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The map label for this gene is gabT [H]

Identifier: 50086410

GI number: 50086410

Start: 3366309

End: 3367595

Strand: Reverse

Name: gabT [H]

Synonym: ACIAD3446

Alternate gene names: 50086410

Gene position: 3367595-3366309 (Counterclockwise)

Preceding gene: 50086412

Following gene: 50086409

Centisome position: 93.58

GC content: 47.4

Gene sequence:

>1287_bases
ATGGACACTAAACATTCTGCACTTAATCAGCGTAAACAACAAGCAACGCCACGTGGCGTGGGCGTAATGTGCCAGTGGTA
CGCAGATAAAGCCGAAAATGCAACAATTTGGGACGCAGAAGGGAATACCTATATCGATTTCGCAGGTGGTATTGCAGTTT
TAAATACAGGTCATCGTCATCCAAAAGTATTGGCGGCGGTGAAAGCACAACTTGAACGATTTACCCACACTGCTTATCAG
GTCACACCTTACGAGAGCTATGTGGCATTGGCTGAACGCATCAATGAGTTGGCGCCGATTGCAGGCCCGGCAAAAACCAC
ATTCTTTACCACGGGTGCGGAAGCGGTTGAAAATGCCGTTAAGATTGCACGTTGTTATACAGGTCGCCAGGGGATTATTA
CGTTTGGTAATGGTTTCCACGGTCGTTCATTCATGACCATGGCTATGACAGGTAAAACAGCACCTTACAAACGCGATTTC
GGTTTAATGCCTGGTGGCGTATTCCACGCACGTTATCCTGTAGAGTCTCGTGGCATTAGCGTCGATGATGCGCTTGAAAG
CATTGAAAATATCTTTAGTGAAGATGTTGCACCGCATGATGTGGCTGCAATTGTACTTGAGCCAGTTCAGGGCGAAGGTG
GTTTCAATGTGGTTCCAGCAGATTTCCTCAAACGCCTACGTGCTTTATGTGACAAACATGGCATCTTATTGGTTGCAGAT
GAAGTGCAGACTGGCTTTGCTCGTACAGGCAAACTGTATGCCATGGACCATTATGAAACCAAAGCAGATTTAATTACCAT
GGCCAAAAGCCTGGGTGGCGGTTTCCCAATTTCAGGTGTGGTGGGTCGTGCCGAGGTGATGGATGCGCCAAACCCAGGTG
GTTTGGGAGGTACATATGCAGGTAACCCAGTTGCCGTTGCCGCAGCCCATGCCGTGATTGATGCGATTCAGGAAGAAAAA
TTGTGTGAACGTGCCAATGAGCTTGGTGCTGAACTGGTACACGTATTGAAAGGCCTGCAACAATCGACCGATCAGGTGAT
TACGGATATTCGCGCCTTGGGTTCGATGGTTGCTGCCGAGTTTGAAACTGCCGAGCAAGCAAAAGCTGTTCAAAACTATG
CGATGCAAAACGGATTGTTATTATTGACCTGTGGTAAATATGGCAATGTCATTCGTTTCTTGTATCCATTAACGATTCCT
GTTGAGCAGTTCCGTTCTGGTCTGGACATTTTAAAACAAGGCGTAGCCAGCCTTGCAACAGATCACACCACACAGGCAAT
TGGGTAA

Upstream 100 bases:

>100_bases
GCGAAATTACAGACATAGACAGCTATTGTAAAGCATTCTGAAATTTATAGCGGGAATGTATCGACCAAAGCTGTAACGAA
TAACACAAGAGGAAAGATAA

Downstream 100 bases:

>100_bases
GTCATATGATTCAGGAAAGTTTACAGTATTTACTCAAGCATCCTGATATTTCATTTACAGCACCAACATCTGGTGCTGTG
ATTGAAGTGAATGATGCAGC

Product: 4-aminobutyrate aminotransferase, PLP-dependent

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDTKHSALNQRKQQATPRGVGVMCQWYADKAENATIWDAEGNTYIDFAGGIAVLNTGHRHPKVLAAVKAQLERFTHTAYQ
VTPYESYVALAERINELAPIAGPAKTTFFTTGAEAVENAVKIARCYTGRQGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GLMPGGVFHARYPVESRGISVDDALESIENIFSEDVAPHDVAAIVLEPVQGEGGFNVVPADFLKRLRALCDKHGILLVAD
EVQTGFARTGKLYAMDHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGNPVAVAAAHAVIDAIQEEK
LCERANELGAELVHVLKGLQQSTDQVITDIRALGSMVAAEFETAEQAKAVQNYAMQNGLLLLTCGKYGNVIRFLYPLTIP
VEQFRSGLDILKQGVASLATDHTTQAIG

Sequences:

>Translated_428_residues
MDTKHSALNQRKQQATPRGVGVMCQWYADKAENATIWDAEGNTYIDFAGGIAVLNTGHRHPKVLAAVKAQLERFTHTAYQ
VTPYESYVALAERINELAPIAGPAKTTFFTTGAEAVENAVKIARCYTGRQGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GLMPGGVFHARYPVESRGISVDDALESIENIFSEDVAPHDVAAIVLEPVQGEGGFNVVPADFLKRLRALCDKHGILLVAD
EVQTGFARTGKLYAMDHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGNPVAVAAAHAVIDAIQEEK
LCERANELGAELVHVLKGLQQSTDQVITDIRALGSMVAAEFETAEQAKAVQNYAMQNGLLLLTCGKYGNVIRFLYPLTIP
VEQFRSGLDILKQGVASLATDHTTQAIG
>Mature_428_residues
MDTKHSALNQRKQQATPRGVGVMCQWYADKAENATIWDAEGNTYIDFAGGIAVLNTGHRHPKVLAAVKAQLERFTHTAYQ
VTPYESYVALAERINELAPIAGPAKTTFFTTGAEAVENAVKIARCYTGRQGIITFGNGFHGRSFMTMAMTGKTAPYKRDF
GLMPGGVFHARYPVESRGISVDDALESIENIFSEDVAPHDVAAIVLEPVQGEGGFNVVPADFLKRLRALCDKHGILLVAD
EVQTGFARTGKLYAMDHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYAGNPVAVAAAHAVIDAIQEEK
LCERANELGAELVHVLKGLQQSTDQVITDIRALGSMVAAEFETAEQAKAVQNYAMQNGLLLLTCGKYGNVIRFLYPLTIP
VEQFRSGLDILKQGVASLATDHTTQAIG

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=406, Percent_Identity=31.2807881773399, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI13994255, Length=357, Percent_Identity=32.7731092436975, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=33.0218068535826, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=28.0575539568345, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=27.4271844660194, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=28.4615384615385, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226442705, Length=417, Percent_Identity=27.8177458033573, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI188536080, Length=401, Percent_Identity=27.6807980049875, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=401, Percent_Identity=27.6807980049875, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=401, Percent_Identity=27.6807980049875, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=61.9047619047619, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1789016, Length=414, Percent_Identity=53.6231884057971, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=36.4795918367347, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=35.7682619647355, Blast_Score=218, Evalue=7e-58,
Organism=Escherichia coli, GI145693181, Length=402, Percent_Identity=31.592039800995, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1786349, Length=353, Percent_Identity=32.0113314447592, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786991, Length=393, Percent_Identity=28.498727735369, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=31.6953316953317, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=458, Percent_Identity=31.0043668122271, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=29.7727272727273, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=31.864406779661, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=422, Percent_Identity=25.8293838862559, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71981843, Length=150, Percent_Identity=29.3333333333333, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=33.7408312958435, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=30.5970149253731, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321456, Length=403, Percent_Identity=25.3101736972705, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=346, Percent_Identity=23.9884393063584, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=33.6633663366337, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI28574759, Length=411, Percent_Identity=31.3868613138686, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI161085790, Length=413, Percent_Identity=31.2348668280872, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=28.4037558685446, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281366494, Length=453, Percent_Identity=25.8278145695364, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667139, Length=453, Percent_Identity=25.8278145695364, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667143, Length=453, Percent_Identity=25.8278145695364, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45947; Mature: 45947

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTKHSALNQRKQQATPRGVGVMCQWYADKAENATIWDAEGNTYIDFAGGIAVLNTGHRH
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCEEEECCCCCC
PKVLAAVKAQLERFTHTAYQVTPYESYVALAERINELAPIAGPAKTTFFTTGAEAVENAV
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
KIARCYTGRQGIITFGNGFHGRSFMTMAMTGKTAPYKRDFGLMPGGVFHARYPVESRGIS
HHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCC
VDDALESIENIFSEDVAPHDVAAIVLEPVQGEGGFNVVPADFLKRLRALCDKHGILLVAD
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
EVQTGFARTGKLYAMDHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYA
CHHCCHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GNPVAVAAAHAVIDAIQEEKLCERANELGAELVHVLKGLQQSTDQVITDIRALGSMVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FETAEQAKAVQNYAMQNGLLLLTCGKYGNVIRFLYPLTIPVEQFRSGLDILKQGVASLAT
HHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
DHTTQAIG
CCHHHCCC
>Mature Secondary Structure
MDTKHSALNQRKQQATPRGVGVMCQWYADKAENATIWDAEGNTYIDFAGGIAVLNTGHRH
CCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCEEEEECCCEEEECCCCCC
PKVLAAVKAQLERFTHTAYQVTPYESYVALAERINELAPIAGPAKTTFFTTGAEAVENAV
HHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHH
KIARCYTGRQGIITFGNGFHGRSFMTMAMTGKTAPYKRDFGLMPGGVFHARYPVESRGIS
HHHHHHCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCC
VDDALESIENIFSEDVAPHDVAAIVLEPVQGEGGFNVVPADFLKRLRALCDKHGILLVAD
HHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
EVQTGFARTGKLYAMDHYETKADLITMAKSLGGGFPISGVVGRAEVMDAPNPGGLGGTYA
CHHCCHHHCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCC
GNPVAVAAAHAVIDAIQEEKLCERANELGAELVHVLKGLQQSTDQVITDIRALGSMVAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FETAEQAKAVQNYAMQNGLLLLTCGKYGNVIRFLYPLTIPVEQFRSGLDILKQGVASLAT
HHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
DHTTQAIG
CCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]