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The map label for this gene is tpm

Identifier: 50085949

GI number: 50085949

Start: 2852552

End: 2853205

Strand: Direct

Name: tpm

Synonym: ACIAD2922

Alternate gene names: 50085949

Gene position: 2852552-2853205 (Clockwise)

Preceding gene: 50085948

Following gene: 50085952

Centisome position: 79.27

GC content: 39.6

Gene sequence:

>654_bases
ATGCAACATGAATTCTGGCATCAACGCTGGCAGGAAAACAGAATCGGTTTTCATCAATTTACACCGAGTCCACTGTTAGT
CGATTATTTTAACGAACTTGGCTTAAAAACCTCTGCCCGTATCTTTGTTCCATTGAGTGGTAAAACACTGGATATTAGTT
GGTTATTACAACAAGGCTACCATGTTGTGGCAATTGAGCTTAGCCAAATCGCTGTAACATCATTGATTGAGCAATTAGTT
GAAGACTTCGATATACAATTTGAGTCTTCCGAAAAGAATAATCTGATCCATTACCATCACCCACAAATCGATATTTTTGT
CGGTGATTTTTTTGATCTAAGCAAAGAACAATTAGGACAGGTCGATGCAATTTTTGATCGTGCAGCATTGATTGCTTTAC
CAGACGACATACGCCAAGACTATGTTCAACACTTGATCGAGATCAGTGGTGCTGCATCTCAGTTTTTAATTAGCTACCAA
TACGATGCAGGCAGTCATGAAGGACCTCCTTTTTCGGTCAATGCAGAAGAAATTAAACAACTTTATGCTGAGGCTTATGA
TATCCGACTTTTGAAGGAGCAACTTGTCGATGCATCTCAAAACAAAGGAAATCACCCCAAGAGCACACTATGGATACTCA
CTGCCAAGTTCTGA

Upstream 100 bases:

>100_bases
CATCATCTTATTTTTGGTTTAGGTCTATATTTATCATTTCAAATCTACCATTATGTCTGGTTGAGCTAAGTTATGACAAA
ATCATCAATTCGAGGCAGTT

Downstream 100 bases:

>100_bases
GCATAAAAAAACACCTCTATTTTTAGAGATGTTTTTTATATATTTTCATCGGATGTGTGATATGCCATAAGCATAACAAC
ACACTTCACTAATTTTAACT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MQHEFWHQRWQENRIGFHQFTPSPLLVDYFNELGLKTSARIFVPLSGKTLDISWLLQQGYHVVAIELSQIAVTSLIEQLV
EDFDIQFESSEKNNLIHYHHPQIDIFVGDFFDLSKEQLGQVDAIFDRAALIALPDDIRQDYVQHLIEISGAASQFLISYQ
YDAGSHEGPPFSVNAEEIKQLYAEAYDIRLLKEQLVDASQNKGNHPKSTLWILTAKF

Sequences:

>Translated_217_residues
MQHEFWHQRWQENRIGFHQFTPSPLLVDYFNELGLKTSARIFVPLSGKTLDISWLLQQGYHVVAIELSQIAVTSLIEQLV
EDFDIQFESSEKNNLIHYHHPQIDIFVGDFFDLSKEQLGQVDAIFDRAALIALPDDIRQDYVQHLIEISGAASQFLISYQ
YDAGSHEGPPFSVNAEEIKQLYAEAYDIRLLKEQLVDASQNKGNHPKSTLWILTAKF
>Mature_217_residues
MQHEFWHQRWQENRIGFHQFTPSPLLVDYFNELGLKTSARIFVPLSGKTLDISWLLQQGYHVVAIELSQIAVTSLIEQLV
EDFDIQFESSEKNNLIHYHHPQIDIFVGDFFDLSKEQLGQVDAIFDRAALIALPDDIRQDYVQHLIEISGAASQFLISYQ
YDAGSHEGPPFSVNAEEIKQLYAEAYDIRLLKEQLVDASQNKGNHPKSTLWILTAKF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family

Homologues:

Organism=Homo sapiens, GI4507653, Length=202, Percent_Identity=28.7128712871287, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TPMT_ACIAD (Q6F8H8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047459.1
- ProteinModelPortal:   Q6F8H8
- SMR:   Q6F8H8
- STRING:   Q6F8H8
- GeneID:   2880726
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2922
- NMPDR:   fig|62977.3.peg.2652
- eggNOG:   COG0500
- HOGENOM:   HBG444929
- OMA:   VDAIYDR
- BioCyc:   ASP62977:ACIAD2922-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00812
- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822
- PIRSF:   PIRSF023956
- TIGRFAMs:   TIGR03840

Pfam domain/function: PF05724 TPMT

EC number: =2.1.1.67

Molecular weight: Translated: 24988; Mature: 24988

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: BINDING 10-10 BINDING 45-45 BINDING 66-66 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHEFWHQRWQENRIGFHQFTPSPLLVDYFNELGLKTSARIFVPLSGKTLDISWLLQQGY
CCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHCCC
HVVAIELSQIAVTSLIEQLVEDFDIQFESSEKNNLIHYHHPQIDIFVGDFFDLSKEQLGQ
EEEEEEHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEECCEEEEEECCCHHCCHHHHCC
VDAIFDRAALIALPDDIRQDYVQHLIEISGAASQFLISYQYDAGSHEGPPFSVNAEEIKQ
HHHHHHCEEEEECCHHHHHHHHHHHHHHCCCHHEEEEEEEECCCCCCCCCCCCCHHHHHH
LYAEAYDIRLLKEQLVDASQNKGNHPKSTLWILTAKF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MQHEFWHQRWQENRIGFHQFTPSPLLVDYFNELGLKTSARIFVPLSGKTLDISWLLQQGY
CCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEEECCCEEEHHHHHHCCC
HVVAIELSQIAVTSLIEQLVEDFDIQFESSEKNNLIHYHHPQIDIFVGDFFDLSKEQLGQ
EEEEEEHHHHHHHHHHHHHHHHHCCEECCCCCCCEEEEECCEEEEEECCCHHCCHHHHCC
VDAIFDRAALIALPDDIRQDYVQHLIEISGAASQFLISYQYDAGSHEGPPFSVNAEEIKQ
HHHHHHCEEEEECCHHHHHHHHHHHHHHCCCHHEEEEEEEECCCCCCCCCCCCCHHHHHH
LYAEAYDIRLLKEQLVDASQNKGNHPKSTLWILTAKF
HHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA