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The map label for this gene is lpxH [H]

Identifier: 50085062

GI number: 50085062

Start: 1912838

End: 1913566

Strand: Direct

Name: lpxH [H]

Synonym: ACIAD1922

Alternate gene names: 50085062

Gene position: 1912838-1913566 (Clockwise)

Preceding gene: 50085061

Following gene: 161349965

Centisome position: 53.15

GC content: 38.0

Gene sequence:

>729_bases
GTGACTTATTTGTTTATTTCAGATTTACATTTGTCACCTGAACACCCTCGACTCATTCGAGGGTTTTTAGATTTATTACA
ATCTTATCAAGACCGACATACTCAGCTTTATATCTTGGGCGACTGGTTTAATGCCTGGATTGGCGATGATTATACTGCCC
CCTGGCTGGATGAAATCGTAGAAAAACTTCAGGATTTTCATCGACACGGCAATCAAGTCTATTTTCAGGTGGGTAATCGT
GACTTTGCATTGGGATATGATTTTTTAAAGCAATTTCATGGCATTTTACTTCCTGATATCTATACGCTTAATATCTCTGG
TGTCACGTATAGGCTCGAGCATGGCGATGCACTATGTACAGATGATGTCGCTTATCAACGCTTCAAAAAGATCATTCGAA
ATCCTTATCTTATTGCATTATTAAAACGTACGCCGTTAAGTTTTAGACAGAAACTGGCCAATGGCTTTCGTAAAAAAAGT
CATGATGACAAGCAACAAAAAACTTATGCCATTATGGATGTACATCCCAAAGCTGTCGAAACTGCGCTATTTGATGTCGA
TATTTTAATTCATGGTCATACTCACCGCCCTGCAATACATCCTTTGGGACAAAAAACCCGAATCGTTTTAGGGGATTGGC
GAGAAAAAACAAATCAAGCCATGATTTTAGAAATCGATGAACAAGGTCACCAAAATTTTATTCAATGGAATATTAGTTCA
TCACGCTAA

Upstream 100 bases:

>100_bases
CGTACTGGCAACCGTGGCTATCACGCTGATGTACCTTTAGAAAATGTTGTCATTGAATCTGCTAAAATTATCGCTGAATA
ATTTTTAAACGGATTATTTT

Downstream 100 bases:

>100_bases
AAATCTATTTTGTTACCTCAATTTTTATTTGAAAGCATTTCATCTGATAATTTTTCGATTTATGATCATGTTTTATCTAA
CCTTTAAATATGAGGGACAT

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTYLFISDLHLSPEHPRLIRGFLDLLQSYQDRHTQLYILGDWFNAWIGDDYTAPWLDEIVEKLQDFHRHGNQVYFQVGNR
DFALGYDFLKQFHGILLPDIYTLNISGVTYRLEHGDALCTDDVAYQRFKKIIRNPYLIALLKRTPLSFRQKLANGFRKKS
HDDKQQKTYAIMDVHPKAVETALFDVDILIHGHTHRPAIHPLGQKTRIVLGDWREKTNQAMILEIDEQGHQNFIQWNISS
SR

Sequences:

>Translated_242_residues
MTYLFISDLHLSPEHPRLIRGFLDLLQSYQDRHTQLYILGDWFNAWIGDDYTAPWLDEIVEKLQDFHRHGNQVYFQVGNR
DFALGYDFLKQFHGILLPDIYTLNISGVTYRLEHGDALCTDDVAYQRFKKIIRNPYLIALLKRTPLSFRQKLANGFRKKS
HDDKQQKTYAIMDVHPKAVETALFDVDILIHGHTHRPAIHPLGQKTRIVLGDWREKTNQAMILEIDEQGHQNFIQWNISS
SR
>Mature_241_residues
TYLFISDLHLSPEHPRLIRGFLDLLQSYQDRHTQLYILGDWFNAWIGDDYTAPWLDEIVEKLQDFHRHGNQVYFQVGNRD
FALGYDFLKQFHGILLPDIYTLNISGVTYRLEHGDALCTDDVAYQRFKKIIRNPYLIALLKRTPLSFRQKLANGFRKKSH
DDKQQKTYAIMDVHPKAVETALFDVDILIHGHTHRPAIHPLGQKTRIVLGDWREKTNQAMILEIDEQGHQNFIQWNISSS
R

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=232, Percent_Identity=39.6551724137931, Blast_Score=162, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 28457; Mature: 28326

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYLFISDLHLSPEHPRLIRGFLDLLQSYQDRHTQLYILGDWFNAWIGDDYTAPWLDEIV
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCCCCHHHHHHH
EKLQDFHRHGNQVYFQVGNRDFALGYDFLKQFHGILLPDIYTLNISGVTYRLEHGDALCT
HHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHCCCCCCCEEEEEECCEEEEEECCCEECC
DDVAYQRFKKIIRNPYLIALLKRTPLSFRQKLANGFRKKSHDDKQQKTYAIMDVHPKAVE
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHEEEEEECCHHHHH
TALFDVDILIHGHTHRPAIHPLGQKTRIVLGDWREKTNQAMILEIDEQGHQNFIQWNISS
HHHEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECC
SR
CC
>Mature Secondary Structure 
TYLFISDLHLSPEHPRLIRGFLDLLQSYQDRHTQLYILGDWFNAWIGDDYTAPWLDEIV
EEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHCCCCCCCHHHHHHH
EKLQDFHRHGNQVYFQVGNRDFALGYDFLKQFHGILLPDIYTLNISGVTYRLEHGDALCT
HHHHHHHHCCCEEEEEECCEEEEHHHHHHHHHCCCCCCCEEEEEECCEEEEEECCCEECC
DDVAYQRFKKIIRNPYLIALLKRTPLSFRQKLANGFRKKSHDDKQQKTYAIMDVHPKAVE
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHEEEEEECCHHHHH
TALFDVDILIHGHTHRPAIHPLGQKTRIVLGDWREKTNQAMILEIDEQGHQNFIQWNISS
HHHEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCEEEEEECC
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA