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The map label for this gene is sdhB [H]

Identifier: 50085917

GI number: 50085917

Start: 2820882

End: 2821592

Strand: Reverse

Name: sdhB [H]

Synonym: ACIAD2879

Alternate gene names: 50085917

Gene position: 2821592-2820882 (Counterclockwise)

Preceding gene: 50085918

Following gene: 50085916

Centisome position: 78.41

GC content: 40.79

Gene sequence:

>711_bases
ATGAGTAGAGGTACTCGTACATTCGAAATCTACCGCTATGATCCTGATAAGGATAAAGCGCCGTACATGCAAACTTTTAA
GCTTGAATTGACAGATAAGCACCGTATGTTGCTTGATGCTTTACTTGCATTGAAAGTTCAGGATGAAACATTGACATTCC
GTCGTTCATGCCGTGAAGGAATCTGTGGTTCTGATGGTGTGAACATTAACGGTAAAAATGGTTTGGCTTGTCTGTGGAAT
TTGAACGATTTACCAGAAAAAATCGTGATTCGTCCACTTCCTGGTTTGCCAGTGATTAAAGATTTGGTTGTTGATATGAA
CCAGTTCTATGATCAATATGACAAAATCCAGCCGTTTTTGATTAATAATCAGCCTGCGCCACCTAAAGAACGTTTACAGT
CTCCAGAAGAGCGTGAACACTTAAATGGTCTATATGAGTGTATCTTGTGTGCATGCTGTTCGACATCATGCCCATCATTT
TGGTGGAATCCAGATAAGTTCCTGGGGCCTTCAGCACTTCTTAATGCGTATCGTTTTATTATCGATTCGCGTGATACAGC
CACTCAAGATCGTTTATCGCGCTTGGATGATCCGTTCAGCTTATTCCGTTGTAAAGGAATTATGAACTGTGTATCTGTTT
GTCCAAAAGGACTGAACCCAACCAAAGCGATTGGACATATTCGTAATATGTTATTCGATCAGGCGGGTTAA

Upstream 100 bases:

>100_bases
GGCAGATAACCGTCTTGAATACAAGCCTGTGCGTTACGTTCCATTAACAGTTGACGCAATTCCACCTGCACCACGTACAT
TCTAATTCGGGAGAATAAAG

Downstream 100 bases:

>100_bases
TATGCGTCAAAAAAGCGTGCATTTAGATGTGCGCTTTTTTTTATGTAAAAAGAAATGGGACTAAGGTCTAAATTGCATCT
AAAATCTATATGAAGCACCA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSRGTRTFEIYRYDPDKDKAPYMQTFKLELTDKHRMLLDALLALKVQDETLTFRRSCREGICGSDGVNINGKNGLACLWN
LNDLPEKIVIRPLPGLPVIKDLVVDMNQFYDQYDKIQPFLINNQPAPPKERLQSPEEREHLNGLYECILCACCSTSCPSF
WWNPDKFLGPSALLNAYRFIIDSRDTATQDRLSRLDDPFSLFRCKGIMNCVSVCPKGLNPTKAIGHIRNMLFDQAG

Sequences:

>Translated_236_residues
MSRGTRTFEIYRYDPDKDKAPYMQTFKLELTDKHRMLLDALLALKVQDETLTFRRSCREGICGSDGVNINGKNGLACLWN
LNDLPEKIVIRPLPGLPVIKDLVVDMNQFYDQYDKIQPFLINNQPAPPKERLQSPEEREHLNGLYECILCACCSTSCPSF
WWNPDKFLGPSALLNAYRFIIDSRDTATQDRLSRLDDPFSLFRCKGIMNCVSVCPKGLNPTKAIGHIRNMLFDQAG
>Mature_235_residues
SRGTRTFEIYRYDPDKDKAPYMQTFKLELTDKHRMLLDALLALKVQDETLTFRRSCREGICGSDGVNINGKNGLACLWNL
NDLPEKIVIRPLPGLPVIKDLVVDMNQFYDQYDKIQPFLINNQPAPPKERLQSPEEREHLNGLYECILCACCSTSCPSFW
WNPDKFLGPSALLNAYRFIIDSRDTATQDRLSRLDDPFSLFRCKGIMNCVSVCPKGLNPTKAIGHIRNMLFDQAG

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=57.3275862068966, Blast_Score=265, Evalue=2e-71,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=68.5344827586207, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI1790596, Length=219, Percent_Identity=34.703196347032, Blast_Score=139, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17533915, Length=231, Percent_Identity=54.5454545454545, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6322987, Length=230, Percent_Identity=53.0434782608696, Blast_Score=251, Evalue=7e-68,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=54.0772532188841, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=53.448275862069, Blast_Score=247, Evalue=6e-66,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26969; Mature: 26838

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRGTRTFEIYRYDPDKDKAPYMQTFKLELTDKHRMLLDALLALKVQDETLTFRRSCREG
CCCCCEEEEEEEECCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ICGSDGVNINGKNGLACLWNLNDLPEKIVIRPLPGLPVIKDLVVDMNQFYDQYDKIQPFL
CCCCCCCEECCCCCEEEEECCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEE
INNQPAPPKERLQSPEEREHLNGLYECILCACCSTSCPSFWWNPDKFLGPSALLNAYRFI
ECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHH
IDSRDTATQDRLSRLDDPFSLFRCKGIMNCVSVCPKGLNPTKAIGHIRNMLFDQAG
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRGTRTFEIYRYDPDKDKAPYMQTFKLELTDKHRMLLDALLALKVQDETLTFRRSCREG
CCCCEEEEEEEECCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
ICGSDGVNINGKNGLACLWNLNDLPEKIVIRPLPGLPVIKDLVVDMNQFYDQYDKIQPFL
CCCCCCCEECCCCCEEEEECCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEE
INNQPAPPKERLQSPEEREHLNGLYECILCACCSTSCPSFWWNPDKFLGPSALLNAYRFI
ECCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHH
IDSRDTATQDRLSRLDDPFSLFRCKGIMNCVSVCPKGLNPTKAIGHIRNMLFDQAG
HCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]