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The map label for this gene is cioA [H]

Identifier: 50084902

GI number: 50084902

Start: 1757096

End: 1758523

Strand: Reverse

Name: cioA [H]

Synonym: ACIAD1750

Alternate gene names: 50084902

Gene position: 1758523-1757096 (Counterclockwise)

Preceding gene: 50084903

Following gene: 50084901

Centisome position: 48.87

GC content: 42.44

Gene sequence:

>1428_bases
ATGACCTTAGGACTGACAGCTTTAGAACTAGCACGAATCCAGTTTGCATTTACGGTTTCATTTCATATTATCTTTCCAGC
AATTTCAATTGGTCTGGCCAGTTTTCTCGCAGTTCTGGAATGGCGCTGGTTACATACTGGCAATCCTGTTTATCAGGATT
TATTCAAATTTTGGGTCAAAATCTTTGCAGTCGCCTTCGGGATGGGTGTGGTTTCCGGTGTGGTCATGAGCTACCAGTTT
GGAACCAACTGGAGTGAGTTTTCTCGATTTGCAGGCGGCGTAACAGGGCCATTACTCAGCTATGAAGTACTCAGTGCTTT
TTTCCTTGAGGCAGGTTTCTTAGGCATCATGCTTTTTGGATGGGGCCGTGTTGGGAAAAAAGCCCATTTCTTTGCGACTT
TAATGGTTGCAGTTGGAACATGTATTTCGATGTTCTGGATCTTATCATCCAATAGCTGGATGCAAACCCCTCAAGGATTT
ACGATTGAAAATGGCATTATCGTTCCACAAGACTGGTTTGCCATTGTATTTAATCCATCTTTTCCTTATCGATTGGCACA
TATGGCAATTGCTGCATTTATGGTGTCATCGTTATTGGTGGCTGCAACTGCCGCTTGGCACTTACTCAAAGGCCGCCGTG
ATGACTTGGTAAAAAAATCTTTTTCAATGGCACTTTGGCTAATTTTGATTTTAGCCCCGTTGCAAGTTTTTGTGGGCGAT
GCACATGGTTTAAACACTTTAGAGCATCAACCAGCAAAACTCGCGGCTATGGAAGGTCATTGGGAAACCAACCATGATCA
TGCTATGCCTCTTTATTTATTCGGTATTCCAGACATGCAGGAAGAACGAACCAAATATGCGATTGCTATTCCTCATCTAG
GGAGCTTGATCTTAACTCACTCTATGAATGGTACCGTCAAAGGTTTGAAAGACTTTGCACCTGAAGATCGTCCAAACTCC
ACTATCGTCTTTTGGAGCTTCCGAGTCATGGTAGGTTTAGGGATGTTAATGGTTTTACTTGCATTGGCAGGACTTTTACT
TAGAAAATCTGGAAAGCTTTACGAAAATAAATGGTTTCAACGCTTTGCACTATTTATGGGGCCTTCAGGTTTTATTGCAC
TATTAGCAGGCTGGTTTACTACTGAGGTTGGTCGTCAGCCGTGGGTGGTTTATGGTGTGATGCGTACCAAAGATGCACTT
TCGCCCGTATCTGCCGAACAAGTCGGTTTAACTTTAATCATTTTTGTACTGGTTTATTTTGTTGTTTTTGGCATTGGTAT
TTACTACATGCTTAAACTGATCAACAAAGGTCCTGAATTTATTCATAGCCAACCTGAACAAGTCGGTGGTGTTGGACATT
TTAAAACCCCAATGCGCCCACTCAGTGCCGCTGATGAGCAAATTGATGATCAGAATAAAGGAGCTTGA

Upstream 100 bases:

>100_bases
TAAGCATGCCTTATTGTTTAAAAAATACCCTATACTGGATAGAAATAGCCATATCTAAAGATTGGCTAAATTTCACGAAT
ATAAAATGTGAGGTGCAGTC

Downstream 100 bases:

>100_bases
TCATGATTGATTTATCTTTAATCTGGATTGTCATCATTGCTGTAGGTGTATTTATTTATATTGTTCTGGATGGCTTTGAC
TTAGGAATTGGTATTTTATT

Product: ubiquinol oxidase subunit I, cyanide insensitive

Products: NA

Alternate protein names: Cytochrome d ubiquinol oxidase subunit I [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MTLGLTALELARIQFAFTVSFHIIFPAISIGLASFLAVLEWRWLHTGNPVYQDLFKFWVKIFAVAFGMGVVSGVVMSYQF
GTNWSEFSRFAGGVTGPLLSYEVLSAFFLEAGFLGIMLFGWGRVGKKAHFFATLMVAVGTCISMFWILSSNSWMQTPQGF
TIENGIIVPQDWFAIVFNPSFPYRLAHMAIAAFMVSSLLVAATAAWHLLKGRRDDLVKKSFSMALWLILILAPLQVFVGD
AHGLNTLEHQPAKLAAMEGHWETNHDHAMPLYLFGIPDMQEERTKYAIAIPHLGSLILTHSMNGTVKGLKDFAPEDRPNS
TIVFWSFRVMVGLGMLMVLLALAGLLLRKSGKLYENKWFQRFALFMGPSGFIALLAGWFTTEVGRQPWVVYGVMRTKDAL
SPVSAEQVGLTLIIFVLVYFVVFGIGIYYMLKLINKGPEFIHSQPEQVGGVGHFKTPMRPLSAADEQIDDQNKGA

Sequences:

>Translated_475_residues
MTLGLTALELARIQFAFTVSFHIIFPAISIGLASFLAVLEWRWLHTGNPVYQDLFKFWVKIFAVAFGMGVVSGVVMSYQF
GTNWSEFSRFAGGVTGPLLSYEVLSAFFLEAGFLGIMLFGWGRVGKKAHFFATLMVAVGTCISMFWILSSNSWMQTPQGF
TIENGIIVPQDWFAIVFNPSFPYRLAHMAIAAFMVSSLLVAATAAWHLLKGRRDDLVKKSFSMALWLILILAPLQVFVGD
AHGLNTLEHQPAKLAAMEGHWETNHDHAMPLYLFGIPDMQEERTKYAIAIPHLGSLILTHSMNGTVKGLKDFAPEDRPNS
TIVFWSFRVMVGLGMLMVLLALAGLLLRKSGKLYENKWFQRFALFMGPSGFIALLAGWFTTEVGRQPWVVYGVMRTKDAL
SPVSAEQVGLTLIIFVLVYFVVFGIGIYYMLKLINKGPEFIHSQPEQVGGVGHFKTPMRPLSAADEQIDDQNKGA
>Mature_474_residues
TLGLTALELARIQFAFTVSFHIIFPAISIGLASFLAVLEWRWLHTGNPVYQDLFKFWVKIFAVAFGMGVVSGVVMSYQFG
TNWSEFSRFAGGVTGPLLSYEVLSAFFLEAGFLGIMLFGWGRVGKKAHFFATLMVAVGTCISMFWILSSNSWMQTPQGFT
IENGIIVPQDWFAIVFNPSFPYRLAHMAIAAFMVSSLLVAATAAWHLLKGRRDDLVKKSFSMALWLILILAPLQVFVGDA
HGLNTLEHQPAKLAAMEGHWETNHDHAMPLYLFGIPDMQEERTKYAIAIPHLGSLILTHSMNGTVKGLKDFAPEDRPNST
IVFWSFRVMVGLGMLMVLLALAGLLLRKSGKLYENKWFQRFALFMGPSGFIALLAGWFTTEVGRQPWVVYGVMRTKDALS
PVSAEQVGLTLIIFVLVYFVVFGIGIYYMLKLINKGPEFIHSQPEQVGGVGHFKTPMRPLSAADEQIDDQNKGA

Specific function: Cytochrome D Terminal Oxidase Complex Is The Component Of The Aerobic Respiratory Chain Of E.Coli That Predominates When Cells Are Grown At Low Aeration. [C]

COG id: COG1271

COG function: function code C; Cytochrome bd-type quinol oxidase, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome ubiquinol oxidase subunit 1 family [H]

Homologues:

Organism=Escherichia coli, GI87081779, Length=506, Percent_Identity=30.4347826086957, Blast_Score=243, Evalue=3e-65,
Organism=Escherichia coli, GI1787212, Length=316, Percent_Identity=37.0253164556962, Blast_Score=229, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002585 [H]

Pfam domain/function: PF01654 Bac_Ubq_Cox [H]

EC number: 1.10.3.-

Molecular weight: Translated: 52887; Mature: 52756

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLGLTALELARIQFAFTVSFHIIFPAISIGLASFLAVLEWRWLHTGNPVYQDLFKFWVK
CCCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IFAVAFGMGVVSGVVMSYQFGTNWSEFSRFAGGVTGPLLSYEVLSAFFLEAGFLGIMLFG
HHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WGRVGKKAHFFATLMVAVGTCISMFWILSSNSWMQTPQGFTIENGIIVPQDWFAIVFNPS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEECCCCCEEEEECCC
FPYRLAHMAIAAFMVSSLLVAATAAWHLLKGRRDDLVKKSFSMALWLILILAPLQVFVGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHGLNTLEHQPAKLAAMEGHWETNHDHAMPLYLFGIPDMQEERTKYAIAIPHLGSLILTH
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHCCCEEEEECCCCCHHHHHC
SMNGTVKGLKDFAPEDRPNSTIVFWSFRVMVGLGMLMVLLALAGLLLRKSGKLYENKWFQ
CCCCCHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RFALFMGPSGFIALLAGWFTTEVGRQPWVVYGVMRTKDALSPVSAEQVGLTLIIFVLVYF
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHH
VVFGIGIYYMLKLINKGPEFIHSQPEQVGGVGHFKTPMRPLSAADEQIDDQNKGA
HHHHHHHHHHHHHHHCCHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TLGLTALELARIQFAFTVSFHIIFPAISIGLASFLAVLEWRWLHTGNPVYQDLFKFWVK
CCCHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IFAVAFGMGVVSGVVMSYQFGTNWSEFSRFAGGVTGPLLSYEVLSAFFLEAGFLGIMLFG
HHHHHHHHHHHHHHHHHEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WGRVGKKAHFFATLMVAVGTCISMFWILSSNSWMQTPQGFTIENGIIVPQDWFAIVFNPS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEECCCCCEEEEECCC
FPYRLAHMAIAAFMVSSLLVAATAAWHLLKGRRDDLVKKSFSMALWLILILAPLQVFVGD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AHGLNTLEHQPAKLAAMEGHWETNHDHAMPLYLFGIPDMQEERTKYAIAIPHLGSLILTH
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCHHCCCEEEEECCCCCHHHHHC
SMNGTVKGLKDFAPEDRPNSTIVFWSFRVMVGLGMLMVLLALAGLLLRKSGKLYENKWFQ
CCCCCHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RFALFMGPSGFIALLAGWFTTEVGRQPWVVYGVMRTKDALSPVSAEQVGLTLIIFVLVYF
HHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHCCCCCHHHHHHHHHHHHHHHH
VVFGIGIYYMLKLINKGPEFIHSQPEQVGGVGHFKTPMRPLSAADEQIDDQNKGA
HHHHHHHHHHHHHHHCCHHHHCCCHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on diphenols and related substances as donors; With oxygen as acceptor [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969509; 9384377 [H]