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The map label for this gene is dxr

Identifier: 50084554

GI number: 50084554

Start: 1370882

End: 1372078

Strand: Direct

Name: dxr

Synonym: ACIAD1376

Alternate gene names: 50084554

Gene position: 1370882-1372078 (Clockwise)

Preceding gene: 50084553

Following gene: 50084555

Centisome position: 38.09

GC content: 39.68

Gene sequence:

>1197_bases
ATGACACAATCTGTTTGTATATTGGGTGTAACGGGTTCAATCGGACAAAGCACTTTAAAAGTTTTAGCGCAGCATCCAGA
TAAGTATTCGATTTACGCCATTACTGCGCATAGTCGGATTCAAGAACTCGTTGAAATATGCAAACAATTTAAGCCTAAGC
GGGTGGTTGTACCTGATGAGCATATAGATCAATTGAGACAGTTGCTTTTACAAGCTGGGCTAGCTGATATTGATATTTTA
TCTGGTACTACAGGTCTTGTTTCTGTTGCTCAGGATGAGGCTGTTGATGTGGTTATGGCTGCTATTGTGGGGGCAGCTGG
GTTATTGCCTACATTGGCCGCTGTAAAAGCGGGTAAGCGAGTATTATTGGCAAATAAAGAAGCTTTGGTAATGTCTGGTA
ATATCATGATGCAGGCTGCACGTGATCATCAAGCATTATTATTGCCTGTAGATTCGGAACACAATGCAATATTTCAATCA
TTGCCAAGTAATTATTTGACACTCGAAAATACTGGTCAACCACAGCTAGGTGTATCAAGGATTTTACTCACCGCATCTGG
GGGCCCATTTTTGGATTATCCTCTAGAACAGCTAAGCGAAGTGACGCCCCAACAAGCATGTAAGCATCCAAATTGGTCTA
TGGGGCAAAAAATCTCAGTTGATTCTGCAACTTTAATGAATAAGGGGCTGGAGTTAATAGAAGCGTGTCATTTGTTTTCA
ATTTCAGAACATTTTGTTACAGTTGTGGTGCATCCACAAAGTATCATTCATTCAATGGTTCAATATATTGATGGTTCTAC
ATTGGCACAAATGGGAAATCCAGACATGTGTACACCGATTGCACATGCATTAGCATGGCCTGATCGTTTACAAACACATG
TTCCTGCTTTAGATTTATTTACACATACACATCTTGATTTTAGAGAACCTGATACAAATAAATTTCCAGCATTAAATCTT
GCAAGACAAGCAATGCGCGCAGGCGGCTTAAGTCCGTGTATACTTAATGCGGCCAATGAAATTGCGGTGGATGCATTTTT
GAAGCTACAAATAAAATTTACCGTAATCCCAGAAGTGATTGAGCATGTGTTGAATCACGTGCAAAATGATACAGCAGTAA
ATATAGAGCAAGTTTTAGAAACCGATATGATTGCAAGACAGATTGCGCATCAATATGTAAATCAGATACGAGGCTAA

Upstream 100 bases:

>100_bases
TCATGGTGGTGTGCTGGATCGTATTGACTCATTATTGGCTGCGGCTCCTGTATTTGCGGCAGGAATCTACTTATTGAAAC
TCATTGGTGTAGATTTATAA

Downstream 100 bases:

>100_bases
TGAGATGAATGTTTTATATATCGTCATCGCTGCAATTTTGCTGCTCGGACCTCTGATTGCAATTCATGAATTCGGTCATT
ATTGGGTTGCCAGAAAACTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTQSVCILGVTGSIGQSTLKVLAQHPDKYSIYAITAHSRIQELVEICKQFKPKRVVVPDEHIDQLRQLLLQAGLADIDIL
SGTTGLVSVAQDEAVDVVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGNIMMQAARDHQALLLPVDSEHNAIFQS
LPSNYLTLENTGQPQLGVSRILLTASGGPFLDYPLEQLSEVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
ISEHFVTVVVHPQSIIHSMVQYIDGSTLAQMGNPDMCTPIAHALAWPDRLQTHVPALDLFTHTHLDFREPDTNKFPALNL
ARQAMRAGGLSPCILNAANEIAVDAFLKLQIKFTVIPEVIEHVLNHVQNDTAVNIEQVLETDMIARQIAHQYVNQIRG

Sequences:

>Translated_398_residues
MTQSVCILGVTGSIGQSTLKVLAQHPDKYSIYAITAHSRIQELVEICKQFKPKRVVVPDEHIDQLRQLLLQAGLADIDIL
SGTTGLVSVAQDEAVDVVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGNIMMQAARDHQALLLPVDSEHNAIFQS
LPSNYLTLENTGQPQLGVSRILLTASGGPFLDYPLEQLSEVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
ISEHFVTVVVHPQSIIHSMVQYIDGSTLAQMGNPDMCTPIAHALAWPDRLQTHVPALDLFTHTHLDFREPDTNKFPALNL
ARQAMRAGGLSPCILNAANEIAVDAFLKLQIKFTVIPEVIEHVLNHVQNDTAVNIEQVLETDMIARQIAHQYVNQIRG
>Mature_397_residues
TQSVCILGVTGSIGQSTLKVLAQHPDKYSIYAITAHSRIQELVEICKQFKPKRVVVPDEHIDQLRQLLLQAGLADIDILS
GTTGLVSVAQDEAVDVVMAAIVGAAGLLPTLAAVKAGKRVLLANKEALVMSGNIMMQAARDHQALLLPVDSEHNAIFQSL
PSNYLTLENTGQPQLGVSRILLTASGGPFLDYPLEQLSEVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFSI
SEHFVTVVVHPQSIIHSMVQYIDGSTLAQMGNPDMCTPIAHALAWPDRLQTHVPALDLFTHTHLDFREPDTNKFPALNLA
RQAMRAGGLSPCILNAANEIAVDAFLKLQIKFTVIPEVIEHVLNHVQNDTAVNIEQVLETDMIARQIAHQYVNQIRG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=49.75, Blast_Score=360, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_ACIAD (Q6FCG9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046064.1
- ProteinModelPortal:   Q6FCG9
- SMR:   Q6FCG9
- STRING:   Q6FCG9
- GeneID:   2879772
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1376
- NMPDR:   fig|62977.3.peg.607
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q6FCG9
- ProtClustDB:   PRK05447
- BioCyc:   ASP62977:ACIAD1376-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43384; Mature: 43253

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 153-153 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSVCILGVTGSIGQSTLKVLAQHPDKYSIYAITAHSRIQELVEICKQFKPKRVVVPDE
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCEEECCHH
HIDQLRQLLLQAGLADIDILSGTTGLVSVAQDEAVDVVMAAIVGAAGLLPTLAAVKAGKR
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLANKEALVMSGNIMMQAARDHQALLLPVDSEHNAIFQSLPSNYLTLENTGQPQLGVSR
EEEECCCEEEEECCEEEEECCCCCEEEEEECCCCHHHHHHCCCCEEEECCCCCCCCCCEE
ILLTASGGPFLDYPLEQLSEVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
EEEEECCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHE
ISEHFVTVVVHPQSIIHSMVQYIDGSTLAQMGNPDMCTPIAHALAWPDRLQTHVPALDLF
ECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHCCHHHHH
THTHLDFREPDTNKFPALNLARQAMRAGGLSPCILNAANEIAVDAFLKLQIKFTVIPEVI
HHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHEEEEEEEEEEEEHHHHH
EHVLNHVQNDTAVNIEQVLETDMIARQIAHQYVNQIRG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQSVCILGVTGSIGQSTLKVLAQHPDKYSIYAITAHSRIQELVEICKQFKPKRVVVPDE
CCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCEEECCHH
HIDQLRQLLLQAGLADIDILSGTTGLVSVAQDEAVDVVMAAIVGAAGLLPTLAAVKAGKR
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VLLANKEALVMSGNIMMQAARDHQALLLPVDSEHNAIFQSLPSNYLTLENTGQPQLGVSR
EEEECCCEEEEECCEEEEECCCCCEEEEEECCCCHHHHHHCCCCEEEECCCCCCCCCCEE
ILLTASGGPFLDYPLEQLSEVTPQQACKHPNWSMGQKISVDSATLMNKGLELIEACHLFS
EEEEECCCCCCCCCHHHHHHCCHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHE
ISEHFVTVVVHPQSIIHSMVQYIDGSTLAQMGNPDMCTPIAHALAWPDRLQTHVPALDLF
ECCCEEEEEECCHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHCCHHHHH
THTHLDFREPDTNKFPALNLARQAMRAGGLSPCILNAANEIAVDAFLKLQIKFTVIPEVI
HHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCHHHHHHEEEEEEEEEEEEHHHHH
EHVLNHVQNDTAVNIEQVLETDMIARQIAHQYVNQIRG
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA