Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 50086363

GI number: 50086363

Start: 3302651

End: 3304108

Strand: Direct

Name: envZ [H]

Synonym: ACIAD3389

Alternate gene names: 50086363

Gene position: 3302651-3304108 (Clockwise)

Preceding gene: 50086362

Following gene: 50086364

Centisome position: 91.78

GC content: 44.92

Gene sequence:

>1458_bases
GTGAAGTTAGATCCCGTCGATTTACAGGCGTATACCGATTTTGTCGCTTACTCAGAACGTAAGCGAACACGTTGGGAACG
TTTTCTAGATAAAATCAAGCCCCGCTCAGCAGCCATGCGTACTACGGTGCTGGTGGGTTTTGTGGTTTTATTTAGCTTAT
CGATGTCGTTATGGTTTTTCTGGCGCACACTTTACCTCCCTGAAATTCAACAACATGCGCGTTATTTGGCGGTCGAATTA
GAGCTGGTCAATAACCCTGATATTCGGATTTTTCATCGCGATAAAGAAGTCGATGTAGACACATGGCTGAAAAATCGCGT
CGGAATCGAATACGTCACCAATCCGAAAGAATATCCCAATGTTCGTGACAAAGTGATTGCGGATTTTTTTACTGATCATG
TCCAAGCCAAACTGGCCAATGAGCTGAAAGTAGAAGATGTGACCGTCTATTTTCAGTTTAAGCCAAGCCCTCGAATCTGG
ATTCAAACCCCAGAAATGCATGGCAATTGGGTGCGTGAGCCGCTCAAAACTTATGCCAACTATAGCCCTGAACTGGTTTT
CGGCTGGTTGCTTGGGGTGCCGATCATTGCATCCATTATTATTTTAACGCTGGTGCGCCAGTTGAATCGCCCACTTCGTC
GTCTTCAAAATGCAGCCAATGCTTATAGTAAAACAGGCAAAGCACCATATTTGGGAACAAATCACGGCCCGCTTGAAATC
CGTCAGGTCAATCAAGCGTTTAATCACATGATTTATACGCTTGAGCAAACCGAACGTGATCGTCAGATCATGCTGGCGGG
TATTTCGCACGATTTGCGCACGCCGCTTACACGTATCCGTCTTACCGCAGAGATGTTACCCGACGAATTTTTACGTGAAG
GACTGGTTTATGATGTGGATGATATGGATGCCATATTGAATCAGTTTATTTCGTATATGCGCGATGGCTCCGACGAAGAA
CTGCGCGACACCAATATTAATATTTTGCTGCAAGAATTGGTGGTTCAGTTTAAACCACTCGAGATTCACTTCGAAGCACA
AGATGTTCCGATTATTCCAGCACGCAGCTTGTCGCTTAAGCGCCTGATTGCCAATCTGATTAACAATGCCAAACGCTACG
GTGCAGAGCCAATTGAGCTGACCGCACAGGTTGAAGGAGATCATATTCTGATTATTGTCGCCGACCACGGCGAAGGTATT
CCAGAAGATCAGATCGAAGAATTGATGCAGCCCTTTGTCCGCGGTAATTCAGCGCGAACGATTCAAGGAAGTGGACTGGG
TCTTGCGATTGTCAAACGTATTGTTGATATTCACCAAGGTGAATTACTCATCCATAATCGTGAAGGTGGTGGGCTTGAGG
CCAGAATTTTATTACCGTTACCTAAACATATGACGCCAGATGCGCCACATCCAAACCCAATTGAAAAAATAAAACAAAGT
TTAACCGAACGTTTTTAA

Upstream 100 bases:

>100_bases
AGATAATCCAGCACGTGCTCGTTATATTCAAACTGTGTGGGGAATTGGCTACGTGTTTGTTCCAGATGGTGCAGAATAAT
AAGTGCCCTAGGATAATCGT

Downstream 100 bases:

>100_bases
TTACAAACGATCAAAATTTAAACATTTAATTCATGGTAAAAATCATTTCATTTAAATTTATACCTTTAATTTCAAAGCGA
TAATTATCATCAATAAATTT

Product: sensory histidine kinase in two-component regulatory system with OmpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKLDPVDLQAYTDFVAYSERKRTRWERFLDKIKPRSAAMRTTVLVGFVVLFSLSMSLWFFWRTLYLPEIQQHARYLAVEL
ELVNNPDIRIFHRDKEVDVDTWLKNRVGIEYVTNPKEYPNVRDKVIADFFTDHVQAKLANELKVEDVTVYFQFKPSPRIW
IQTPEMHGNWVREPLKTYANYSPELVFGWLLGVPIIASIIILTLVRQLNRPLRRLQNAANAYSKTGKAPYLGTNHGPLEI
RQVNQAFNHMIYTLEQTERDRQIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEE
LRDTNINILLQELVVQFKPLEIHFEAQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELTAQVEGDHILIIVADHGEGI
PEDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGELLIHNREGGGLEARILLPLPKHMTPDAPHPNPIEKIKQS
LTERF

Sequences:

>Translated_485_residues
MKLDPVDLQAYTDFVAYSERKRTRWERFLDKIKPRSAAMRTTVLVGFVVLFSLSMSLWFFWRTLYLPEIQQHARYLAVEL
ELVNNPDIRIFHRDKEVDVDTWLKNRVGIEYVTNPKEYPNVRDKVIADFFTDHVQAKLANELKVEDVTVYFQFKPSPRIW
IQTPEMHGNWVREPLKTYANYSPELVFGWLLGVPIIASIIILTLVRQLNRPLRRLQNAANAYSKTGKAPYLGTNHGPLEI
RQVNQAFNHMIYTLEQTERDRQIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEE
LRDTNINILLQELVVQFKPLEIHFEAQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELTAQVEGDHILIIVADHGEGI
PEDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGELLIHNREGGGLEARILLPLPKHMTPDAPHPNPIEKIKQS
LTERF
>Mature_485_residues
MKLDPVDLQAYTDFVAYSERKRTRWERFLDKIKPRSAAMRTTVLVGFVVLFSLSMSLWFFWRTLYLPEIQQHARYLAVEL
ELVNNPDIRIFHRDKEVDVDTWLKNRVGIEYVTNPKEYPNVRDKVIADFFTDHVQAKLANELKVEDVTVYFQFKPSPRIW
IQTPEMHGNWVREPLKTYANYSPELVFGWLLGVPIIASIIILTLVRQLNRPLRRLQNAANAYSKTGKAPYLGTNHGPLEI
RQVNQAFNHMIYTLEQTERDRQIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEE
LRDTNINILLQELVVQFKPLEIHFEAQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELTAQVEGDHILIIVADHGEGI
PEDQIEELMQPFVRGNSARTIQGSGLGLAIVKRIVDIHQGELLIHNREGGGLEARILLPLPKHMTPDAPHPNPIEKIKQS
LTERF

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=444, Percent_Identity=34.4594594594595, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=30, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87082128, Length=302, Percent_Identity=27.8145695364238, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790551, Length=264, Percent_Identity=29.1666666666667, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=31.2775330396476, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.5, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=29.4871794871795, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=27.6450511945392, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=26.7206477732794, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=28.0276816608997, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=26.3888888888889, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=27.3913043478261, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=24.2214532871972, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=215, Percent_Identity=30.2325581395349, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=25.0936329588015, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788279, Length=270, Percent_Identity=25.5555555555556, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=24.0740740740741, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55973; Mature: 55973

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDPVDLQAYTDFVAYSERKRTRWERFLDKIKPRSAAMRTTVLVGFVVLFSLSMSLWFF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WRTLYLPEIQQHARYLAVELELVNNPDIRIFHRDKEVDVDTWLKNRVGIEYVTNPKEYPN
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEEECCCCCCHHHHHHHCCCCEEECCCCCCCC
VRDKVIADFFTDHVQAKLANELKVEDVTVYFQFKPSPRIWIQTPEMHGNWVREPLKTYAN
HHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHC
YSPELVFGWLLGVPIIASIIILTLVRQLNRPLRRLQNAANAYSKTGKAPYLGTNHGPLEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
RQVNQAFNHMIYTLEQTERDRQIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVD
HHHHHHHHHHEEHHHHCCCCCEEEEEECCHHHHCHHHHHHHHHHHCCHHHHHCCCEECCH
DMDAILNQFISYMRDGSDEELRDTNINILLQELVVQFKPLEIHFEAQDVPIIPARSLSLK
HHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
RLIANLINNAKRYGAEPIELTAQVEGDHILIIVADHGEGIPEDQIEELMQPFVRGNSART
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCE
IQGSGLGLAIVKRIVDIHQGELLIHNREGGGLEARILLPLPKHMTPDAPHPNPIEKIKQS
EECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
LTERF
HHHCC
>Mature Secondary Structure
MKLDPVDLQAYTDFVAYSERKRTRWERFLDKIKPRSAAMRTTVLVGFVVLFSLSMSLWFF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WRTLYLPEIQQHARYLAVELELVNNPDIRIFHRDKEVDVDTWLKNRVGIEYVTNPKEYPN
HHHHHHHHHHHHHHEEEEEEEEECCCCEEEEECCCCCCHHHHHHHCCCCEEECCCCCCCC
VRDKVIADFFTDHVQAKLANELKVEDVTVYFQFKPSPRIWIQTPEMHGNWVREPLKTYAN
HHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHC
YSPELVFGWLLGVPIIASIIILTLVRQLNRPLRRLQNAANAYSKTGKAPYLGTNHGPLEI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
RQVNQAFNHMIYTLEQTERDRQIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDVD
HHHHHHHHHHEEHHHHCCCCCEEEEEECCHHHHCHHHHHHHHHHHCCHHHHHCCCEECCH
DMDAILNQFISYMRDGSDEELRDTNINILLQELVVQFKPLEIHFEAQDVPIIPARSLSLK
HHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHH
RLIANLINNAKRYGAEPIELTAQVEGDHILIIVADHGEGIPEDQIEELMQPFVRGNSART
HHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCE
IQGSGLGLAIVKRIVDIHQGELLIHNREGGGLEARILLPLPKHMTPDAPHPNPIEKIKQS
EECCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
LTERF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]