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The map label for this gene is grxD [H]

Identifier: 50084419

GI number: 50084419

Start: 1233098

End: 1233463

Strand: Direct

Name: grxD [H]

Synonym: ACIAD1232

Alternate gene names: 50084419

Gene position: 1233098-1233463 (Clockwise)

Preceding gene: 50084417

Following gene: 50084422

Centisome position: 34.27

GC content: 43.17

Gene sequence:

>366_bases
ATGAGATTAGTTGAGGATTTATCTATGACTGAACAAGCGCGTGATACAGAAGCGTTAATTCGTGATCAAATTGCTAAACA
TGCGGTATTGCTTTATATGAAAGGCACGCCACAATTTCCACAGTGCGGTTTTTCTGCACGTGCAGTTGAAGCACTCAGTC
AAATTGGGCGCCCATTTGCGTATGTGAATATTCTGGAGAATCCAGATATTCGCGCAACACTTCCTGCGATTGCAAACTGG
CCAACGTTCCCTCAATTATGGGTTAATGGCGAACTCATCGGTGGTAGCGATATCATGTTGGAAATGTTCCAAAATGGTGA
GTTAAAACCATTGGTTGAACAATATAGTGCTGCGCCAGACGCTTAA

Upstream 100 bases:

>100_bases
ATATAAGCAAAAACCATCACGGAATGAAAGAGTAAAACCAAAATTAAAATAGAAATCTCATGATCGGTCACACTGTTTGA
ATACTTTTAGGTATAATGTG

Downstream 100 bases:

>100_bases
TTTTCTAATCCGTCTGACATAAAAAATCCCACATTATGTGGGATTTTTTATGTGGTGATACTTAGTTCTTAGCATCTTCT
TTCACATTTTTAGCAGTCTT

Product: glutaredoxin

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MRLVEDLSMTEQARDTEALIRDQIAKHAVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPAIANW
PTFPQLWVNGELIGGSDIMLEMFQNGELKPLVEQYSAAPDA

Sequences:

>Translated_121_residues
MRLVEDLSMTEQARDTEALIRDQIAKHAVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPAIANW
PTFPQLWVNGELIGGSDIMLEMFQNGELKPLVEQYSAAPDA
>Mature_121_residues
MRLVEDLSMTEQARDTEALIRDQIAKHAVLLYMKGTPQFPQCGFSARAVEALSQIGRPFAYVNILENPDIRATLPAIANW
PTFPQLWVNGELIGGSDIMLEMFQNGELKPLVEQYSAAPDA

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=46.5116279069767, Blast_Score=97, Evalue=3e-21,
Organism=Homo sapiens, GI95113651, Length=87, Percent_Identity=47.1264367816092, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787943, Length=107, Percent_Identity=60.7476635514019, Blast_Score=142, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17556042, Length=91, Percent_Identity=35.1648351648352, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988153, Length=82, Percent_Identity=40.2439024390244, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71988159, Length=82, Percent_Identity=40.2439024390244, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325198, Length=101, Percent_Identity=44.5544554455446, Blast_Score=95, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321022, Length=73, Percent_Identity=45.2054794520548, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320303, Length=73, Percent_Identity=45.2054794520548, Blast_Score=77, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24642023, Length=85, Percent_Identity=38.8235294117647, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921242, Length=85, Percent_Identity=36.4705882352941, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 13463; Mature: 13463

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVEDLSMTEQARDTEALIRDQIAKHAVLLYMKGTPQFPQCGFSARAVEALSQIGRPFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEE
YVNILENPDIRATLPAIANWPTFPQLWVNGELIGGSDIMLEMFQNGELKPLVEQYSAAPD
EEEEECCCCCEEECCCCCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCHHHHHHCCCCC
A
C
>Mature Secondary Structure
MRLVEDLSMTEQARDTEALIRDQIAKHAVLLYMKGTPQFPQCGFSARAVEALSQIGRPFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEE
YVNILENPDIRATLPAIANWPTFPQLWVNGELIGGSDIMLEMFQNGELKPLVEQYSAAPD
EEEEECCCCCEEECCCCCCCCCCCEEEECCEEECCHHHHHHHHCCCCCCHHHHHHCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]