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
LDHLCTLKFKDDELQYLRSFRFIKSDFVDYLELFQLKRRFITAGIDEEGRLDIWVEGPMV
HHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHH
QAMMFEIFVLAIVNELYFRRIRSDAVLEEGERRLQAKLALLEQYQTQHQSDEPPFLVSDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
GTRRRYSFEWQKHVIAAFHHHFPNIFRGTSNVLLAKELNITPIGTMAHEFLQAFQALDVR
CCCCCCCHHHHHHHHHHHHHHCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LRDFQKAALETWVQEYRGDLGIALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYEWGD
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KAYAHYRKLKIDTKTKMLTFSDGLNLEKAWELHQYFKGRFKVSFGIGTNLTNDMGQTPLN
HHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHH
IVLKLVECNGQSVAKISDSPGKTMTDNDTFLAYLRQVFQIAEEEPVA
HHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA