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The map label for this gene is purM

Identifier: 50085704

GI number: 50085704

Start: 2587442

End: 2588512

Strand: Direct

Name: purM

Synonym: ACIAD2634

Alternate gene names: 50085704

Gene position: 2587442-2588512 (Clockwise)

Preceding gene: 50085699

Following gene: 50085705

Centisome position: 71.9

GC content: 42.58

Gene sequence:

>1071_bases
ATGAGCAACTCAACTTCTACCCCTAATACTGGTTTAAGCTATAAAGATGCGGGTGTCGACATTGAAGCGGGCGACGCGCT
AGTCGATCGTATCAAGTCGGTAGCTAAACGTACTACTCGTCCTGAAGTAATGGGCGGTCTTGGTGGCTTTGGCGCACTTT
GTAAAATTCCTAAAGGCTATGAAGAGCCAGTTCTGGTTTCTGGAACAGATGGTGTAGGGACTAAATTACGTTTAGCACTT
AACCTTAACCGTCACGACACCATTGGTCAGGATTTAGTTGCCATGTGTGTAAACGATCTTCTGGTATGTGGTGCTGAACC
ATTATTTTTCCTTGATTATTATGCAACAGGTCATTTAAATGTCGATGTTGCAGCCAATGTTGTAACAGGTATTGGTAAAG
GATGTGAGCTTGCTGGTTGTGCGCTTGTTGGTGGTGAAACTGCCGAAATGCCAGGTATGTATGAAGGCGAAGATTACGAC
TTGGCTGGTTTTGCAGTAGGTGTGGTTGAGCAAAGTAAAATCATTGATGGCTCTAAAGTCAAAGCGGGTGATGTTTTAAT
TGGGGTTGCTTCGAGTGGTGCTCACTCAAATGGTTACTCATTACTCCGTAAAATTCTTGATGTTAAAAATGTAGATTTAA
CCCAGGAAATTGATGGTCGTTCTTTGGCAGATGCTGCAATGGAACCAACACGTATTTATGTGAAACCTGTACTTGAACTT
TGCAAACAAGTCGATGTACATGCAATGGCGCATATTACTGGTGGCGGTTTACCAGGCAACTTGCCGCGTGTTTTACCAAA
TGGTGCACAAGCTGTGATTGATGAAGCATCATGGGAATGGCCTGAATTGTTCAAACTTTTACAGCGTGAAGGCGGTGTAG
AGCAATTTGAAATGTACCGTACCTTTAACTGTGGTGTTGGTATGGTCATTGCAGTTGATGCAGCAGATGCAGACAAAACA
ATTCAAGTGCTCAATGCTCAAGGTGAAAAATCTTGGAAAATTGGTCATATTCAAGATAATGCTGAATCTATTGAAGGTGC
AGACGAAAAAATTCGTGTGATCTTTGCATGA

Upstream 100 bases:

>100_bases
ATGCAAAAATATTTAAATAAAGATAGCATTTTCGGTCATAAATACCATAAGAGTTTCGTATATTCAGGTTATAATCTGCC
GCCAATGCGGAGACTTCACT

Downstream 100 bases:

>100_bases
TAAAAATTGCGGTACTTGTTTCTGGAAATGGTAGTAATTTACAAGCCCTGATAGATGCCAATCTGTCAGGCAGCATAGTC
GGTGTTATTTCCAACAAACC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLAL
NLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYD
LAGFAVGVVEQSKIIDGSKVKAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLEL
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYRTFNCGVGMVIAVDAADADKT
IQVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA

Sequences:

>Translated_356_residues
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLAL
NLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYD
LAGFAVGVVEQSKIIDGSKVKAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLEL
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYRTFNCGVGMVIAVDAADADKT
IQVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA
>Mature_355_residues
SNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGYEEPVLVSGTDGVGTKLRLALN
LNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLNVDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDL
AGFAVGVVEQSKIIDGSKVKAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLELC
KQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYRTFNCGVGMVIAVDAADADKTI
QVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=49.2581602373887, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=49.2581602373887, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=49.2581602373887, Blast_Score=319, Evalue=2e-87,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=70.5705705705706, Blast_Score=483, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17567511, Length=355, Percent_Identity=41.4084507042254, Blast_Score=247, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=44.6629213483146, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24582400, Length=316, Percent_Identity=43.9873417721519, Blast_Score=224, Evalue=8e-59,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ACIAD (Q6F973)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047214.1
- HSSP:   P08178
- ProteinModelPortal:   Q6F973
- SMR:   Q6F973
- STRING:   Q6F973
- GeneID:   2880908
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2634
- NMPDR:   fig|62977.3.peg.2407
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   Q6F973
- ProtClustDB:   PRK05385
- BioCyc:   ASP62977:ACIAD2634-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37697; Mature: 37566

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGY
CCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCC
EEPVLVSGTDGVGTKLRLALNLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLN
CCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEE
VDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDLAGFAVGVVEQSKIIDGSKV
EEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCE
KAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLEL
ECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEHHHHHHHH
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYR
HHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHE
TFNCGVGMVIAVDAADADKTIQVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA
EECCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCHHHHCCCCCEEEEEEC
>Mature Secondary Structure 
SNSTSTPNTGLSYKDAGVDIEAGDALVDRIKSVAKRTTRPEVMGGLGGFGALCKIPKGY
CCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCCC
EEPVLVSGTDGVGTKLRLALNLNRHDTIGQDLVAMCVNDLLVCGAEPLFFLDYYATGHLN
CCCEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCEE
VDVAANVVTGIGKGCELAGCALVGGETAEMPGMYEGEDYDLAGFAVGVVEQSKIIDGSKV
EEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEEHHHCCCCCCE
KAGDVLIGVASSGAHSNGYSLLRKILDVKNVDLTQEIDGRSLADAAMEPTRIYVKPVLEL
ECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEHHHHHHHH
CKQVDVHAMAHITGGGLPGNLPRVLPNGAQAVIDEASWEWPELFKLLQREGGVEQFEMYR
HHHCCHHEEEEEECCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHE
TFNCGVGMVIAVDAADADKTIQVLNAQGEKSWKIGHIQDNAESIEGADEKIRVIFA
EECCCCEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA