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The map label for this gene is proC [H]

Identifier: 50086046

GI number: 50086046

Start: 2962514

End: 2963350

Strand: Reverse

Name: proC [H]

Synonym: ACIAD3032

Alternate gene names: 50086046

Gene position: 2963350-2962514 (Counterclockwise)

Preceding gene: 50086047

Following gene: 50086045

Centisome position: 82.35

GC content: 42.41

Gene sequence:

>837_bases
ATGAGTGCGACATTAAAATCAAATATCACATTTATTGGTGGTGGTAACATGGCGCAAGCCCTCATCGGAGGGCTGATTGC
GCGTGGATTACCTTCAACTCGGATTATGGTTTCTGATCCAGTAGAAGCGATTCGCCAAGTATTGCAAGAAAAAGAGATTC
AAGCACTTAACAACAATGTTGAAGCAATTCAGCATGCAGATGTTGTTGTATTAGCAGTTAAGCCACAAGTTTTGGCTACC
GTCCTCAAACCTTTACAGGGTTTATTCGATGGAAAACTGATTGTTTCGATTATTGCAGGTGCAGAGATTGAAACTATTGC
TGAATTATCTGGTACAGACCGAATTGTACGTGTGATGCCAAATACCCCTGCTTTAGTTCAAACGGGTGCACATGGTTTAT
ATGCCAATGAAAATGTCGGTAGTGATGACCGTGATCTCGCGAGCCAGATTTTAGCTGCAACAGGTTTAACGATTTGGGTT
AATTCAGAAGCCCAGATTGATGCAGTCACTGCAGTTTCAGGTTCGGGTCCTGCATATTTTTTCTACTTGATGGAAAGTAT
GATTCGTGCAGGTAAAAATATGGGGCTGGACGAAAAAGTTGCAACAGCATTAACTTTGCAAACAGCTTTGGGAGCGGCAC
AAATGGCAATTACCAGTTCAAATACCCCATCTGAATTACGTAAGAATGTTACGTCTCCAAATGGAACGACACAAGCCGCA
CTTGAAGTATTTGATCGTGCCCAGATTTCACAAAATATTCAGACTGCACTTGCTGCAGCCCAAAAAAGAAGTCAAGAGTT
AGCCCATGAGCTCAGTGACAGCACCAAAACGACTTAA

Upstream 100 bases:

>100_bases
CCAAAGGTTTTTGGCTGGCACAATCATCGTATTGTGAAGCTGGGGGATGGCAACCTAATTTAATTTCTGATGTAAATTAT
TTGCGAGTTGAGCAGAATTC

Downstream 100 bases:

>100_bases
GTAGGATAGTAACACTATGGCGAGTTCTGCGCTCATTTTTGGTATTTTAATTAACGTTGCCATTTTATTGGTATTTTTCC
GTTTTCTGATCCAGTTGACA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSATLKSNITFIGGGNMAQALIGGLIARGLPSTRIMVSDPVEAIRQVLQEKEIQALNNNVEAIQHADVVVLAVKPQVLAT
VLKPLQGLFDGKLIVSIIAGAEIETIAELSGTDRIVRVMPNTPALVQTGAHGLYANENVGSDDRDLASQILAATGLTIWV
NSEAQIDAVTAVSGSGPAYFFYLMESMIRAGKNMGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAA
LEVFDRAQISQNIQTALAAAQKRSQELAHELSDSTKTT

Sequences:

>Translated_278_residues
MSATLKSNITFIGGGNMAQALIGGLIARGLPSTRIMVSDPVEAIRQVLQEKEIQALNNNVEAIQHADVVVLAVKPQVLAT
VLKPLQGLFDGKLIVSIIAGAEIETIAELSGTDRIVRVMPNTPALVQTGAHGLYANENVGSDDRDLASQILAATGLTIWV
NSEAQIDAVTAVSGSGPAYFFYLMESMIRAGKNMGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAA
LEVFDRAQISQNIQTALAAAQKRSQELAHELSDSTKTT
>Mature_277_residues
SATLKSNITFIGGGNMAQALIGGLIARGLPSTRIMVSDPVEAIRQVLQEKEIQALNNNVEAIQHADVVVLAVKPQVLATV
LKPLQGLFDGKLIVSIIAGAEIETIAELSGTDRIVRVMPNTPALVQTGAHGLYANENVGSDDRDLASQILAATGLTIWVN
SEAQIDAVTAVSGSGPAYFFYLMESMIRAGKNMGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAAL
EVFDRAQISQNIQTALAAAQKRSQELAHELSDSTKTT

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=35.0746268656716, Blast_Score=144, Evalue=8e-35,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=35.0746268656716, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI21361454, Length=279, Percent_Identity=32.258064516129, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI198041662, Length=264, Percent_Identity=31.8181818181818, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786585, Length=268, Percent_Identity=33.2089552238806, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=34.6007604562738, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17540664, Length=286, Percent_Identity=29.7202797202797, Blast_Score=98, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=213, Percent_Identity=28.6384976525822, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI21358587, Length=272, Percent_Identity=37.5, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=31.7857142857143, Blast_Score=131, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=35.2941176470588, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29251; Mature: 29120

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATLKSNITFIGGGNMAQALIGGLIARGLPSTRIMVSDPVEAIRQVLQEKEIQALNNNV
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCH
EAIQHADVVVLAVKPQVLATVLKPLQGLFDGKLIVSIIAGAEIETIAELSGTDRIVRVMP
HHHHHCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCCEEEECC
NTPALVQTGAHGLYANENVGSDDRDLASQILAATGLTIWVNSEAQIDAVTAVSGSGPAYF
CCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCHHH
FYLMESMIRAGKNMGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCCCHHHHH
LEVFDRAQISQNIQTALAAAQKRSQELAHELSDSTKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SATLKSNITFIGGGNMAQALIGGLIARGLPSTRIMVSDPVEAIRQVLQEKEIQALNNNV
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCH
EAIQHADVVVLAVKPQVLATVLKPLQGLFDGKLIVSIIAGAEIETIAELSGTDRIVRVMP
HHHHHCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHCCCCCEEEECC
NTPALVQTGAHGLYANENVGSDDRDLASQILAATGLTIWVNSEAQIDAVTAVSGSGPAYF
CCCHHHHCCCCCEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCHHH
FYLMESMIRAGKNMGLDEKVATALTLQTALGAAQMAITSSNTPSELRKNVTSPNGTTQAA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHCCCCCCHHHHH
LEVFDRAQISQNIQTALAAAQKRSQELAHELSDSTKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]