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The map label for this gene is mucK

Identifier: 50084838

GI number: 50084838

Start: 1685937

End: 1687178

Strand: Reverse

Name: mucK

Synonym: ACIAD1681

Alternate gene names: 50084838

Gene position: 1687178-1685937 (Counterclockwise)

Preceding gene: 50084841

Following gene: 50084837

Centisome position: 46.88

GC content: 40.02

Gene sequence:

>1242_bases
ATGTACAGCAACAATCAGAGATCCAGAATTGGATCACACACATGGAAAATTGCTTTTTTATTTGCATTTTTAGCGTTGCT
TGTGGATGGAGCAGACCTGATGTTGCTCTCTTATAGTTTAAACAGTATTAAAGCTGAGTTTAATTTAAGTACAGTTGAAG
CTGGAATGTTGGGAAGTTTTACTTTAGCTGGCATGGCGATAGGTGGAATCTTTGGTGGGTGGGCGTGTGACCGATTTGGT
CGTGTACGCATTGTTGTGATTTCAATTCTCACGTTCTCAATCCTAACGTGTGGCCTTGGATTGACTCAGAGCTTTATACA
ATTTGGTGTTTTACGTTTCTTCGCTTCACTCGGTTTAGGTTCTTTATATATTGCCTGCAATACCCTCATGGCCGAATATG
TTCCAACAAAATACCGTACTACTGTTTTAGGTACATTACAGGCTGGCTGGACTGTTGGCTATATTGTTGCCACCTTACTG
GCTGGTTGGTTAATACCCGATCATGGTTGGCGTGTGCTGTTTTATGTTGCGATTATTCCTGTACTTATGGCTGTACTTAT
GCATTTTTTTGTACCAGAACCAGCAGCATGGCAACAATCACGCTTAGCACCATCCAAACAAACTGAAACAGTCAAAACTT
CTGCCTTTAAATTAATCTTTCAAGATAAACGTAACCGTAACATGTTCATTCTGTGGGCACTCACCGCAGGCTTTCTACAA
TTTGGTTACTATGGCGTAAACAATTGGATGCCATCTTATCTTGAAAGTGAATTGGGAATGAAGTTTAAGGAAATGACAGC
CTATATGGTCGGAACATACACTGCCATGATTTTAGGAAAAATCTTGGCTGGCTTTATGGCTGATAAACTCGGCCGTCGTT
TTACTTATGCATTTGGTGCTATCGGAACCGCAATTTTTTTACCTCTAATCGTGTTTTATAACTCACCAGATAATATTTTA
TATCTATTGGTTATTTTTGGTTTCTTGTACGGTATTCCATACGGTGTCAATGCAACTTACATGACAGAAAGCTTCCCAAC
AGCAATACGTGGTACAGCCATTGGTGGAGCTTATAATGTAGGAAGATTAGGCGCAGCGATTGCCCCAGCAACTATTGGTT
TTCTAGCTTCTGGCGGTTCAATTGGTTTGGGCTTTGTTGTAATGGGAGCTGCATATTTTATTTGTGGTGTAATTCCAGCA
CTGTTTATCAAAGAAAAACAATATGATCCACAACAGTCTTAA

Upstream 100 bases:

>100_bases
GATTTAATTAAATCTTTATTTTACTATCCGAAAAATTTTTAGAATTTGTTCTGTGATTTCAATTCATACAATTCAACTTC
TTTGCTAAAGGAATATAGCT

Downstream 100 bases:

>100_bases
CTTATAAATGCTTATACACTTCAATATATAGCCAGTAATATACACACTGGCTTTTTAACATTAAATAATGGTTGTTTTAA
TATTTTTTTCAAATTAAAAT

Product: major facilitator superfamily cis,cis-muconate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSFTLAGMAIGGIFGGWACDRFG
RVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLGSLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLL
AGWLIPDHGWRVLFYVAIIPVLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQ
FGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGAIGTAIFLPLIVFYNSPDNIL
YLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNVGRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPA
LFIKEKQYDPQQS

Sequences:

>Translated_413_residues
MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSFTLAGMAIGGIFGGWACDRFG
RVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLGSLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLL
AGWLIPDHGWRVLFYVAIIPVLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQ
FGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGAIGTAIFLPLIVFYNSPDNIL
YLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNVGRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPA
LFIKEKQYDPQQS
>Mature_413_residues
MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSFTLAGMAIGGIFGGWACDRFG
RVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLGSLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLL
AGWLIPDHGWRVLFYVAIIPVLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQ
FGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGAIGTAIFLPLIVFYNSPDNIL
YLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNVGRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPA
LFIKEKQYDPQQS

Specific function: Probable uptake of muconate

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family

Homologues:

Organism=Homo sapiens, GI213021148, Length=422, Percent_Identity=25.1184834123223, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI24308167, Length=404, Percent_Identity=24.7524752475248, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI24497497, Length=365, Percent_Identity=23.5616438356164, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI90669191, Length=364, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI33457322, Length=314, Percent_Identity=24.8407643312102, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI166064021, Length=368, Percent_Identity=22.8260869565217, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI7662270, Length=196, Percent_Identity=25.5102040816327, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082404, Length=381, Percent_Identity=25.9842519685039, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87082231, Length=406, Percent_Identity=25.615763546798, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082159, Length=376, Percent_Identity=25.7978723404255, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790550, Length=373, Percent_Identity=23.3243967828418, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786229, Length=361, Percent_Identity=23.8227146814404, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081723, Length=391, Percent_Identity=25.5754475703325, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789152, Length=409, Percent_Identity=22.9828850855746, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790463, Length=401, Percent_Identity=26.9326683291771, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789515, Length=410, Percent_Identity=23.6585365853659, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=423, Percent_Identity=24.5862884160757, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640198, Length=471, Percent_Identity=23.5668789808917, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640196, Length=471, Percent_Identity=23.5668789808917, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640200, Length=471, Percent_Identity=23.5668789808917, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221330907, Length=332, Percent_Identity=20.7831325301205, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUCK_ACIAD (P94131)

Other databases:

- EMBL:   U87258
- EMBL:   CR543861
- RefSeq:   YP_046348.1
- ProteinModelPortal:   P94131
- STRING:   P94131
- GeneID:   2879152
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1681
- NMPDR:   fig|62977.3.peg.1610
- eggNOG:   COG0477
- HOGENOM:   HBG289429
- OMA:   SECVGTK
- PhylomeDB:   P94131
- ProtClustDB:   CLSK866283
- BioCyc:   ASP62977:ACIAD1681-MONOMER
- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- TIGRFAMs:   TIGR00895

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 45246; Mature: 45246

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50850 MFS; PS00216 SUGAR_TRANSPORT_1; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17ef4880)-; HASH(0x180b0904)-; HASH(0x186ab194)-; HASH(0x17ebcb4c)-; HASH(0x16d1685c)-; HASH(0x186840ec)-; HASH(0x179117e4)-; HASH(0x186b0914)-; HASH(0x1840e6e0)-; HASH(0x17d8d2b0)-; HASH(0x186a92fc)-; HASH(0x18058384)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSF
CCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHEEECCCHHHCCCHHHHH
TLAGMAIGGIFGGWACDRFGRVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
SLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLLAGWLIPDHGWRVLFYVAIIP
HHHHHHHHHHHHHCCCCHHHHHEEHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQ
HHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
FGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGA
HHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
IGTAIFLPLIVFYNSPDNILYLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCH
GRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPALFIKEKQYDPQQS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MYSNNQRSRIGSHTWKIAFLFAFLALLVDGADLMLLSYSLNSIKAEFNLSTVEAGMLGSF
CCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHEEECCCHHHCCCHHHHH
TLAGMAIGGIFGGWACDRFGRVRIVVISILTFSILTCGLGLTQSFIQFGVLRFFASLGLG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
SLYIACNTLMAEYVPTKYRTTVLGTLQAGWTVGYIVATLLAGWLIPDHGWRVLFYVAIIP
HHHHHHHHHHHHHCCCCHHHHHEEHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VLMAVLMHFFVPEPAAWQQSRLAPSKQTETVKTSAFKLIFQDKRNRNMFILWALTAGFLQ
HHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHH
FGYYGVNNWMPSYLESELGMKFKEMTAYMVGTYTAMILGKILAGFMADKLGRRFTYAFGA
HHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
IGTAIFLPLIVFYNSPDNILYLLVIFGFLYGIPYGVNATYMTESFPTAIRGTAIGGAYNV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCH
GRLGAAIAPATIGFLASGGSIGLGFVVMGAAYFICGVIPALFIKEKQYDPQQS
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9294455