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The map label for this gene is lpxD

Identifier: 50084558

GI number: 50084558

Start: 1376509

End: 1377579

Strand: Direct

Name: lpxD

Synonym: ACIAD1380

Alternate gene names: 50084558

Gene position: 1376509-1377579 (Clockwise)

Preceding gene: 50084557

Following gene: 50084559

Centisome position: 38.25

GC content: 40.15

Gene sequence:

>1071_bases
ATGAACATACCCCATTATTCATTGGAAACTTTAGCTCATCTTGTTCAAGGTGAGCTTTTTGGTGATGAGCACTTTAATTT
ATCTGGATTGGCCAGTCTTGAGCAGGCACAATCTCATCATATTTCATTTGTAAATGGTGAGAAGTATGTTGAGGCTGCGA
AACAGAGTAAAGCTGGAGCTTTGATTGTTACATCTGCATTTAAAGATCAATTGCCCGCGAGTCAAAATTACATTGTTGTA
AAAAACCCTTATCTTGCTTTCGCACAGCTGACCCATGTTTTTGAAAAAAAAATGACTCAGAGAGGGATTGAGAGTACGGC
GAAAATCCATCCATCTGCCATGATAGCAGACAATGCATATATTGGTCATTACGTGATCATAGGTGCGGAATGTGTTGTAG
GGGAAAATACAGTCATACTTGCACATAGTTTTTTAGGCGACAACGTAGAAATTGGTCGAGATGGATTTGTCGAGTCAAAT
GTTAGCTTATTGCAAGGCACAAAAATAAAGGATCGAGTTCGAATTCATGCCAATACAGTGATTGGCAGTGAGGGGTTTGG
TTTCGCACCTTATCAAGGTAAGTGGCATAGGATTGTGCAACTGGGTACGGTTCAAATTGGTCACGATGTTCGAATTGGGT
CAAATTGTAGTATTGACCGGGGTGCTTTGGATGACACGATTATTGAAGATGGTGTAATTATTGATAACCTTGTGCAAATC
GCGCATAACGTTCGAATTGGTTCAAATACGGCTATTGCGGCTAAATGTGGAATTGCAGGAAGCACGGTAATTGGCAAAAA
CTGTATCCTTGCAGGGGCCTGTGGTGTGGTGGGTCATATTACTATCACCGATAATGTGACACTCACAGGAATGTCAATGG
TCACAAAAAGTATTTCTGAAGCAGGAACCTATTCTTCAGGAACAGCACTTATGGAAAATAATCAATGGAAACGAACCATT
GTTCGCTTTAGACAATTAGCAGATGTGCCATTGACCCAAATCATGAAACGACTCGATCATATACAGACTCAAATTGAGTC
TCTTGAATCAACTTTTAAATTGCGTAAATAG

Upstream 100 bases:

>100_bases
TCTAGATTATGTTTTGAATAAAAATGCAGTGATTGCATCTGATATAAAAGATGATTTAACTGATAAAATGATTCAAAAGG
TTAATGCAATTAAATAATTC

Downstream 100 bases:

>100_bases
AATATGATGACTGAGTCAAACACTCCTGCGTTTACGATCCCTGAATTGCCAATGGACATTCAAAAAATTCGTGAATATTT
GCCACATCGCTATCCATTCC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGALIVTSAFKDQLPASQNYIVV
KNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAYIGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESN
VSLLQGTKIKDRVRIHANTVIGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQI
AHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISEAGTYSSGTALMENNQWKRTI
VRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK

Sequences:

>Translated_356_residues
MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGALIVTSAFKDQLPASQNYIVV
KNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAYIGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESN
VSLLQGTKIKDRVRIHANTVIGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQI
AHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISEAGTYSSGTALMENNQWKRTI
VRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK
>Mature_356_residues
MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGALIVTSAFKDQLPASQNYIVV
KNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAYIGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESN
VSLLQGTKIKDRVRIHANTVIGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQI
AHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISEAGTYSSGTALMENNQWKRTI
VRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=350, Percent_Identity=40, Blast_Score=241, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_ACIAD (Q6FCG5)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046068.1
- ProteinModelPortal:   Q6FCG5
- SMR:   Q6FCG5
- STRING:   Q6FCG5
- GeneID:   2879761
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1380
- NMPDR:   fig|62977.3.peg.682
- eggNOG:   COG1044
- HOGENOM:   HBG469615
- OMA:   CFVGKNT
- PhylomeDB:   Q6FCG5
- ProtClustDB:   PRK00892
- BioCyc:   ASP62977:ACIAD1380-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 38636; Mature: 38636

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGA
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEEECCHHHHHHHHHCCCCE
LIVTSAFKDQLPASQNYIVVKNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAY
EEEEECHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCE
IGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESNVSLLQGTKIKDRVRIHANTV
EEEEEEEECEEEECCCEEEEEEECCCCCEEECCCCCCCCCCHHHCCCCCCCEEEEEEEEE
IGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQI
ECCCCCCCCCCCCCCEEEEEEEEEEECCEEEECCCCCCCCCCCCCHHHCCCCHHHHHHHH
AHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISE
HHCEEECCCCEEEEECCCCCCCEECCCEEEEECCCEEEEEEEECCEEEEHHHHHHHHHHH
AGTYSSGTALMENNQWKRTIVRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK
CCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIPHYSLETLAHLVQGELFGDEHFNLSGLASLEQAQSHHISFVNGEKYVEAAKQSKAGA
CCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCEEEECCHHHHHHHHHCCCCE
LIVTSAFKDQLPASQNYIVVKNPYLAFAQLTHVFEKKMTQRGIESTAKIHPSAMIADNAY
EEEEECHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCEEEECCCE
IGHYVIIGAECVVGENTVILAHSFLGDNVEIGRDGFVESNVSLLQGTKIKDRVRIHANTV
EEEEEEEECEEEECCCEEEEEEECCCCCEEECCCCCCCCCCHHHCCCCCCCEEEEEEEEE
IGSEGFGFAPYQGKWHRIVQLGTVQIGHDVRIGSNCSIDRGALDDTIIEDGVIIDNLVQI
ECCCCCCCCCCCCCCEEEEEEEEEEECCEEEECCCCCCCCCCCCCHHHCCCCHHHHHHHH
AHNVRIGSNTAIAAKCGIAGSTVIGKNCILAGACGVVGHITITDNVTLTGMSMVTKSISE
HHCEEECCCCEEEEECCCCCCCEECCCEEEEECCCEEEEEEEECCEEEEHHHHHHHHHHH
AGTYSSGTALMENNQWKRTIVRFRQLADVPLTQIMKRLDHIQTQIESLESTFKLRK
CCCCCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA