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The map label for this gene is ppiB [H]

Identifier: 50085061

GI number: 50085061

Start: 1912309

End: 1912818

Strand: Direct

Name: ppiB [H]

Synonym: ACIAD1921

Alternate gene names: 50085061

Gene position: 1912309-1912818 (Clockwise)

Preceding gene: 50085059

Following gene: 50085062

Centisome position: 53.14

GC content: 40.98

Gene sequence:

>510_bases
ATGAGTTTTCCTCAAGTCGAATTAAACACCAATAAAGGTCGTATTGTTCTTGAGCTTAACCCTGAAAAAGCGCCTAAAAC
AGTTGCTAACTTCTTGGAATATGTTCGTGATGGTTTCTATGACGGCGTGATTTTTCACCGCGTCATTGATGGTTTTATGA
TCCAAGGCGGCGGCATGGACGAAAACTTCAAAGAAAAAGCCACTCGTGATGCAATTGAAAACGAAGCTGACAATGGTTTG
AGCAATGATGAAGGTACGATTGCTATGGCACGTACTCAAGCACCTCACTCTGCTTCTGCTCAATTCTTTATTAATGTGAA
AAACAACTCTTTCCTTAACCACACAGGTAAAACTGCGCAAGGTTGGGGTTATGCGGTGTTTGGTAAAGTTGTTGAAGGTC
TGGACGTTGTAACTGCAATTAAAAACGTTCGTACTGGCAACCGTGGCTATCACGCTGATGTACCTTTAGAAAATGTTGTC
ATTGAATCTGCTAAAATTATCGCTGAATAA

Upstream 100 bases:

>100_bases
AAATTTACGTTTTTTACTTGCTATGTAGTTTACAGTTTGCTTATGCTTCTCTCAACCAAAAAACCCATGGCTTTCGTGTC
CATGATTAGGAGATTATGTA

Downstream 100 bases:

>100_bases
TTTTTAAACGGATTATTTTGTGACTTATTTGTTTATTTCAGATTTACATTTGTCACCTGAACACCCTCGACTCATTCGAG
GGTTTTTAGATTTATTACAA

Product: peptidyl-prolyl cis-trans isomerase precursor (PPIase)

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSFPQVELNTNKGRIVLELNPEKAPKTVANFLEYVRDGFYDGVIFHRVIDGFMIQGGGMDENFKEKATRDAIENEADNGL
SNDEGTIAMARTQAPHSASAQFFINVKNNSFLNHTGKTAQGWGYAVFGKVVEGLDVVTAIKNVRTGNRGYHADVPLENVV
IESAKIIAE

Sequences:

>Translated_169_residues
MSFPQVELNTNKGRIVLELNPEKAPKTVANFLEYVRDGFYDGVIFHRVIDGFMIQGGGMDENFKEKATRDAIENEADNGL
SNDEGTIAMARTQAPHSASAQFFINVKNNSFLNHTGKTAQGWGYAVFGKVVEGLDVVTAIKNVRTGNRGYHADVPLENVV
IESAKIIAE
>Mature_168_residues
SFPQVELNTNKGRIVLELNPEKAPKTVANFLEYVRDGFYDGVIFHRVIDGFMIQGGGMDENFKEKATRDAIENEADNGLS
NDEGTIAMARTQAPHSASAQFFINVKNNSFLNHTGKTAQGWGYAVFGKVVEGLDVVTAIKNVRTGNRGYHADVPLENVVI
ESAKIIAE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=35.3658536585366, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI7657473, Length=171, Percent_Identity=32.7485380116959, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI24308049, Length=160, Percent_Identity=35, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI19557636, Length=172, Percent_Identity=31.9767441860465, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=60.8695652173913, Blast_Score=209, Evalue=7e-56,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=53.6585365853659, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=169, Percent_Identity=32.5443786982249, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=146, Percent_Identity=33.5616438356164, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=33.5616438356164, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=171, Percent_Identity=31.5789473684211, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=33.5365853658537, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=36.0759493670886, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559074, Length=176, Percent_Identity=31.25, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=163, Percent_Identity=35.5828220858896, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=32.1212121212121, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=33.7349397590361, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI19922912, Length=164, Percent_Identity=32.3170731707317, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=35.1851851851852, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45549139, Length=150, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18548; Mature: 18417

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFPQVELNTNKGRIVLELNPEKAPKTVANFLEYVRDGFYDGVIFHRVIDGFMIQGGGMD
CCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCC
ENFKEKATRDAIENEADNGLSNDEGTIAMARTQAPHSASAQFFINVKNNSFLNHTGKTAQ
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCC
GWGYAVFGKVVEGLDVVTAIKNVRTGNRGYHADVPLENVVIESAKIIAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFPQVELNTNKGRIVLELNPEKAPKTVANFLEYVRDGFYDGVIFHRVIDGFMIQGGGMD
CCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEECCCCC
ENFKEKATRDAIENEADNGLSNDEGTIAMARTQAPHSASAQFFINVKNNSFLNHTGKTAQ
CHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCEECCCCCCCC
GWGYAVFGKVVEGLDVVTAIKNVRTGNRGYHADVPLENVVIESAKIIAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]