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The map label for this gene is pbpA [H]

Identifier: 50084297

GI number: 50084297

Start: 1090713

End: 1092740

Strand: Reverse

Name: pbpA [H]

Synonym: ACIAD1101

Alternate gene names: 50084297

Gene position: 1092740-1090713 (Counterclockwise)

Preceding gene: 50084302

Following gene: 50084296

Centisome position: 30.37

GC content: 42.9

Gene sequence:

>2028_bases
ATGAAGCAGCACTTTCCTTTAAAAGATAATCAGCAAGAAAAGCGCCTGTATCGAGGTCGAATTTTTTTCGCAATTGGTCT
GGTGTGTTGTTGTTTACTGCTACTGATGAGCCGCTATGCTTATCTACAGATTGTGCATTATGATGAGTTTTCAACGGCTT
CAGACAAAAACCGAATTCGCTTACAACCTTTGGCGCCTGCGCGTGGCTATATTTATGATCGGAATGGTATTTTGCTTGCC
GACAATTATCCTGTCTTTACCGCCACAATGAGCCGTGCAGATGTTGAAGATATTGATGGAACTATTGCGCGTCTAACACC
CATACTCAGTCTGACACAAGAAGATATTGATCGCTTCAAAAGCCGTATAAAAACAGCACGAAAGACTGAACGAGTTTCGA
TCAAATTGAATCTCACAGAAACAGATATTGCAAAATTTAGTGAACTTAAATACAACTTCCCTGGGGTTAAAATAGAAACG
CAAATGACGCGCTATTATCCCCATGGCGATCTATTTGCGCATGTGATTGGCTATGTCGGGCGCATCAATGAAAAAGAATT
AAAATCTCTCAATAAAGATACTTATGCAGGGACCAACCTGATTGGTAAAATTGGTGTCGAAAAAACCTATGAAGATTTAT
TGCATGGTACGCCAGGATATGAATCTGTAGAAGCCGATGCACATAGCAATGTTTTACGCCATCTTGGACGCAAAGAACCT
ATTCGCGGCAATGATCTTTACCTGTCGTTAGATTATGGGTTACAGATGGTTGCAGCCGAACAACTTAAAGACAAGCGTGG
TGCTGTAGTCGCTATTGATCCACGTACAGGTGAAATTCTGGCATTGGTCTCAAGCCCAAGCTTTAATCCAAATCTGTTTG
TTACAGGTATCAGTCATGTCGATTATAGCGCCTTGCGAGATAATCTGGATCAACCCCTTTATAACCGCGCACTACAAGGT
GTTTATCCACCAGGTTCAACCATTAAACCAATGGAAGGTTTAGGGGGCATCCATTACGGTACAGTCGACTGGGGAACCAC
GATTTATGATCCAGGTTATTTCCATTTACCTGGTGATTCACATAAATTTCGTGACTGGAAAAAGACTGGACATGGCAGTG
TAAATTTGCACAAATCTATCGTTGAGTCTTGTGATACATATTTCTACGTCCTTTCCTATCAGTTAGGCATTGACCGCATG
AATGAATGGATGCGACAGTTCGGATTTGGTCAAAAAACGGGTGTCGACCTTCCAAGTGAAAGTGAAGGACTTTACCCAAA
TCCAGAATGGAAGATGCGTACCCGTAAATCAAAATGGTTAAAAGGCGAAACAATTTCTGTCAGTATTGGACAAGGTGCAT
TTACTGCCACACCATTACAGCTTGCTATGGCAACTTCAATTATGGCGAACCACGGTGCGCATGTTGTCCCACATGTATTG
AGAGCCTCACATGGTGCAAAACCACATACGGTTCATAACGCTCCAGATGGTAAAATTAACTTTAATGGCACCGAGCAAGA
CTGGATCAATATGCGTGATGCCATGGTTGATGTGGTTCAATCAGGAACAGGTCGTGGTATTCGTACTCCGCTTTATCAAA
TCGCAGGTAAAACGGGGACAGCACAGGTTAAAAGTATTGCGCAAGGTAAAAAATATAACGAATCCATTTTAAGTGAACGC
CAGCTCGATCATGGTTTATTTGTTGGTTTTGCGCCAGCAGATAATCCTGAAATCGCAATTGCAGTCGTATGGGAAAATGG
TCGTCATGGCGGATCTGCTGCTCAGATTGCACGACCTATTTTTGATTACTGGATTGTGAACCGTAAGAAAAATCCAATTC
GCCCAGCCAATCATCAGATCAGTGGCGGATTAATGACGGCTGGCATTAAACCTGGCGAGTTACCAAGCGGTGCTTTACTT
GAAGCTAATCCGCATGCCACTGTGAATCAACCTCAACAAAAACCTGGTACTTCTGCCTCTGCACCTGCTGCGACAACTGC
CCCAGCAAATATTGAGGTGACTGAATAA

Upstream 100 bases:

>100_bases
GATTTATTTTGTAATATTCAAAATTTATCTCATTTTTATGATCGTGATGGGTTAAACTTATCGGCTGTTTATTTGTCCCG
CTCTATTTAAGTCCATTTGT

Downstream 100 bases:

>100_bases
TGAAAAATCAACTGAGAATTATAGGTGGCGAATGGAAACGGCGTATCCTTCCATTTGCCAGTATTGATGGTTTACGTCCA
ACTCCAGATCGTGTTCGTGA

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 675; Mature: 675

Protein sequence:

>675_residues
MKQHFPLKDNQQEKRLYRGRIFFAIGLVCCCLLLLMSRYAYLQIVHYDEFSTASDKNRIRLQPLAPARGYIYDRNGILLA
DNYPVFTATMSRADVEDIDGTIARLTPILSLTQEDIDRFKSRIKTARKTERVSIKLNLTETDIAKFSELKYNFPGVKIET
QMTRYYPHGDLFAHVIGYVGRINEKELKSLNKDTYAGTNLIGKIGVEKTYEDLLHGTPGYESVEADAHSNVLRHLGRKEP
IRGNDLYLSLDYGLQMVAAEQLKDKRGAVVAIDPRTGEILALVSSPSFNPNLFVTGISHVDYSALRDNLDQPLYNRALQG
VYPPGSTIKPMEGLGGIHYGTVDWGTTIYDPGYFHLPGDSHKFRDWKKTGHGSVNLHKSIVESCDTYFYVLSYQLGIDRM
NEWMRQFGFGQKTGVDLPSESEGLYPNPEWKMRTRKSKWLKGETISVSIGQGAFTATPLQLAMATSIMANHGAHVVPHVL
RASHGAKPHTVHNAPDGKINFNGTEQDWINMRDAMVDVVQSGTGRGIRTPLYQIAGKTGTAQVKSIAQGKKYNESILSER
QLDHGLFVGFAPADNPEIAIAVVWENGRHGGSAAQIARPIFDYWIVNRKKNPIRPANHQISGGLMTAGIKPGELPSGALL
EANPHATVNQPQQKPGTSASAPAATTAPANIEVTE

Sequences:

>Translated_675_residues
MKQHFPLKDNQQEKRLYRGRIFFAIGLVCCCLLLLMSRYAYLQIVHYDEFSTASDKNRIRLQPLAPARGYIYDRNGILLA
DNYPVFTATMSRADVEDIDGTIARLTPILSLTQEDIDRFKSRIKTARKTERVSIKLNLTETDIAKFSELKYNFPGVKIET
QMTRYYPHGDLFAHVIGYVGRINEKELKSLNKDTYAGTNLIGKIGVEKTYEDLLHGTPGYESVEADAHSNVLRHLGRKEP
IRGNDLYLSLDYGLQMVAAEQLKDKRGAVVAIDPRTGEILALVSSPSFNPNLFVTGISHVDYSALRDNLDQPLYNRALQG
VYPPGSTIKPMEGLGGIHYGTVDWGTTIYDPGYFHLPGDSHKFRDWKKTGHGSVNLHKSIVESCDTYFYVLSYQLGIDRM
NEWMRQFGFGQKTGVDLPSESEGLYPNPEWKMRTRKSKWLKGETISVSIGQGAFTATPLQLAMATSIMANHGAHVVPHVL
RASHGAKPHTVHNAPDGKINFNGTEQDWINMRDAMVDVVQSGTGRGIRTPLYQIAGKTGTAQVKSIAQGKKYNESILSER
QLDHGLFVGFAPADNPEIAIAVVWENGRHGGSAAQIARPIFDYWIVNRKKNPIRPANHQISGGLMTAGIKPGELPSGALL
EANPHATVNQPQQKPGTSASAPAATTAPANIEVTE
>Mature_675_residues
MKQHFPLKDNQQEKRLYRGRIFFAIGLVCCCLLLLMSRYAYLQIVHYDEFSTASDKNRIRLQPLAPARGYIYDRNGILLA
DNYPVFTATMSRADVEDIDGTIARLTPILSLTQEDIDRFKSRIKTARKTERVSIKLNLTETDIAKFSELKYNFPGVKIET
QMTRYYPHGDLFAHVIGYVGRINEKELKSLNKDTYAGTNLIGKIGVEKTYEDLLHGTPGYESVEADAHSNVLRHLGRKEP
IRGNDLYLSLDYGLQMVAAEQLKDKRGAVVAIDPRTGEILALVSSPSFNPNLFVTGISHVDYSALRDNLDQPLYNRALQG
VYPPGSTIKPMEGLGGIHYGTVDWGTTIYDPGYFHLPGDSHKFRDWKKTGHGSVNLHKSIVESCDTYFYVLSYQLGIDRM
NEWMRQFGFGQKTGVDLPSESEGLYPNPEWKMRTRKSKWLKGETISVSIGQGAFTATPLQLAMATSIMANHGAHVVPHVL
RASHGAKPHTVHNAPDGKINFNGTEQDWINMRDAMVDVVQSGTGRGIRTPLYQIAGKTGTAQVKSIAQGKKYNESILSER
QLDHGLFVGFAPADNPEIAIAVVWENGRHGGSAAQIARPIFDYWIVNRKKNPIRPANHQISGGLMTAGIKPGELPSGALL
EANPHATVNQPQQKPGTSASAPAATTAPANIEVTE

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=615, Percent_Identity=42.2764227642276, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786272, Length=603, Percent_Identity=26.5339966832504, Blast_Score=170, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74860; Mature: 74860

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQHFPLKDNQQEKRLYRGRIFFAIGLVCCCLLLLMSRYAYLQIVHYDEFSTASDKNRIR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEE
LQPLAPARGYIYDRNGILLADNYPVFTATMSRADVEDIDGTIARLTPILSLTQEDIDRFK
EEECCCCCCEEECCCCEEEECCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
SRIKTARKTERVSIKLNLTETDIAKFSELKYNFPGVKIETQMTRYYPHGDLFAHVIGYVG
HHHHHHHCCEEEEEEEECCHHHHHHHHHHEECCCCEEEEEEHEEECCCHHHHHHHHHHHH
RINEKELKSLNKDTYAGTNLIGKIGVEKTYEDLLHGTPGYESVEADAHSNVLRHLGRKEP
CCCHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
IRGNDLYLSLDYGLQMVAAEQLKDKRGAVVAIDPRTGEILALVSSPSFNPNLFVTGISHV
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCEEEEEECCC
DYSALRDNLDQPLYNRALQGVYPPGSTIKPMEGLGGIHYGTVDWGTTIYDPGYFHLPGDS
CHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCEEECCCEEECCCCC
HKFRDWKKTGHGSVNLHKSIVESCDTYFYVLSYQLGIDRMNEWMRQFGFGQKTGVDLPSE
CCCCHHHHCCCCCCCHHHHHHHHHCCEEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCCCC
SEGLYPNPEWKMRTRKSKWLKGETISVSIGQGAFTATPLQLAMATSIMANHGAHVVPHVL
CCCCCCCCCCHHHHCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
RASHGAKPHTVHNAPDGKINFNGTEQDWINMRDAMVDVVQSGTGRGIRTPLYQIAGKTGT
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCH
AQVKSIAQGKKYNESILSERQLDHGLFVGFAPADNPEIAIAVVWENGRHGGSAAQIARPI
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHH
FDYWIVNRKKNPIRPANHQISGGLMTAGIKPGELPSGALLEANPHATVNQPQQKPGTSAS
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
APAATTAPANIEVTE
CCCCCCCCCCEEECC
>Mature Secondary Structure
MKQHFPLKDNQQEKRLYRGRIFFAIGLVCCCLLLLMSRYAYLQIVHYDEFSTASDKNRIR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCEE
LQPLAPARGYIYDRNGILLADNYPVFTATMSRADVEDIDGTIARLTPILSLTQEDIDRFK
EEECCCCCCEEECCCCEEEECCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
SRIKTARKTERVSIKLNLTETDIAKFSELKYNFPGVKIETQMTRYYPHGDLFAHVIGYVG
HHHHHHHCCEEEEEEEECCHHHHHHHHHHEECCCCEEEEEEHEEECCCHHHHHHHHHHHH
RINEKELKSLNKDTYAGTNLIGKIGVEKTYEDLLHGTPGYESVEADAHSNVLRHLGRKEP
CCCHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCC
IRGNDLYLSLDYGLQMVAAEQLKDKRGAVVAIDPRTGEILALVSSPSFNPNLFVTGISHV
CCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCCCCCEEEEEECCC
DYSALRDNLDQPLYNRALQGVYPPGSTIKPMEGLGGIHYGTVDWGTTIYDPGYFHLPGDS
CHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCEEECCCEEECCCCC
HKFRDWKKTGHGSVNLHKSIVESCDTYFYVLSYQLGIDRMNEWMRQFGFGQKTGVDLPSE
CCCCHHHHCCCCCCCHHHHHHHHHCCEEEEEEEHHCHHHHHHHHHHHCCCCCCCCCCCCC
SEGLYPNPEWKMRTRKSKWLKGETISVSIGQGAFTATPLQLAMATSIMANHGAHVVPHVL
CCCCCCCCCCHHHHCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHH
RASHGAKPHTVHNAPDGKINFNGTEQDWINMRDAMVDVVQSGTGRGIRTPLYQIAGKTGT
HHCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCH
AQVKSIAQGKKYNESILSERQLDHGLFVGFAPADNPEIAIAVVWENGRHGGSAAQIARPI
HHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHH
FDYWIVNRKKNPIRPANHQISGGLMTAGIKPGELPSGALLEANPHATVNQPQQKPGTSAS
HHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
APAATTAPANIEVTE
CCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]