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The map label for this gene is hcaD [H]

Identifier: 50084877

GI number: 50084877

Start: 1730745

End: 1731884

Strand: Reverse

Name: hcaD [H]

Synonym: ACIAD1723

Alternate gene names: 50084877

Gene position: 1731884-1730745 (Counterclockwise)

Preceding gene: 50084878

Following gene: 50084876

Centisome position: 48.13

GC content: 46.23

Gene sequence:

>1140_bases
ATGCAGCAAGATACTGATTTTGAATTGTTCCGCGATACTTACAAACGTTTTTTAAACGATCATGTTGCGCCCTATTACGA
GCAATGGGAGCACGATGGTCTGATTCCTCGACATATCTGGAACTTACTCGGTGAAAATGGGTTCTTGTGTGTCGATGTTC
CAGAAGAATACGGTGGATATGGCGCACCAGTTCACTACTCGCTCATGCTGGTGCAAGAAACTGCACGCGCAGGATTTGGC
TCACTTGCGGTTGCCATTGGTGGACAAAATGAACTGGTCTCTCCTTATATCCAAAATATGGGTAGTGAGGCGCAAAAGAA
ATACTGGTTACCCAAAATGGTATCGGGCGAAGTGGTAACAGCAATTGCCATGACCGAAGCCAATGCCGGATCAGACCTTC
AAGCTATTCGCACTCAAGCGATTTTAAAAAACGAGCATTACGTCATTGATGGTTCAAAAACCTTTATCTCCAACGGACTA
CATGCCGATTTAATTGTTCTGGTTGCCAAAACAGACCCACAGGCACGCGCAAAAGGTATTTCTCTGTTTTTGGTCGATGC
GCAACTTGAAGGTGTTGAAAAAGGACGTTCGCTTAAAAAAATTGGACTGCATGCACAAGACACTGCCGAACTCTTTTTCG
ATGGCGTTCATGTACCAGTAACTCAGCGCCTTGGTCAAGAAGGCCAAGGCTTTGCATATCTGATGCAAGAGCTCCCTCGT
GAACGTTTAAGTATCGCGATGATGGGTATGGGGTCGATTTGGGGCGCGATTGACCTGACCACCAGTTATGTACGAGAGCG
CAAAGCATTTGGCCAAACACTGGCGCAGCTTCAAAACACGCGCTTTGTGATTGCCAATGCACAAATCAAAGCCAAAGCAG
CGCAAGCGTTTATTCATGAATGTGCCCAAATGTACCATCAGGGGGCGCTGACTGTGGGCCATGTTGCTGCATTGAAATGC
TTTATTACCGATACCCAGTGCGACGTGATCGATCAACTGCTGCAATTATTTGGGGGATACGGCTATATGCAGGAATATCC
GATTTCTCGTTTTTTTGTCGATTCACGTGTGCAAAAAATTTACGGTGGCACCAACGAAATCATGAAGGAAATCGTGGCGC
GAGACGTACTCGGAAAATAA

Upstream 100 bases:

>100_bases
TGTACGTATACCCGTTTTAAATCACTCCTAAGTTTATTTCTTGTTCTCAAGCTCATTTCGTATGGGGTTAGGCCTTGATC
ATGCTAAAAAAAGGTGAAAT

Downstream 100 bases:

>100_bases
TTAATATTTTTTAAACCTCATGGTTGGTACGACCAACCCTGTCAAAACAACAAAGATGTTTCAGGAAGAAATACAATGTC
AAAATTATGGATGTACTCTG

Product: acyl coenzyme A dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MQQDTDFELFRDTYKRFLNDHVAPYYEQWEHDGLIPRHIWNLLGENGFLCVDVPEEYGGYGAPVHYSLMLVQETARAGFG
SLAVAIGGQNELVSPYIQNMGSEAQKKYWLPKMVSGEVVTAIAMTEANAGSDLQAIRTQAILKNEHYVIDGSKTFISNGL
HADLIVLVAKTDPQARAKGISLFLVDAQLEGVEKGRSLKKIGLHAQDTAELFFDGVHVPVTQRLGQEGQGFAYLMQELPR
ERLSIAMMGMGSIWGAIDLTTSYVRERKAFGQTLAQLQNTRFVIANAQIKAKAAQAFIHECAQMYHQGALTVGHVAALKC
FITDTQCDVIDQLLQLFGGYGYMQEYPISRFFVDSRVQKIYGGTNEIMKEIVARDVLGK

Sequences:

>Translated_379_residues
MQQDTDFELFRDTYKRFLNDHVAPYYEQWEHDGLIPRHIWNLLGENGFLCVDVPEEYGGYGAPVHYSLMLVQETARAGFG
SLAVAIGGQNELVSPYIQNMGSEAQKKYWLPKMVSGEVVTAIAMTEANAGSDLQAIRTQAILKNEHYVIDGSKTFISNGL
HADLIVLVAKTDPQARAKGISLFLVDAQLEGVEKGRSLKKIGLHAQDTAELFFDGVHVPVTQRLGQEGQGFAYLMQELPR
ERLSIAMMGMGSIWGAIDLTTSYVRERKAFGQTLAQLQNTRFVIANAQIKAKAAQAFIHECAQMYHQGALTVGHVAALKC
FITDTQCDVIDQLLQLFGGYGYMQEYPISRFFVDSRVQKIYGGTNEIMKEIVARDVLGK
>Mature_379_residues
MQQDTDFELFRDTYKRFLNDHVAPYYEQWEHDGLIPRHIWNLLGENGFLCVDVPEEYGGYGAPVHYSLMLVQETARAGFG
SLAVAIGGQNELVSPYIQNMGSEAQKKYWLPKMVSGEVVTAIAMTEANAGSDLQAIRTQAILKNEHYVIDGSKTFISNGL
HADLIVLVAKTDPQARAKGISLFLVDAQLEGVEKGRSLKKIGLHAQDTAELFFDGVHVPVTQRLGQEGQGFAYLMQELPR
ERLSIAMMGMGSIWGAIDLTTSYVRERKAFGQTLAQLQNTRFVIANAQIKAKAAQAFIHECAQMYHQGALTVGHVAALKC
FITDTQCDVIDQLLQLFGGYGYMQEYPISRFFVDSRVQKIYGGTNEIMKEIVARDVLGK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=40.6417112299465, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI226958412, Length=369, Percent_Identity=31.4363143631436, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=30.5039787798408, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=31.7647058823529, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4557233, Length=370, Percent_Identity=30.5405405405405, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI7656849, Length=364, Percent_Identity=30.2197802197802, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=30.2387267904509, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=30.2387267904509, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=31.7333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4557235, Length=375, Percent_Identity=31.7333333333333, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI21361497, Length=373, Percent_Identity=30.5630026809651, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4503943, Length=384, Percent_Identity=28.3854166666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI7669494, Length=367, Percent_Identity=28.0653950953678, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI48976061, Length=295, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=28.8135593220339, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI38505218, Length=283, Percent_Identity=25.4416961130742, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87081958, Length=357, Percent_Identity=30.5322128851541, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1786223, Length=355, Percent_Identity=26.7605633802817, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87081702, Length=334, Percent_Identity=23.6526946107784, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=23.5087719298246, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538396, Length=367, Percent_Identity=32.1525885558583, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17508101, Length=364, Percent_Identity=31.3186813186813, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17551932, Length=365, Percent_Identity=32.0547945205479, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=359, Percent_Identity=31.7548746518106, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17570075, Length=388, Percent_Identity=28.8659793814433, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=30.7277628032345, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=28.9544235924933, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=30.3664921465969, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.1345646437995, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=285, Percent_Identity=31.5789473684211, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=30.8571428571429, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=228, Percent_Identity=32.8947368421053, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=263, Percent_Identity=30.0380228136882, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=284, Percent_Identity=31.6901408450704, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=355, Percent_Identity=28.169014084507, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17534353, Length=329, Percent_Identity=27.0516717325228, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=27.5, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=389, Percent_Identity=23.9074550128535, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI86563381, Length=389, Percent_Identity=23.9074550128535, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=29.4594594594595, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=31.5363881401617, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=29.4429708222812, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI24666513, Length=369, Percent_Identity=27.10027100271, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=28.0839895013123, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI281363737, Length=372, Percent_Identity=29.8387096774194, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI19920834, Length=375, Percent_Identity=28.8, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42183; Mature: 42183

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQDTDFELFRDTYKRFLNDHVAPYYEQWEHDGLIPRHIWNLLGENGFLCVDVPEEYGGY
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHCCC
GAPVHYSLMLVQETARAGFGSLAVAIGGQNELVSPYIQNMGSEAQKKYWLPKMVSGEVVT
CCCHHHEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCEEE
AIAMTEANAGSDLQAIRTQAILKNEHYVIDGSKTFISNGLHADLIVLVAKTDPQARAKGI
EEEEECCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEEEEECCCCHHHHCCE
SLFLVDAQLEGVEKGRSLKKIGLHAQDTAELFFDGVHVPVTQRLGQEGQGFAYLMQELPR
EEEEEECHHHHHHCCCCHHHHCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHCCH
ERLSIAMMGMGSIWGAIDLTTSYVRERKAFGQTLAQLQNTRFVIANAQIKAKAAQAFIHE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
CAQMYHQGALTVGHVAALKCFITDTQCDVIDQLLQLFGGYGYMQEYPISRFFVDSRVQKI
HHHHHHCCCCHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHH
YGGTNEIMKEIVARDVLGK
HCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQDTDFELFRDTYKRFLNDHVAPYYEQWEHDGLIPRHIWNLLGENGFLCVDVPEEYGGY
CCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHCCC
GAPVHYSLMLVQETARAGFGSLAVAIGGQNELVSPYIQNMGSEAQKKYWLPKMVSGEVVT
CCCHHHEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCEEE
AIAMTEANAGSDLQAIRTQAILKNEHYVIDGSKTFISNGLHADLIVLVAKTDPQARAKGI
EEEEECCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHCCCCEEEEEEEECCCCHHHHCCE
SLFLVDAQLEGVEKGRSLKKIGLHAQDTAELFFDGVHVPVTQRLGQEGQGFAYLMQELPR
EEEEEECHHHHHHCCCCHHHHCCCCCHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHCCH
ERLSIAMMGMGSIWGAIDLTTSYVRERKAFGQTLAQLQNTRFVIANAQIKAKAAQAFIHE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
CAQMYHQGALTVGHVAALKCFITDTQCDVIDQLLQLFGGYGYMQEYPISRFFVDSRVQKI
HHHHHHCCCCHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHH
YGGTNEIMKEIVARDVLGK
HCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]