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The map label for this gene is pyrH

Identifier: 50084550

GI number: 50084550

Start: 1367938

End: 1368666

Strand: Direct

Name: pyrH

Synonym: ACIAD1372

Alternate gene names: 50084550

Gene position: 1367938-1368666 (Clockwise)

Preceding gene: 50084549

Following gene: 50084551

Centisome position: 38.01

GC content: 42.52

Gene sequence:

>729_bases
ATGGCTGAAACTAACAGTCCTCGTTATTCACGAATTTTGTTAAAGCTGTCTGGTGAAGCTTTGTCTGGTAACAAAGACAT
GGGAATCGATGCTCAAGTACTGGACCAGATGTCTTTATCGATTGCTCATCTTGTTGGTTTGGGTGTGCAGGTCGGTATTG
TTGTGGGTGGCGGTAACTTGTACCGTGGTAGCCAATTGCAAAAAGATGGTCTGGTTGGTCGTGTAACAGGCGACCAAATG
GGTATGCTTGCAACAGTCATGAATGGTTTGGCGATGCGTGATGCATTGGTGCGTCGTAATATTAAAACACGTCTCATGTC
TGCATTATCGATTGGAACTGTAGTTGAGCCTTACTCAAGTCGTGATGCGATTCGTTATTTGAGCCAGGGTGAAGTATGTG
TGTTTGTGGCTGGGACAGGTAATCCGTTCTTTACCACAGATACAGCAGCATGCTTGCGCGGAATTGAAATTGAAGCAAAC
CTCATTCTTAAGGCAACAAAAGTAGATGGTGTTTACAATAAGGATCCAAGCAAATACGATGATGCTGTTAAGTATGACAA
CTTAACCTTTGATCAGGTACTTGATGAAAAGTTAGGTGTAATGGATTTGACTGCAATTTGCTTGTGTCGTGACCATAATG
TGCCATTGCAAGTGTTTGATATGAATAAACCTGGCGCATTGTTATCTGTCATTATGGGCGAAAAAGAGGGTACACACGTC
ACTAAATAA

Upstream 100 bases:

>100_bases
GACGAATATGATTTGTTTGCCAAACTGATTCAGATCAAGACCGCCTAGGCAGTCGTTTTAAACAGAATTCAATTTAAACA
TCGCATTTTGGAGCGTAATT

Downstream 100 bases:

>100_bases
TGACGTGTAACTCAAAGCTCTTTATACTACCCCACTAATTTAGTTTTACACCTTTGAATGAATAAGTAAGGAAGATCATA
TGATTAACGATCTCAAGAAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAETNSPRYSRILLKLSGEALSGNKDMGIDAQVLDQMSLSIAHLVGLGVQVGIVVGGGNLYRGSQLQKDGLVGRVTGDQM
GMLATVMNGLAMRDALVRRNIKTRLMSALSIGTVVEPYSSRDAIRYLSQGEVCVFVAGTGNPFFTTDTAACLRGIEIEAN
LILKATKVDGVYNKDPSKYDDAVKYDNLTFDQVLDEKLGVMDLTAICLCRDHNVPLQVFDMNKPGALLSVIMGEKEGTHV
TK

Sequences:

>Translated_242_residues
MAETNSPRYSRILLKLSGEALSGNKDMGIDAQVLDQMSLSIAHLVGLGVQVGIVVGGGNLYRGSQLQKDGLVGRVTGDQM
GMLATVMNGLAMRDALVRRNIKTRLMSALSIGTVVEPYSSRDAIRYLSQGEVCVFVAGTGNPFFTTDTAACLRGIEIEAN
LILKATKVDGVYNKDPSKYDDAVKYDNLTFDQVLDEKLGVMDLTAICLCRDHNVPLQVFDMNKPGALLSVIMGEKEGTHV
TK
>Mature_241_residues
AETNSPRYSRILLKLSGEALSGNKDMGIDAQVLDQMSLSIAHLVGLGVQVGIVVGGGNLYRGSQLQKDGLVGRVTGDQMG
MLATVMNGLAMRDALVRRNIKTRLMSALSIGTVVEPYSSRDAIRYLSQGEVCVFVAGTGNPFFTTDTAACLRGIEIEANL
ILKATKVDGVYNKDPSKYDDAVKYDNLTFDQVLDEKLGVMDLTAICLCRDHNVPLQVFDMNKPGALLSVIMGEKEGTHVT
K

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=242, Percent_Identity=59.9173553719008, Blast_Score=295, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ACIAD (Q6FCH3)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046060.1
- HSSP:   P0A7E9
- ProteinModelPortal:   Q6FCH3
- SMR:   Q6FCH3
- STRING:   Q6FCH3
- GeneID:   2879569
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1372
- NMPDR:   fig|62977.3.peg.604
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q6FCH3
- ProtClustDB:   PRK00358
- BioCyc:   ASP62977:ACIAD1372-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26104; Mature: 25972

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: BINDING 57-57 BINDING 58-58 BINDING 62-62 BINDING 78-78 BINDING 166-166 BINDING 172-172 BINDING 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETNSPRYSRILLKLSGEALSGNKDMGIDAQVLDQMSLSIAHLVGLGVQVGIVVGGGNL
CCCCCCCHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
YRGSQLQKDGLVGRVTGDQMGMLATVMNGLAMRDALVRRNIKTRLMSALSIGTVVEPYSS
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCC
RDAIRYLSQGEVCVFVAGTGNPFFTTDTAACLRGIEIEANLILKATKVDGVYNKDPSKYD
HHHHHHHCCCCEEEEEEECCCCEEECCHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCC
DAVKYDNLTFDQVLDEKLGVMDLTAICLCRDHNVPLQVFDMNKPGALLSVIMGEKEGTHV
CCCCCCCCCHHHHHHHHCCHHHHEEEEEEECCCCCEEEEECCCCCCEEHEEECCCCCCCC
TK
CC
>Mature Secondary Structure 
AETNSPRYSRILLKLSGEALSGNKDMGIDAQVLDQMSLSIAHLVGLGVQVGIVVGGGNL
CCCCCCHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
YRGSQLQKDGLVGRVTGDQMGMLATVMNGLAMRDALVRRNIKTRLMSALSIGTVVEPYSS
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCC
RDAIRYLSQGEVCVFVAGTGNPFFTTDTAACLRGIEIEANLILKATKVDGVYNKDPSKYD
HHHHHHHCCCCEEEEEEECCCCEEECCHHHHHHCCEEEEEEEEEEEEECCCCCCCCCCCC
DAVKYDNLTFDQVLDEKLGVMDLTAICLCRDHNVPLQVFDMNKPGALLSVIMGEKEGTHV
CCCCCCCCCHHHHHHHHCCHHHHEEEEEEECCCCCEEEEECCCCCCEEHEEECCCCCCCC
TK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA