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The map label for this gene is cat1 [H]

Identifier: 50086364

GI number: 50086364

Start: 3304318

End: 3305832

Strand: Direct

Name: cat1 [H]

Synonym: ACIAD3390

Alternate gene names: 50086364

Gene position: 3304318-3305832 (Clockwise)

Preceding gene: 50086363

Following gene: 50086365

Centisome position: 91.82

GC content: 43.56

Gene sequence:

>1515_bases
ATGTCTTTAGATCGTATTCGATTAGCCTCATTACATGACAAAGTGATCAGCGCAGATGCTGCTGCTGCATTTATCCAAGA
CGGTATGACAGTCGGTATGAGCGGTTTTACTCGTGCGGGAGAAGCAAAAGCTGTCCCACAAGCTTTAGTTGAACGTGCAA
AACAAAACCCGTTAAAAATTACATTAATTACGGGTGCGAGCTTAGGGAATGATCTCGACAAACAGTTAACAGAAGCAGGT
GTGCTCGCACGCCGCCTTCCTTTCCAAGTTGACAATACTTTACGTCGCGCTATCAACAACGGCGAAGTCATGTTTATTGA
CCAGCACTTGTCTGAAACAGTTGAACAAATGCGTAATTTACAGCTTAAACGCCCAGACGTTGCTGTAATCGAAGCGATTG
CAATTACTGAAGATGGCGGCATTATTCCAACCACATCTGTAGGTAACTCAGCCAGTTTTGCCATCTTTGCAGAAAAAGTA
ATTGTTGAAATCAATACTTCTTTGAGCGAAGCATTCGAAGGCTTACACGATATTTATATTCCGTCTTACCGTCCAACGCG
CCAGCCAATTCCATTAACTAAAGTGGACGAGCGCATTGGAACAACCGCTATTCAGATTGATCCTGCAAAAATTGTCGGGA
TTGTGTTTAACGACACCGCAGATTCACCATCGACCGTCACGCTTCCAGATGATGAAACACAAGGTATTGCCAATCACCTG
ATCGCGTTCTTTGAAAAAGAAGTTGCAGAAGGTCGTTTGCCTCAAAATCTTGGACCTTTACAGGCGGGCATTGGCTCTAT
TGCCAATGCAGTACTCACAGGTCTTAAAGATTCAAATTTTGAAGATTTAGTGATGTATTCCGAAGTACTTCAAGACTGTA
CTTTTGAATTGATTGATGCAGGTAAAATGAAATTTGCATCGGGCAGCTCAATTACACTTTCTGCAAAATGCGGTGAAAAA
GTATTTGGCAATATTGAAGCCTACAAAGACAAGTTGGTACTTCGTCCGCAAGAAATCTCAAACCACCCTGAGCTGGTGCG
TCGTTTAGGGATTATTGGTATCAACACTGCACTTGAGTTTGATATTTACGGAAACGTTAACTCAACGCATGTGTGTGGAA
CCAAAATGATGAACGGCATTGGTGGTTCTGGTGACTTTGCACGTAATGCACACCTCGCCATCTTTGTCACCAAGTCGATT
GCAAAAGGTGGTGATATTTCATCGATCGTACCAATGGTTTCTCACGTTGACCATTCTGAGCACGATGTTGATATTCTGGT
GACAGAACAAGGTCTTGCAGATCTTCGTGGTCTTGCACCTCGTGAACGTGCTCGTGCAGTCATCGATCACTGTGTACATC
CATTGTATAAAGATGCTTTAAACGATTACTTCTCACGTGCGAGTGCGAAAGGTGGGCACACCCCTCACCTGCTACGTGAG
GCATTGTCTTGGCATGTAAATTTTGAAGAAAATGGCCACATGCTTGCCATTGAGCCTGAAGCTAAATCTGCTTAA

Upstream 100 bases:

>100_bases
ATTTTTTAAAAAAATTAGACCTTAGCCTAACACCCCGTCAAAACCCCAGTAACAGGCGTACAATCGCCGATGTGAACTAA
AACAGATTGAGAGTAAACCC

Downstream 100 bases:

>100_bases
AAGTATTTTGCCTTTCACAATCAGCACTCTAAATTAGGGTGCTTTTTTGTACCTGAACGAAAAACACTTATCAAACCCCG
TGTTTTATTTTATCTTTAAA

Product: acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSLDRIRLASLHDKVISADAAAAFIQDGMTVGMSGFTRAGEAKAVPQALVERAKQNPLKITLITGASLGNDLDKQLTEAG
VLARRLPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNLQLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKV
IVEINTSLSEAFEGLHDIYIPSYRPTRQPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTADSPSTVTLPDDETQGIANHL
IAFFEKEVAEGRLPQNLGPLQAGIGSIANAVLTGLKDSNFEDLVMYSEVLQDCTFELIDAGKMKFASGSSITLSAKCGEK
VFGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEFDIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSI
AKGGDISSIVPMVSHVDHSEHDVDILVTEQGLADLRGLAPRERARAVIDHCVHPLYKDALNDYFSRASAKGGHTPHLLRE
ALSWHVNFEENGHMLAIEPEAKSA

Sequences:

>Translated_504_residues
MSLDRIRLASLHDKVISADAAAAFIQDGMTVGMSGFTRAGEAKAVPQALVERAKQNPLKITLITGASLGNDLDKQLTEAG
VLARRLPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNLQLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKV
IVEINTSLSEAFEGLHDIYIPSYRPTRQPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTADSPSTVTLPDDETQGIANHL
IAFFEKEVAEGRLPQNLGPLQAGIGSIANAVLTGLKDSNFEDLVMYSEVLQDCTFELIDAGKMKFASGSSITLSAKCGEK
VFGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEFDIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSI
AKGGDISSIVPMVSHVDHSEHDVDILVTEQGLADLRGLAPRERARAVIDHCVHPLYKDALNDYFSRASAKGGHTPHLLRE
ALSWHVNFEENGHMLAIEPEAKSA
>Mature_503_residues
SLDRIRLASLHDKVISADAAAAFIQDGMTVGMSGFTRAGEAKAVPQALVERAKQNPLKITLITGASLGNDLDKQLTEAGV
LARRLPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNLQLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKVI
VEINTSLSEAFEGLHDIYIPSYRPTRQPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTADSPSTVTLPDDETQGIANHLI
AFFEKEVAEGRLPQNLGPLQAGIGSIANAVLTGLKDSNFEDLVMYSEVLQDCTFELIDAGKMKFASGSSITLSAKCGEKV
FGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEFDIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSIA
KGGDISSIVPMVSHVDHSEHDVDILVTEQGLADLRGLAPRERARAVIDHCVHPLYKDALNDYFSRASAKGGHTPHLLREA
LSWHVNFEENGHMLAIEPEAKSA

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=486, Percent_Identity=44.8559670781893, Blast_Score=425, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17538151, Length=236, Percent_Identity=31.3559322033898, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI32563853, Length=232, Percent_Identity=31.8965517241379, Blast_Score=75, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319456, Length=515, Percent_Identity=44.2718446601942, Blast_Score=428, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 54530; Mature: 54399

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDRIRLASLHDKVISADAAAAFIQDGMTVGMSGFTRAGEAKAVPQALVERAKQNPLKI
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCEEE
TLITGASLGNDLDKQLTEAGVLARRLPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNL
EEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCC
QLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKVIVEINTSLSEAFEGLHDIYI
CCCCCCCEEEEEEEEECCCCEECCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHCC
PSYRPTRQPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTADSPSTVTLPDDETQGIANHL
CCCCCCCCCCCCHHHHHHHCCEEEEECCCEEEEEEEECCCCCCCEEECCCCHHHHHHHHH
IAFFEKEVAEGRLPQNLGPLQAGIGSIANAVLTGLKDSNFEDLVMYSEVLQDCTFELIDA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GKMKFASGSSITLSAKCGEKVFGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEF
CCEEECCCCCEEEECCCCHHHHCCHHHHHHHEEECHHHHCCCHHHHHHHCCEEECCEEEE
DIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSIAKGGDISSIVPMVSHVDHSE
EEECCCCCCEECHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCC
HDVDILVTEQGLADLRGLAPRERARAVIDHCVHPLYKDALNDYFSRASAKGGHTPHLLRE
CCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ALSWHVNFEENGHMLAIEPEAKSA
HHHEEEEECCCCCEEEECCCCCCC
>Mature Secondary Structure 
SLDRIRLASLHDKVISADAAAAFIQDGMTVGMSGFTRAGEAKAVPQALVERAKQNPLKI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHCCCCEEE
TLITGASLGNDLDKQLTEAGVLARRLPFQVDNTLRRAINNGEVMFIDQHLSETVEQMRNL
EEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCC
QLKRPDVAVIEAIAITEDGGIIPTTSVGNSASFAIFAEKVIVEINTSLSEAFEGLHDIYI
CCCCCCCEEEEEEEEECCCCEECCCCCCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHCC
PSYRPTRQPIPLTKVDERIGTTAIQIDPAKIVGIVFNDTADSPSTVTLPDDETQGIANHL
CCCCCCCCCCCCHHHHHHHCCEEEEECCCEEEEEEEECCCCCCCEEECCCCHHHHHHHHH
IAFFEKEVAEGRLPQNLGPLQAGIGSIANAVLTGLKDSNFEDLVMYSEVLQDCTFELIDA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
GKMKFASGSSITLSAKCGEKVFGNIEAYKDKLVLRPQEISNHPELVRRLGIIGINTALEF
CCEEECCCCCEEEECCCCHHHHCCHHHHHHHEEECHHHHCCCHHHHHHHCCEEECCEEEE
DIYGNVNSTHVCGTKMMNGIGGSGDFARNAHLAIFVTKSIAKGGDISSIVPMVSHVDHSE
EEECCCCCCEECHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCCC
HDVDILVTEQGLADLRGLAPRERARAVIDHCVHPLYKDALNDYFSRASAKGGHTPHLLRE
CCEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
ALSWHVNFEENGHMLAIEPEAKSA
HHHEEEEECCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]