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The map label for this gene is dgdA [H]

Identifier: 50084627

GI number: 50084627

Start: 1449889

End: 1451232

Strand: Direct

Name: dgdA [H]

Synonym: ACIAD1452

Alternate gene names: 50084627

Gene position: 1449889-1451232 (Clockwise)

Preceding gene: 50084626

Following gene: 50084629

Centisome position: 40.29

GC content: 43.75

Gene sequence:

>1344_bases
ATGGTTACACGTTCAACCATCATGGATACCAATAGTTTCCGCGCAGAACATGCAGCCGCACTGGATGCTGAAACCCGAAA
ATTAACAGATAAACGTAGCCAAGTGCTCGGTGAGTCTTATCGATTATTTTATCGTAATCCTGTGCATTTGGTAAAAGGGC
AAGGGCAGTATCTTTGGGATGCTGCGGGCCATAAATATCTCGATGTATACAATAATGTAGCCAGTATTGGGCATTGTCAT
CCTGCTGTCATTGAGGCAGTGAATGAGCAGATGAAAATGCTCAACACACATACACGCTATTTGCATGAAAATATTCTGAA
TTACACCGAAGAGCTTTTAAAAACAACACCAAGCGAAATTGACCGTGCCATGTATATGTGTACAGGTTCTGAAGCCAATG
ATTTAGCCATTCGAATTGCCCGTGAATATAGTGGCGGAACAGGTATCATTGTTTCGCAAGAAGCTTATCACGGCACCAGT
GAGTTAACTTCAGGCTGTTCTCCTGCATTAGGTTCTGGTCAGGCTTTGGCAGCTACAACTCGTTTGGTTCCTGCACCGGA
TGCATACCGAATTGCAGCAGATGATTTAGGTGATTGGTTTGCAGCGCAAATTCAACAGCAAATCGATGACATGAACGCCA
ACGGTATTAAGTTTGCAGGCTTTCTGGCAGATTCAATTTTCTCTTCAGATGGTGTAATGCCAAATCCGGTTGGATTTTTG
AAAAAAGCAGTAGATGTGATTCATGCCAATGGCGGAATATTTATTGCCGATGAAGTACAACCTGGGTTTGCACGTACTGG
AGACTCATTTTGGGGATTCGGTCGCCATGGTGTAGTGCCAGATATTATTACCACAGGTAAACCGATGGGCAATGGAATTC
CGGTATCTGGTCTACTTGCCAAAAGCGATGTATTGGCAGCATTTAGCGATAATATTCCATATTTCAATACTTTCGGTGGA
AACCCAGTATCGATGGCGGCAGCTCAAGCTGTTCTCAAGGTAATTCATGATGAAGACTTACAAGCACACAGCAAATATGT
GGGTGCTAAACTTCAGGCCGAACTTAGCAAACTCATGGATATACATGAATGTGTGGGCGATGTACGCGGTGCGGGCTTGT
TTATCGGATTTGAACTGGTGAAAGATCGTGACAGTAAATCGCCAGATAAAGCCTTGGCACTGAATCTGATTGAAGAATTA
CGTAATACTCACCGCGTATTGACTTCGGTTGCTGGCCCATATGGCAATGTACTGAAATTACGTCCACCGCTGGCATTTCA
GGAACACGATATCGACTGGTTGGTTAGCGCACTCGATCAATCTATTCGTAAACTCAAAGATTAA

Upstream 100 bases:

>100_bases
ATATAAGTCAAACAGTGACATATACATTCGAAAGGACATGGCCCGATTTGATTCGATTTCAAGTGTGCCATTTTGAATTA
TTTAAATACAGGAGTCATTC

Downstream 100 bases:

>100_bases
AACTCAGCTAATCTTTAAGCCTTATCACTCGATAAGGCTTTTTTTATCCTGCCTGAGCGGTAATTTCTGTGTGCTGCTCA
CGCTCATTATGCTGCTCAGT

Product: aminotransferase

Products: NA

Alternate protein names: DGD [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MVTRSTIMDTNSFRAEHAAALDAETRKLTDKRSQVLGESYRLFYRNPVHLVKGQGQYLWDAAGHKYLDVYNNVASIGHCH
PAVIEAVNEQMKMLNTHTRYLHENILNYTEELLKTTPSEIDRAMYMCTGSEANDLAIRIAREYSGGTGIIVSQEAYHGTS
ELTSGCSPALGSGQALAATTRLVPAPDAYRIAADDLGDWFAAQIQQQIDDMNANGIKFAGFLADSIFSSDGVMPNPVGFL
KKAVDVIHANGGIFIADEVQPGFARTGDSFWGFGRHGVVPDIITTGKPMGNGIPVSGLLAKSDVLAAFSDNIPYFNTFGG
NPVSMAAAQAVLKVIHDEDLQAHSKYVGAKLQAELSKLMDIHECVGDVRGAGLFIGFELVKDRDSKSPDKALALNLIEEL
RNTHRVLTSVAGPYGNVLKLRPPLAFQEHDIDWLVSALDQSIRKLKD

Sequences:

>Translated_447_residues
MVTRSTIMDTNSFRAEHAAALDAETRKLTDKRSQVLGESYRLFYRNPVHLVKGQGQYLWDAAGHKYLDVYNNVASIGHCH
PAVIEAVNEQMKMLNTHTRYLHENILNYTEELLKTTPSEIDRAMYMCTGSEANDLAIRIAREYSGGTGIIVSQEAYHGTS
ELTSGCSPALGSGQALAATTRLVPAPDAYRIAADDLGDWFAAQIQQQIDDMNANGIKFAGFLADSIFSSDGVMPNPVGFL
KKAVDVIHANGGIFIADEVQPGFARTGDSFWGFGRHGVVPDIITTGKPMGNGIPVSGLLAKSDVLAAFSDNIPYFNTFGG
NPVSMAAAQAVLKVIHDEDLQAHSKYVGAKLQAELSKLMDIHECVGDVRGAGLFIGFELVKDRDSKSPDKALALNLIEEL
RNTHRVLTSVAGPYGNVLKLRPPLAFQEHDIDWLVSALDQSIRKLKD
>Mature_447_residues
MVTRSTIMDTNSFRAEHAAALDAETRKLTDKRSQVLGESYRLFYRNPVHLVKGQGQYLWDAAGHKYLDVYNNVASIGHCH
PAVIEAVNEQMKMLNTHTRYLHENILNYTEELLKTTPSEIDRAMYMCTGSEANDLAIRIAREYSGGTGIIVSQEAYHGTS
ELTSGCSPALGSGQALAATTRLVPAPDAYRIAADDLGDWFAAQIQQQIDDMNANGIKFAGFLADSIFSSDGVMPNPVGFL
KKAVDVIHANGGIFIADEVQPGFARTGDSFWGFGRHGVVPDIITTGKPMGNGIPVSGLLAKSDVLAAFSDNIPYFNTFGG
NPVSMAAAQAVLKVIHDEDLQAHSKYVGAKLQAELSKLMDIHECVGDVRGAGLFIGFELVKDRDSKSPDKALALNLIEEL
RNTHRVLTSVAGPYGNVLKLRPPLAFQEHDIDWLVSALDQSIRKLKD

Specific function: The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=426, Percent_Identity=41.3145539906103, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI226442705, Length=426, Percent_Identity=40.1408450704225, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI24119277, Length=425, Percent_Identity=38.8235294117647, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=41.4698162729659, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI13994255, Length=431, Percent_Identity=34.1067285382831, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI4557809, Length=413, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=29.8245614035088, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI188536080, Length=438, Percent_Identity=26.027397260274, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679950, Length=438, Percent_Identity=26.027397260274, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38679946, Length=438, Percent_Identity=26.027397260274, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=29.7921478060046, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789759, Length=407, Percent_Identity=28.2555282555283, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=29.25, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=28.894472361809, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=25.7425742574257, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=305, Percent_Identity=29.5081967213115, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786991, Length=421, Percent_Identity=24.7030878859857, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992977, Length=445, Percent_Identity=36.1797752808989, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI32564660, Length=440, Percent_Identity=33.4090909090909, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI25144271, Length=433, Percent_Identity=27.2517321016166, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71992985, Length=142, Percent_Identity=33.0985915492958, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25144274, Length=249, Percent_Identity=29.3172690763052, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71981843, Length=100, Percent_Identity=36, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=430, Percent_Identity=26.5116279069767, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324432, Length=352, Percent_Identity=25, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356575, Length=431, Percent_Identity=39.2111368909513, Blast_Score=328, Evalue=3e-90,
Organism=Drosophila melanogaster, GI161085790, Length=427, Percent_Identity=35.1288056206089, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI28574759, Length=452, Percent_Identity=34.2920353982301, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21357415, Length=454, Percent_Identity=25.1101321585903, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =4.1.1.64 [H]

Molecular weight: Translated: 48664; Mature: 48664

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTRSTIMDTNSFRAEHAAALDAETRKLTDKRSQVLGESYRLFYRNPVHLVKGQGQYLWD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCEEEC
AAGHKYLDVYNNVASIGHCHPAVIEAVNEQMKMLNTHTRYLHENILNYTEELLKTTPSEI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DRAMYMCTGSEANDLAIRIAREYSGGTGIIVSQEAYHGTSELTSGCSPALGSGQALAATT
HHEEEEECCCCCCCEEEEEEEECCCCCEEEEECHHHCCHHHHHCCCCCCCCCCCCHHHHE
RLVPAPDAYRIAADDLGDWFAAQIQQQIDDMNANGIKFAGFLADSIFSSDGVMPNPVGFL
ECCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHH
KKAVDVIHANGGIFIADEVQPGFARTGDSFWGFGRHGVVPDIITTGKPMGNGIPVSGLLA
HHHHHHEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
KSDVLAAFSDNIPYFNTFGGNPVSMAAAQAVLKVIHDEDLQAHSKYVGAKLQAELSKLMD
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
IHECVGDVRGAGLFIGFELVKDRDSKSPDKALALNLIEELRNTHRVLTSVAGPYGNVLKL
HHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPPLAFQEHDIDWLVSALDQSIRKLKD
CCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTRSTIMDTNSFRAEHAAALDAETRKLTDKRSQVLGESYRLFYRNPVHLVKGQGQYLWD
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCCEEEC
AAGHKYLDVYNNVASIGHCHPAVIEAVNEQMKMLNTHTRYLHENILNYTEELLKTTPSEI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
DRAMYMCTGSEANDLAIRIAREYSGGTGIIVSQEAYHGTSELTSGCSPALGSGQALAATT
HHEEEEECCCCCCCEEEEEEEECCCCCEEEEECHHHCCHHHHHCCCCCCCCCCCCHHHHE
RLVPAPDAYRIAADDLGDWFAAQIQQQIDDMNANGIKFAGFLADSIFSSDGVMPNPVGFL
ECCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCHHHHH
KKAVDVIHANGGIFIADEVQPGFARTGDSFWGFGRHGVVPDIITTGKPMGNGIPVSGLLA
HHHHHHEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
KSDVLAAFSDNIPYFNTFGGNPVSMAAAQAVLKVIHDEDLQAHSKYVGAKLQAELSKLMD
HHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
IHECVGDVRGAGLFIGFELVKDRDSKSPDKALALNLIEELRNTHRVLTSVAGPYGNVLKL
HHHHHHHHCCCEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPPLAFQEHDIDWLVSALDQSIRKLKD
CCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180928; 8342040; 7947767; 7799433; 10556038 [H]