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The map label for this gene is htpX

Identifier: 50085876

GI number: 50085876

Start: 2768149

End: 2769054

Strand: Direct

Name: htpX

Synonym: ACIAD2833

Alternate gene names: 50085876

Gene position: 2768149-2769054 (Clockwise)

Preceding gene: 50085875

Following gene: 50085880

Centisome position: 76.92

GC content: 45.47

Gene sequence:

>906_bases
ATGATGCGGATTGGTTTGTTTTTGCTAACCAACCTCGCGGTACTGGTTGTGGCTGGCATTATCTTGTCACTGTTCGGTGT
CGGTAGTTACCATGGCGCGGGTGGCTTAAATCTAGGCAACCTTTTGGTTATCTGTTTCGTGTTTGGTATGGTTGGCTCGC
TGATCTCCCTTTTGATGTCCAAATGGATGGCTAAAAAAACCACCGGTACAGAAATTATTGATCCGAATGCACCCCGTAAC
CAGGCTGAAGCTTGGCTATTACAAACTGTTGCAGAACTTTCACAACGTGCTGGCATCCAAATGCCAGAAGTTGGAATTTT
CCCATCCTATCAATCTAATGCCTTTGCAACAGGCTGGAACAAAAACGATGCCCTCGTTTCGGTTTCAACAGGATTAATGG
AACGCATGAATAAAGATGAATTGCGTGCTGTATTGGCGCATGAAATTGGTCACGTTGCCAATGGTGACATGGTGACACTT
GCGCTGATTCAAGGTGTCGTCAACGCGTTTGTGATGTTCTTTGCCCGTGTAGTCGGTGATTTTATTGATCGAAACGTGTT
TGGTCGCCAAGATGGTGAAGCACCTGGCATGGGTTACTTCGCGATTACGATTGTCCTTGATATTGTATTTGGTATTCTTG
CCTCAGCGATTGTGATGTGGTTCTCCCGCCATCGTGAATATCGTGCCGATGAAGCTGGTGCTCGTTTAGCAGGTAAACAA
GCGATGATTTCTGCCCTATTACGCTTACAGGCAGAGTCAGAAATGCCAGATCAAATGCCAAAAGAAATGAAAGCCTTTGC
AATTGCGGAAGGTAAAGAACAAGGTTTTAGTCTTGCTGCCTTATTCCAAACCCACCCAAGTATCGAGCAACGTGTTGCTG
CGCTACAGCAATTAAATTGTCCATAA

Upstream 100 bases:

>100_bases
TAATTTGTCTTGAATTTTGGCAAGAATCCCCCCATATTTAACGCAATGATTTAACATTTCATAAATCAGATCAGATTTTA
TTTATAAGAGGATTTTCTCA

Downstream 100 bases:

>100_bases
TTTCCGCTTCAAAAAAGCCTCCAGATGGAGGCTTTTTTTATTGGCCTTGATACCAGTTCCAGAGATAGCTGGTCCCGAGC
CAAATAGCAGCAATAAAGAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: Heat shock protein HtpX

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLLMSKWMAKKTTGTEIIDPNAPRN
QAEAWLLQTVAELSQRAGIQMPEVGIFPSYQSNAFATGWNKNDALVSVSTGLMERMNKDELRAVLAHEIGHVANGDMVTL
ALIQGVVNAFVMFFARVVGDFIDRNVFGRQDGEAPGMGYFAITIVLDIVFGILASAIVMWFSRHREYRADEAGARLAGKQ
AMISALLRLQAESEMPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPSIEQRVAALQQLNCP

Sequences:

>Translated_301_residues
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLLMSKWMAKKTTGTEIIDPNAPRN
QAEAWLLQTVAELSQRAGIQMPEVGIFPSYQSNAFATGWNKNDALVSVSTGLMERMNKDELRAVLAHEIGHVANGDMVTL
ALIQGVVNAFVMFFARVVGDFIDRNVFGRQDGEAPGMGYFAITIVLDIVFGILASAIVMWFSRHREYRADEAGARLAGKQ
AMISALLRLQAESEMPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPSIEQRVAALQQLNCP
>Mature_301_residues
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLLMSKWMAKKTTGTEIIDPNAPRN
QAEAWLLQTVAELSQRAGIQMPEVGIFPSYQSNAFATGWNKNDALVSVSTGLMERMNKDELRAVLAHEIGHVANGDMVTL
ALIQGVVNAFVMFFARVVGDFIDRNVFGRQDGEAPGMGYFAITIVLDIVFGILASAIVMWFSRHREYRADEAGARLAGKQ
AMISALLRLQAESEMPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPSIEQRVAALQQLNCP

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=300, Percent_Identity=49.6666666666667, Blast_Score=270, Evalue=9e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_ACIAD (Q6F8Q1)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047386.1
- ProteinModelPortal:   Q6F8Q1
- SMR:   Q6F8Q1
- STRING:   Q6F8Q1
- MEROPS:   M48.002
- GeneID:   2878290
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2833
- NMPDR:   fig|62977.3.peg.2579
- eggNOG:   COG0501
- HOGENOM:   HBG739460
- OMA:   DTMKAFG
- PhylomeDB:   Q6F8Q1
- ProtClustDB:   PRK05457
- BioCyc:   ASP62977:ACIAD2833-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32683; Mature: 32683

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 148-148

Signals:

None

Transmembrane regions:

HASH(0x1994c168)-; HASH(0x19f04ae4)-; HASH(0x19af6b38)-; HASH(0x16b696f4)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLLMS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KWMAKKTTGTEIIDPNAPRNQAEAWLLQTVAELSQRAGIQMPEVGIFPSYQSNAFATGWN
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCC
KNDALVSVSTGLMERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMFFARVVGD
CCCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FIDRNVFGRQDGEAPGMGYFAITIVLDIVFGILASAIVMWFSRHREYRADEAGARLAGKQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AMISALLRLQAESEMPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPSIEQRVAALQQLNC
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCHHHHHHHHHHCCC
P
H
>Mature Secondary Structure
MMRIGLFLLTNLAVLVVAGIILSLFGVGSYHGAGGLNLGNLLVICFVFGMVGSLISLLMS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KWMAKKTTGTEIIDPNAPRNQAEAWLLQTVAELSQRAGIQMPEVGIFPSYQSNAFATGWN
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCC
KNDALVSVSTGLMERMNKDELRAVLAHEIGHVANGDMVTLALIQGVVNAFVMFFARVVGD
CCCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FIDRNVFGRQDGEAPGMGYFAITIVLDIVFGILASAIVMWFSRHREYRADEAGARLAGKQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AMISALLRLQAESEMPDQMPKEMKAFAIAEGKEQGFSLAALFQTHPSIEQRVAALQQLNC
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHCCCHHHHHHHCCCCHHHHHHHHHHCCC
P
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA