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The map label for this gene is qor [C]

Identifier: 50084629

GI number: 50084629

Start: 1451791

End: 1452804

Strand: Direct

Name: qor [C]

Synonym: ACIAD1454

Alternate gene names: 50084629

Gene position: 1451791-1452804 (Clockwise)

Preceding gene: 50084627

Following gene: 50084633

Centisome position: 40.34

GC content: 46.15

Gene sequence:

>1014_bases
ATGAAAGCGGTAGGCTATAAAGAACAAGGTGAGATTACACGTCCAGATGCATTGGTGGATATCGAGATCGATCAGCCCGT
GGCGCGCGGTAAAGATATTCTGGTCGAGGTAAAAGCGATCTCAGTGAATCCGGTTGATACCAAAGTTCGCAAACGTGCAG
CAGCAGAAGCAGGACAGTGGAAAATTTTAGGTTGGGATGCAGCTGGCGTTGTGGTCAGTGTAGGCGACGAAGTCACCGAA
TTTAAAGTAGGCGATGAAGTCTGGTATGCAGGTGATTTAACCCGTCCGGGCAGTAATGCACAGTTTCAATTGGTCGATGC
GCGCATTGTGGGGCATAAACCGAAACGCCTTTCTTTTGCAGAAGCGGCAGCTATGCCTCTGACCACCATTACTGCATGGG
AAATGTTGTTTGACCGTTTAAAAATTGAAGATCCAGTGCCAGGTGGAGACCGAAGTATCCTAATTATTGGTGGGGCAGGC
GGTGTTGGCTCAATCACGATTCAATTACTTAAAGCAAAATCAGATTTGAAAGTTATTGCGACAGCATCACGCGCAGAGAC
ACAAGCGTGGGTGAAACAGCTCGGAGCGGATTACGTGATTGATCATTCAAAACCACTTAAGGCGCAAATGGATGAACTGG
GTTTAAAGGCACCTAGTTATGTTTTTTCTACCAATTATACCGATCAATATATGGAGCAGATTGCTGCATTGACCGCACCT
CAGGGGCGTTTGGGCCTGATTGATGATCCAGCCGAACTGAGTATCAGCCCACTCAAAACCAAATCGATCTCGTTACATTG
GGAGTTTATGTATACCCGCTCAATGTACCAAACGGAAGATATTGCACAGCAGCGTGAACTGTTAAATGCAGTGGCCAAAC
TGGTCGATGATGGCGTCATTCAAACTACATTGACTGAGGTATATGGCAAGATCAATGCCGAAAATCTCAAAGAGGTGCAT
AGCCTGATTGAAGGTGGTAAAGCCAAAGGCAAAATTGTGCTTGAAGGGTTTTAA

Upstream 100 bases:

>100_bases
ATAACAGTATCCTTTTTGACACTATGTGCGAAATTTGTCTGTATATACGGTGATTAAGCTTAAGGTATGCTACCACGCAA
TACAAGTGAGGAACGTTAAG

Downstream 100 bases:

>100_bases
ATCGAATCAATCAACAAATAGCTGGAACCGCTTAATTGCGTGTTCCGGCTGTATTAGTTACGCCATTGTCTTGGATTAAC
ACCAAACCAGCGCTTAAATG

Product: Zn-dependent oxidoreductase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAVGYKEQGEITRPDALVDIEIDQPVARGKDILVEVKAISVNPVDTKVRKRAAAEAGQWKILGWDAAGVVVSVGDEVTE
FKVGDEVWYAGDLTRPGSNAQFQLVDARIVGHKPKRLSFAEAAAMPLTTITAWEMLFDRLKIEDPVPGGDRSILIIGGAG
GVGSITIQLLKAKSDLKVIATASRAETQAWVKQLGADYVIDHSKPLKAQMDELGLKAPSYVFSTNYTDQYMEQIAALTAP
QGRLGLIDDPAELSISPLKTKSISLHWEFMYTRSMYQTEDIAQQRELLNAVAKLVDDGVIQTTLTEVYGKINAENLKEVH
SLIEGGKAKGKIVLEGF

Sequences:

>Translated_337_residues
MKAVGYKEQGEITRPDALVDIEIDQPVARGKDILVEVKAISVNPVDTKVRKRAAAEAGQWKILGWDAAGVVVSVGDEVTE
FKVGDEVWYAGDLTRPGSNAQFQLVDARIVGHKPKRLSFAEAAAMPLTTITAWEMLFDRLKIEDPVPGGDRSILIIGGAG
GVGSITIQLLKAKSDLKVIATASRAETQAWVKQLGADYVIDHSKPLKAQMDELGLKAPSYVFSTNYTDQYMEQIAALTAP
QGRLGLIDDPAELSISPLKTKSISLHWEFMYTRSMYQTEDIAQQRELLNAVAKLVDDGVIQTTLTEVYGKINAENLKEVH
SLIEGGKAKGKIVLEGF
>Mature_337_residues
MKAVGYKEQGEITRPDALVDIEIDQPVARGKDILVEVKAISVNPVDTKVRKRAAAEAGQWKILGWDAAGVVVSVGDEVTE
FKVGDEVWYAGDLTRPGSNAQFQLVDARIVGHKPKRLSFAEAAAMPLTTITAWEMLFDRLKIEDPVPGGDRSILIIGGAG
GVGSITIQLLKAKSDLKVIATASRAETQAWVKQLGADYVIDHSKPLKAQMDELGLKAPSYVFSTNYTDQYMEQIAALTAP
QGRLGLIDDPAELSISPLKTKSISLHWEFMYTRSMYQTEDIAQQRELLNAVAKLVDDGVIQTTLTEVYGKINAENLKEVH
SLIEGGKAKGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI194239676, Length=194, Percent_Identity=30.9278350515464, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI194239674, Length=194, Percent_Identity=31.4432989690722, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI13236495, Length=194, Percent_Identity=31.4432989690722, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI24308257, Length=165, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI18379349, Length=139, Percent_Identity=34.5323741007194, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1790485, Length=188, Percent_Identity=31.3829787234043, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507255, Length=250, Percent_Identity=32.8, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71987554, Length=215, Percent_Identity=34.8837209302326, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319520, Length=183, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 36735; Mature: 36735

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYKEQGEITRPDALVDIEIDQPVARGKDILVEVKAISVNPVDTKVRKRAAAEAGQW
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCE
KILGWDAAGVVVSVGDEVTEFKVGDEVWYAGDLTRPGSNAQFQLVDARIVGHKPKRLSFA
EEEEECCCCEEEECCCCCEEEECCCCEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHH
EAAAMPLTTITAWEMLFDRLKIEDPVPGGDRSILIIGGAGGVGSITIQLLKAKSDLKVIA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEE
TASRAETQAWVKQLGADYVIDHSKPLKAQMDELGLKAPSYVFSTNYTDQYMEQIAALTAP
ECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCC
QGRLGLIDDPAELSISPLKTKSISLHWEFMYTRSMYQTEDIAQQRELLNAVAKLVDDGVI
CCCCCCCCCCHHCEECCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QTTLTEVYGKINAENLKEVHSLIEGGKAKGKIVLEGF
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVGYKEQGEITRPDALVDIEIDQPVARGKDILVEVKAISVNPVDTKVRKRAAAEAGQW
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHCCCCE
KILGWDAAGVVVSVGDEVTEFKVGDEVWYAGDLTRPGSNAQFQLVDARIVGHKPKRLSFA
EEEEECCCCEEEECCCCCEEEECCCCEEEECCCCCCCCCCEEEEEEEEEECCCCCCCCHH
EAAAMPLTTITAWEMLFDRLKIEDPVPGGDRSILIIGGAGGVGSITIQLLKAKSDLKVIA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEE
TASRAETQAWVKQLGADYVIDHSKPLKAQMDELGLKAPSYVFSTNYTDQYMEQIAALTAP
ECCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCC
QGRLGLIDDPAELSISPLKTKSISLHWEFMYTRSMYQTEDIAQQRELLNAVAKLVDDGVI
CCCCCCCCCCHHCEECCCEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QTTLTEVYGKINAENLKEVHSLIEGGKAKGKIVLEGF
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA