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The map label for this gene is ribA

Identifier: 50086243

GI number: 50086243

Start: 3164715

End: 3165317

Strand: Direct

Name: ribA

Synonym: ACIAD3249

Alternate gene names: 50086243

Gene position: 3164715-3165317 (Clockwise)

Preceding gene: 50086234

Following gene: 50086244

Centisome position: 87.94

GC content: 40.8

Gene sequence:

>603_bases
GTGGCTATTGAGTTTGTCGCGACGTCTAAACTTCCGACCAAGTTTGGTGACTTCAATATTTCTGTGTTCCAAGATCCAGT
CACAGGCGAAGAACATGTTGCTCTGTCCAAAGGTTTAGAAATAGCACCAACAGGCCCAGTACTGGTTCGTATCCATTCAG
AATGTCTGACTGGCGATGCTTTCGCTTCTCTGAAATGTGATTGCGGCCCACAGTTACAAGCGACTCAAAAGCTCATCAAT
GATGTGGGACAAGGTGTTATTTTATATTTGCGCCAAGAAGGTCGCGGAATTGGATTAACCAACAAAATTCGTGCCTATGC
CTTGCAGGATCAAGGACACGATACAGTCGATGCCAACTTATTGCTTAATCTGCCTGCAGATGCTAGACGTTATGATATGT
GCAGTATCATGCTCGATCATCTACAAGTGAAACAAGTAAAGTTAATCACCAATAATCCTTTAAAATTAAAGGCATTGACT
GATTTAGGTATTAATGTGATAGACCGTGTTCCATTAACAGTCGGGAAAAATCCATTTAATGAACAGTATCTAAAAACAAA
AAAAGAACGCATGGCCCATCTTTATCAAAAGGATGACTTCTAA

Upstream 100 bases:

>100_bases
AAAGAAAATGTTCTGTATAAATTCAGCATTAGAATTCTACCAATGTCCTAGCATTAAGCTATACTTTAGCCGATTTCCTT
AACAGATAGATGAGTAATTT

Downstream 100 bases:

>100_bases
TTTCTTAACCCGATCACTCAGTAAGGGATCATAATCGTTAAAAATCCCTTACTTTTTTTATGGTTTTATGTTTTGATGTC
ATTAGTCCTTTCGCTCTTTC

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGPQLQATQKLIN
DVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALT
DLGINVIDRVPLTVGKNPFNEQYLKTKKERMAHLYQKDDF

Sequences:

>Translated_200_residues
MAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGPQLQATQKLIN
DVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALT
DLGINVIDRVPLTVGKNPFNEQYLKTKKERMAHLYQKDDF
>Mature_199_residues
AIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDAFASLKCDCGPQLQATQKLIND
VGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTD
LGINVIDRVPLTVGKNPFNEQYLKTKKERMAHLYQKDDF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=197, Percent_Identity=55.8375634517767, Blast_Score=224, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319438, Length=191, Percent_Identity=42.4083769633508, Blast_Score=128, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_ACIAD (Q6F7N4)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047753.1
- ProteinModelPortal:   Q6F7N4
- SMR:   Q6F7N4
- STRING:   Q6F7N4
- GeneID:   2880866
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3249
- NMPDR:   fig|62977.3.peg.2946
- eggNOG:   COG0807
- HOGENOM:   HBG735778
- OMA:   MVIYLRQ
- PhylomeDB:   Q6F7N4
- ProtClustDB:   PRK00393
- BioCyc:   ASP62977:ACIAD3249-MONOMER
- HAMAP:   MF_00179
- InterPro:   IPR000926
- TIGRFAMs:   TIGR00505

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22189; Mature: 22058

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: ACT_SITE 127-127 ACT_SITE 129-129 BINDING 71-71 BINDING 115-115 BINDING 150-150 BINDING 155-155

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA
CEEEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCEECCCCCEEEEEECHHHCCCC
FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL
CEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEECCEE
LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN
EEECCCCCHHHHHHHHHHHHHHEEEEEEEECCCEEEEEECCCCCCHHHCCCEEECCCCCC
EQYLKTKKERMAHLYQKDDF
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIEFVATSKLPTKFGDFNISVFQDPVTGEEHVALSKGLEIAPTGPVLVRIHSECLTGDA
EEEEEECCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCEECCCCCEEEEEECHHHCCCC
FASLKCDCGPQLQATQKLINDVGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL
CEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEECCEE
LLNLPADARRYDMCSIMLDHLQVKQVKLITNNPLKLKALTDLGINVIDRVPLTVGKNPFN
EEECCCCCHHHHHHHHHHHHHHEEEEEEEECCCEEEEEECCCCCCHHHCCCEEECCCCCC
EQYLKTKKERMAHLYQKDDF
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA