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The map label for this gene is gltA [H]

Identifier: 50085921

GI number: 50085921

Start: 2825328

End: 2826602

Strand: Direct

Name: gltA [H]

Synonym: ACIAD2886

Alternate gene names: 50085921

Gene position: 2825328-2826602 (Clockwise)

Preceding gene: 50085911

Following gene: 50085923

Centisome position: 78.51

GC content: 42.67

Gene sequence:

>1275_bases
ATGTCTGAAGCAACTGGCAAGAAAGCCGTATTAAAGCTTGATGGCAAAGAAATTGAATTACCAATTTACAGCGGCACATT
GGGCCCAGATGTAATTGACGTTAAGGATGTATTGGCTGCAGGTCATTTTACTTTTGATCCTGGTTTCATGGCGACCGCTT
CATGTGAATCGAAGATTACATTCATTGACGGAAACGAAGGTGTGTTATTACACCGCGGTTACCCAATTGATCAGCTTGCA
ACTCAAGCAGATTATTTGGAAACTTGCTATTTGTTATTAAATGGTGAACTTCCTACGCCAGAGCAAAAACAAGAATTTGA
TGCTAAAGTTCGTAACCACACCATGGTTCACGATCAAGTTAGCCGTTTCTTCAATGGTTTCCGTCGTGATGCGCACCCTA
TGGCAATCATGGTGGGTGTAGTCGGTGCTTTATCTGCGTTTTATCACAACCAGTTAAACATTGAAGATGTCAATCATCGT
GAAATTACTGCAATTCGTTTGATTGCAAAAATTCCAACGCTTGCTGCTTGGAGTTATAAATACACTGTCGGCCAACCGTT
CATTTACCCTCGTAATGATCTTGGTTATGCAGAAAACTTCCTGCACATGATGTTTGCAACCCCAGCAGACCGTGATTACA
AAGTTAATCCAATTCTTGCTAAGGCAATGGATCGTATTTTCACGCTTCATGCAGATCATGAACAAAATGCTTCAACATCT
ACAGTCCGTTTGGCTGGTTCAACCGGTGCGAATCCGTATGCGTGTATCGCAGCAGGTATTTCTGCACTTTGGGGCCCTGC
TCATGGTGGTGCAAACGAAGCTGTTCTGAAAATGCTTGATGAAATTGGCACTGTTGAGAACGTTGCTGGTTTCATGGAAA
AAGTGAAAACCAAAGAAGTTAAACTCATGGGCTTTGGTCACCGTGTGTATAAAAACTTCGATCCACGCGCGAAAGTCATG
AAAGAAACATGTGATGAAGTTCTTGCCGCACTCGGCATTAACGATCCACAACTTGAACTTGCGATGGAACTTGAGCGCAT
TGCGTTGTCTGATGAATACTTCATCAAGCGTAATTTGTATCCAAACGTAGACTTCTATTCAGGTATCATTCTTAAAGCGA
TTGGTATTCCAACAGAAATGTTTACAGTGATCTTTGCACTTGCACGTACTGTGGGCTGGATCAGCCACTGGTTAGAAATG
CACAGTGCTCCGTACAAAATTGGTCGTCCTCGTCAGCTTTACACTGGCGAAACCAAACGCGACATTAAACGTTAA

Upstream 100 bases:

>100_bases
CACTAATCTTAGTAACAATTTTTGACCCGTCTGAATTCGTGCATTAAAAGATTAATACTTCGATTCAGATCAACATTCAC
CAGGACAGGAGATCTATTGA

Downstream 100 bases:

>100_bases
TTTTCGAAAGAAGAGCAACTTAAAAGACCGCCTAGTGCGGTCTTTTTTATTTTGATGATTGACTAAGATCATATATTGTT
ACGCGAGACAAATGGAATAC

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSEATGKKAVLKLDGKEIELPIYSGTLGPDVIDVKDVLAAGHFTFDPGFMATASCESKITFIDGNEGVLLHRGYPIDQLA
TQADYLETCYLLLNGELPTPEQKQEFDAKVRNHTMVHDQVSRFFNGFRRDAHPMAIMVGVVGALSAFYHNQLNIEDVNHR
EITAIRLIAKIPTLAAWSYKYTVGQPFIYPRNDLGYAENFLHMMFATPADRDYKVNPILAKAMDRIFTLHADHEQNASTS
TVRLAGSTGANPYACIAAGISALWGPAHGGANEAVLKMLDEIGTVENVAGFMEKVKTKEVKLMGFGHRVYKNFDPRAKVM
KETCDEVLAALGINDPQLELAMELERIALSDEYFIKRNLYPNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEM
HSAPYKIGRPRQLYTGETKRDIKR

Sequences:

>Translated_424_residues
MSEATGKKAVLKLDGKEIELPIYSGTLGPDVIDVKDVLAAGHFTFDPGFMATASCESKITFIDGNEGVLLHRGYPIDQLA
TQADYLETCYLLLNGELPTPEQKQEFDAKVRNHTMVHDQVSRFFNGFRRDAHPMAIMVGVVGALSAFYHNQLNIEDVNHR
EITAIRLIAKIPTLAAWSYKYTVGQPFIYPRNDLGYAENFLHMMFATPADRDYKVNPILAKAMDRIFTLHADHEQNASTS
TVRLAGSTGANPYACIAAGISALWGPAHGGANEAVLKMLDEIGTVENVAGFMEKVKTKEVKLMGFGHRVYKNFDPRAKVM
KETCDEVLAALGINDPQLELAMELERIALSDEYFIKRNLYPNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEM
HSAPYKIGRPRQLYTGETKRDIKR
>Mature_423_residues
SEATGKKAVLKLDGKEIELPIYSGTLGPDVIDVKDVLAAGHFTFDPGFMATASCESKITFIDGNEGVLLHRGYPIDQLAT
QADYLETCYLLLNGELPTPEQKQEFDAKVRNHTMVHDQVSRFFNGFRRDAHPMAIMVGVVGALSAFYHNQLNIEDVNHRE
ITAIRLIAKIPTLAAWSYKYTVGQPFIYPRNDLGYAENFLHMMFATPADRDYKVNPILAKAMDRIFTLHADHEQNASTST
VRLAGSTGANPYACIAAGISALWGPAHGGANEAVLKMLDEIGTVENVAGFMEKVKTKEVKLMGFGHRVYKNFDPRAKVMK
ETCDEVLAALGINDPQLELAMELERIALSDEYFIKRNLYPNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEMH
SAPYKIGRPRQLYTGETKRDIKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=349, Percent_Identity=28.3667621776504, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786939, Length=419, Percent_Identity=67.0644391408115, Blast_Score=606, Evalue=1e-174,
Organism=Escherichia coli, GI1786527, Length=360, Percent_Identity=31.9444444444444, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17555174, Length=398, Percent_Identity=28.1407035175879, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319850, Length=360, Percent_Identity=26.1111111111111, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=355, Percent_Identity=26.7605633802817, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6325257, Length=356, Percent_Identity=27.247191011236, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640126, Length=347, Percent_Identity=28.5302593659942, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24640124, Length=347, Percent_Identity=28.5302593659942, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21356863, Length=400, Percent_Identity=26, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47340; Mature: 47209

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEATGKKAVLKLDGKEIELPIYSGTLGPDVIDVKDVLAAGHFTFDPGFMATASCESKIT
CCCCCCCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHCCCEEECCCCEEECCCCCEEE
FIDGNEGVLLHRGYPIDQLATQADYLETCYLLLNGELPTPEQKQEFDAKVRNHTMVHDQV
EEECCCCEEEECCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCHHHHHHH
SRFFNGFRRDAHPMAIMVGVVGALSAFYHNQLNIEDVNHREITAIRLIAKIPTLAAWSYK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEE
YTVGQPFIYPRNDLGYAENFLHMMFATPADRDYKVNPILAKAMDRIFTLHADHEQNASTS
EECCCCEEECCCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHEEEECCCCCCCCCC
TVRLAGSTGANPYACIAAGISALWGPAHGGANEAVLKMLDEIGTVENVAGFMEKVKTKEV
EEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHE
KLMGFGHRVYKNFDPRAKVMKETCDEVLAALGINDPQLELAMELERIALSDEYFIKRNLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCC
PNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEMHSAPYKIGRPRQLYTGETKR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHH
DIKR
HHCC
>Mature Secondary Structure 
SEATGKKAVLKLDGKEIELPIYSGTLGPDVIDVKDVLAAGHFTFDPGFMATASCESKIT
CCCCCCCEEEEECCCEEEEEEECCCCCCCCCCHHHHHHCCCEEECCCCEEECCCCCEEE
FIDGNEGVLLHRGYPIDQLATQADYLETCYLLLNGELPTPEQKQEFDAKVRNHTMVHDQV
EEECCCCEEEECCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCHHHHHHH
SRFFNGFRRDAHPMAIMVGVVGALSAFYHNQLNIEDVNHREITAIRLIAKIPTLAAWSYK
HHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCHHEEEEE
YTVGQPFIYPRNDLGYAENFLHMMFATPADRDYKVNPILAKAMDRIFTLHADHEQNASTS
EECCCCEEECCCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHEEEECCCCCCCCCC
TVRLAGSTGANPYACIAAGISALWGPAHGGANEAVLKMLDEIGTVENVAGFMEKVKTKEV
EEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHE
KLMGFGHRVYKNFDPRAKVMKETCDEVLAALGINDPQLELAMELERIALSDEYFIKRNLY
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHEECCCC
PNVDFYSGIILKAIGIPTEMFTVIFALARTVGWISHWLEMHSAPYKIGRPRQLYTGETKR
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCHHH
DIKR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3442626 [H]