Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 50086307

GI number: 50086307

Start: 3228534

End: 3229157

Strand: Direct

Name: gmk

Synonym: ACIAD3324

Alternate gene names: 50086307

Gene position: 3228534-3229157 (Clockwise)

Preceding gene: 50086294

Following gene: 50086308

Centisome position: 89.72

GC content: 41.83

Gene sequence:

>624_bases
ATGTCGGGTCTATTGTTTGTCGTTTCTGCTGCATCAGGAACAGGCAAAACTTCTCTCGTCAAAGCTCTTCTGGAACGTGT
AACCAACTTACACGTTTCTGTATCGCATACTACGCGAGGCCAAAGACCTGGTGAGCTCGATGGTGTTCACTATCACTTTA
CCACGAAAGAAAACTTTCTCTCACAAGTTGAAGATAACGGTTTTATCGAATATGCCGAAGTGTTTGGCAATTATTATGGA
ACCTCTCAAGCCACGGTAAAACAACAACTGGCAAAAGGTCATGATGTATTGTTAGAAATCGATTGGCAAGGTGCACAGCA
GGTTCGCCGTATTTTTCCTGAATCCAAACAAATTTTTATTTTGCCACCAAGTCAGTTCGATTTACGTCAACGGTTATCCA
ACCGTGGAACAGATGCGGTTGATGTCATTGAACATCGCTTGAGCTGCGCCGTCGAAGACATGCAACAATATGTCAATTTT
GACTATATTATCATCAATGACGACTTTAATAAGGCGCTTCATGACCTTGAATCAGTGATTACTGCAAATCGATTAATGCT
TGCTCAGCAAGTACAGCGTCATCATAAGCTGATCGAACAACTCATCACACCAAATAGCGAATAA

Upstream 100 bases:

>100_bases
AATTTGGCATCTATACAAACTTTTATAGTGGACTATATTCAGTTTAGTCCCGTAGTACACTACAATAGCCAAGATATTTT
ATCATATCAGGAAAAATATC

Downstream 100 bases:

>100_bases
ACTTGAGTATAAATTGAAAGCATTTTATACTTTGCAGTCTAGTCAGATTTACTTAACCGAGAACTTATATGGCACGCGTA
ACCGTTGAAGATTGTTTAGA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSGLLFVVSAASGTGKTSLVKALLERVTNLHVSVSHTTRGQRPGELDGVHYHFTTKENFLSQVEDNGFIEYAEVFGNYYG
TSQATVKQQLAKGHDVLLEIDWQGAQQVRRIFPESKQIFILPPSQFDLRQRLSNRGTDAVDVIEHRLSCAVEDMQQYVNF
DYIIINDDFNKALHDLESVITANRLMLAQQVQRHHKLIEQLITPNSE

Sequences:

>Translated_207_residues
MSGLLFVVSAASGTGKTSLVKALLERVTNLHVSVSHTTRGQRPGELDGVHYHFTTKENFLSQVEDNGFIEYAEVFGNYYG
TSQATVKQQLAKGHDVLLEIDWQGAQQVRRIFPESKQIFILPPSQFDLRQRLSNRGTDAVDVIEHRLSCAVEDMQQYVNF
DYIIINDDFNKALHDLESVITANRLMLAQQVQRHHKLIEQLITPNSE
>Mature_206_residues
SGLLFVVSAASGTGKTSLVKALLERVTNLHVSVSHTTRGQRPGELDGVHYHFTTKENFLSQVEDNGFIEYAEVFGNYYGT
SQATVKQQLAKGHDVLLEIDWQGAQQVRRIFPESKQIFILPPSQFDLRQRLSNRGTDAVDVIEHRLSCAVEDMQQYVNFD
YIIINDDFNKALHDLESVITANRLMLAQQVQRHHKLIEQLITPNSE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=186, Percent_Identity=37.6344086021505, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI4504221, Length=186, Percent_Identity=37.6344086021505, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI226874831, Length=186, Percent_Identity=37.6344086021505, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI111154074, Length=177, Percent_Identity=34.4632768361582, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=30.3370786516854, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=50.7389162561576, Blast_Score=220, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=37.1428571428571, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=36.4640883977901, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=31.1111111111111, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71988041, Length=178, Percent_Identity=25.8426966292135, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988048, Length=178, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=41.5300546448087, Blast_Score=136, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21356141, Length=194, Percent_Identity=33.5051546391753, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI116007136, Length=179, Percent_Identity=28.4916201117318, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI85724806, Length=179, Percent_Identity=28.4916201117318, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45554481, Length=173, Percent_Identity=28.9017341040462, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45554489, Length=179, Percent_Identity=28.4916201117318, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640542, Length=173, Percent_Identity=28.9017341040462, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077626, Length=173, Percent_Identity=28.9017341040462, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_ACIAD (Q6F7H0)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047817.1
- ProteinModelPortal:   Q6F7H0
- STRING:   Q6F7H0
- GeneID:   2880609
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3324
- NMPDR:   fig|62977.3.peg.3010
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- PhylomeDB:   Q6F7H0
- ProtClustDB:   PRK00300
- BioCyc:   ASP62977:ACIAD3324-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23483; Mature: 23352

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLLFVVSAASGTGKTSLVKALLERVTNLHVSVSHTTRGQRPGELDGVHYHFTTKENFL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEECHHHHH
SQVEDNGFIEYAEVFGNYYGTSQATVKQQLAKGHDVLLEIDWQGAQQVRRIFPESKQIFI
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEE
LPPSQFDLRQRLSNRGTDAVDVIEHRLSCAVEDMQQYVNFDYIIINDDFNKALHDLESVI
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
TANRLMLAQQVQRHHKLIEQLITPNSE
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SGLLFVVSAASGTGKTSLVKALLERVTNLHVSVSHTTRGQRPGELDGVHYHFTTKENFL
CCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCEEEEEECHHHHH
SQVEDNGFIEYAEVFGNYYGTSQATVKQQLAKGHDVLLEIDWQGAQQVRRIFPESKQIFI
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCEEEE
LPPSQFDLRQRLSNRGTDAVDVIEHRLSCAVEDMQQYVNFDYIIINDDFNKALHDLESVI
ECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHH
TANRLMLAQQVQRHHKLIEQLITPNSE
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA