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The map label for this gene is sdhA [H]

Identifier: 50085918

GI number: 50085918

Start: 2821608

End: 2823506

Strand: Reverse

Name: sdhA [H]

Synonym: ACIAD2880

Alternate gene names: 50085918

Gene position: 2823506-2821608 (Counterclockwise)

Preceding gene: 50085919

Following gene: 50085917

Centisome position: 78.46

GC content: 44.76

Gene sequence:

>1899_bases
ATGGGCGCGATAAACCCTAAAGAAGATTATTCAAATATTCAAAACCTCACTTTTGATGCTGTCATCGTAGGTGGCGGTGG
TTCTGGTATGCGTGCTTCTTATCAGTTGGCACAAGCTGGTTTGAAAGTTGCGGTACTCACCAAAGTATTCCCAACCCGTT
CTCATACAGTGGCAGCGCAGGGTGGTATTGGTGCTTCACTAGGCAACATGCAGGAAGACAACTGGCATTTCCATTTTTAC
GATACAGTAAAAGGTTCTGACTGGTTAGGTGACCAAGACGCCATTGAATTTATGACACGTGAAGCGCCAAAAGTTGTATA
TGAGCTTGAACACTTAGGTATGCCATTTGACCGTAACGCAGATGGTACGATCTATCAACGTCCGTTTGGTGGTCACTCTG
CAAACTATGGTGATAAACCAGTTCCACGTGCTTGTGCTGCTGCTGACCGTACAGGTCATGCGCTATTGCATACCTTGTAT
CAAAGCAACGTCAAAATGGGCACTCAGTTTTTCGTTGAGTGGATTGCGCTTGACTTGATCCGTAATGAAGCAGGTGATGT
ACTCGGTGTAACTGCTTACGACCAGGAAACAGGTAATATTGCAGTATTCCAAGCCAAAGCGACTTTGTTTGCTACAGGTG
GTGCAGGTCGTGTTTACCGTGCATCTACCAACGCTTATATCAATACTGGTGATGGTCTTGGTATGGCTGCACGTGCAGGT
ATTCCATTGCAAGATATGGAATTCTGGCAATTCCACCCAACAGGTGTAGCGGGTGCGGGCGTACTTCTGACCGAAGGCTG
TCGTGGTGAAGGTGCGATTCTTCGTAACAAAGATGGTGAGCCGTTCATGGAACGTTATGCACCAACTTTGAAAGACTTGG
CGCCGCGTGACTTTGTTTCACGTTCAATGGACCAAGAAATTAAAGAAGGTCGTGGCTGTGGCCCTAAAGCGGATTATATC
TTGCTCGATATGACTCACTTAGGTGCGGATACCATTATGAAGCGTTTACCATCTGTATTTGAGATTGGTAAAAAATTCGC
AAACGTGGATATCACCAAAGAGCCAATTCCGGTTGTACCGACGATTCATTATCAAATGGGTGGTATTCCAACCAATATTC
ATGGTCAGGTGGTGGTTCCAGTGGCAACTGAAAACCTTCACTTGGAAGCGCATTATAACAATGCGACCAAAGAATATACT
TTTGAGACCAACTGTCCAGATTTCGTAAAACCAGTAAAAGGTTTTTATGCGATTGGTGAATGTTCTTGCGTATCTGTACA
TGGTGCAAACCGTTTGGGTACCAACTCTTTGCTTGACCTGGTTGTATTTGGTAAAGCCGCGGGTGAGCATATCATTGATT
ATGTGACCAAGCATCATGGTGATGAATATGCACCGCTTCCAACAGATGTATTAGAGAGTACATTAAAACGTATTCGTCAT
CTGGATGAATCAACTTCTGGTGAAAATGCGCAAGAAGTTGCAGATGCGATTCGTGACATTGTGCAGGATCATGCTGCAGT
ATTCCGTACTCAAGAGTTGCTGGATGAAGGTGTAAGACAAATTCTTGCGCTAGAGCCACGAGTTCGCAATATTTACTTAA
AAGACAAATCTAAGGTATTTAACACTGCACGTGTAGAGGCTTTGGAGGTTGAAAACCTGTATGAAGTTGCGAAAGCAACA
TTGATTTCGGCTGCCGCACGTAAAGAGTGTCGTGGTGCGCATACAGTTGTCGATTATGAATTGGCGCCAGATCATCCTGA
TTACCCATATGGTCGTCGTGATGATGAGTGGATGAAGCATACACTGTGGTATTCGGCAGATAACCGTCTTGAATACAAGC
CTGTGCGTTACGTTCCATTAACAGTTGACGCAATTCCACCTGCACCACGTACATTCTAA

Upstream 100 bases:

>100_bases
AGGTTTACGTCTGGTTCTTACATCGGCTGTGATTATTGCCGTGTTTGTATTTGCAATCTGGGGTATCCAGATTTTCTGGG
CGAATTGATAGGAAGACATC

Downstream 100 bases:

>100_bases
TTCGGGAGAATAAAGATGAGTAGAGGTACTCGTACATTCGAAATCTACCGCTATGATCCTGATAAGGATAAAGCGCCGTA
CATGCAAACTTTTAAGCTTG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFY
DTVKGSDWLGDQDAIEFMTREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLY
QSNVKMGTQFFVEWIALDLIRNEAGDVLGVTAYDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKADYI
LLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVVPVATENLHLEAHYNNATKEYT
FETNCPDFVKPVKGFYAIGECSCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTDVLESTLKRIRH
LDESTSGENAQEVADAIRDIVQDHAAVFRTQELLDEGVRQILALEPRVRNIYLKDKSKVFNTARVEALEVENLYEVAKAT
LISAAARKECRGAHTVVDYELAPDHPDYPYGRRDDEWMKHTLWYSADNRLEYKPVRYVPLTVDAIPPAPRTF

Sequences:

>Translated_632_residues
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFY
DTVKGSDWLGDQDAIEFMTREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLY
QSNVKMGTQFFVEWIALDLIRNEAGDVLGVTAYDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKADYI
LLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVVPVATENLHLEAHYNNATKEYT
FETNCPDFVKPVKGFYAIGECSCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTDVLESTLKRIRH
LDESTSGENAQEVADAIRDIVQDHAAVFRTQELLDEGVRQILALEPRVRNIYLKDKSKVFNTARVEALEVENLYEVAKAT
LISAAARKECRGAHTVVDYELAPDHPDYPYGRRDDEWMKHTLWYSADNRLEYKPVRYVPLTVDAIPPAPRTF
>Mature_631_residues
GAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQGGIGASLGNMQEDNWHFHFYD
TVKGSDWLGDQDAIEFMTREAPKVVYELEHLGMPFDRNADGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQ
SNVKMGTQFFVEWIALDLIRNEAGDVLGVTAYDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAGI
PLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPKADYIL
LDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVPTIHYQMGGIPTNIHGQVVVPVATENLHLEAHYNNATKEYTF
ETNCPDFVKPVKGFYAIGECSCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTDVLESTLKRIRHL
DESTSGENAQEVADAIRDIVQDHAAVFRTQELLDEGVRQILALEPRVRNIYLKDKSKVFNTARVEALEVENLYEVAKATL
ISAAARKECRGAHTVVDYELAPDHPDYPYGRRDDEWMKHTLWYSADNRLEYKPVRYVPLTVDAIPPAPRTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=49.1830065359477, Blast_Score=557, Evalue=1e-159,
Organism=Escherichia coli, GI1786942, Length=616, Percent_Identity=51.2987012987013, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI1790597, Length=608, Percent_Identity=37.6644736842105, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1788928, Length=577, Percent_Identity=32.2357019064125, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17505833, Length=633, Percent_Identity=48.3412322274881, Blast_Score=540, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17550100, Length=612, Percent_Identity=48.3660130718954, Blast_Score=536, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6322701, Length=625, Percent_Identity=48.96, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6322416, Length=626, Percent_Identity=48.4025559105431, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17137288, Length=632, Percent_Identity=48.2594936708861, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655642, Length=632, Percent_Identity=48.2594936708861, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24655647, Length=632, Percent_Identity=48.2594936708861, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24663005, Length=645, Percent_Identity=44.3410852713178, Blast_Score=515, Evalue=1e-146,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 69634; Mature: 69503

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQ
CCCCCCHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHCCCCCCEEEEC
GGIGASLGNMQEDNWHFHFYDTVKGSDWLGDQDAIEFMTREAPKVVYELEHLGMPFDRNA
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
DGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQSNVKMGTQFFVEWIALDLI
CCCEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RNEAGDVLGVTAYDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
HCCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCHHHCC
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVS
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHHCCHHHHCCCHHHHH
RSMDQEIKEGRGCGPKADYILLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVP
HHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCE
TIHYQMGGIPTNIHGQVVVPVATENLHLEAHYNNATKEYTFETNCPDFVKPVKGFYAIGE
EEEEECCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHEEECC
CSCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTDVLESTLKRIRH
CEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LDESTSGENAQEVADAIRDIVQDHAAVFRTQELLDEGVRQILALEPRVRNIYLKDKSKVF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
NTARVEALEVENLYEVAKATLISAAARKECRGAHTVVDYELAPDHPDYPYGRRDDEWMKH
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHH
TLWYSADNRLEYKPVRYVPLTVDAIPPAPRTF
HHEECCCCCEEECCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
GAINPKEDYSNIQNLTFDAVIVGGGGSGMRASYQLAQAGLKVAVLTKVFPTRSHTVAAQ
CCCCCHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEEHHCCCCCCEEEEC
GGIGASLGNMQEDNWHFHFYDTVKGSDWLGDQDAIEFMTREAPKVVYELEHLGMPFDRNA
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
DGTIYQRPFGGHSANYGDKPVPRACAAADRTGHALLHTLYQSNVKMGTQFFVEWIALDLI
CCCEEECCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RNEAGDVLGVTAYDQETGNIAVFQAKATLFATGGAGRVYRASTNAYINTGDGLGMAARAG
HCCCCCEEEEEEECCCCCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCCHHHCC
IPLQDMEFWQFHPTGVAGAGVLLTEGCRGEGAILRNKDGEPFMERYAPTLKDLAPRDFVS
CCCCCCCCEEECCCCCCCCCEEEECCCCCCCCEEECCCCCHHHHHHCCHHHHCCCHHHHH
RSMDQEIKEGRGCGPKADYILLDMTHLGADTIMKRLPSVFEIGKKFANVDITKEPIPVVP
HHHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCE
TIHYQMGGIPTNIHGQVVVPVATENLHLEAHYNNATKEYTFETNCPDFVKPVKGFYAIGE
EEEEECCCCCCCCCCEEEEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHHHHHEEECC
CSCVSVHGANRLGTNSLLDLVVFGKAAGEHIIDYVTKHHGDEYAPLPTDVLESTLKRIRH
CEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
LDESTSGENAQEVADAIRDIVQDHAAVFRTQELLDEGVRQILALEPRVRNIYLKDKSKVF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHH
NTARVEALEVENLYEVAKATLISAAARKECRGAHTVVDYELAPDHPDYPYGRRDDEWMKH
HHHHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHH
TLWYSADNRLEYKPVRYVPLTVDAIPPAPRTF
HHEECCCCCEEECCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]