Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 50085454

GI number: 50085454

Start: 2321290

End: 2322300

Strand: Reverse

Name: lpxK [H]

Synonym: ACIAD2363

Alternate gene names: 50085454

Gene position: 2322300-2321290 (Counterclockwise)

Preceding gene: 50085455

Following gene: 50085453

Centisome position: 64.53

GC content: 41.54

Gene sequence:

>1011_bases
ATGTCTTTTGCCCAGACGATACAGAATGCATGGAACCGTCAAGCAAAATGGTTGATTCTATTACGCCCGCTATCTTGGTT
ATATTCTGCTGGCTTTCAGATTAATAAACGTTTATATACATTGGGCCTGAAAAAAACATATCACGCGCCAGTTCCTATAA
TGGTCATTGGAAATATTACTGTAGGAGGAAGTGGCAAGACACCGCTACTTATTGGTCTGGTCAATTATTTACAACAGAAG
GGTGTGAGAGTTGGTGTAATTAGTCGTGGCTATGGTGCGGAAGGGCCATTTCCAGCATTGGTTGCAGTAAACTCTTTACC
AGATCAGGTTGGAGATGAGCCTTGCCTGATTGTGCAATCTACTCATGTGCCTATGGCCGTTGGTCCAGATCGTCAGGCCT
CAATCGAGCTTTTACTTTCATCTTATGCATTAGATTTAATTATTAGTGATGATGGTTTGCAGCATTGGGCGTTGGCGCGA
CAAATCGAATGGATCGTATTAGATGCTCATCGGGGCTTAGGTAATCAAAGAATGTTACCTGAAGGTTTTTTACGTGAGTC
TAAGAAACGTCTAAATACGGGTACCGTGATTGAGCATGGTTTGAACCCTAAAACATCACTGAATATGCATCTTGAGCCTG
GGCAGCCTTATTTGCTATGTCCAGCGACTGAAACTCATGAACCTTTTAATGCCAACGCCAGCTTTTACGCTGTTGTGGGA
ATTGGTTTCCCTCAAAGATTTTATAATACATTGGAATCTTTAGGTATTCATAATTTTCAATGTCACGAATTTCCTGATCA
TCATGATTACGAGCTTACAGATATCGACTTTGATGATCTAAATCCAGTGATTACCACTGAAAAAGATGCAGTTAAGTTAC
TGCCATTATTGAAACAATATCCAGAATACCCTCGCCAAATTTGGGTGGTGCCTGTCGAGGCTGTCATGTCTGACGCATGT
TACATCCGACTTGAACAACAGTTAGCACAGTTGGGTGTTTGCTTTTCTTAG

Upstream 100 bases:

>100_bases
CAAGGGGCAAATTATTGAGCAGGGTACTCATCAAGAGCTGCTTTTAAAGCAGGGTGCGTATTTTCAGCTCCATCAGCGTA
ATTTTGAGGAATAATACTGC

Downstream 100 bases:

>100_bases
GAACTAATCATGAAACATATCGTCATCCCGGCGCGTTTTTCAAGCACTCGCTTGCCAGGCAAACCTTTACTTGAAATTCA
TGGGCGCGCCATGATTTTAC

Product: tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase)

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSFAQTIQNAWNRQAKWLILLRPLSWLYSAGFQINKRLYTLGLKKTYHAPVPIMVIGNITVGGSGKTPLLIGLVNYLQQK
GVRVGVISRGYGAEGPFPALVAVNSLPDQVGDEPCLIVQSTHVPMAVGPDRQASIELLLSSYALDLIISDDGLQHWALAR
QIEWIVLDAHRGLGNQRMLPEGFLRESKKRLNTGTVIEHGLNPKTSLNMHLEPGQPYLLCPATETHEPFNANASFYAVVG
IGFPQRFYNTLESLGIHNFQCHEFPDHHDYELTDIDFDDLNPVITTEKDAVKLLPLLKQYPEYPRQIWVVPVEAVMSDAC
YIRLEQQLAQLGVCFS

Sequences:

>Translated_336_residues
MSFAQTIQNAWNRQAKWLILLRPLSWLYSAGFQINKRLYTLGLKKTYHAPVPIMVIGNITVGGSGKTPLLIGLVNYLQQK
GVRVGVISRGYGAEGPFPALVAVNSLPDQVGDEPCLIVQSTHVPMAVGPDRQASIELLLSSYALDLIISDDGLQHWALAR
QIEWIVLDAHRGLGNQRMLPEGFLRESKKRLNTGTVIEHGLNPKTSLNMHLEPGQPYLLCPATETHEPFNANASFYAVVG
IGFPQRFYNTLESLGIHNFQCHEFPDHHDYELTDIDFDDLNPVITTEKDAVKLLPLLKQYPEYPRQIWVVPVEAVMSDAC
YIRLEQQLAQLGVCFS
>Mature_335_residues
SFAQTIQNAWNRQAKWLILLRPLSWLYSAGFQINKRLYTLGLKKTYHAPVPIMVIGNITVGGSGKTPLLIGLVNYLQQKG
VRVGVISRGYGAEGPFPALVAVNSLPDQVGDEPCLIVQSTHVPMAVGPDRQASIELLLSSYALDLIISDDGLQHWALARQ
IEWIVLDAHRGLGNQRMLPEGFLRESKKRLNTGTVIEHGLNPKTSLNMHLEPGQPYLLCPATETHEPFNANASFYAVVGI
GFPQRFYNTLESLGIHNFQCHEFPDHHDYELTDIDFDDLNPVITTEKDAVKLLPLLKQYPEYPRQIWVVPVEAVMSDACY
IRLEQQLAQLGVCFS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=331, Percent_Identity=38.0664652567976, Blast_Score=207, Evalue=9e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 37597; Mature: 37466

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFAQTIQNAWNRQAKWLILLRPLSWLYSAGFQINKRLYTLGLKKTYHAPVPIMVIGNIT
CCHHHHHHHHHCCCCEEEEEECCHHHHHHCCCEECCEEEEEECCCCCCCCCCEEEEEEEE
VGGSGKTPLLIGLVNYLQQKGVRVGVISRGYGAEGPFPALVAVNSLPDQVGDEPCLIVQS
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCHHHCCCCEEEEEE
THVPMAVGPDRQASIELLLSSYALDLIISDDGLQHWALARQIEWIVLDAHRGLGNQRMLP
CCCCEEECCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHEEEEEEEECCCCCCCCCCCC
EGFLRESKKRLNTGTVIEHGLNPKTSLNMHLEPGQPYLLCPATETHEPFNANASFYAVVG
HHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEE
IGFPQRFYNTLESLGIHNFQCHEFPDHHDYELTDIDFDDLNPVITTEKDAVKLLPLLKQY
CCCHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCHHCCCCCEECCHHHHHHHHHHHHC
PEYPRQIWVVPVEAVMSDACYIRLEQQLAQLGVCFS
CCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SFAQTIQNAWNRQAKWLILLRPLSWLYSAGFQINKRLYTLGLKKTYHAPVPIMVIGNIT
CHHHHHHHHHCCCCEEEEEECCHHHHHHCCCEECCEEEEEECCCCCCCCCCEEEEEEEE
VGGSGKTPLLIGLVNYLQQKGVRVGVISRGYGAEGPFPALVAVNSLPDQVGDEPCLIVQS
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCHHHCCCCEEEEEE
THVPMAVGPDRQASIELLLSSYALDLIISDDGLQHWALARQIEWIVLDAHRGLGNQRMLP
CCCCEEECCCCHHHHHHHHHHHEEEEEECCCCCHHHHHHHEEEEEEEECCCCCCCCCCCC
EGFLRESKKRLNTGTVIEHGLNPKTSLNMHLEPGQPYLLCPATETHEPFNANASFYAVVG
HHHHHHHHHHCCCCCEEECCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCEEEEEE
IGFPQRFYNTLESLGIHNFQCHEFPDHHDYELTDIDFDDLNPVITTEKDAVKLLPLLKQY
CCCHHHHHHHHHHCCCCCEECCCCCCCCCCEEEECCHHCCCCCEECCHHHHHHHHHHHHC
PEYPRQIWVVPVEAVMSDACYIRLEQQLAQLGVCFS
CCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA