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The map label for this gene is phrB [H]

Identifier: 50084372

GI number: 50084372

Start: 1178836

End: 1180269

Strand: Reverse

Name: phrB [H]

Synonym: ACIAD1182

Alternate gene names: 50084372

Gene position: 1180269-1178836 (Counterclockwise)

Preceding gene: 50084373

Following gene: 50084371

Centisome position: 32.8

GC content: 36.61

Gene sequence:

>1434_bases
ATGAATCAATTGATCTGGTTTCGAAATGATCTACGTTTAAATGACCATGCTGCTTTATGGCATGCAACTCAAGCAGGCAG
CACGATTGCCTTTGTTGCTTTATCGCCTTTACAATGGCAACAGCATGATGATGCAATCATTAAAATTGACTTTTATATGC
GCCAGCTTACACAGCTCAAACAAGAGTTAAATACAATCAATATTCCTTTAATTGTACAGATCATTCCCTTATGGAAAGAT
ATAGCGACTGAAATTATCTCTATCTCAGATCGTTATCATATACAAGATGTCTATGCCAATATTGAAACTGGCATCAATGA
AATTGAACGTGATCATGCTGTTCAGGAAGCACTGAGTAAAATTGGAAAAAATCTGATTTTATTTCATGACAAAACATTAT
TTCCATTGGGCAGTATTAGAAACAAAAGTCAGGCACCTTATCAGGTGTTTACACCATTTAAAAAAACATGCTATGAACGA
TTGAATATAGACATCCCCAAGTGTTTCCCTTATCCACACAAACAAAAGCAACAACCAGAAATTGCAAAAAAAGAAGCGGC
TATTCCTTCTCTCAAACAACTTGGATATTCCCAAATAGATCAACACATTCAGAATGAATGGCCAATTGGTGAAACTTTTG
CTTTAAATTTGCTTGAAGACTTTACGCAAGACAAGATCAATCGTTATCACGAATCACGTGATTATCCTGCACAGGATGGA
ACTAGCCATATCTCTGCGTACTTAACCATTGGGATATTATCGATTCGTCAATGTATTCAAGCTATTTTTCAGAAGCAGCA
TGGTCAGTTCTTTCTTAACAATAAGGGTCAAGAGATTTGGTTAAATGAATTACTCTGGCGCGAATTTTATCAACAGCTTC
TATTCGACTTCCCTAAATTGTCACGTCATCAGCCTTTTCAGGATCATACCAAGAATATTCCATGGAATGAAAACGATGAG
CATTTTGAAGCATGGATACAAGGCAAAACAGGTATTCCTATCGTTGATGCAGGCATGCGTCAATTAAAAGCAACGGGTTG
GATGCATAATCGGGTTCGAATGATTTGTGCAATGTTCCTCAGCAAAAATTTGCTTATCGATTGGAGAAAAGGCGAAAAAT
GGTTTATGCAACATTTAATCGATGGCGATCTCGCTGCAAATGACGGTGGATGGCAATGGAGCGCTTCAACAGGCACTGAT
GCTTCGCCTTATTTTAGAATTTTTAATCCAGTCACTCAATCACAAAAGTTTGATCCAGAAGGCGTATTTTTAAAGAAATG
GATTCCTGAACTCAAACATTTAGATAGTAAACATATTCATGATCCATATGCATATCAGCATAAAACTGAATTGAATTACC
CTAAGCCGATTATTGACCTAAAAGCCACTCGAAAAAATGCGATTGAAGTGTTTAAAAAAAGTAGCTCATTATAA

Upstream 100 bases:

>100_bases
CCCTTCACAAAACCCTCACTTTATACCTTCTAAAATTATTTTATTGTGATATCGCTTATTTAAAACTTTATAAATCTAAG
AGTATTTAAAGGTCTTACCA

Downstream 100 bases:

>100_bases
TCAACTTACTTGAGAATATTAATTGTATAAAATTTATGATTATTGAATAGAAATGTTAATTTTACATGTTTATTTAAGTA
TTCATTATTTTTTATGTCAG

Product: deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNQLIWFRNDLRLNDHAALWHATQAGSTIAFVALSPLQWQQHDDAIIKIDFYMRQLTQLKQELNTINIPLIVQIIPLWKD
IATEIISISDRYHIQDVYANIETGINEIERDHAVQEALSKIGKNLILFHDKTLFPLGSIRNKSQAPYQVFTPFKKTCYER
LNIDIPKCFPYPHKQKQQPEIAKKEAAIPSLKQLGYSQIDQHIQNEWPIGETFALNLLEDFTQDKINRYHESRDYPAQDG
TSHISAYLTIGILSIRQCIQAIFQKQHGQFFLNNKGQEIWLNELLWREFYQQLLFDFPKLSRHQPFQDHTKNIPWNENDE
HFEAWIQGKTGIPIVDAGMRQLKATGWMHNRVRMICAMFLSKNLLIDWRKGEKWFMQHLIDGDLAANDGGWQWSASTGTD
ASPYFRIFNPVTQSQKFDPEGVFLKKWIPELKHLDSKHIHDPYAYQHKTELNYPKPIIDLKATRKNAIEVFKKSSSL

Sequences:

>Translated_477_residues
MNQLIWFRNDLRLNDHAALWHATQAGSTIAFVALSPLQWQQHDDAIIKIDFYMRQLTQLKQELNTINIPLIVQIIPLWKD
IATEIISISDRYHIQDVYANIETGINEIERDHAVQEALSKIGKNLILFHDKTLFPLGSIRNKSQAPYQVFTPFKKTCYER
LNIDIPKCFPYPHKQKQQPEIAKKEAAIPSLKQLGYSQIDQHIQNEWPIGETFALNLLEDFTQDKINRYHESRDYPAQDG
TSHISAYLTIGILSIRQCIQAIFQKQHGQFFLNNKGQEIWLNELLWREFYQQLLFDFPKLSRHQPFQDHTKNIPWNENDE
HFEAWIQGKTGIPIVDAGMRQLKATGWMHNRVRMICAMFLSKNLLIDWRKGEKWFMQHLIDGDLAANDGGWQWSASTGTD
ASPYFRIFNPVTQSQKFDPEGVFLKKWIPELKHLDSKHIHDPYAYQHKTELNYPKPIIDLKATRKNAIEVFKKSSSL
>Mature_477_residues
MNQLIWFRNDLRLNDHAALWHATQAGSTIAFVALSPLQWQQHDDAIIKIDFYMRQLTQLKQELNTINIPLIVQIIPLWKD
IATEIISISDRYHIQDVYANIETGINEIERDHAVQEALSKIGKNLILFHDKTLFPLGSIRNKSQAPYQVFTPFKKTCYER
LNIDIPKCFPYPHKQKQQPEIAKKEAAIPSLKQLGYSQIDQHIQNEWPIGETFALNLLEDFTQDKINRYHESRDYPAQDG
TSHISAYLTIGILSIRQCIQAIFQKQHGQFFLNNKGQEIWLNELLWREFYQQLLFDFPKLSRHQPFQDHTKNIPWNENDE
HFEAWIQGKTGIPIVDAGMRQLKATGWMHNRVRMICAMFLSKNLLIDWRKGEKWFMQHLIDGDLAANDGGWQWSASTGTD
ASPYFRIFNPVTQSQKFDPEGVFLKKWIPELKHLDSKHIHDPYAYQHKTELNYPKPIIDLKATRKNAIEVFKKSSSL

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=503, Percent_Identity=27.037773359841, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI188536100, Length=504, Percent_Identity=26.1904761904762, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI188536103, Length=387, Percent_Identity=27.390180878553, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786926, Length=477, Percent_Identity=40.251572327044, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324962, Length=516, Percent_Identity=34.1085271317829, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI17137248, Length=503, Percent_Identity=30.0198807157058, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24585455, Length=503, Percent_Identity=30.0198807157058, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24648152, Length=298, Percent_Identity=28.1879194630872, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 55856; Mature: 55856

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLIWFRNDLRLNDHAALWHATQAGSTIAFVALSPLQWQQHDDAIIKIDFYMRQLTQLK
CCCEEEEECCCCCCCCHHHEEECCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHH
QELNTINIPLIVQIIPLWKDIATEIISISDRYHIQDVYANIETGINEIERDHAVQEALSK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKNLILFHDKTLFPLGSIRNKSQAPYQVFTPFKKTCYERLNIDIPKCFPYPHKQKQQPE
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
IAKKEAAIPSLKQLGYSQIDQHIQNEWPIGETFALNLLEDFTQDKINRYHESRDYPAQDG
HHHHHHCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSHISAYLTIGILSIRQCIQAIFQKQHGQFFLNNKGQEIWLNELLWREFYQQLLFDFPKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
SRHQPFQDHTKNIPWNENDEHFEAWIQGKTGIPIVDAGMRQLKATGWMHNRVRMICAMFL
CCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
SKNLLIDWRKGEKWFMQHLIDGDLAANDGGWQWSASTGTDASPYFRIFNPVTQSQKFDPE
CCCCEEEECCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEECCHHHHCCCCCCC
GVFLKKWIPELKHLDSKHIHDPYAYQHKTELNYPKPIIDLKATRKNAIEVFKKSSSL
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQLIWFRNDLRLNDHAALWHATQAGSTIAFVALSPLQWQQHDDAIIKIDFYMRQLTQLK
CCCEEEEECCCCCCCCHHHEEECCCCCEEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHH
QELNTINIPLIVQIIPLWKDIATEIISISDRYHIQDVYANIETGINEIERDHAVQEALSK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKNLILFHDKTLFPLGSIRNKSQAPYQVFTPFKKTCYERLNIDIPKCFPYPHKQKQQPE
CCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
IAKKEAAIPSLKQLGYSQIDQHIQNEWPIGETFALNLLEDFTQDKINRYHESRDYPAQDG
HHHHHHCCCHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSHISAYLTIGILSIRQCIQAIFQKQHGQFFLNNKGQEIWLNELLWREFYQQLLFDFPKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
SRHQPFQDHTKNIPWNENDEHFEAWIQGKTGIPIVDAGMRQLKATGWMHNRVRMICAMFL
CCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
SKNLLIDWRKGEKWFMQHLIDGDLAANDGGWQWSASTGTDASPYFRIFNPVTQSQKFDPE
CCCCEEEECCCHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEECCHHHHCCCCCCC
GVFLKKWIPELKHLDSKHIHDPYAYQHKTELNYPKPIIDLKATRKNAIEVFKKSSSL
CCHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]