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The map label for this gene is trpD

Identifier: 50085544

GI number: 50085544

Start: 2423651

End: 2424700

Strand: Direct

Name: trpD

Synonym: ACIAD2462

Alternate gene names: 50085544

Gene position: 2423651-2424700 (Clockwise)

Preceding gene: 50085543

Following gene: 50085545

Centisome position: 67.35

GC content: 43.52

Gene sequence:

>1050_bases
ATGAATATTCAACAAGCATTAAACCATATCACCAAAAATATTCATCTGACCCAAGCGCAAATGGAAGATGTGATGCGTAG
CATCATGCAAGGCGAAGCCACTGAAGCACAAATTGGTGCGTTAATGATGGGTTTGCGCATGAAGGGTGAAAGTATCGATG
AAATTACCGCAGCCGCACGGGTTATGCGTGAGCTGGCGATTAAAATCGATGTCAGTGATATTCAATATCTAGTCGATATT
GTAGGGACAGGTGGCGATGGTCAAAACCTGTTTAACGTCTCTACGGCATCCAGCTTTGTAATTGCTGCTGCAGGTGCAAC
CATTGCTAAGCACGGTAATCGTGGCGTTTCTAGCAAATCTGGATCATCAGATCTGCTTGAACAGGCAGGGATTAATCTGG
ATCTGGATATGCAACAGACGGAACGTTGCATTCGCGAGATGGGTGTCGGTTTCTTATTTGCTCCCAACCATCACAAAGCC
ATGAAATATGCAGTGGGCCCTCGTCGTGAACTCGGGATTCGTAGTATTTTTAATTTACTTGGCCCGCTTACGAATCCGGC
TGGGGTAAAGCGCTTTGTGATTGGCGTATTTTCAGATGAACTTTGTCGACCAATTGCAGAAGTCATGAAACAACTTGGTG
CTGAGCATGTGATGGTTGTGCATTCCAAAGATGGTTTGGATGAAATTAGTCTTGCCTCGCAAACTTATATTGCGGAACTC
AAAAACGGTGAAGTGACTGAATGGGTGCTTAATCCAGAAGATGTGAATATTCCGTCTCAAACGTTAAGCGGTTTAATTGT
CGAAGATTCCAATGCCAGTCTAAAATTGATCAAAGATGCTTTGGGCCGCAAAAAATCGGACATCGGTGAAAAAGCAGCCA
ATATGATTGCCTTAAATGCAGGCGCGGGTATTTATGTATCAGGCTTAGCTACCAGCTATAAACAAGGTGTGGCGTTGGCA
CATGATATTATTTACGGCGGACAAGCACTCGAAAAAATGAGTATTTTGTCTGAATTTACTAAAGCGCTTAAAGAATACGC
AAACAACTGA

Upstream 100 bases:

>100_bases
TAAGACATTACCTGTAGAGGGTGTGCAGTTTCATCCAGAATCGATTTTGAGCCAGCATGGACACCAAATCTTCAAGAATT
TTTTAGAGATTTATGCATAA

Downstream 100 bases:

>100_bases
GGTTATCCAAATGATTCAGATTCAAAATACTATTCTGGGTAAAATCGTTGATCGTAAACATGAAGAACTGGCAGATCGTT
TAAAGCAGCGCAACCTAAAA

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MNIQQALNHITKNIHLTQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAARVMRELAIKIDVSDIQYLVDI
VGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKSGSSDLLEQAGINLDLDMQQTERCIREMGVGFLFAPNHHKA
MKYAVGPRRELGIRSIFNLLGPLTNPAGVKRFVIGVFSDELCRPIAEVMKQLGAEHVMVVHSKDGLDEISLASQTYIAEL
KNGEVTEWVLNPEDVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNAGAGIYVSGLATSYKQGVALA
HDIIYGGQALEKMSILSEFTKALKEYANN

Sequences:

>Translated_349_residues
MNIQQALNHITKNIHLTQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAARVMRELAIKIDVSDIQYLVDI
VGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKSGSSDLLEQAGINLDLDMQQTERCIREMGVGFLFAPNHHKA
MKYAVGPRRELGIRSIFNLLGPLTNPAGVKRFVIGVFSDELCRPIAEVMKQLGAEHVMVVHSKDGLDEISLASQTYIAEL
KNGEVTEWVLNPEDVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNAGAGIYVSGLATSYKQGVALA
HDIIYGGQALEKMSILSEFTKALKEYANN
>Mature_349_residues
MNIQQALNHITKNIHLTQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAARVMRELAIKIDVSDIQYLVDI
VGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKSGSSDLLEQAGINLDLDMQQTERCIREMGVGFLFAPNHHKA
MKYAVGPRRELGIRSIFNLLGPLTNPAGVKRFVIGVFSDELCRPIAEVMKQLGAEHVMVVHSKDGLDEISLASQTYIAEL
KNGEVTEWVLNPEDVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNAGAGIYVSGLATSYKQGVALA
HDIIYGGQALEKMSILSEFTKALKEYANN

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=256, Percent_Identity=43.359375, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320561, Length=326, Percent_Identity=28.2208588957055, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_ACIAD (P00500)

Other databases:

- EMBL:   M36636
- EMBL:   CR543861
- PIR:   A00585
- RefSeq:   YP_047054.1
- ProteinModelPortal:   P00500
- SMR:   P00500
- STRING:   P00500
- GeneID:   2880736
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2462
- NMPDR:   fig|62977.3.peg.2063
- eggNOG:   COG0547
- HOGENOM:   HBG559996
- OMA:   HGNKSAS
- PhylomeDB:   P00500
- ProtClustDB:   PRK00188
- BioCyc:   ASP62977:ACIAD2462-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 37557; Mature: 37557

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQQALNHITKNIHLTQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAAR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
VMRELAIKIDVSDIQYLVDIVGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKS
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHCCCCCCCCCC
GSSDLLEQAGINLDLDMQQTERCIREMGVGFLFAPNHHKAMKYAVGPRRELGIRSIFNLL
CCHHHHHHCCCCCEECHHHHHHHHHHHCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHH
GPLTNPAGVKRFVIGVFSDELCRPIAEVMKQLGAEHVMVVHSKDGLDEISLASQTYIAEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
KNGEVTEWVLNPEDVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNA
CCCCEEEEEECCCCCCCCHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCEEEEEC
GAGIYVSGLATSYKQGVALAHDIIYGGQALEKMSILSEFTKALKEYANN
CCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIQQALNHITKNIHLTQAQMEDVMRSIMQGEATEAQIGALMMGLRMKGESIDEITAAAR
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
VMRELAIKIDVSDIQYLVDIVGTGGDGQNLFNVSTASSFVIAAAGATIAKHGNRGVSSKS
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCHHHHCCCCCCCCCC
GSSDLLEQAGINLDLDMQQTERCIREMGVGFLFAPNHHKAMKYAVGPRRELGIRSIFNLL
CCHHHHHHCCCCCEECHHHHHHHHHHHCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHH
GPLTNPAGVKRFVIGVFSDELCRPIAEVMKQLGAEHVMVVHSKDGLDEISLASQTYIAEL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHH
KNGEVTEWVLNPEDVNIPSQTLSGLIVEDSNASLKLIKDALGRKKSDIGEKAANMIALNA
CCCCEEEEEECCCCCCCCHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHCEEEEEC
GAGIYVSGLATSYKQGVALAHDIIYGGQALEKMSILSEFTKALKEYANN
CCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6599977