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The map label for this gene is gabP [H]

Identifier: 50086412

GI number: 50086412

Start: 3369317

End: 3370756

Strand: Reverse

Name: gabP [H]

Synonym: ACIAD3448

Alternate gene names: 50086412

Gene position: 3370756-3369317 (Counterclockwise)

Preceding gene: 50086413

Following gene: 50086410

Centisome position: 93.67

GC content: 44.93

Gene sequence:

>1440_bases
ATGGCAGCGCCCAAGAACGTGTCTGAATCTGGCCATTCCGAAGGTTTAAAAAGTGGTCTTCAATCTCGTCACCTCACCAT
GATTTCAATTGCTGGTGTCATTGGTGGTGCATTATTTGTGGGTTCGGGAAGTGTAATTTATTCTGCAGGTCCTGCGGCGA
TATTGGCCTATACACTGGGCGGTTTGCTGGTCTTGCTGATCATGCGCATGTTAGGTGAAATGGCAGTAATGAACCCAGAT
AGTGGTTCATTCTCCACGTATGCAGATCGTGCCATTGGCCGCTGGGCTGGTTTCAGTATCGGCTGGTTATATTGGTGTTT
CTGGACGTTGTTGATGGGCTGGGAAGCCTACGTCGCTGGTAAAATTCTCAATAGCTGGTTCCCGTTTATTCCGATCTGGG
GCTATATGCTGTTGGTGATTGTAGGATTGGTGTGGGTCAATCTACAAGATGTTAAAAACTATGGTGAGTTTGAATTCTGG
TTTGCCTTGATCAAAGTGGTTGCCATCGTCATGTTTCTGGTAGTGGGCAGTTTGGCAATCATGCATTTATGGCCTTGGGG
TGATCCTAGCGCAGCTGGATTTACCAATCTTACCGCACAGGGTTTTATGCCAGGCGGATTCTCCTCTGTGATCACGGCGT
TGCTGGGTGTCATGTTTGCCTACATGGGTGCTGAAATTGTCACAGTTGCGGCTGCCGAGTCGAAAGATCCAGCAAAAGAA
ATTCGTAAGGCGTCCAACTCGATTGTATGGCGTATCATTCTGTTTTATGTGGGTTCCATGTTTATTACGGTTTGTTTGAT
TCCGCATAACAATCCATTGCTTAAAGATCCAACTTGGGGAACCTACAGTGTGACCTTGTCTACCTTGGGTATTCCAGAAG
CTCGCCATATTGTGAACTTTGTCGTTTTAACCTCTGTGTGTAGCTGCTTTAACTCGGCGTTATATACCTGTTCACGTATG
ATGTTCTCGTTGTCTAAGCGTGGCGATGCACCGAAGATATTTGCCAAAACCAATCGCAACAGTAGTCCTTGGGCTGGTGT
TATTTTCTCAAGTATTTTTTCGATTGTTGCCGTGTATTTAACGGCTACAGAAAGTATGAATGTCTATGATGTACTGATGC
TGGCAACAGGTACAGTTGCACTGTATGTTTATCTGGCAGTTGCGTTTTCACAGCTTCGGATGCGTAAGAAGATTGAAGCA
GAAGGTAAAGCCGTTGATTTTAAAATGTGGTTATTTCCTTGGCTGACCTATGCCGTGATTATCACGATCATTGGTGCAAT
CATTACCATGCTGATTGAAGGCACTTACTTTAAGGAAGTAACCTATACTACTGGCCTGGCCCTGGTGATTGTGATTTTAG
GTATCTTGACGCATAAGTTTAACTGGGGAAAAGATGCCCGTGAGAAAATGCTAGAGCAAAGCAAGAAATCGATGACTTAA

Upstream 100 bases:

>100_bases
ATGAAGCAGACCAAGCGAATTGAAAAAATTTAAGAGGAGAGCGAGCTCGCAAAGTCATGTTTTGCCAGCCTCTGCTCTTG
ATGTATTAAGGAAAATATTT

Downstream 100 bases:

>100_bases
GCATTAGAATTTAAAAAAGAACCTCATAAGAGGTTCTTTTTTTATGGGAAAAAATCTGGCACACAGGCTTTAACTACGTG
TTTGGACGTTGGCTTCTCGT

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MAAPKNVSESGHSEGLKSGLQSRHLTMISIAGVIGGALFVGSGSVIYSAGPAAILAYTLGGLLVLLIMRMLGEMAVMNPD
SGSFSTYADRAIGRWAGFSIGWLYWCFWTLLMGWEAYVAGKILNSWFPFIPIWGYMLLVIVGLVWVNLQDVKNYGEFEFW
FALIKVVAIVMFLVVGSLAIMHLWPWGDPSAAGFTNLTAQGFMPGGFSSVITALLGVMFAYMGAEIVTVAAAESKDPAKE
IRKASNSIVWRIILFYVGSMFITVCLIPHNNPLLKDPTWGTYSVTLSTLGIPEARHIVNFVVLTSVCSCFNSALYTCSRM
MFSLSKRGDAPKIFAKTNRNSSPWAGVIFSSIFSIVAVYLTATESMNVYDVLMLATGTVALYVYLAVAFSQLRMRKKIEA
EGKAVDFKMWLFPWLTYAVIITIIGAIITMLIEGTYFKEVTYTTGLALVIVILGILTHKFNWGKDAREKMLEQSKKSMT

Sequences:

>Translated_479_residues
MAAPKNVSESGHSEGLKSGLQSRHLTMISIAGVIGGALFVGSGSVIYSAGPAAILAYTLGGLLVLLIMRMLGEMAVMNPD
SGSFSTYADRAIGRWAGFSIGWLYWCFWTLLMGWEAYVAGKILNSWFPFIPIWGYMLLVIVGLVWVNLQDVKNYGEFEFW
FALIKVVAIVMFLVVGSLAIMHLWPWGDPSAAGFTNLTAQGFMPGGFSSVITALLGVMFAYMGAEIVTVAAAESKDPAKE
IRKASNSIVWRIILFYVGSMFITVCLIPHNNPLLKDPTWGTYSVTLSTLGIPEARHIVNFVVLTSVCSCFNSALYTCSRM
MFSLSKRGDAPKIFAKTNRNSSPWAGVIFSSIFSIVAVYLTATESMNVYDVLMLATGTVALYVYLAVAFSQLRMRKKIEA
EGKAVDFKMWLFPWLTYAVIITIIGAIITMLIEGTYFKEVTYTTGLALVIVILGILTHKFNWGKDAREKMLEQSKKSMT
>Mature_478_residues
AAPKNVSESGHSEGLKSGLQSRHLTMISIAGVIGGALFVGSGSVIYSAGPAAILAYTLGGLLVLLIMRMLGEMAVMNPDS
GSFSTYADRAIGRWAGFSIGWLYWCFWTLLMGWEAYVAGKILNSWFPFIPIWGYMLLVIVGLVWVNLQDVKNYGEFEFWF
ALIKVVAIVMFLVVGSLAIMHLWPWGDPSAAGFTNLTAQGFMPGGFSSVITALLGVMFAYMGAEIVTVAAAESKDPAKEI
RKASNSIVWRIILFYVGSMFITVCLIPHNNPLLKDPTWGTYSVTLSTLGIPEARHIVNFVVLTSVCSCFNSALYTCSRMM
FSLSKRGDAPKIFAKTNRNSSPWAGVIFSSIFSIVAVYLTATESMNVYDVLMLATGTVALYVYLAVAFSQLRMRKKIEAE
GKAVDFKMWLFPWLTYAVIITIIGAIITMLIEGTYFKEVTYTTGLALVIVILGILTHKFNWGKDAREKMLEQSKKSMT

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=444, Percent_Identity=51.1261261261261, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI1786302, Length=422, Percent_Identity=33.8862559241706, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI87081708, Length=411, Percent_Identity=33.5766423357664, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788480, Length=419, Percent_Identity=35.0835322195704, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=33.2613390928726, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1786789, Length=451, Percent_Identity=33.0376940133038, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081915, Length=458, Percent_Identity=35.589519650655, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1786602, Length=398, Percent_Identity=37.6884422110553, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1790653, Length=409, Percent_Identity=34.4743276283619, Blast_Score=228, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17532491, Length=429, Percent_Identity=23.7762237762238, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=31.0502283105023, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324061, Length=437, Percent_Identity=29.7482837528604, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=32.258064516129, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=433, Percent_Identity=29.0993071593533, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324924, Length=460, Percent_Identity=30.4347826086957, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321053, Length=498, Percent_Identity=26.1044176706827, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6320717, Length=441, Percent_Identity=27.2108843537415, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319824, Length=488, Percent_Identity=26.2295081967213, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=472, Percent_Identity=28.6016949152542, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321629, Length=416, Percent_Identity=25, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=408, Percent_Identity=27.9411764705882, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=408, Percent_Identity=27.9411764705882, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=407, Percent_Identity=29.4840294840295, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319543, Length=470, Percent_Identity=25.9574468085106, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=418, Percent_Identity=25.5980861244019, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=498, Percent_Identity=25.3012048192771, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=480, Percent_Identity=25, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=486, Percent_Identity=23.2510288065844, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221512776, Length=434, Percent_Identity=20.7373271889401, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666159, Length=434, Percent_Identity=20.7373271889401, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52654; Mature: 52523

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPKNVSESGHSEGLKSGLQSRHLTMISIAGVIGGALFVGSGSVIYSAGPAAILAYTLG
CCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEECCHHHHHHHHHH
GLLVLLIMRMLGEMAVMNPDSGSFSTYADRAIGRWAGFSIGWLYWCFWTLLMGWEAYVAG
HHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KILNSWFPFIPIWGYMLLVIVGLVWVNLQDVKNYGEFEFWFALIKVVAIVMFLVVGSLAI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MHLWPWGDPSAAGFTNLTAQGFMPGGFSSVITALLGVMFAYMGAEIVTVAAAESKDPAKE
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHH
IRKASNSIVWRIILFYVGSMFITVCLIPHNNPLLKDPTWGTYSVTLSTLGIPEARHIVNF
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHH
VVLTSVCSCFNSALYTCSRMMFSLSKRGDAPKIFAKTNRNSSPWAGVIFSSIFSIVAVYL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TATESMNVYDVLMLATGTVALYVYLAVAFSQLRMRKKIEAEGKAVDFKMWLFPWLTYAVI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
ITIIGAIITMLIEGTYFKEVTYTTGLALVIVILGILTHKFNWGKDAREKMLEQSKKSMT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAPKNVSESGHSEGLKSGLQSRHLTMISIAGVIGGALFVGSGSVIYSAGPAAILAYTLG
CCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEECCHHHHHHHHHH
GLLVLLIMRMLGEMAVMNPDSGSFSTYADRAIGRWAGFSIGWLYWCFWTLLMGWEAYVAG
HHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
KILNSWFPFIPIWGYMLLVIVGLVWVNLQDVKNYGEFEFWFALIKVVAIVMFLVVGSLAI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MHLWPWGDPSAAGFTNLTAQGFMPGGFSSVITALLGVMFAYMGAEIVTVAAAESKDPAKE
HHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCCHHHH
IRKASNSIVWRIILFYVGSMFITVCLIPHNNPLLKDPTWGTYSVTLSTLGIPEARHIVNF
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEEEEEEECCCCHHHHHHHH
VVLTSVCSCFNSALYTCSRMMFSLSKRGDAPKIFAKTNRNSSPWAGVIFSSIFSIVAVYL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
TATESMNVYDVLMLATGTVALYVYLAVAFSQLRMRKKIEAEGKAVDFKMWLFPWLTYAVI
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHH
ITIIGAIITMLIEGTYFKEVTYTTGLALVIVILGILTHKFNWGKDAREKMLEQSKKSMT
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]