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The map label for this gene is fadE [H]

Identifier: 50085377

GI number: 50085377

Start: 2246152

End: 2248641

Strand: Direct

Name: fadE [H]

Synonym: ACIAD2277

Alternate gene names: 50085377

Gene position: 2246152-2248641 (Clockwise)

Preceding gene: 50085376

Following gene: 50085378

Centisome position: 62.42

GC content: 40.8

Gene sequence:

>2490_bases
ATGACTTTTTTCCTGTTTATCGTTGCCATTCTCGTACAGTTATTCACGATCTGGGCTGTTTTTTATTTTAGCCTTTCTAG
AACTGTCGGTAGCATCGTAACGATTGTAGTGGCGATATCGTCTGCCTTTGTTTTTACCGCTTGGTCTTTATTATTAGGAA
TTCCACTCATTATTTTGAGCCTGATCTTACTCATTGATCCGCTACGTTTTAACTTAATCACCAAGCCCGCTTTCAACACA
TTAGCGAATTCAATGCCAAGTATCAGTACGACTGAACAAGAAGCGCTTGAAGCAGGCACAAGCTGGTGGGAAAAAGAATT
ATTTACAGGTGCCCCGGATTGGGATCAGTTCAATACTTATCCATTTCCACAATTATCAGAAGAAGAGCAATCTTTCATTG
ATAATGAAGTAGAACAACTTTGTAGTATGTTAAACGAGTGGGAAATTCATCATCATCGTAAAGATTTACCAGAACACGTC
TGGCAATTTATTAAAGATAAAGGCTTTCTTAGCTTGATCATTCCCAAATCATATGGTGGGAAAGAGTTTACATCATTTGC
GCAAAGTCGCATTATGAGCAAAATTGCCTCTCGCTCGCTCACGGCTGCGGTCAGTTGTATGGTGCCCAATTCATTGGGTC
CAGGTGAATTGTTAATGCACTATGGAACCGATGAACAGAAACAACGTTATCTGCCTGGCTTGGCAGCAGGAACTGAAATT
CCATGCTTTGGACTGACTAGTCCAGAAGCGGGTTCAGATGCAGGCGCGATTCCTGATACTGGCGTCGTATGTTATGGGGA
ATTCGAAGGTCAGGATGTCCTTGGCTTACGTATGAACTTTTCTAAGCGATGGATTACATTGGCTCCTATTGCAACTGTGG
TTGGATTAGCATTTAAACTCTACGACCCAGAAGGTTTACTGGGTGATTCATCCAAAACGGAATACGGTATTACGTGCGCA
TTGATTCCAGCTAACCATCACGGTGTAGAAATTGGCCCTCGACACTACCCTGGTTCACCCTTTATGAATGGTACTGTTGA
AGGGCGCGATGTTTTTATTCCAATCGACTGGATTATTGGTGGCCCTAAAAATGCTGGAAAAGGCTGGCGGATGTTAATGG
AATGTCTAGGTGTTGGCCGTGGTATTTCCTTACCTGCACTTGCAACAGCAGCAGGTGAAATGAGTTATCTTACTGTGGGT
GCATTTGCCAAAGTGCGTGAACAATTCAAATTATCGGTAGGTAAATTTGAAGGTGTACAAGAAGCCACCAGTGATATTGC
CAGTGATACGTACATGCTAGAGTCTTTCCGTTATTTAGTGACCTGTGGTCTTAATCAAGGTGGTACTCCCGCCGTGATGA
CAGCAATGGCGAAGTACTATGCAACCGAAACCATGCGTAAAGTTATCAATCATGGTATGGATGTGGTGGGTGGACGTGCT
ATTCAGCTTGGACCACGTAACTTTCTCGCTTTATCTTATCAAGCGATTCCTGTTGCAATTACCGTCGAAGGTGCCAACAT
TCTGACCCGTTCATTAATGATTTTCGGTCAAGGCTCTATGCGTTGTCATCCTTATTTATTTAATGAATTGCAATTGTTGC
AATCAGAAGATAAGCCAAATGCATTGAAGCAATTTCATGAAATTCTATTTAAGCATTTGGGATACACCTTCAACCGAGGC
GCGCGTTCATTTGCTTATGGCTTTACGGGTGGCTCAGGCGATGCACCGCTTATTGCAGATGACTTTACCCATCCATATTA
TAAAATTATTAACCGATTCAGTGCTAATTTGGCATTGACCGCAGATATGGCATTAGGTTTACTCGCTGGAGATATTAAAC
GCAAAGAAATGCTGTCAGGTCGTTTAGCCGATATGCATGCCCATCTCTTTATCGCGACTGCAATCTTGAAATACTACGCA
CATGGTCGTAAATCAGATGCTGAACAATTACATGCCAAGCTTGCTTTGGAAAAATCACTCTACAATGTTCAAGAAGCTTT
TTATGGTTTATTTGAGAATTTCCCAATCAAACCAGCTGCTGCATTGGTTAAATTGGTCTGTTTTCCTTTAGGTCGACCAA
TTGAAAAACCAAGTGATGATTTAAAACAGTCTGTAGCTGAACTGATGATGCAAGAAAATCCATTTAGAGATCAACTCAAA
AAGCATGTCTATTATTCGCAAGATGTGGGTGATGTTACAGGTCGTATGGAATCTGCCTTTCAGATGTTATTAGAAATTGA
GCCTCTATGGCACAAATTTAAAAAAGCGGAATCTAAGGATCAATTTAAAGGTTTAACTTTTGAAGAACATATTACTGATG
CAGTAGAAACAGGTTTTATCACCGAATCAGAAGCTCAAAGTTTAATTCTTTATAATGCAAAACGCTTCGATAGTATGTTG
ACTGATATTTTTGACATGGAATTAAATCGGGATTTAGAGCTTGAAAATCCACACATGCCTATTACAGGTGAAGTAGCCTT
AGATAAATAA

Upstream 100 bases:

>100_bases
TAAAGACATATAAATACGTCATTGATTCAAATAAAGAAGTTAAATATTTTTCATTCAATGCATTCATTCCATTAAAAGTG
CAACAACCCAAGGAGTAAGT

Downstream 100 bases:

>100_bases
TTGATTCATCTAGTAACATTAATATGATAAAAGCGTCTTGGGACGCTTTTATCATTTGAACACTAAAATCAACTTAAGGG
AAAAAAATGTCACAACAAGA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 829; Mature: 828

Protein sequence:

>829_residues
MTFFLFIVAILVQLFTIWAVFYFSLSRTVGSIVTIVVAISSAFVFTAWSLLLGIPLIILSLILLIDPLRFNLITKPAFNT
LANSMPSISTTEQEALEAGTSWWEKELFTGAPDWDQFNTYPFPQLSEEEQSFIDNEVEQLCSMLNEWEIHHHRKDLPEHV
WQFIKDKGFLSLIIPKSYGGKEFTSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDEQKQRYLPGLAAGTEI
PCFGLTSPEAGSDAGAIPDTGVVCYGEFEGQDVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDSSKTEYGITCA
LIPANHHGVEIGPRHYPGSPFMNGTVEGRDVFIPIDWIIGGPKNAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVG
AFAKVREQFKLSVGKFEGVQEATSDIASDTYMLESFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVINHGMDVVGGRA
IQLGPRNFLALSYQAIPVAITVEGANILTRSLMIFGQGSMRCHPYLFNELQLLQSEDKPNALKQFHEILFKHLGYTFNRG
ARSFAYGFTGGSGDAPLIADDFTHPYYKIINRFSANLALTADMALGLLAGDIKRKEMLSGRLADMHAHLFIATAILKYYA
HGRKSDAEQLHAKLALEKSLYNVQEAFYGLFENFPIKPAAALVKLVCFPLGRPIEKPSDDLKQSVAELMMQENPFRDQLK
KHVYYSQDVGDVTGRMESAFQMLLEIEPLWHKFKKAESKDQFKGLTFEEHITDAVETGFITESEAQSLILYNAKRFDSML
TDIFDMELNRDLELENPHMPITGEVALDK

Sequences:

>Translated_829_residues
MTFFLFIVAILVQLFTIWAVFYFSLSRTVGSIVTIVVAISSAFVFTAWSLLLGIPLIILSLILLIDPLRFNLITKPAFNT
LANSMPSISTTEQEALEAGTSWWEKELFTGAPDWDQFNTYPFPQLSEEEQSFIDNEVEQLCSMLNEWEIHHHRKDLPEHV
WQFIKDKGFLSLIIPKSYGGKEFTSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDEQKQRYLPGLAAGTEI
PCFGLTSPEAGSDAGAIPDTGVVCYGEFEGQDVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDSSKTEYGITCA
LIPANHHGVEIGPRHYPGSPFMNGTVEGRDVFIPIDWIIGGPKNAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVG
AFAKVREQFKLSVGKFEGVQEATSDIASDTYMLESFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVINHGMDVVGGRA
IQLGPRNFLALSYQAIPVAITVEGANILTRSLMIFGQGSMRCHPYLFNELQLLQSEDKPNALKQFHEILFKHLGYTFNRG
ARSFAYGFTGGSGDAPLIADDFTHPYYKIINRFSANLALTADMALGLLAGDIKRKEMLSGRLADMHAHLFIATAILKYYA
HGRKSDAEQLHAKLALEKSLYNVQEAFYGLFENFPIKPAAALVKLVCFPLGRPIEKPSDDLKQSVAELMMQENPFRDQLK
KHVYYSQDVGDVTGRMESAFQMLLEIEPLWHKFKKAESKDQFKGLTFEEHITDAVETGFITESEAQSLILYNAKRFDSML
TDIFDMELNRDLELENPHMPITGEVALDK
>Mature_828_residues
TFFLFIVAILVQLFTIWAVFYFSLSRTVGSIVTIVVAISSAFVFTAWSLLLGIPLIILSLILLIDPLRFNLITKPAFNTL
ANSMPSISTTEQEALEAGTSWWEKELFTGAPDWDQFNTYPFPQLSEEEQSFIDNEVEQLCSMLNEWEIHHHRKDLPEHVW
QFIKDKGFLSLIIPKSYGGKEFTSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDEQKQRYLPGLAAGTEIP
CFGLTSPEAGSDAGAIPDTGVVCYGEFEGQDVLGLRMNFSKRWITLAPIATVVGLAFKLYDPEGLLGDSSKTEYGITCAL
IPANHHGVEIGPRHYPGSPFMNGTVEGRDVFIPIDWIIGGPKNAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVGA
FAKVREQFKLSVGKFEGVQEATSDIASDTYMLESFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVINHGMDVVGGRAI
QLGPRNFLALSYQAIPVAITVEGANILTRSLMIFGQGSMRCHPYLFNELQLLQSEDKPNALKQFHEILFKHLGYTFNRGA
RSFAYGFTGGSGDAPLIADDFTHPYYKIINRFSANLALTADMALGLLAGDIKRKEMLSGRLADMHAHLFIATAILKYYAH
GRKSDAEQLHAKLALEKSLYNVQEAFYGLFENFPIKPAAALVKLVCFPLGRPIEKPSDDLKQSVAELMMQENPFRDQLKK
HVYYSQDVGDVTGRMESAFQMLLEIEPLWHKFKKAESKDQFKGLTFEEHITDAVETGFITESEAQSLILYNAKRFDSMLT
DIFDMELNRDLELENPHMPITGEVALDK

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=592, Percent_Identity=25.8445945945946, Blast_Score=126, Evalue=8e-29,
Organism=Homo sapiens, GI4557235, Length=411, Percent_Identity=25.7907542579075, Blast_Score=112, Evalue=2e-24,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=26.1658031088083, Blast_Score=106, Evalue=8e-23,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=28.4210526315789, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226958412, Length=365, Percent_Identity=23.8356164383562, Blast_Score=68, Evalue=4e-11,
Organism=Escherichia coli, GI87081702, Length=807, Percent_Identity=44.7335811648079, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17508101, Length=368, Percent_Identity=28.804347826087, Blast_Score=100, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71985184, Length=377, Percent_Identity=24.6684350132626, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71985192, Length=345, Percent_Identity=24.6376811594203, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=24.0932642487047, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=414, Percent_Identity=25.6038647342995, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71990804, Length=303, Percent_Identity=27.3927392739274, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=331, Percent_Identity=24.1691842900302, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281363737, Length=370, Percent_Identity=24.5945945945946, Blast_Score=93, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24646207, Length=335, Percent_Identity=26.5671641791045, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21356377, Length=363, Percent_Identity=24.5179063360882, Blast_Score=81, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 92136; Mature: 92005

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFFLFIVAILVQLFTIWAVFYFSLSRTVGSIVTIVVAISSAFVFTAWSLLLGIPLIILS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLIDPLRFNLITKPAFNTLANSMPSISTTEQEALEAGTSWWEKELFTGAPDWDQFNTY
HHHHHCCHHHEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PFPQLSEEEQSFIDNEVEQLCSMLNEWEIHHHRKDLPEHVWQFIKDKGFLSLIIPKSYGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCC
KEFTSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDEQKQRYLPGLAAGTEI
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHEEECCCCHHHHHHCCCCCCCCCC
PCFGLTSPEAGSDAGAIPDTGVVCYGEFEGQDVLGLRMNFSKRWITLAPIATVVGLAFKL
CEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHEE
YDPEGLLGDSSKTEYGITCALIPANHHGVEIGPRHYPGSPFMNGTVEGRDVFIPIDWIIG
ECCCCCCCCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCEECCCEEEEEEEEEEC
GPKNAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVGAFAKVREQFKLSVGKFEGVQ
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
EATSDIASDTYMLESFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVINHGMDVVGGRA
HHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEE
IQLGPRNFLALSYQAIPVAITVEGANILTRSLMIFGQGSMRCHPYLFNELQLLQSEDKPN
EEECCCCEEEEEEEEEEEEEEECCHHHHHHHHHEECCCCCEECHHHHHHHHHHHCCCCCH
ALKQFHEILFKHLGYTFNRGARSFAYGFTGGSGDAPLIADDFTHPYYKIINRFSANLALT
HHHHHHHHHHHHCCCHHCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHCCCEEEE
ADMALGLLAGDIKRKEMLSGRLADMHAHLFIATAILKYYAHGRKSDAEQLHAKLALEKSL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YNVQEAFYGLFENFPIKPAAALVKLVCFPLGRPIEKPSDDLKQSVAELMMQENPFRDQLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
KHVYYSQDVGDVTGRMESAFQMLLEIEPLWHKFKKAESKDQFKGLTFEEHITDAVETGFI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCC
TESEAQSLILYNAKRFDSMLTDIFDMELNRDLELENPHMPITGEVALDK
CCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEECCC
>Mature Secondary Structure 
TFFLFIVAILVQLFTIWAVFYFSLSRTVGSIVTIVVAISSAFVFTAWSLLLGIPLIILS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LILLIDPLRFNLITKPAFNTLANSMPSISTTEQEALEAGTSWWEKELFTGAPDWDQFNTY
HHHHHCCHHHEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PFPQLSEEEQSFIDNEVEQLCSMLNEWEIHHHRKDLPEHVWQFIKDKGFLSLIIPKSYGG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECCCCC
KEFTSFAQSRIMSKIASRSLTAAVSCMVPNSLGPGELLMHYGTDEQKQRYLPGLAAGTEI
HHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHEEECCCCHHHHHHCCCCCCCCCC
PCFGLTSPEAGSDAGAIPDTGVVCYGEFEGQDVLGLRMNFSKRWITLAPIATVVGLAFKL
CEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEHHHHHHHHHHHHEE
YDPEGLLGDSSKTEYGITCALIPANHHGVEIGPRHYPGSPFMNGTVEGRDVFIPIDWIIG
ECCCCCCCCCCCCCCCEEEEEEECCCCCCEECCCCCCCCCCCCCEECCCEEEEEEEEEEC
GPKNAGKGWRMLMECLGVGRGISLPALATAAGEMSYLTVGAFAKVREQFKLSVGKFEGVQ
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
EATSDIASDTYMLESFRYLVTCGLNQGGTPAVMTAMAKYYATETMRKVINHGMDVVGGRA
HHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEE
IQLGPRNFLALSYQAIPVAITVEGANILTRSLMIFGQGSMRCHPYLFNELQLLQSEDKPN
EEECCCCEEEEEEEEEEEEEEECCHHHHHHHHHEECCCCCEECHHHHHHHHHHHCCCCCH
ALKQFHEILFKHLGYTFNRGARSFAYGFTGGSGDAPLIADDFTHPYYKIINRFSANLALT
HHHHHHHHHHHHCCCHHCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHCCCEEEE
ADMALGLLAGDIKRKEMLSGRLADMHAHLFIATAILKYYAHGRKSDAEQLHAKLALEKSL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YNVQEAFYGLFENFPIKPAAALVKLVCFPLGRPIEKPSDDLKQSVAELMMQENPFRDQLK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
KHVYYSQDVGDVTGRMESAFQMLLEIEPLWHKFKKAESKDQFKGLTFEEHITDAVETGFI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHCCC
TESEAQSLILYNAKRFDSMLTDIFDMELNRDLELENPHMPITGEVALDK
CCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]