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The map label for this gene is rbsK [H]

Identifier: 50085479

GI number: 50085479

Start: 2348944

End: 2349882

Strand: Direct

Name: rbsK [H]

Synonym: ACIAD2392

Alternate gene names: 50085479

Gene position: 2348944-2349882 (Clockwise)

Preceding gene: 50085473

Following gene: 50085481

Centisome position: 65.27

GC content: 47.07

Gene sequence:

>939_bases
ATGAGTTCAACCCCTCCTTTGCTTACTGTGATTGGTAGCATTAATGTCGATCATATCCTTGGCCTCGAGCACTTTCCACA
TCCTGGACAAACCTTGAATGGTCAGAGCTATCAGGTTGCATTTGGTGGAAAAGGTGCAAATCAGGCTGTGGCAGCAGGCC
GAAGTGGCGCCAATACCAGTTTTATTGCCTGTGTAGGTAGCGATGCCGTGGGTGAACAAATTCGTCATCAACTCATCAAA
GACAACATTGATACTCAGGCCGTGCGTGCTGTTGAAGGTTTCACCACAGGTGTCGCACTGATTTTTGTTAATCAGCATGC
AGAGAACTTCATTGGTATTCATGCCGGTGCCAATGCTGCGCTTGATATTGCGTACATCGATCAGCATGCAGAGCTGATTC
AACGCTCAAGCGCAATTCTGTTACAGCTCGAAACACCATTAGCCACTATTTTACACGCTGCAAAGCTTGCCAAAGCCGCT
GGTGTAAAAGTGATTTTAAATCCGGCGCCAGCCTGTGAGTTACCTGAAGAATTATTACGTTTGGTCGATATTATTACCCC
CAACGAAACCGAAGCGTTAAGCCTCACCAATGTGATTGTGCATGATGATCATGACGCTGCCGAAGCGGCAAATGTGCTGC
ATCAAAAAGGTATTAAAACTGTAGTCATCACGATGGGCTCTCGTGGTGTCTGGCTAAGTGAATATGGTCAGGGCAAAATG
ATTGAAGGTTTTAAAGTGAGTGCAATCGATACCATTGCCGCAGGCGATACGTTTAATGGTGCATTTGTGACGGCACTTCT
TGAAGGAAAAACCGCTCAAGACGCTGCACGCTTTGCCAATGCAGCCGCTGCAATTGCCGTTACCCGATCTGGTGCCCAGC
CTTCTGTGCCATGGCGTCAAGAAATTGATCTGTTTCTTTCTGCTCAAACGGCACTATAA

Upstream 100 bases:

>100_bases
TTGAACAATAACGCAATGCCATTTAAAACATCTTGTTTGATAAAACCGACATCGCGTAAAATTATAGGCATAATACGCTG
CTTTTAATTTAGAGTTTCTA

Downstream 100 bases:

>100_bases
TTCTAAATTGTTTTGTGGTTTAATACGCGCAGTTTGAGATGAGCCTCATACAGTATATGACTCGATTTATATACGACTAG
CCCCGCTAATATGCGGGGCT

Product: ribokinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSSTPPLLTVIGSINVDHILGLEHFPHPGQTLNGQSYQVAFGGKGANQAVAAGRSGANTSFIACVGSDAVGEQIRHQLIK
DNIDTQAVRAVEGFTTGVALIFVNQHAENFIGIHAGANAALDIAYIDQHAELIQRSSAILLQLETPLATILHAAKLAKAA
GVKVILNPAPACELPEELLRLVDIITPNETEALSLTNVIVHDDHDAAEAANVLHQKGIKTVVITMGSRGVWLSEYGQGKM
IEGFKVSAIDTIAAGDTFNGAFVTALLEGKTAQDAARFANAAAAIAVTRSGAQPSVPWRQEIDLFLSAQTAL

Sequences:

>Translated_312_residues
MSSTPPLLTVIGSINVDHILGLEHFPHPGQTLNGQSYQVAFGGKGANQAVAAGRSGANTSFIACVGSDAVGEQIRHQLIK
DNIDTQAVRAVEGFTTGVALIFVNQHAENFIGIHAGANAALDIAYIDQHAELIQRSSAILLQLETPLATILHAAKLAKAA
GVKVILNPAPACELPEELLRLVDIITPNETEALSLTNVIVHDDHDAAEAANVLHQKGIKTVVITMGSRGVWLSEYGQGKM
IEGFKVSAIDTIAAGDTFNGAFVTALLEGKTAQDAARFANAAAAIAVTRSGAQPSVPWRQEIDLFLSAQTAL
>Mature_311_residues
SSTPPLLTVIGSINVDHILGLEHFPHPGQTLNGQSYQVAFGGKGANQAVAAGRSGANTSFIACVGSDAVGEQIRHQLIKD
NIDTQAVRAVEGFTTGVALIFVNQHAENFIGIHAGANAALDIAYIDQHAELIQRSSAILLQLETPLATILHAAKLAKAAG
VKVILNPAPACELPEELLRLVDIITPNETEALSLTNVIVHDDHDAAEAANVLHQKGIKTVVITMGSRGVWLSEYGQGKMI
EGFKVSAIDTIAAGDTFNGAFVTALLEGKTAQDAARFANAAAAIAVTRSGAQPSVPWRQEIDLFLSAQTAL

Specific function: Ribose metabolism; first step. [C]

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family [H]

Homologues:

Organism=Homo sapiens, GI11545855, Length=300, Percent_Identity=38, Blast_Score=178, Evalue=7e-45,
Organism=Escherichia coli, GI1790193, Length=302, Percent_Identity=64.9006622516556, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI87081971, Length=282, Percent_Identity=31.9148936170213, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788491, Length=288, Percent_Identity=26.3888888888889, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082343, Length=310, Percent_Identity=28.3870967741935, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788484, Length=279, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532905, Length=314, Percent_Identity=35.6687898089172, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319884, Length=328, Percent_Identity=29.2682926829268, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20128807, Length=300, Percent_Identity=34.6666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583886, Length=314, Percent_Identity=30.5732484076433, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR011877
- InterPro:   IPR002139 [H]

Pfam domain/function: PF00294 PfkB [H]

EC number: =2.7.1.15 [H]

Molecular weight: Translated: 32702; Mature: 32570

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00584 PFKB_KINASES_2 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPPLLTVIGSINVDHILGLEHFPHPGQTLNGQSYQVAFGGKGANQAVAAGRSGANTS
CCCCCCEEEEEECCCHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCE
FIACVGSDAVGEQIRHQLIKDNIDTQAVRAVEGFTTGVALIFVNQHAENFIGIHAGANAA
EEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCE
LDIAYIDQHAELIQRSSAILLQLETPLATILHAAKLAKAAGVKVILNPAPACELPEELLR
EEEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHH
LVDIITPNETEALSLTNVIVHDDHDAAEAANVLHQKGIKTVVITMGSRGVWLSEYGQGKM
HHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCCCE
IEGFKVSAIDTIAAGDTFNGAFVTALLEGKTAQDAARFANAAAAIAVTRSGAQPSVPWRQ
ECCEEEEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHEEEEEEECCCCCCCCHHH
EIDLFLSAQTAL
HHEEEEEECCCC
>Mature Secondary Structure 
SSTPPLLTVIGSINVDHILGLEHFPHPGQTLNGQSYQVAFGGKGANQAVAAGRSGANTS
CCCCCEEEEEECCCHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCCE
FIACVGSDAVGEQIRHQLIKDNIDTQAVRAVEGFTTGVALIFVNQHAENFIGIHAGANAA
EEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCE
LDIAYIDQHAELIQRSSAILLQLETPLATILHAAKLAKAAGVKVILNPAPACELPEELLR
EEEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHH
LVDIITPNETEALSLTNVIVHDDHDAAEAANVLHQKGIKTVVITMGSRGVWLSEYGQGKM
HHHHCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCCCCE
IEGFKVSAIDTIAAGDTFNGAFVTALLEGKTAQDAARFANAAAAIAVTRSGAQPSVPWRQ
ECCEEEEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHEEEEEEECCCCCCCCHHH
EIDLFLSAQTAL
HHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]