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The map label for this gene is ddc [H]

Identifier: 50084400

GI number: 50084400

Start: 1213493

End: 1215025

Strand: Direct

Name: ddc [H]

Synonym: ACIAD1211

Alternate gene names: 50084400

Gene position: 1213493-1215025 (Clockwise)

Preceding gene: 50084399

Following gene: 50084401

Centisome position: 33.72

GC content: 43.9

Gene sequence:

>1533_bases
ATGGTTGATTTTGCAGAACATCGTAAAGCTTTGCTCTGTAATGATGCTGCATCCATTGCTGAATATCAGTCAGCAATGGA
TGAGGCAGTGAAAGCTGTCGCAGCATGGTTGCAAAATGACAAAATGTATACGGGTGGTAGCATTAAAGAGTTGCGTTCAG
CAATTGCTTTTAACCCATCTAAAGAAGGCTTGGGTTTACATCAGTCGCTCGGCCGTATGGTTGAATTGTTTCTGAATAAA
AGCCTGAAAGTTCATCATCCGTACTCGCTTGCTCACTTACATTGTCCAACGATGGTCACCAGCCAAATTGCTGAGGTGTT
GATTAACGCAACCAATCAGTCAATGGATTCTTGGGATCAGAGCCCTGCAGGTTCATTGATGGAAGTTCAGTTGATCGACT
GGCTTCGTCAAAAAGTAGGGTACGGCGTAGGTCAGGCTGGTGTATTCACCTCAGGTGGAACGCAATCAAACCTGATGGGC
GTGTTACTTGCACGTGACTGGGCAATTGCCAAAAATTTTACAGATGAAAATGGTCAGCCGTGGTCTGTACAGCGTGATGG
TATTCCTGCCGAAGCGATGCGTAACATCAAAGTCATTTGTTCTGAAAATGCACATTTTTCTGTGCAAAAGAACATGGCAA
TGATGGGCATGGGCTTCCAGTCCGTTGTGACTGTTCCTGTAAATGAAAATGCACAGATGGATGTTGATGCGCTTGAAAAA
ACCATGTCACATCTGCAATCTGAAGGTAAGATTGTAGCGTGTGTAGTGGCGACTGCAGGCACAACCGATGCAGGCGCGAT
TGATCCATTGAAGAAAATTCGTGAAATCACCACAAAATACGGCGCGTGGATGCATATCGACGCAGCGTGGGGTGGTGCAC
TGATTCTGTCAAATGATTATCGTGATATGCTAGATGGTATTGAGCTATCTGACTCAATCACGCTTGATTTCCACAAGCAT
TATTTCCAAAGCATTAGCTGTGGTGCATTCTTGCTCAAAGATGAAGCGAATTATCGTTTCATGCATTATGAAGCAGAATA
TCTGAACTCGGCTTATGATGAAGAACACGGTGTACCAAACCTGGTCTCTAAATCATTACAAACAACACGTCGCTTTGATG
CGCTTAAGTTGTGGATGACTGTAGAAGCACTGGGTGAAGAGCTATACGGTTCAATGATTGATCATGGTGTGAAGTTGACA
CGTGAAGTGGCTGACTACATTAAGGCAACCGAAGGACTCGAATTGTTGGTTGAACCACAATTTGCATCGGTATTGTTCCG
TGTAGTACCAGACGGTTATCCCGTTGAATTGATTGATACCTTGAATCAAAACGTTGCAGATGAACTTTTTGCACGTGGTG
ATGCCAATATTGGTGTAACTAAGGTAGGTGCAGTACAGTCATTGAAAATGACGACTTTAAGCCCTGTTGCGACATTGGAA
AATGTCAAAGGTCTATTGGCGATGGTACTGGCTGAAAGTGATCGAATCAAAGATTCAATTGCTGCTGGAACTTACGTGCC
AGCGATTGATTAA

Upstream 100 bases:

>100_bases
TTGCCCATTGATTATTACTCAAGATGAATGTGTTCAAGTGATTGAACGTTTCAAGAAATCAGTTGCAGAAGCACTCAAAG
CGGTTCGAGGCTAAAAACAT

Downstream 100 bases:

>100_bases
ATTGCATGTTTTGAAAAAAGATCACTTCGGTGATCTTTTTTTTATGACAAAAAAATGAAAAATAACATTTTCTCGAACAA
AAAATAAGAATACTAGACGT

Product: L-2,4-diaminobutyrate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MVDFAEHRKALLCNDAASIAEYQSAMDEAVKAVAAWLQNDKMYTGGSIKELRSAIAFNPSKEGLGLHQSLGRMVELFLNK
SLKVHHPYSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIDWLRQKVGYGVGQAGVFTSGGTQSNLMG
VLLARDWAIAKNFTDENGQPWSVQRDGIPAEAMRNIKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEK
TMSHLQSEGKIVACVVATAGTTDAGAIDPLKKIREITTKYGAWMHIDAAWGGALILSNDYRDMLDGIELSDSITLDFHKH
YFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPNLVSKSLQTTRRFDALKLWMTVEALGEELYGSMIDHGVKLT
REVADYIKATEGLELLVEPQFASVLFRVVPDGYPVELIDTLNQNVADELFARGDANIGVTKVGAVQSLKMTTLSPVATLE
NVKGLLAMVLAESDRIKDSIAAGTYVPAID

Sequences:

>Translated_510_residues
MVDFAEHRKALLCNDAASIAEYQSAMDEAVKAVAAWLQNDKMYTGGSIKELRSAIAFNPSKEGLGLHQSLGRMVELFLNK
SLKVHHPYSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIDWLRQKVGYGVGQAGVFTSGGTQSNLMG
VLLARDWAIAKNFTDENGQPWSVQRDGIPAEAMRNIKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEK
TMSHLQSEGKIVACVVATAGTTDAGAIDPLKKIREITTKYGAWMHIDAAWGGALILSNDYRDMLDGIELSDSITLDFHKH
YFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPNLVSKSLQTTRRFDALKLWMTVEALGEELYGSMIDHGVKLT
REVADYIKATEGLELLVEPQFASVLFRVVPDGYPVELIDTLNQNVADELFARGDANIGVTKVGAVQSLKMTTLSPVATLE
NVKGLLAMVLAESDRIKDSIAAGTYVPAID
>Mature_510_residues
MVDFAEHRKALLCNDAASIAEYQSAMDEAVKAVAAWLQNDKMYTGGSIKELRSAIAFNPSKEGLGLHQSLGRMVELFLNK
SLKVHHPYSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSLMEVQLIDWLRQKVGYGVGQAGVFTSGGTQSNLMG
VLLARDWAIAKNFTDENGQPWSVQRDGIPAEAMRNIKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEK
TMSHLQSEGKIVACVVATAGTTDAGAIDPLKKIREITTKYGAWMHIDAAWGGALILSNDYRDMLDGIELSDSITLDFHKH
YFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPNLVSKSLQTTRRFDALKLWMTVEALGEELYGSMIDHGVKLT
REVADYIKATEGLELLVEPQFASVLFRVVPDGYPVELIDTLNQNVADELFARGDANIGVTKVGAVQSLKMTTLSPVATLE
NVKGLLAMVLAESDRIKDSIAAGTYVPAID

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI194294551, Length=438, Percent_Identity=30.1369863013699, Blast_Score=192, Evalue=9e-49,
Organism=Homo sapiens, GI197383062, Length=462, Percent_Identity=27.9220779220779, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI197276620, Length=432, Percent_Identity=29.1666666666667, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI4503875, Length=432, Percent_Identity=29.1666666666667, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI58331246, Length=425, Percent_Identity=26.8235294117647, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI4503281, Length=356, Percent_Identity=25, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI132814448, Length=356, Percent_Identity=25, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI92110055, Length=387, Percent_Identity=26.0981912144703, Blast_Score=124, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71993062, Length=410, Percent_Identity=28.5365853658537, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555682, Length=411, Percent_Identity=28.4671532846715, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71993058, Length=373, Percent_Identity=28.1501340482574, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17534817, Length=422, Percent_Identity=24.1706161137441, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17534819, Length=422, Percent_Identity=24.1706161137441, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17551992, Length=477, Percent_Identity=21.8029350104822, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71981211, Length=394, Percent_Identity=20.3045685279188, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71981217, Length=403, Percent_Identity=19.8511166253102, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI133931025, Length=391, Percent_Identity=20.460358056266, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136594, Length=468, Percent_Identity=28.4188034188034, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI21356415, Length=337, Percent_Identity=30.5637982195846, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24657193, Length=359, Percent_Identity=30.08356545961, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24657185, Length=359, Percent_Identity=30.08356545961, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24657188, Length=359, Percent_Identity=30.08356545961, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI221476190, Length=423, Percent_Identity=25.2955082742317, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585143, Length=423, Percent_Identity=25.2955082742317, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585139, Length=423, Percent_Identity=25.2955082742317, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136190, Length=372, Percent_Identity=24.1935483870968, Blast_Score=111, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24652373, Length=476, Percent_Identity=22.8991596638655, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24585135, Length=372, Percent_Identity=24.7311827956989, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24586044, Length=420, Percent_Identity=22.3809523809524, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28573972, Length=360, Percent_Identity=21.9444444444444, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 55925; Mature: 55925

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDFAEHRKALLCNDAASIAEYQSAMDEAVKAVAAWLQNDKMYTGGSIKELRSAIAFNPS
CCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
KEGLGLHQSLGRMVELFLNKSLKVHHPYSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQ
CCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHCCC
SPAGSLMEVQLIDWLRQKVGYGVGQAGVFTSGGTQSNLMGVLLARDWAIAKNFTDENGQP
CCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHCHHHHCCCCCCCCCC
WSVQRDGIPAEAMRNIKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEK
CEEECCCCCHHHHCCEEEEECCCCCEEHHCCHHHHCCCHHHEEEEECCCCCCCCHHHHHH
TMSHLQSEGKIVACVVATAGTTDAGAIDPLKKIREITTKYGAWMHIDAAWGGALILSNDY
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCH
RDMLDGIELSDSITLDFHKHYFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPN
HHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCCHH
LVSKSLQTTRRFDALKLWMTVEALGEELYGSMIDHGVKLTREVADYIKATEGLELLVEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
FASVLFRVVPDGYPVELIDTLNQNVADELFARGDANIGVTKVGAVQSLKMTTLSPVATLE
HHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCHHHHHH
NVKGLLAMVLAESDRIKDSIAAGTYVPAID
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MVDFAEHRKALLCNDAASIAEYQSAMDEAVKAVAAWLQNDKMYTGGSIKELRSAIAFNPS
CCCHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
KEGLGLHQSLGRMVELFLNKSLKVHHPYSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQ
CCCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHCCC
SPAGSLMEVQLIDWLRQKVGYGVGQAGVFTSGGTQSNLMGVLLARDWAIAKNFTDENGQP
CCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHCHHHHCCCCCCCCCC
WSVQRDGIPAEAMRNIKVICSENAHFSVQKNMAMMGMGFQSVVTVPVNENAQMDVDALEK
CEEECCCCCHHHHCCEEEEECCCCCEEHHCCHHHHCCCHHHEEEEECCCCCCCCHHHHHH
TMSHLQSEGKIVACVVATAGTTDAGAIDPLKKIREITTKYGAWMHIDAAWGGALILSNDY
HHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCEEEEECCH
RDMLDGIELSDSITLDFHKHYFQSISCGAFLLKDEANYRFMHYEAEYLNSAYDEEHGVPN
HHHHCCCCCCCCEEEHHHHHHHHHCCCCEEEEECCCCEEEEEEEHHHHHHHHHHHCCCHH
LVSKSLQTTRRFDALKLWMTVEALGEELYGSMIDHGVKLTREVADYIKATEGLELLVEPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCH
FASVLFRVVPDGYPVELIDTLNQNVADELFARGDANIGVTKVGAVQSLKMTTLSPVATLE
HHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCHHHHHH
NVKGLLAMVLAESDRIKDSIAAGTYVPAID
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]