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The map label for this gene is alkK [H]

Identifier: 50084965

GI number: 50084965

Start: 1824526

End: 1826163

Strand: Direct

Name: alkK [H]

Synonym: ACIAD1818

Alternate gene names: 50084965

Gene position: 1824526-1826163 (Clockwise)

Preceding gene: 50084964

Following gene: 50084966

Centisome position: 50.7

GC content: 43.96

Gene sequence:

>1638_bases
ATGCAAGGATTAATGCAAAATAAACAACTTTTAATCTCGACTTTAATCGAACATGCGGGATTAAATCATCCTGAAGTACA
GATTGTGTCTAGAACTTGTGAGGGCACGATACATCGCACCAATTACGCTACGCTACGTAAACGCGCTAAGCAATTGGCGA
AGGCATTGCTTGCACTGGGTATTGAGTCTGGAGATCGGGTTGGAACTTTGGCGTGGAATACCTATCGACATCAAGAATTA
TATTTTGCTGTACCAGGAATGGGAGCTGTTTTACACACCATTAATCCACGTCTGTTTGCAGATCAAATTGAATACATTAT
TCAACATGCCGAAGATACAGTACTGTTTTTCGATATTACCTTTAGTACTTTACTTGAGCCGTTATTGCCTAAGCTCAAAC
ATGTACGAGCTTTTATTGCCTTATGCGATATCGATCAGCTACCACAAAACATTCCAAACTGTTTAAGTTACGAGCAGTTG
CTTCGTGAGCAAAATGATGAATTCGAGTGGCCTGAATTTGCAGAAACTCAGGCAGCCTCCTTGTGTTATACCTCTGGAAC
GACGGGTAATCCTAAAGGGGTGTTATACAGTCATCGATCAACTTTATTGCATGCTTTTACTGTATGTACCGTCGATGGAT
TACAGCTATCGAGAAAAGATTGTGTATTGCTCGCAGTTCCTATGTTTCATGTAAATGCATGGGGCTTTCCTTATGCGGCG
GCAATGTGTGGAGCTAAGGTCTGTTTCCCTGCTGCGCAAATTGATGCAGCCAGTTTGTGCGAATTGGCCGCACAAGAACA
ATGCACCATGTCGATTGGTGTACCAACGGTATGGCTCAGTGTCATGGATTATCTTGAGCATCATCCTGAAAAAACAAAAC
AGCTCAATATCAATCGGATTGTAATGGGCGGATCAGCCACACCACGTGCATTGATTGACCGGATTCAAAACAATTTAAAT
GCCACCACCATTCAGGCATGGGGCATGACCGAGACCAGCCCTATGGGGACTATTGGAAATCTGCTACCCGAACATATGGC
ATTAGAGCAAAGTGAACGTTTTGACATACAGTCCAAACAGGGACGTGCCATTTACGGAGTTGAGATTCGGGTGATCGATG
ATCACGGGCAAGTTTTAGCACGTGATGGCGTGAGTGCTGGACATTTACAAGTACGTGGGCCTTGGATTGTGAGTGCCTAT
TTTAAGGCGGATGAACAAAACATACTCGATGCCCATGGCTGGTTCAGTACGGGAGATATTGCTTGTATTTCGGCAGAGGG
ATATTTACAAATTACCGACCGATCTAAAGATGTCATTAAGTCAGGGGGCGAGTGGATCAGTTCGATCGATTTAGAAAATA
CAGCTGTGGCGCACCCTGCCATTCAGGAAGCTGCGGTGATCGGGTTAAACCACAGTAAATGGCAAGAACGGCCTTTACTG
GTGGCAATTAAACGCCCAGATATGCAAATCGATGAACAGGAATTGATTCATTTTCTGTCAAAACGGGTAGCTAAATGGTG
GCTTCCAGATGATGTGGTGTTTGTTCAATCACTGCCACACACGGCGACCGGAAAATTACAAAAAAATGTGTTACGCGAAC
AGTTTAAGGATTTTGTCTTCAGTTCAGACCGATCATGA

Upstream 100 bases:

>100_bases
AATACCTTGGATTGCATGCTGTAAATAAGAAAATCTTAAAAATTAATGAAACTTTATTGGGTTTTAAATAAGAGGTTGAA
GTGTACATGGAGTCTCAGAA

Downstream 100 bases:

>100_bases
AGACGTATTAAAGGAAGCGAATAATGTCAAAGTTAATGATTGAAGATAGCGACGGCGTATTGGGTATGTTGCAAGAGAGT
GTCCATAGCTTCGCACAGCA

Product: medium-chain-fatty-acid-CoA ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MQGLMQNKQLLISTLIEHAGLNHPEVQIVSRTCEGTIHRTNYATLRKRAKQLAKALLALGIESGDRVGTLAWNTYRHQEL
YFAVPGMGAVLHTINPRLFADQIEYIIQHAEDTVLFFDITFSTLLEPLLPKLKHVRAFIALCDIDQLPQNIPNCLSYEQL
LREQNDEFEWPEFAETQAASLCYTSGTTGNPKGVLYSHRSTLLHAFTVCTVDGLQLSRKDCVLLAVPMFHVNAWGFPYAA
AMCGAKVCFPAAQIDAASLCELAAQEQCTMSIGVPTVWLSVMDYLEHHPEKTKQLNINRIVMGGSATPRALIDRIQNNLN
ATTIQAWGMTETSPMGTIGNLLPEHMALEQSERFDIQSKQGRAIYGVEIRVIDDHGQVLARDGVSAGHLQVRGPWIVSAY
FKADEQNILDAHGWFSTGDIACISAEGYLQITDRSKDVIKSGGEWISSIDLENTAVAHPAIQEAAVIGLNHSKWQERPLL
VAIKRPDMQIDEQELIHFLSKRVAKWWLPDDVVFVQSLPHTATGKLQKNVLREQFKDFVFSSDRS

Sequences:

>Translated_545_residues
MQGLMQNKQLLISTLIEHAGLNHPEVQIVSRTCEGTIHRTNYATLRKRAKQLAKALLALGIESGDRVGTLAWNTYRHQEL
YFAVPGMGAVLHTINPRLFADQIEYIIQHAEDTVLFFDITFSTLLEPLLPKLKHVRAFIALCDIDQLPQNIPNCLSYEQL
LREQNDEFEWPEFAETQAASLCYTSGTTGNPKGVLYSHRSTLLHAFTVCTVDGLQLSRKDCVLLAVPMFHVNAWGFPYAA
AMCGAKVCFPAAQIDAASLCELAAQEQCTMSIGVPTVWLSVMDYLEHHPEKTKQLNINRIVMGGSATPRALIDRIQNNLN
ATTIQAWGMTETSPMGTIGNLLPEHMALEQSERFDIQSKQGRAIYGVEIRVIDDHGQVLARDGVSAGHLQVRGPWIVSAY
FKADEQNILDAHGWFSTGDIACISAEGYLQITDRSKDVIKSGGEWISSIDLENTAVAHPAIQEAAVIGLNHSKWQERPLL
VAIKRPDMQIDEQELIHFLSKRVAKWWLPDDVVFVQSLPHTATGKLQKNVLREQFKDFVFSSDRS
>Mature_545_residues
MQGLMQNKQLLISTLIEHAGLNHPEVQIVSRTCEGTIHRTNYATLRKRAKQLAKALLALGIESGDRVGTLAWNTYRHQEL
YFAVPGMGAVLHTINPRLFADQIEYIIQHAEDTVLFFDITFSTLLEPLLPKLKHVRAFIALCDIDQLPQNIPNCLSYEQL
LREQNDEFEWPEFAETQAASLCYTSGTTGNPKGVLYSHRSTLLHAFTVCTVDGLQLSRKDCVLLAVPMFHVNAWGFPYAA
AMCGAKVCFPAAQIDAASLCELAAQEQCTMSIGVPTVWLSVMDYLEHHPEKTKQLNINRIVMGGSATPRALIDRIQNNLN
ATTIQAWGMTETSPMGTIGNLLPEHMALEQSERFDIQSKQGRAIYGVEIRVIDDHGQVLARDGVSAGHLQVRGPWIVSAY
FKADEQNILDAHGWFSTGDIACISAEGYLQITDRSKDVIKSGGEWISSIDLENTAVAHPAIQEAAVIGLNHSKWQERPLL
VAIKRPDMQIDEQELIHFLSKRVAKWWLPDDVVFVQSLPHTATGKLQKNVLREQFKDFVFSSDRS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=527, Percent_Identity=25.0474383301708, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI187761345, Length=540, Percent_Identity=25.7407407407407, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI187761343, Length=540, Percent_Identity=25.7407407407407, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI122937307, Length=398, Percent_Identity=25.1256281407035, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI28416953, Length=545, Percent_Identity=23.1192660550459, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38505220, Length=537, Percent_Identity=21.7877094972067, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI27477105, Length=500, Percent_Identity=23.6, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI58082049, Length=548, Percent_Identity=22.4452554744526, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI83745141, Length=490, Percent_Identity=23.265306122449, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI157311624, Length=541, Percent_Identity=22.735674676525, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI157311622, Length=541, Percent_Identity=22.735674676525, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI42544132, Length=388, Percent_Identity=21.9072164948454, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI13375727, Length=541, Percent_Identity=21.996303142329, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI115511026, Length=183, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI145693145, Length=502, Percent_Identity=28.4860557768924, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788107, Length=520, Percent_Identity=23.0769230769231, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI221142682, Length=509, Percent_Identity=23.5756385068762, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786810, Length=358, Percent_Identity=27.3743016759777, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1789201, Length=368, Percent_Identity=23.9130434782609, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1790505, Length=537, Percent_Identity=23.463687150838, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994703, Length=538, Percent_Identity=26.3940520446097, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71994694, Length=538, Percent_Identity=26.3940520446097, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI71994690, Length=538, Percent_Identity=26.3940520446097, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI32563687, Length=509, Percent_Identity=26.3261296660118, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17558820, Length=507, Percent_Identity=26.0355029585799, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=537, Percent_Identity=23.8361266294227, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560308, Length=546, Percent_Identity=23.6263736263736, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=533, Percent_Identity=22.8893058161351, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=533, Percent_Identity=21.3883677298311, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=371, Percent_Identity=26.6846361185984, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=519, Percent_Identity=22.1579961464355, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=504, Percent_Identity=23.4126984126984, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=363, Percent_Identity=23.9669421487603, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319699, Length=378, Percent_Identity=29.1005291005291, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324893, Length=343, Percent_Identity=24.4897959183673, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581924, Length=567, Percent_Identity=26.63139329806, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI18859661, Length=470, Percent_Identity=26.5957446808511, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21355181, Length=504, Percent_Identity=25.1984126984127, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI19922652, Length=518, Percent_Identity=24.3243243243243, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656500, Length=507, Percent_Identity=23.6686390532544, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24648253, Length=538, Percent_Identity=22.1189591078067, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648255, Length=538, Percent_Identity=22.1189591078067, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24648260, Length=533, Percent_Identity=24.765478424015, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21356947, Length=501, Percent_Identity=21.3572854291417, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648257, Length=484, Percent_Identity=21.900826446281, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281365686, Length=516, Percent_Identity=20.1550387596899, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356441, Length=533, Percent_Identity=22.3264540337711, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653035, Length=502, Percent_Identity=19.9203187250996, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358303, Length=464, Percent_Identity=20.2586206896552, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=509, Percent_Identity=20.2357563850688, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI20130357, Length=363, Percent_Identity=21.763085399449, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI62472339, Length=180, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24667959, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667955, Length=180, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 60863; Mature: 60863

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGLMQNKQLLISTLIEHAGLNHPEVQIVSRTCEGTIHRTNYATLRKRAKQLAKALLALG
CCCCHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHC
IESGDRVGTLAWNTYRHQELYFAVPGMGAVLHTINPRLFADQIEYIIQHAEDTVLFFDIT
CCCCCCEEEEEECCEECCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECC
FSTLLEPLLPKLKHVRAFIALCDIDQLPQNIPNCLSYEQLLREQNDEFEWPEFAETQAAS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LCYTSGTTGNPKGVLYSHRSTLLHAFTVCTVDGLQLSRKDCVLLAVPMFHVNAWGFPYAA
EEEECCCCCCCCCEEEEHHHHHHHHHHHHEECCCEECCCCEEEEEEEHHEECCCCCHHHH
AMCGAKVCFPAAQIDAASLCELAAQEQCTMSIGVPTVWLSVMDYLEHHPEKTKQLNINRI
HHHCCHHCCCCHHCCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCHHHEECCEEE
VMGGSATPRALIDRIQNNLNATTIQAWGMTETSPMGTIGNLLPEHMALEQSERFDIQSKQ
EECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCCCC
GRAIYGVEIRVIDDHGQVLARDGVSAGHLQVRGPWIVSAYFKADEQNILDAHGWFSTGDI
CCEEEEEEEEEECCCCCEEEECCCCCCEEEEECCEEEEEEEECCCCCCEECCCCCCCCCE
ACISAEGYLQITDRSKDVIKSGGEWISSIDLENTAVAHPAIQEAAVIGLNHSKWQERPLL
EEEECCCEEEEECCCHHHHHCCCHHHHHCCCCCCEECCCHHHHHHEECCCCCCCCCCCEE
VAIKRPDMQIDEQELIHFLSKRVAKWWLPDDVVFVQSLPHTATGKLQKNVLREQFKDFVF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SSDRS
CCCCC
>Mature Secondary Structure
MQGLMQNKQLLISTLIEHAGLNHPEVQIVSRTCEGTIHRTNYATLRKRAKQLAKALLALG
CCCCHHHHHHHHHHHHHHHCCCCCHHEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHC
IESGDRVGTLAWNTYRHQELYFAVPGMGAVLHTINPRLFADQIEYIIQHAEDTVLFFDIT
CCCCCCEEEEEECCEECCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECC
FSTLLEPLLPKLKHVRAFIALCDIDQLPQNIPNCLSYEQLLREQNDEFEWPEFAETQAAS
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LCYTSGTTGNPKGVLYSHRSTLLHAFTVCTVDGLQLSRKDCVLLAVPMFHVNAWGFPYAA
EEEECCCCCCCCCEEEEHHHHHHHHHHHHEECCCEECCCCEEEEEEEHHEECCCCCHHHH
AMCGAKVCFPAAQIDAASLCELAAQEQCTMSIGVPTVWLSVMDYLEHHPEKTKQLNINRI
HHHCCHHCCCCHHCCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCHHHEECCEEE
VMGGSATPRALIDRIQNNLNATTIQAWGMTETSPMGTIGNLLPEHMALEQSERFDIQSKQ
EECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCCCC
GRAIYGVEIRVIDDHGQVLARDGVSAGHLQVRGPWIVSAYFKADEQNILDAHGWFSTGDI
CCEEEEEEEEEECCCCCEEEECCCCCCEEEEECCEEEEEEEECCCCCCEECCCCCCCCCE
ACISAEGYLQITDRSKDVIKSGGEWISSIDLENTAVAHPAIQEAAVIGLNHSKWQERPLL
EEEECCCEEEEECCCHHHHHCCCHHHHHCCCCCCEECCCHHHHHHEECCCCCCCCCCCEE
VAIKRPDMQIDEQELIHFLSKRVAKWWLPDDVVFVQSLPHTATGKLQKNVLREQFKDFVF
EEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
SSDRS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]