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The map label for this gene is aaeR [H]

Identifier: 50084417

GI number: 50084417

Start: 1230760

End: 1231689

Strand: Direct

Name: aaeR [H]

Synonym: ACIAD1230

Alternate gene names: 50084417

Gene position: 1230760-1231689 (Clockwise)

Preceding gene: 50084416

Following gene: 50084419

Centisome position: 34.2

GC content: 41.4

Gene sequence:

>930_bases
ATGTTAGATCAACTTCGAGCAATGGGAGTATTTGCTTGTGTTGTAGAGAAAAGCTCGTTCAGCGGCGCTGCGCGTAATCT
GGGGATTACCACTAGTGCTGTCAGCCAGCAAATTCGGTCACTAGAACAAGAGATGGATGTCACGCTTTTACATCGTTCTA
CCCGTAAGTTAAGCTTAACTGAAGCTGGACAAGCCTTTTTCCATAGCTGTCAAGAAATGCTCGCTGCTGCAGAGCGTGGA
AAAATTCGTATTAATGAATTAAGAGATGATTTAATCGGGGATCTTCGTATTGCGACGACACCTGAATTAGGGGCTCTCCA
CGTTGTTCCTGCATTATCACATTGGATGTCTGCGCATCGTGGATTATCTGTTCATTTTGAAGCTGATCATCGTTATATAG
ATCTTATCGAAGGGCGTATTGATATTGCAATTCGAATGAGCCCACGTATTGACGATCAAAGTTTAAATGCCATTCCGATG
GTCCGTGTAGACCAGATTTTAGTGGCTTCACCCAGTTATCTTAATCAATCGGCGCCTATTTCTCGTCCTGAAGATTTGAT
GAATCATGATCTGATTCCAGTCAATCTTATGAGCGGTTATCAACATCTTTCATTCCAGCATCTATCCACTGGAGAAAGCA
TTGATATTGAAATGAAAAATCGTTTACAAACAAATAATGTGTTTATAGCGAAATCGCTTTGTCAGCATGGTCATGGCGTT
GCCAGAATTTTATATCTGGATGTACAGAAAGAACTCATTAATGGTTCACTGGTCGAAGTGTTACCTGAGTGGAATCTGCC
TGCATTTACGTTATATGCGCTTACGCAAAAACGTGAACAACAGCCAATGAAGATTCATCGCTGTCTGGATGCACTTAAGC
AATATTTTAGTCAGTTGCCAGGTGGTCGTAATTTACAGGAAGTTTCTTAA

Upstream 100 bases:

>100_bases
TGAATTAAATAATGCAAAACATAGATTTCTCCGTATAATACAACGAGTTGCTTTTATCATATTTTGATAGGGAGCATCTC
ATAAGTTCAGAGGGAAATTT

Downstream 100 bases:

>100_bases
TGCAATAAAAAAGCCGCTTAAGCGGCTTTTTTATTGCATTAAAGATATTCAGATTAAGCAGCAAGAAAGTTCTGAATTGC
TGGAACCAAACGATTGATCA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLDQLRAMGVFACVVEKSSFSGAARNLGITTSAVSQQIRSLEQEMDVTLLHRSTRKLSLTEAGQAFFHSCQEMLAAAERG
KIRINELRDDLIGDLRIATTPELGALHVVPALSHWMSAHRGLSVHFEADHRYIDLIEGRIDIAIRMSPRIDDQSLNAIPM
VRVDQILVASPSYLNQSAPISRPEDLMNHDLIPVNLMSGYQHLSFQHLSTGESIDIEMKNRLQTNNVFIAKSLCQHGHGV
ARILYLDVQKELINGSLVEVLPEWNLPAFTLYALTQKREQQPMKIHRCLDALKQYFSQLPGGRNLQEVS

Sequences:

>Translated_309_residues
MLDQLRAMGVFACVVEKSSFSGAARNLGITTSAVSQQIRSLEQEMDVTLLHRSTRKLSLTEAGQAFFHSCQEMLAAAERG
KIRINELRDDLIGDLRIATTPELGALHVVPALSHWMSAHRGLSVHFEADHRYIDLIEGRIDIAIRMSPRIDDQSLNAIPM
VRVDQILVASPSYLNQSAPISRPEDLMNHDLIPVNLMSGYQHLSFQHLSTGESIDIEMKNRLQTNNVFIAKSLCQHGHGV
ARILYLDVQKELINGSLVEVLPEWNLPAFTLYALTQKREQQPMKIHRCLDALKQYFSQLPGGRNLQEVS
>Mature_309_residues
MLDQLRAMGVFACVVEKSSFSGAARNLGITTSAVSQQIRSLEQEMDVTLLHRSTRKLSLTEAGQAFFHSCQEMLAAAERG
KIRINELRDDLIGDLRIATTPELGALHVVPALSHWMSAHRGLSVHFEADHRYIDLIEGRIDIAIRMSPRIDDQSLNAIPM
VRVDQILVASPSYLNQSAPISRPEDLMNHDLIPVNLMSGYQHLSFQHLSTGESIDIEMKNRLQTNNVFIAKSLCQHGHGV
ARILYLDVQKELINGSLVEVLPEWNLPAFTLYALTQKREQQPMKIHRCLDALKQYFSQLPGGRNLQEVS

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=313, Percent_Identity=30.3514376996805, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786401, Length=309, Percent_Identity=30.0970873786408, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789440, Length=296, Percent_Identity=29.0540540540541, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI87081978, Length=302, Percent_Identity=29.4701986754967, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI145693193, Length=279, Percent_Identity=26.5232974910394, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787589, Length=269, Percent_Identity=24.907063197026, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1787128, Length=267, Percent_Identity=23.5955056179775, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789173, Length=197, Percent_Identity=30.9644670050761, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI157672245, Length=186, Percent_Identity=29.5698924731183, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI145693105, Length=213, Percent_Identity=23.0046948356808, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34711; Mature: 34711

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQLRAMGVFACVVEKSSFSGAARNLGITTSAVSQQIRSLEQEMDVTLLHRSTRKLSLT
CCCHHHHHHHHHEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEHH
EAGQAFFHSCQEMLAAAERGKIRINELRDDLIGDLRIATTPELGALHVVPALSHWMSAHR
HHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHC
GLSVHFEADHRYIDLIEGRIDIAIRMSPRIDDQSLNAIPMVRVDQILVASPSYLNQSAPI
CCEEEEECCCCEEEEECCEEEEEEEECCCCCCCCCCCCCCEEHHHHEECCCHHCCCCCCC
SRPEDLMNHDLIPVNLMSGYQHLSFQHLSTGESIDIEMKNRLQTNNVFIAKSLCQHGHGV
CCCHHHHCCCCEEEEHHCCCHHHCEEECCCCCEEEEEECCCCCCCCCCEEHHHHHCCCCE
ARILYLDVQKELINGSLVEVLPEWNLPAFTLYALTQKREQQPMKIHRCLDALKQYFSQLP
EEEEEEEHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
GGRNLQEVS
CCCCHHCCC
>Mature Secondary Structure
MLDQLRAMGVFACVVEKSSFSGAARNLGITTSAVSQQIRSLEQEMDVTLLHRSTRKLSLT
CCCHHHHHHHHHEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEHH
EAGQAFFHSCQEMLAAAERGKIRINELRDDLIGDLRIATTPELGALHVVPALSHWMSAHR
HHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHC
GLSVHFEADHRYIDLIEGRIDIAIRMSPRIDDQSLNAIPMVRVDQILVASPSYLNQSAPI
CCEEEEECCCCEEEEECCEEEEEEEECCCCCCCCCCCCCCEEHHHHEECCCHHCCCCCCC
SRPEDLMNHDLIPVNLMSGYQHLSFQHLSTGESIDIEMKNRLQTNNVFIAKSLCQHGHGV
CCCHHHHCCCCEEEEHHCCCHHHCEEECCCCCEEEEEECCCCCCCCCCEEHHHHHCCCCE
ARILYLDVQKELINGSLVEVLPEWNLPAFTLYALTQKREQQPMKIHRCLDALKQYFSQLP
EEEEEEEHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
GGRNLQEVS
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]