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The map label for this gene is phoR [H]

Identifier: 50086512

GI number: 50086512

Start: 3483248

End: 3484612

Strand: Direct

Name: phoR [H]

Synonym: ACIAD3558

Alternate gene names: 50086512

Gene position: 3483248-3484612 (Clockwise)

Preceding gene: 50086511

Following gene: 50086513

Centisome position: 96.79

GC content: 41.83

Gene sequence:

>1365_bases
TTGACTATGTATGAACCCTATCCTGTACCCGAACTGGCACGTGAGCATAAACGCTTTCGTTATAGCAGTTTGTGGACTTT
TGCCAAACAGGACTTACGTTTACTGGCATTTCTTCTGTTGGTTGCGACTTGTATTGGATTAGGCGTGGGTTACTTCTGGG
CAAGTATTTTTATTGCCTTTCTTATTTTCTTTGGTTTCCAGCTCAGATCACTCTATATGGTGAATGAATGGATTTCGAAT
CGCCCTTATGACACACCTCCCAATCTCAACGGAATCTGGGGGGCTTTATTGTTTAATGTCTATCGTGCTCAACGTCAGGA
ACGTATTGTTCAGGCTGAAATGGTTGGATTAATTGATCGGGCACAATCATCATTGGTGGCACTTAATGAAGCCGTGGTAC
TGATTGATGATTTGCATCAAATTGAATGGTGCAACCCTGCTGCTGAAAATCTGTTAGGTATCAGGGTCTTTGACCGCGGG
CATAACATTTTGAGTATTTTAAGACAGCCCAAATTTATCGAATATTTTAATCATATCGATCAGGCACCAGACGGCATTAA
AATTAAATCATCTATTTTTGATGACCATTATGTCCAGATCAAACTGACCCGTTTTGGCGAACAGAGCCGTTTGCTGGTGG
CGTATGATGTAACACGAGTGCATAATCTTGAACAAATGCGTAAAGATTTTGTCGACAATATTTCACATGAACTGCGTACC
CCACTCACGGTACTGAGTGGTTATATCGAGACTTTTACTGATCAGGAAGATCTCAATCCGCGCTGGAAACGTGCCTTTGA
CCAAATGCAATCTCAAACCAAACGCATGAATGCTTTGGTAAATGATTTACTGCTTTTGTCCAATCTTGAAAACAACAAAA
CCATCGCCAAAAATCAGATCATTGAAATGCCAAGTCTGATGAATCAGCTCTTTGACGATGCGCAAGCCTATAATGCAGAT
TATGGTCATACCTTAAATCTGGATATTGATAGTCACTGTGACCTGATCGGCTCAGACACTGAAATTGCCAGTGCGTTTAG
CAACCTCATTACCAATGCCATCAAATATACACCCAAGGGCGGTATCATAACGATTGGCTGGCATGATGATGGTGTGCATG
GCTATTTTACCGTACAAGATAATGGTATTGGTATTGACCCTAAACATTTACCTCGTTTGACTGAACGCTTCTACCGCGTG
GACAGCGCACGTAGTCGTGCTACAGGTGGAACAGGACTTGGGCTGGCCATTGTTAAACACGTCCTCATGCAGCATGGTGC
CTATCTGGATGTTATTTCTAAAGAAAATGAAGGTTCAATTTTTAAGGCAGTTTTTCCAAAAGAACGTTTGTACCAGATGA
TGTAA

Upstream 100 bases:

>100_bases
TAAAGTTTTAGAACCTTTTGGCGCCGACCGTTTTGTACAAACCGTTCGTGGCACAGGTTACCGTTTTTCTACCCGAGCAG
ATTTAGCAGCAGGCTAACCC

Downstream 100 bases:

>100_bases
ATATCTCAGGTTGTACAAATCCACGTGTAAAGGTAGATCGATTGATTTAAATTTCACTTTAGTATTTTGATCTATAAAAA
ACGATATGTATGTCGTGTGA

Product: two-component sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTMYEPYPVPELAREHKRFRYSSLWTFAKQDLRLLAFLLLVATCIGLGVGYFWASIFIAFLIFFGFQLRSLYMVNEWISN
RPYDTPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDRAQSSLVALNEAVVLIDDLHQIEWCNPAAENLLGIRVFDRG
HNILSILRQPKFIEYFNHIDQAPDGIKIKSSIFDDHYVQIKLTRFGEQSRLLVAYDVTRVHNLEQMRKDFVDNISHELRT
PLTVLSGYIETFTDQEDLNPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKTIAKNQIIEMPSLMNQLFDDAQAYNAD
YGHTLNLDIDSHCDLIGSDTEIASAFSNLITNAIKYTPKGGIITIGWHDDGVHGYFTVQDNGIGIDPKHLPRLTERFYRV
DSARSRATGGTGLGLAIVKHVLMQHGAYLDVISKENEGSIFKAVFPKERLYQMM

Sequences:

>Translated_454_residues
MTMYEPYPVPELAREHKRFRYSSLWTFAKQDLRLLAFLLLVATCIGLGVGYFWASIFIAFLIFFGFQLRSLYMVNEWISN
RPYDTPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDRAQSSLVALNEAVVLIDDLHQIEWCNPAAENLLGIRVFDRG
HNILSILRQPKFIEYFNHIDQAPDGIKIKSSIFDDHYVQIKLTRFGEQSRLLVAYDVTRVHNLEQMRKDFVDNISHELRT
PLTVLSGYIETFTDQEDLNPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKTIAKNQIIEMPSLMNQLFDDAQAYNAD
YGHTLNLDIDSHCDLIGSDTEIASAFSNLITNAIKYTPKGGIITIGWHDDGVHGYFTVQDNGIGIDPKHLPRLTERFYRV
DSARSRATGGTGLGLAIVKHVLMQHGAYLDVISKENEGSIFKAVFPKERLYQMM
>Mature_453_residues
TMYEPYPVPELAREHKRFRYSSLWTFAKQDLRLLAFLLLVATCIGLGVGYFWASIFIAFLIFFGFQLRSLYMVNEWISNR
PYDTPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDRAQSSLVALNEAVVLIDDLHQIEWCNPAAENLLGIRVFDRGH
NILSILRQPKFIEYFNHIDQAPDGIKIKSSIFDDHYVQIKLTRFGEQSRLLVAYDVTRVHNLEQMRKDFVDNISHELRTP
LTVLSGYIETFTDQEDLNPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKTIAKNQIIEMPSLMNQLFDDAQAYNADY
GHTLNLDIDSHCDLIGSDTEIASAFSNLITNAIKYTPKGGIITIGWHDDGVHGYFTVQDNGIGIDPKHLPRLTERFYRVD
SARSRATGGTGLGLAIVKHVLMQHGAYLDVISKENEGSIFKAVFPKERLYQMM

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=414, Percent_Identity=37.43961352657, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=30.7086614173228, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=30.3030303030303, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=29.6943231441048, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790346, Length=215, Percent_Identity=28.8372093023256, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=28.4444444444444, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789403, Length=226, Percent_Identity=30.0884955752212, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=26.1904761904762, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1787894, Length=239, Percent_Identity=27.1966527196653, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=27.906976744186, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1790861, Length=234, Percent_Identity=29.4871794871795, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=24.6913580246914, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1789808, Length=228, Percent_Identity=25.4385964912281, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=234, Percent_Identity=23.0769230769231, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=23.2456140350877, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790551, Length=229, Percent_Identity=28.82096069869, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=24.4635193133047, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=21.8181818181818, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52074; Mature: 51943

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMYEPYPVPELAREHKRFRYSSLWTFAKQDLRLLAFLLLVATCIGLGVGYFWASIFIAF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFFGFQLRSLYMVNEWISNRPYDTPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSSLVALNEAVVLIDDLHQIEWCNPAAENLLGIRVFDRGHNILSILRQPKFIEYFNHID
HHHHHHHHHHHEEEEHHHHHHHCCCHHHHCEEEEEEECCCHHHHHHHHCCHHHHHHHHHH
QAPDGIKIKSSIFDDHYVQIKLTRFGEQSRLLVAYDVTRVHNLEQMRKDFVDNISHELRT
CCCCCCEEEHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHC
PLTVLSGYIETFTDQEDLNPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKTIAKNQI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEMPSLMNQLFDDAQAYNADYGHTLNLDIDSHCDLIGSDTEIASAFSNLITNAIKYTPKG
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GIITIGWHDDGVHGYFTVQDNGIGIDPKHLPRLTERFYRVDSARSRATGGTGLGLAIVKH
CEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VLMQHGAYLDVISKENEGSIFKAVFPKERLYQMM
HHHHCCCEEEEECCCCCCCEEEECCCHHHHHHCC
>Mature Secondary Structure 
TMYEPYPVPELAREHKRFRYSSLWTFAKQDLRLLAFLLLVATCIGLGVGYFWASIFIAF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIFFGFQLRSLYMVNEWISNRPYDTPPNLNGIWGALLFNVYRAQRQERIVQAEMVGLIDR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSSLVALNEAVVLIDDLHQIEWCNPAAENLLGIRVFDRGHNILSILRQPKFIEYFNHID
HHHHHHHHHHHEEEEHHHHHHHCCCHHHHCEEEEEEECCCHHHHHHHHCCHHHHHHHHHH
QAPDGIKIKSSIFDDHYVQIKLTRFGEQSRLLVAYDVTRVHNLEQMRKDFVDNISHELRT
CCCCCCEEEHHHCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHC
PLTVLSGYIETFTDQEDLNPRWKRAFDQMQSQTKRMNALVNDLLLLSNLENNKTIAKNQI
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IEMPSLMNQLFDDAQAYNADYGHTLNLDIDSHCDLIGSDTEIASAFSNLITNAIKYTPKG
HHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
GIITIGWHDDGVHGYFTVQDNGIGIDPKHLPRLTERFYRVDSARSRATGGTGLGLAIVKH
CEEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VLMQHGAYLDVISKENEGSIFKAVFPKERLYQMM
HHHHCCCEEEEECCCCCCCEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043; 2115874 [H]