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The map label for this gene is mutT [C]

Identifier: 50085342

GI number: 50085342

Start: 2207329

End: 2208243

Strand: Reverse

Name: mutT [C]

Synonym: ACIAD2236

Alternate gene names: 50085342

Gene position: 2208243-2207329 (Counterclockwise)

Preceding gene: 50085343

Following gene: 50085338

Centisome position: 61.36

GC content: 40.11

Gene sequence:

>915_bases
TTGAGAAAATTTGAGGAGCTGCAAAAGTATATGCCAAAACCTGTTATTGATGTCTCGATTGGAATCTTGCTACATAAGAA
TAAAGTCTTGATTGGGTGGCGTGAGGCCAGTCAACATCAGGGTAATAAACATGAATTTCCAGGTGGAAAAGTTGAACATA
ATGAAAGTCCAGTTGATGCTTGCCGCCGCGAGATTTATGAAGAGGTTGGGGTAGGTATTAAAGAGTGGCATGTATTTGAT
CAGATTACGCATGAGTATGATGATGTCATTGTAAAATTGCATTTATTTCATGCTTTTGTACCAGATGAATTGTTGGCATT
AATCCATCAGCCATGGTCATGGTTTGGCAGAGACCAGCTCAAAAATCTAAATTTTCCAAAAGCAAATGATGCAATTTTGC
AGCGTTTAAGCTGGCCCCATTACATTAAAATCTCCGAATTACCCCCTAACTTTTCATCTGATCGTTTGCAGTATTGGCGT
TCTCAAGATAGTGTTCAACAAAATATTGAGCATATGTCAGAAGCGCAGCTTAGTGTGCTGATTATTAATCAAGATCAATG
GCAACGACTTGATCATTATTTACAGGAACAGATTAAGACGATTCATTTGAAGCAACATCAACTGATGCAGCTGAAGCAAG
GAGATTTAGTTGTAAGTAAGCGCTATATTGCAGCTTGTCATGATCTGGTTGCAATAAATCATGCCCATAAATTGGGTTGT
GATGCAGTGTTTATTAGTCCTGTTCAGCCAACACCGACACATCCTGAAGCAGTTACTTTGGGATGGGACGGTTTGGCTCA
AATGGCGCAGCACAGCCATATTCCCGTTTTTGCATTGGGTGGTTTACATCCAGATGATCTTGAGCAAGCGGTAAAACATG
GGGCTTACGGTGTTGCAGGAATTCGAAATTTTTGA

Upstream 100 bases:

>100_bases
CTCCGTGGTTGTTTATTTAACGATTTAAATGATAATCATTATCGAATAGGCCTGTCAATTAAAATTTTGTGATTTTATAA
AAAATAAAATTTATTTACAC

Downstream 100 bases:

>100_bases
AATATCGCGCTGAAGTCTAGAGAGACTTCAGTGCTTGTTGTGCCTGCTGGATGGATTTTGCATTATTTTGCTTTTGTGCA
GCATTGAGAATATTTAACCA

Product: bifunctional dGTP-pyrophosphohydrolase/thiamine phosphate synthase

Products: diphosphate; thiamine monophosphate

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MRKFEELQKYMPKPVIDVSIGILLHKNKVLIGWREASQHQGNKHEFPGGKVEHNESPVDACRREIYEEVGVGIKEWHVFD
QITHEYDDVIVKLHLFHAFVPDELLALIHQPWSWFGRDQLKNLNFPKANDAILQRLSWPHYIKISELPPNFSSDRLQYWR
SQDSVQQNIEHMSEAQLSVLIINQDQWQRLDHYLQEQIKTIHLKQHQLMQLKQGDLVVSKRYIAACHDLVAINHAHKLGC
DAVFISPVQPTPTHPEAVTLGWDGLAQMAQHSHIPVFALGGLHPDDLEQAVKHGAYGVAGIRNF

Sequences:

>Translated_304_residues
MRKFEELQKYMPKPVIDVSIGILLHKNKVLIGWREASQHQGNKHEFPGGKVEHNESPVDACRREIYEEVGVGIKEWHVFD
QITHEYDDVIVKLHLFHAFVPDELLALIHQPWSWFGRDQLKNLNFPKANDAILQRLSWPHYIKISELPPNFSSDRLQYWR
SQDSVQQNIEHMSEAQLSVLIINQDQWQRLDHYLQEQIKTIHLKQHQLMQLKQGDLVVSKRYIAACHDLVAINHAHKLGC
DAVFISPVQPTPTHPEAVTLGWDGLAQMAQHSHIPVFALGGLHPDDLEQAVKHGAYGVAGIRNF
>Mature_304_residues
MRKFEELQKYMPKPVIDVSIGILLHKNKVLIGWREASQHQGNKHEFPGGKVEHNESPVDACRREIYEEVGVGIKEWHVFD
QITHEYDDVIVKLHLFHAFVPDELLALIHQPWSWFGRDQLKNLNFPKANDAILQRLSWPHYIKISELPPNFSSDRLQYWR
SQDSVQQNIEHMSEAQLSVLIINQDQWQRLDHYLQEQIKTIHLKQHQLMQLKQGDLVVSKRYIAACHDLVAINHAHKLGC
DAVFISPVQPTPTHPEAVTLGWDGLAQMAQHSHIPVFALGGLHPDDLEQAVKHGAYGVAGIRNF

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=124, Percent_Identity=31.4516129032258, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: 2.5.1.3

Molecular weight: Translated: 35045; Mature: 35045

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFEELQKYMPKPVIDVSIGILLHKNKVLIGWREASQHQGNKHEFPGGKVEHNESPVDA
CCHHHHHHHHCCCCEEEEEEEEEEECCEEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHH
CRREIYEEVGVGIKEWHVFDQITHEYDDVIVKLHLFHAFVPDELLALIHQPWSWFGRDQL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHCCHHHH
KNLNFPKANDAILQRLSWPHYIKISELPPNFSSDRLQYWRSQDSVQQNIEHMSEAQLSVL
CCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEE
IINQDQWQRLDHYLQEQIKTIHLKQHQLMQLKQGDLVVSKRYIAACHDLVAINHAHKLGC
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCC
DAVFISPVQPTPTHPEAVTLGWDGLAQMAQHSHIPVFALGGLHPDDLEQAVKHGAYGVAG
CEEEEECCCCCCCCCCEEEECHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCC
IRNF
CCCC
>Mature Secondary Structure
MRKFEELQKYMPKPVIDVSIGILLHKNKVLIGWREASQHQGNKHEFPGGKVEHNESPVDA
CCHHHHHHHHCCCCEEEEEEEEEEECCEEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHH
CRREIYEEVGVGIKEWHVFDQITHEYDDVIVKLHLFHAFVPDELLALIHQPWSWFGRDQL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHCCHHHH
KNLNFPKANDAILQRLSWPHYIKISELPPNFSSDRLQYWRSQDSVQQNIEHMSEAQLSVL
CCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEE
IINQDQWQRLDHYLQEQIKTIHLKQHQLMQLKQGDLVVSKRYIAACHDLVAINHAHKLGC
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCC
DAVFISPVQPTPTHPEAVTLGWDGLAQMAQHSHIPVFALGGLHPDDLEQAVKHGAYGVAG
CEEEEECCCCCCCCCCEEEECHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCC
IRNF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate; 4-Methyl-5-(2-phosphono-oxyethyl)-thiazole

Specific reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine monophosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]