Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 50084665

GI number: 50084665

Start: 1492762

End: 1493430

Strand: Reverse

Name: mdmC [H]

Synonym: ACIAD1495

Alternate gene names: 50084665

Gene position: 1493430-1492762 (Counterclockwise)

Preceding gene: 50084666

Following gene: 50084663

Centisome position: 41.5

GC content: 39.46

Gene sequence:

>669_bases
ATGCAACAGCTGTGGACAGACATTGATCATTATATTGAATCAAATTTAATCCCAGAGGATTCAAATCTCAAATTCGCACT
TCAAAATACAGAAGATCAGGGCTTTCCAGATCATCTTGCTGTTGCCCCCAATCAAGGCATGTTGCTTCAAATGCTTATTC
AGATGAATCAATGCAAACGTGTACTTGAGTTAGGAACATTTGCTGCGTACAGTACAATCTGGTTAGCTCGTGCGCTTCCC
AAAGATGGATATCTGATGACAATTGAAGGTAGAGATACGCATGCTGCTTTAGCTCAGCAAAATATCGACCATGCAAATTT
ACCCGTGAATATTGAGTTAAAAGTCGGTAGGGCTGCTGATATATTATCCAAGATTGACACTGACACATTTGAACCTTTTG
ATTTTATTTTTATTGATGCTGACAAGCAAAGCTACCCTGAGTATCTCGATTTAAGTCTAAAATTATCACATTCGGGTACT
GTTATCGTGCTTGATAATGTTATTCGTGCAGGTGCTCTAATCGATCTAGATAATCAAAGACCGAGCATTGAAGGCATCCG
ATTGACCTTTGAGGCACTGCAAAACCATCCTCAACTTTTATCTTGTACTGCTTTACAGACAGTTGGTAGCAAAGGTCATG
ACGGTTTCGCTATTGCGATTGTGAAATAG

Upstream 100 bases:

>100_bases
TATTTGTTTTTAAAAACTTTTTCCTTTCGTTTTGAAATCTCATAAAATATTGCAAGTTTTAAAATGCATCATCCATTATC
GGATAAAGGTATAATTTGTT

Downstream 100 bases:

>100_bases
TGTTTAAAAATTAAACTTAACTTTTAAACACTTAAAAAACAAATACCTAAATCAAATTTTCATGCTTTTCCATATAGTTA
TCCACAACATTTGCGGATAA

Product: O-methyltransferase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MQQLWTDIDHYIESNLIPEDSNLKFALQNTEDQGFPDHLAVAPNQGMLLQMLIQMNQCKRVLELGTFAAYSTIWLARALP
KDGYLMTIEGRDTHAALAQQNIDHANLPVNIELKVGRAADILSKIDTDTFEPFDFIFIDADKQSYPEYLDLSLKLSHSGT
VIVLDNVIRAGALIDLDNQRPSIEGIRLTFEALQNHPQLLSCTALQTVGSKGHDGFAIAIVK

Sequences:

>Translated_222_residues
MQQLWTDIDHYIESNLIPEDSNLKFALQNTEDQGFPDHLAVAPNQGMLLQMLIQMNQCKRVLELGTFAAYSTIWLARALP
KDGYLMTIEGRDTHAALAQQNIDHANLPVNIELKVGRAADILSKIDTDTFEPFDFIFIDADKQSYPEYLDLSLKLSHSGT
VIVLDNVIRAGALIDLDNQRPSIEGIRLTFEALQNHPQLLSCTALQTVGSKGHDGFAIAIVK
>Mature_222_residues
MQQLWTDIDHYIESNLIPEDSNLKFALQNTEDQGFPDHLAVAPNQGMLLQMLIQMNQCKRVLELGTFAAYSTIWLARALP
KDGYLMTIEGRDTHAALAQQNIDHANLPVNIELKVGRAADILSKIDTDTFEPFDFIFIDADKQSYPEYLDLSLKLSHSGT
VIVLDNVIRAGALIDLDNQRPSIEGIRLTFEALQNHPQLLSCTALQTVGSKGHDGFAIAIVK

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI6466450, Length=140, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI205830453, Length=140, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI205830451, Length=140, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4502969, Length=140, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25148771, Length=160, Percent_Identity=33.75, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24730; Mature: 24730

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQLWTDIDHYIESNLIPEDSNLKFALQNTEDQGFPDHLAVAPNQGMLLQMLIQMNQCKR
CCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
VLELGTFAAYSTIWLARALPKDGYLMTIEGRDTHAALAQQNIDHANLPVNIELKVGRAAD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEEEEEECCCHHH
ILSKIDTDTFEPFDFIFIDADKQSYPEYLDLSLKLSHSGTVIVLDNVIRAGALIDLDNQR
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCEEEEECHHHCCEEEEECCCC
PSIEGIRLTFEALQNHPQLLSCTALQTVGSKGHDGFAIAIVK
CCCCCEEEEEHHHHCCCCEEEHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MQQLWTDIDHYIESNLIPEDSNLKFALQNTEDQGFPDHLAVAPNQGMLLQMLIQMNQCKR
CCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
VLELGTFAAYSTIWLARALPKDGYLMTIEGRDTHAALAQQNIDHANLPVNIELKVGRAAD
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCCCCEEEEEECCCHHH
ILSKIDTDTFEPFDFIFIDADKQSYPEYLDLSLKLSHSGTVIVLDNVIRAGALIDLDNQR
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCCEEEEECHHHCCEEEEECCCC
PSIEGIRLTFEALQNHPQLLSCTALQTVGSKGHDGFAIAIVK
CCCCCEEEEEHHHHCCCCEEEHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]