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The map label for this gene is macA [H]

Identifier: 50086113

GI number: 50086113

Start: 3033104

End: 3034456

Strand: Direct

Name: macA [H]

Synonym: ACIAD3109

Alternate gene names: 50086113

Gene position: 3033104-3034456 (Clockwise)

Preceding gene: 50086112

Following gene: 50086114

Centisome position: 84.29

GC content: 45.16

Gene sequence:

>1353_bases
ATGCCTAAAATAAAACCATCTCGAATTGTGATTATTGCCATTAGTATTGTGGTCATTGCCCTCTTGGCTTGGTTCTTTTT
CAAGCCTAAACAACAACAGCCACAGTACATTACCGAAACAGCAAACTACGGTAATCTTGAGAATACAGTGCTGGCCACAG
GGACACTCGATGCTACCAAACTCATTAGCGTGGGTGCACAGGTTTCTGGTCAGGTAAAGAAAATGTACGTCCAGTTGGGC
GATGAAGTGAAACAGGGTCAACTGATTGCGCAAATTGATTCGACCACGCAAGAAAATAGTTTAAAAACTGCAGATGCCAA
TATTCGTAATTTAGAAGCTCAGCGTTTACAACAAGAAGCCAATCTCAATGAAGCACAGTTGGCATATCGTCGTCAGCAAC
AGATGTTTGCACAAGATGCAACCTCTAAAGCTGAACTTGAATCTGCCGAAGCAACTTACAAAACCGCTCAAGCTCAGATT
AAGGCCATCAATGCACAGATTGAATCGGCAAAAGTAACACGTTCAACTGCGCAAACCAATATTGGATACACTCGCATTGT
GGCACCGACTGATGGAACAGTAGTCGCCATTGTGACCGAAGAGGGTCAAACGGTAAACGCCAACCAGTCAGCGCCGACCA
TTGTGAAAATTGCGAAATTACAGAACATGACGATTAAAGCGCAAGTCAGCGAAGCTGATATTATGAAGGTTGAAAAAGGT
CAGCAAGTGTATTTCACGACTTTGGGCGATGATAAAAAGCGCTATGCAACATTACGTCAGATCGAACCTGCACCTGACTC
GATTTCAAGTGAATCTACAACCTCAAGCACTTCATCTAGCTCAAGCAGCAGCACTGCCATTTATTACAATGCCCTGTTTG
ATGTGCCTAATGAAGACGGCAAGCTGCGCATTGATATGACAGCCCAGGTGTATATTGTTTTAGATTCGGTAAATCATGCC
TTGCTGGTTCCATCTTCAGCGTTATCAACACGTTCGGCAAATAGCCAAGGCCAGTCTAGCAGCAGTAAAAACACCGCCGC
GTCGTCGGTTGCAGCCACTCATAAAAAAGACAAAACTGATGGGCCTAAACTGGAACGTCTGAACTTAACCGCAGAGCAAA
AGCAGGCGGTCGAGGCAGGAAAAGCCACGCTCAGTGTAGTACGTGTATTAAATGCAGATGGCACAGCGCAACCGAAACAA
GTGCTGATTGGGATTAATAACCGAGTCAGTGCACAAGTTTTGGCAGGGCTTAAAGCGGGTGATCAAGTTGTAATTGCCGA
TAGCTCAGATACTGCTGCATCTACAGCTAACAGTACCAATCGTCGCCGTAATGGCCCACCAATGGGAATGTAA

Upstream 100 bases:

>100_bases
TTTTCGCTTTTAATTCAACTAAATTAATAAAAATATTCACGTTTTATTCTCATTTCACTTCTATACTAGCGCCAGTCCTT
CTTACTTTGCCTGTATCACT

Downstream 100 bases:

>100_bases
TGATGACTAAACAGGCATTACTGGAAGTCCATAATCTGGTTCGAGAGTTCCCTGCTGGCGATAGTACCGTTCAAATTTTA
AAGAATATTAATCTCACGAT

Product: HlyD family secretion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPKIKPSRIVIIAISIVVIALLAWFFFKPKQQQPQYITETANYGNLENTVLATGTLDATKLISVGAQVSGQVKKMYVQLG
DEVKQGQLIAQIDSTTQENSLKTADANIRNLEAQRLQQEANLNEAQLAYRRQQQMFAQDATSKAELESAEATYKTAQAQI
KAINAQIESAKVTRSTAQTNIGYTRIVAPTDGTVVAIVTEEGQTVNANQSAPTIVKIAKLQNMTIKAQVSEADIMKVEKG
QQVYFTTLGDDKKRYATLRQIEPAPDSISSESTTSSTSSSSSSSTAIYYNALFDVPNEDGKLRIDMTAQVYIVLDSVNHA
LLVPSSALSTRSANSQGQSSSSKNTAASSVAATHKKDKTDGPKLERLNLTAEQKQAVEAGKATLSVVRVLNADGTAQPKQ
VLIGINNRVSAQVLAGLKAGDQVVIADSSDTAASTANSTNRRRNGPPMGM

Sequences:

>Translated_450_residues
MPKIKPSRIVIIAISIVVIALLAWFFFKPKQQQPQYITETANYGNLENTVLATGTLDATKLISVGAQVSGQVKKMYVQLG
DEVKQGQLIAQIDSTTQENSLKTADANIRNLEAQRLQQEANLNEAQLAYRRQQQMFAQDATSKAELESAEATYKTAQAQI
KAINAQIESAKVTRSTAQTNIGYTRIVAPTDGTVVAIVTEEGQTVNANQSAPTIVKIAKLQNMTIKAQVSEADIMKVEKG
QQVYFTTLGDDKKRYATLRQIEPAPDSISSESTTSSTSSSSSSSTAIYYNALFDVPNEDGKLRIDMTAQVYIVLDSVNHA
LLVPSSALSTRSANSQGQSSSSKNTAASSVAATHKKDKTDGPKLERLNLTAEQKQAVEAGKATLSVVRVLNADGTAQPKQ
VLIGINNRVSAQVLAGLKAGDQVVIADSSDTAASTANSTNRRRNGPPMGM
>Mature_449_residues
PKIKPSRIVIIAISIVVIALLAWFFFKPKQQQPQYITETANYGNLENTVLATGTLDATKLISVGAQVSGQVKKMYVQLGD
EVKQGQLIAQIDSTTQENSLKTADANIRNLEAQRLQQEANLNEAQLAYRRQQQMFAQDATSKAELESAEATYKTAQAQIK
AINAQIESAKVTRSTAQTNIGYTRIVAPTDGTVVAIVTEEGQTVNANQSAPTIVKIAKLQNMTIKAQVSEADIMKVEKGQ
QVYFTTLGDDKKRYATLRQIEPAPDSISSESTTSSTSSSSSSSTAIYYNALFDVPNEDGKLRIDMTAQVYIVLDSVNHAL
LVPSSALSTRSANSQGQSSSSKNTAASSVAATHKKDKTDGPKLERLNLTAEQKQAVEAGKATLSVVRVLNADGTAQPKQV
LIGINNRVSAQVLAGLKAGDQVVIADSSDTAASTANSTNRRRNGPPMGM

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=425, Percent_Identity=35.7647058823529, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082036, Length=276, Percent_Identity=25, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 48241; Mature: 48110

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIKPSRIVIIAISIVVIALLAWFFFKPKQQQPQYITETANYGNLENTVLATGTLDATK
CCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCHHH
LISVGAQVSGQVKKMYVQLGDEVKQGQLIAQIDSTTQENSLKTADANIRNLEAQRLQQEA
HHHHCCCHHHHHHHHHHHHCCCHHCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHC
NLNEAQLAYRRQQQMFAQDATSKAELESAEATYKTAQAQIKAINAQIESAKVTRSTAQTN
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEHHHHHHHHHHHHCC
IGYTRIVAPTDGTVVAIVTEEGQTVNANQSAPTIVKIAKLQNMTIKAQVSEADIMKVEKG
CCEEEEEECCCCEEEEEEECCCCEECCCCCCCCEEEEEECCCEEEEEEECCCCEEEECCC
QQVYFTTLGDDKKRYATLRQIEPAPDSISSESTTSSTSSSSSSSTAIYYNALFDVPNEDG
CEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCC
KLRIDMTAQVYIVLDSVNHALLVPSSALSTRSANSQGQSSSSKNTAASSVAATHKKDKTD
EEEEEEEEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
GPKLERLNLTAEQKQAVEAGKATLSVVRVLNADGTAQPKQVLIGINNRVSAQVLAGLKAG
CCCEEEECCCHHHHHHHHHHHHHEEHHHEECCCCCCCCCEEEEECCCCHHHHHHHCCCCC
DQVVIADSSDTAASTANSTNRRRNGPPMGM
CEEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKIKPSRIVIIAISIVVIALLAWFFFKPKQQQPQYITETANYGNLENTVLATGTLDATK
CCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEECCCCHHH
LISVGAQVSGQVKKMYVQLGDEVKQGQLIAQIDSTTQENSLKTADANIRNLEAQRLQQEA
HHHHCCCHHHHHHHHHHHHCCCHHCCEEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHC
NLNEAQLAYRRQQQMFAQDATSKAELESAEATYKTAQAQIKAINAQIESAKVTRSTAQTN
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEHHHHHHHHHHHHCC
IGYTRIVAPTDGTVVAIVTEEGQTVNANQSAPTIVKIAKLQNMTIKAQVSEADIMKVEKG
CCEEEEEECCCCEEEEEEECCCCEECCCCCCCCEEEEEECCCEEEEEEECCCCEEEECCC
QQVYFTTLGDDKKRYATLRQIEPAPDSISSESTTSSTSSSSSSSTAIYYNALFDVPNEDG
CEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCC
KLRIDMTAQVYIVLDSVNHALLVPSSALSTRSANSQGQSSSSKNTAASSVAATHKKDKTD
EEEEEEEEEEEEEEECCCCEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
GPKLERLNLTAEQKQAVEAGKATLSVVRVLNADGTAQPKQVLIGINNRVSAQVLAGLKAG
CCCEEEECCCHHHHHHHHHHHHHEEHHHEECCCCCCCCCEEEEECCCCHHHHHHHCCCCC
DQVVIADSSDTAASTANSTNRRRNGPPMGM
CEEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]