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The map label for this gene is aroP [H]

Identifier: 50084523

GI number: 50084523

Start: 1338008

End: 1339384

Strand: Direct

Name: aroP [H]

Synonym: ACIAD1343

Alternate gene names: 50084523

Gene position: 1338008-1339384 (Clockwise)

Preceding gene: 50084520

Following gene: 50084524

Centisome position: 37.18

GC content: 40.38

Gene sequence:

>1377_bases
ATGACAGATCAGCATGCGCATGAATTAAAGAAAGGACTATCAAATAGACATGTCCAGTTGATTGCACTTGGTGGTGCTAT
AGGTACAGGATTATTTTTAGGTATTTCACATACGATTCAGTTGGCTGGACCTGCTGTTCTGTTGGGGTATGCGATTGCGG
GGATGATTGCATTTTTAATTATGCGACAGTTAGGGGAGATGGTGGTAGAAGAGCCTGTAAGTGGATCATTTAGTTATTTT
GCACATAAATATTGGAGCTCTATGGCAGGCTTCATGTCTGGTTGGAATTATTGGGTGCTGTATGTATTGGTAAGTATGGC
GGAGCTGAGCGCAATTGGTATTTTTGTGCAATTTTGGTGGCCGCAAATTCCGACTTGGCTGACAGCATTGGTCTTCTTTG
TCTTAATCAATGCTATCAATCTTATTAATGTTCGATTTTTTGGTGAGCTTGAGTTCTGGTTTTCGTGCATTAAGATTATT
GCGATTATTAGCATGATTGGATTTGGTGCGTATTTACTACTGAGTGGAACAGCAGGGGCTCATGCTGGAATTGCAAACTT
GTGGCAACATGGTGGATTTATGCCCAATGGTTGGACAGGGCTAATCATTGCTATGGCATTCATCATGTTTGCTTTTGGTG
GCCTGGAATTGGTGGGTATAGCAGCAGCAGAAACGAAAAATCCAACGCAAACTATTCCGAAAGCAACCAATCAAATTGTT
TATCGGATTCTGATCTTTTATATCGGTGCAATTGCTATATTGTTGAGTCTTTATCCTTGGAATCAAGTGGCACAAGGGGG
AAGTCCTTTTGTGATGATTTTCCAGTCTTTAAATAATACGGGCGTGGCACATGTCTTGAATATGGTTGTACTGATTGCCG
CAATATCGGTGTATAACAGTTGTGTATATAGTAATAGTCGTATGCTTTTGGGGTTGGCCGAACAGGGCAATGCACCTAAG
CTGTTAAAGCGCGTGAATGCGCGAGGTATTCCAGTGTATGCAGTGTATGCATCAGTAATGGTAACGGCGCTTTGCGTATT
GTTGAATTATGTAATGCCTGAGAAAGCTTTTAATCTTCTCATGATGCTGGTAGTTGCTGCTCTGGTGATTAATTGGCTCA
TGATTTCGATTACTCATCTTAAATTTCGTCAATACATGCTAGAAGCAGGCCGTAAACCAATTTTTAGAAGTTTGGGTGCA
CCATTTACCAATTATATTACAATTGCATTTGTATTTTTTATTCTACTGATCATGAGCTACACCTCAGAGATGCGTATCGC
TGTATTTTTGGTTCCTGTGTGGCTAGGAATTCTTTATATTTTTTATCGTTTTAAGGCACCAGCCAGTAAGATGACTGAGT
CTGTATTGGATCAATAA

Upstream 100 bases:

>100_bases
TTGCAAAATTATTGCTAATATGTATTTTTAATGAGTATACATCCTGATATGGCACATAAATTGCAAATTTATTGCATTGC
TATAATTAGGGTAAATTTGA

Downstream 100 bases:

>100_bases
ATCACTGATCAGTTAATTTGAGGTAGTTTAAATGAGTCAAGGTTTGGATGATTACGATTATAAAATCTTACGGCATTTGC
AAAGCAATGGGCGTTTGAGT

Product: aromatic amino acid APC transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MTDQHAHELKKGLSNRHVQLIALGGAIGTGLFLGISHTIQLAGPAVLLGYAIAGMIAFLIMRQLGEMVVEEPVSGSFSYF
AHKYWSSMAGFMSGWNYWVLYVLVSMAELSAIGIFVQFWWPQIPTWLTALVFFVLINAINLINVRFFGELEFWFSCIKII
AIISMIGFGAYLLLSGTAGAHAGIANLWQHGGFMPNGWTGLIIAMAFIMFAFGGLELVGIAAAETKNPTQTIPKATNQIV
YRILIFYIGAIAILLSLYPWNQVAQGGSPFVMIFQSLNNTGVAHVLNMVVLIAAISVYNSCVYSNSRMLLGLAEQGNAPK
LLKRVNARGIPVYAVYASVMVTALCVLLNYVMPEKAFNLLMMLVVAALVINWLMISITHLKFRQYMLEAGRKPIFRSLGA
PFTNYITIAFVFFILLIMSYTSEMRIAVFLVPVWLGILYIFYRFKAPASKMTESVLDQ

Sequences:

>Translated_458_residues
MTDQHAHELKKGLSNRHVQLIALGGAIGTGLFLGISHTIQLAGPAVLLGYAIAGMIAFLIMRQLGEMVVEEPVSGSFSYF
AHKYWSSMAGFMSGWNYWVLYVLVSMAELSAIGIFVQFWWPQIPTWLTALVFFVLINAINLINVRFFGELEFWFSCIKII
AIISMIGFGAYLLLSGTAGAHAGIANLWQHGGFMPNGWTGLIIAMAFIMFAFGGLELVGIAAAETKNPTQTIPKATNQIV
YRILIFYIGAIAILLSLYPWNQVAQGGSPFVMIFQSLNNTGVAHVLNMVVLIAAISVYNSCVYSNSRMLLGLAEQGNAPK
LLKRVNARGIPVYAVYASVMVTALCVLLNYVMPEKAFNLLMMLVVAALVINWLMISITHLKFRQYMLEAGRKPIFRSLGA
PFTNYITIAFVFFILLIMSYTSEMRIAVFLVPVWLGILYIFYRFKAPASKMTESVLDQ
>Mature_457_residues
TDQHAHELKKGLSNRHVQLIALGGAIGTGLFLGISHTIQLAGPAVLLGYAIAGMIAFLIMRQLGEMVVEEPVSGSFSYFA
HKYWSSMAGFMSGWNYWVLYVLVSMAELSAIGIFVQFWWPQIPTWLTALVFFVLINAINLINVRFFGELEFWFSCIKIIA
IISMIGFGAYLLLSGTAGAHAGIANLWQHGGFMPNGWTGLIIAMAFIMFAFGGLELVGIAAAETKNPTQTIPKATNQIVY
RILIFYIGAIAILLSLYPWNQVAQGGSPFVMIFQSLNNTGVAHVLNMVVLIAAISVYNSCVYSNSRMLLGLAEQGNAPKL
LKRVNARGIPVYAVYASVMVTALCVLLNYVMPEKAFNLLMMLVVAALVINWLMISITHLKFRQYMLEAGRKPIFRSLGAP
FTNYITIAFVFFILLIMSYTSEMRIAVFLVPVWLGILYIFYRFKAPASKMTESVLDQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=276, Percent_Identity=24.2753623188406, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=452, Percent_Identity=63.4955752212389, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=59.8214285714286, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI48994972, Length=434, Percent_Identity=41.0138248847926, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=42.6991150442478, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=37.3362445414847, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI87081915, Length=419, Percent_Identity=34.8448687350835, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=36.5967365967366, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI87081708, Length=462, Percent_Identity=32.9004329004329, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1788480, Length=397, Percent_Identity=36.5239294710327, Blast_Score=238, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI17531343, Length=375, Percent_Identity=22.4, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=33.1818181818182, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=448, Percent_Identity=33.0357142857143, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=467, Percent_Identity=33.4047109207709, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6321053, Length=423, Percent_Identity=30.4964539007092, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319824, Length=406, Percent_Identity=32.0197044334975, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=443, Percent_Identity=32.5056433408578, Blast_Score=196, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=446, Percent_Identity=32.0627802690583, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=32.2335025380711, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=447, Percent_Identity=29.3064876957494, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=440, Percent_Identity=29.7727272727273, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=405, Percent_Identity=28.641975308642, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319543, Length=403, Percent_Identity=31.0173697270471, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319608, Length=461, Percent_Identity=28.4164859002169, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=428, Percent_Identity=29.9065420560748, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=29.2079207920792, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=30.5687203791469, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=402, Percent_Identity=29.8507462686567, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=492, Percent_Identity=25.4065040650407, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50718; Mature: 50587

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQHAHELKKGLSNRHVQLIALGGAIGTGLFLGISHTIQLAGPAVLLGYAIAGMIAFLI
CCCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
MRQLGEMVVEEPVSGSFSYFAHKYWSSMAGFMSGWNYWVLYVLVSMAELSAIGIFVQFWW
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PQIPTWLTALVFFVLINAINLINVRFFGELEFWFSCIKIIAIISMIGFGAYLLLSGTAGA
CCHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HAGIANLWQHGGFMPNGWTGLIIAMAFIMFAFGGLELVGIAAAETKNPTQTIPKATNQIV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHEEEEHHCCCCCHHHHHHHHHHHH
YRILIFYIGAIAILLSLYPWNQVAQGGSPFVMIFQSLNNTGVAHVLNMVVLIAAISVYNS
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
CVYSNSRMLLGLAEQGNAPKLLKRVNARGIPVYAVYASVMVTALCVLLNYVMPEKAFNLL
HHHCCCCEEEEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
MMLVVAALVINWLMISITHLKFRQYMLEAGRKPIFRSLGAPFTNYITIAFVFFILLIMSY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
TSEMRIAVFLVPVWLGILYIFYRFKAPASKMTESVLDQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
TDQHAHELKKGLSNRHVQLIALGGAIGTGLFLGISHTIQLAGPAVLLGYAIAGMIAFLI
CCHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH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CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]