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The map label for this gene is norM [H]

Identifier: 50085817

GI number: 50085817

Start: 2699483

End: 2700823

Strand: Reverse

Name: norM [H]

Synonym: ACIAD2761

Alternate gene names: 50085817

Gene position: 2700823-2699483 (Counterclockwise)

Preceding gene: 50085818

Following gene: 50085815

Centisome position: 75.05

GC content: 34.68

Gene sequence:

>1341_bases
ATGAATATTTTAAAAGACATCTTATTCCCAATTTTGAAATTGGCACTTCCATTGATTCTGATTCAAATTTGTCAGGCATC
TCTAGGGGTGATTAATACTATGGTGGCAGGTCGGTATTATTATATTGATTTAGCTGGAATTGGATTAGGAAGTAATATGT
GGACGCCTGTATTCATTTTATTTACAGGAATTTTATATGTATTGGTACCTAAAATTTCTGCCATGCAACAACACAGTTCT
CAGGAGATTGGAGTACTTATTCAACAAGGAAAAAGAGTTGCTTTTTTACTTTCGATTTTTGGATTTATATTAATTCAATT
ATTAGCATTTTTGTGTCCTTGGCTCATTGGCGATCAGCAAGTGGCACAGATTGCCAAACAGTATCTGCACTTTGTTGCTT
TTGGTGTACCAGGTTTAGTTTATATGACACTATTTCGCTTCGTTAGCGAAGGTCATAGTTTACTAAAACCAATTATCCTG
ACATATGCGATTTTACTTGTTTGCGATGCATCATTGTGTTTGGTGTTGGTTAATGGAATTGGATTTATTCCAGAAATGGG
GGGAGCGGGAACAGGTTTAGCCACAGCTATGAGTGCTTATATTGCTTGTTTTTGTATGTATCAGTTTGTTTCAAAAGCAA
TTCCTGAACTTAAAATTAAACGCATTCAAGTTGGTTTTAAAGAAAGTTTAGGTTTGTTAAAGCAAGGCTTACCTATAGGA
ATTACTTTAATTCTGCAAATTTTAGCATTGGCAACACTGGCATTTTTTGCTTCACAGCTTGGTGCAAAAGCAATTGCAGC
GCATCAAATTGTAATTAATATTGCTATGCTGATCATCATGATTCCGATTGCAATAAGTAGTGCAACAACAATTAGAATTG
CTTATTTTTCTGCGACCAATCATCACCAAGGAAAAATATCTACAAGTTTATGTGTAGTTGTGTTGACCCTGATCTATAGT
TTTTTGATGGCAGGAATTTTGATAGGTTTTGCACAACACATTGTAAGCTTATTTACTCAAGATGCTGAAGTCTTAAATGT
TGCTGTTGGTCTAATGTCATATGTGGCGATATTTTTAATTTTTGATGCAATACAAACGGTAGCTTCTGGTGTCTTACGTG
GTTTACATCAATTTATGCAACCCTTGTTTATTATTTTATTTTGCTATTGGTTTGTAATTATTCCATTAAGTTATTTAATG
GGGGTACAAGGGTGGTTGCAAGTGCGTGCCAATGTGGATGTCATCTGGATTGTATTGACTTGTGGCATTAGCTTAGCTGC
TGTTTTATTAACTATTCAAAGTTATTGTCATGTAACGGGAATAATGAATAAACGGAGTTGA

Upstream 100 bases:

>100_bases
AAAGTTACAGGGTAAAAACAATCATATCAAGGGATATTGGCGACTTCAAAAAGCCCATTAATCCACAGGAACCTAAAGAC
TAAATACTTGTAGATCTACG

Downstream 100 bases:

>100_bases
AAAGCATTCACAGGAGTACATTAAGACTGAGTTTTACCAATAGCTTTTAACAATTTAGTGATTAACCCATTAAACCCTCA
TTAAATTTGGGGTTTTTTCT

Product: multidrug resistance pump

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter; Na(+)/drug antiporter [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNILKDILFPILKLALPLILIQICQASLGVINTMVAGRYYYIDLAGIGLGSNMWTPVFILFTGILYVLVPKISAMQQHSS
QEIGVLIQQGKRVAFLLSIFGFILIQLLAFLCPWLIGDQQVAQIAKQYLHFVAFGVPGLVYMTLFRFVSEGHSLLKPIIL
TYAILLVCDASLCLVLVNGIGFIPEMGGAGTGLATAMSAYIACFCMYQFVSKAIPELKIKRIQVGFKESLGLLKQGLPIG
ITLILQILALATLAFFASQLGAKAIAAHQIVINIAMLIIMIPIAISSATTIRIAYFSATNHHQGKISTSLCVVVLTLIYS
FLMAGILIGFAQHIVSLFTQDAEVLNVAVGLMSYVAIFLIFDAIQTVASGVLRGLHQFMQPLFIILFCYWFVIIPLSYLM
GVQGWLQVRANVDVIWIVLTCGISLAAVLLTIQSYCHVTGIMNKRS

Sequences:

>Translated_446_residues
MNILKDILFPILKLALPLILIQICQASLGVINTMVAGRYYYIDLAGIGLGSNMWTPVFILFTGILYVLVPKISAMQQHSS
QEIGVLIQQGKRVAFLLSIFGFILIQLLAFLCPWLIGDQQVAQIAKQYLHFVAFGVPGLVYMTLFRFVSEGHSLLKPIIL
TYAILLVCDASLCLVLVNGIGFIPEMGGAGTGLATAMSAYIACFCMYQFVSKAIPELKIKRIQVGFKESLGLLKQGLPIG
ITLILQILALATLAFFASQLGAKAIAAHQIVINIAMLIIMIPIAISSATTIRIAYFSATNHHQGKISTSLCVVVLTLIYS
FLMAGILIGFAQHIVSLFTQDAEVLNVAVGLMSYVAIFLIFDAIQTVASGVLRGLHQFMQPLFIILFCYWFVIIPLSYLM
GVQGWLQVRANVDVIWIVLTCGISLAAVLLTIQSYCHVTGIMNKRS
>Mature_446_residues
MNILKDILFPILKLALPLILIQICQASLGVINTMVAGRYYYIDLAGIGLGSNMWTPVFILFTGILYVLVPKISAMQQHSS
QEIGVLIQQGKRVAFLLSIFGFILIQLLAFLCPWLIGDQQVAQIAKQYLHFVAFGVPGLVYMTLFRFVSEGHSLLKPIIL
TYAILLVCDASLCLVLVNGIGFIPEMGGAGTGLATAMSAYIACFCMYQFVSKAIPELKIKRIQVGFKESLGLLKQGLPIG
ITLILQILALATLAFFASQLGAKAIAAHQIVINIAMLIIMIPIAISSATTIRIAYFSATNHHQGKISTSLCVVVLTLIYS
FLMAGILIGFAQHIVSLFTQDAEVLNVAVGLMSYVAIFLIFDAIQTVASGVLRGLHQFMQPLFIILFCYWFVIIPLSYLM
GVQGWLQVRANVDVIWIVLTCGISLAAVLLTIQSYCHVTGIMNKRS

Specific function: Multidrug efflux pump that functions as a Na(+)/drug antiporter [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=439, Percent_Identity=26.879271070615, Blast_Score=167, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6321821, Length=386, Percent_Identity=25.1295336787565, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48731; Mature: 48731

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILKDILFPILKLALPLILIQICQASLGVINTMVAGRYYYIDLAGIGLGSNMWTPVFIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHH
FTGILYVLVPKISAMQQHSSQEIGVLIQQGKRVAFLLSIFGFILIQLLAFLCPWLIGDQQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VAQIAKQYLHFVAFGVPGLVYMTLFRFVSEGHSLLKPIILTYAILLVCDASLCLVLVNGI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFIPEMGGAGTGLATAMSAYIACFCMYQFVSKAIPELKIKRIQVGFKESLGLLKQGLPIG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCHH
ITLILQILALATLAFFASQLGAKAIAAHQIVINIAMLIIMIPIAISSATTIRIAYFSATN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
HHQGKISTSLCVVVLTLIYSFLMAGILIGFAQHIVSLFTQDAEVLNVAVGLMSYVAIFLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FDAIQTVASGVLRGLHQFMQPLFIILFCYWFVIIPLSYLMGVQGWLQVRANVDVIWIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
CGISLAAVLLTIQSYCHVTGIMNKRS
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNILKDILFPILKLALPLILIQICQASLGVINTMVAGRYYYIDLAGIGLGSNMWTPVFIL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHH
FTGILYVLVPKISAMQQHSSQEIGVLIQQGKRVAFLLSIFGFILIQLLAFLCPWLIGDQQ
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VAQIAKQYLHFVAFGVPGLVYMTLFRFVSEGHSLLKPIILTYAILLVCDASLCLVLVNGI
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GFIPEMGGAGTGLATAMSAYIACFCMYQFVSKAIPELKIKRIQVGFKESLGLLKQGLPIG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCCCHH
ITLILQILALATLAFFASQLGAKAIAAHQIVINIAMLIIMIPIAISSATTIRIAYFSATN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
HHQGKISTSLCVVVLTLIYSFLMAGILIGFAQHIVSLFTQDAEVLNVAVGLMSYVAIFLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FDAIQTVASGVLRGLHQFMQPLFIILFCYWFVIIPLSYLMGVQGWLQVRANVDVIWIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHH
CGISLAAVLLTIQSYCHVTGIMNKRS
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA