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The map label for this gene is trpC [H]

Identifier: 50085545

GI number: 50085545

Start: 2424660

End: 2425517

Strand: Direct

Name: trpC [H]

Synonym: ACIAD2463

Alternate gene names: 50085545

Gene position: 2424660-2425517 (Clockwise)

Preceding gene: 50085544

Following gene: 50085547

Centisome position: 67.38

GC content: 39.86

Gene sequence:

>858_bases
CTGAATTTACTAAAGCGCTTAAAGAATACGCAAACAACTGAGGTTATCCAAATGATTCAGATTCAAAATACTATTCTGGG
TAAAATCGTTGATCGTAAACATGAAGAACTGGCAGATCGTTTAAAGCAGCGCAACCTAAAAGATGTGGAACAATGGGTAA
AGGAAGCGCCCCCTGTACGTGGTTTTGCCCAATCATTACGCAGCAAACGCCCTGGTGTAATTGCCGAAATAAAAAAAGCC
TCACCTTCTAAAGGTGTGATTCGGGCTGATTTTAATCCTGCTGAAATTGCTCAACAATACGAGCAAGCAGGTGCAGCTTG
TCTTTCTGTATTAACAGATGTCGATTTTTTCCAAGGTGCTGATGAAAACATTGCCATTGCTCGGCAACATTGTTCTTTGC
CTGCCCTACGTAAAGATTTTTTAATTGATCCATACAATGTTGTCGAAGCACGTGCTTTACAGGCAGACTGTATTTTATTG
ATTGTCGCTTGTTTGTCTGATCAGCAACTCGAAGAGATGTCAAAAACTGCATTTGAATATGATCTTGACGTTTTGGTTGA
AGTGCATGACGAACAAGAATTAGAACGCGCACTCAAACTTTCAGAACAGTGCTTATTGGGTGTAAATAATCGTAATCTTA
AAACCTTTGATGTCGATTTAAATACCAGCTTGCGTTTGAAGAAGCTGCTTGATCCATCACGTTTATTGGTCACTGAAAGT
GGTATCGCAACTCCTCAAGATGTGCAATTAATGCAAGAACATGACATTCATTCATTCTTGGTGGGTGAAAGTTTTATGAA
GCAGCCTCGACCAGATCAGGCATTTACTGAATTATTTGGTGTGCCTAAGCTGGTTTAA

Upstream 100 bases:

>100_bases
ATTTATGTATCAGGCTTAGCTACCAGCTATAAACAAGGTGTGGCGTTGGCACATGATATTATTTACGGCGGACAAGCACT
CGAAAAAATGAGTATTTTGT

Downstream 100 bases:

>100_bases
ACAAATTTTGTTAAAGCAATAGCAAATTGAACATTTGCTATTGTTGTTTCTTCTCTAACCATTCAGTTAAATAATATAAA
TACACATCGAATGCTTCCTT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNLLKRLKNTQTTEVIQMIQIQNTILGKIVDRKHEELADRLKQRNLKDVEQWVKEAPPVRGFAQSLRSKRPGVIAEIKKA
SPSKGVIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARQHCSLPALRKDFLIDPYNVVEARALQADCILL
IVACLSDQQLEEMSKTAFEYDLDVLVEVHDEQELERALKLSEQCLLGVNNRNLKTFDVDLNTSLRLKKLLDPSRLLVTES
GIATPQDVQLMQEHDIHSFLVGESFMKQPRPDQAFTELFGVPKLV

Sequences:

>Translated_285_residues
MNLLKRLKNTQTTEVIQMIQIQNTILGKIVDRKHEELADRLKQRNLKDVEQWVKEAPPVRGFAQSLRSKRPGVIAEIKKA
SPSKGVIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARQHCSLPALRKDFLIDPYNVVEARALQADCILL
IVACLSDQQLEEMSKTAFEYDLDVLVEVHDEQELERALKLSEQCLLGVNNRNLKTFDVDLNTSLRLKKLLDPSRLLVTES
GIATPQDVQLMQEHDIHSFLVGESFMKQPRPDQAFTELFGVPKLV
>Mature_285_residues
MNLLKRLKNTQTTEVIQMIQIQNTILGKIVDRKHEELADRLKQRNLKDVEQWVKEAPPVRGFAQSLRSKRPGVIAEIKKA
SPSKGVIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARQHCSLPALRKDFLIDPYNVVEARALQADCILL
IVACLSDQQLEEMSKTAFEYDLDVLVEVHDEQELERALKLSEQCLLGVNNRNLKTFDVDLNTSLRLKKLLDPSRLLVTES
GIATPQDVQLMQEHDIHSFLVGESFMKQPRPDQAFTELFGVPKLV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=39.5918367346939, Blast_Score=160, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=223, Percent_Identity=39.9103139013453, Blast_Score=149, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 32201; Mature: 32201

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLKRLKNTQTTEVIQMIQIQNTILGKIVDRKHEELADRLKQRNLKDVEQWVKEAPPVR
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHH
GFAQSLRSKRPGVIAEIKKASPSKGVIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGA
HHHHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DENIAIARQHCSLPALRKDFLIDPYNVVEARALQADCILLIVACLSDQQLEEMSKTAFEY
CCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DLDVLVEVHDEQELERALKLSEQCLLGVNNRNLKTFDVDLNTSLRLKKLLDPSRLLVTES
CHHHEEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCHHEEEECC
GIATPQDVQLMQEHDIHSFLVGESFMKQPRPDQAFTELFGVPKLV
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MNLLKRLKNTQTTEVIQMIQIQNTILGKIVDRKHEELADRLKQRNLKDVEQWVKEAPPVR
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHH
GFAQSLRSKRPGVIAEIKKASPSKGVIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGA
HHHHHHHCCCCCHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DENIAIARQHCSLPALRKDFLIDPYNVVEARALQADCILLIVACLSDQQLEEMSKTAFEY
CCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
DLDVLVEVHDEQELERALKLSEQCLLGVNNRNLKTFDVDLNTSLRLKKLLDPSRLLVTES
CHHHEEEECCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHCCCHHEEEECC
GIATPQDVQLMQEHDIHSFLVGESFMKQPRPDQAFTELFGVPKLV
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6599977 [H]