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The map label for this gene is aceA [C]

Identifier: 50084282

GI number: 50084282

Start: 1079899

End: 1081497

Strand: Direct

Name: aceA [C]

Synonym: ACIAD1084

Alternate gene names: 50084282

Gene position: 1079899-1081497 (Clockwise)

Preceding gene: 50084281

Following gene: 50084285

Centisome position: 30.01

GC content: 42.46

Gene sequence:

>1599_bases
ATGACATATCAATCAGCTCTTGAGCACGTACGTGCCGTAAAAAATAAATTAGGTGGCACTTGGGATGCAATTCGTCCTGA
AGACGCTGCTCGTATGATTGTTCAAAACCGTTTCCATACTGGTTTGGATATTGCTAAATATACAGCTGCGATCATGCGTA
AAGACATGGCTGAATATGATGCTGACAACAGCAGCTATACTCAATCTTTGGGTTGCTGGCATGGTTTCATCGCGCAACAA
AAAATGATTGCCAACAAAAAATATTTTGGTACAACCAACAAACGTTATATCTATCTTTCTGGTTGGATGGTTGCTGCACT
TCGTTCTGAATTTGGTCCACTTCCTGACCAATCTATGCACGAAAAAACAGCCGTTCCTAAGTTGATTGCAGAAATCTATA
CATTCTTACGTCAAGCGGATGCAAAAGAATTAAACGATTTGTTCCGTGCTCTACAAAAAGCTGAAGCGGCTGGTGATTCT
GCAAAAGTTAAAGATATCGAATCTCAAATTGATAACTTTGAAACTCACGTTGTGCCAATCATTGCCGACATCGATGCTGG
TTTTGGTAACGAAGAAGCAACTTATTTGTTGACTAAACAAATGATCGAGGCGGGTGCTTGTGCAATCCAAATCGAAAACC
AAGTTTCTGATGCGAAACAATGTGGTCACCAAGCGGGTAAAGTCACTGTTCCACACGAAGACTTCCTTGCAAAAATCAAT
GCTGTACGTTATGCATTCCTTGAGCTTGGTGTTGATGAAGGTGTAATCGTTGCACGTACTGACTCTGAAGGTGCGGACTT
GACTCAAAAGATCCCTGTATCTAAAGAGAAAGGTGACTTGGCTTCTCAATATATTAGCTACTTAGACACTCAAGAAATTG
ATATTGCGGATGCTCAAGAAGATGAAATCCTGATCAAACGCGATGGTAAATTACATCGTCCAACCCGTTTAGCTTCTGGT
TTGTATCAGTTCCGTGAAGGTACTCAACATGACCGCGTTGTACTTGACTGTGTAACAAGCTTACAAAACGGTGCAGACAT
GATCTGGATCGAGACACCAACTCCAGACGTTGCTGGTATTGCTGGTTTCGTAAATGACATCAAAAAACAAGTTCCAAATG
CAAAACTTGTTTATAACAACTCGCCATCATTCAACTGGACTTTAAACTTCCGTCAACAAGCGTACGATCGCTGGGCTGCT
GAAGGTAAAGATGTTTCAGCGTATGACCGCGCTAAATTGATGAGTGCTGAGTACGATAACACTGAATTAGCTGCTGATGC
TGATGAAAAAATCCGTACTTTCCAGGCTGATGCTGCACGTGAAGCAGGTGTGTTTCATCACTTGATCACTCTTCCGACTT
ACCACACCGCTGCTCTTTCTACGCATGAGCTTGCTAAAGGTTACTTCGGTGAAGAAGGTATGTTGGCTTATGTTGCTGGC
GTACAACGTAAAGAAATCCGCGGTGGTATCGCATGTGTTAAACACCAAGCAATGGCTGGTTCTGACATCGGTGATGACCA
TAAAGAAATCTTTGCTGGTGAACAAGCGCTTAAAGCGGGTGATGCAAGCAAAAACACTATGAACCAGTTCGCTCACTAA

Upstream 100 bases:

>100_bases
CTGTATTCATATTGATGAAGTGGCTAAATAATAGTCTAGTCAAATAAACATGAGATTTAGCACGACATCTCTTCGATGAA
ATCCTAAAAGGGAATATATC

Downstream 100 bases:

>100_bases
GGCGTATGGTTTAAAAAACCCTGCATAAGCAGGGTTTTTTATTTTAGAGTTAAAAACATGATTTTATTTTTTCAAGATAT
AAAGATCGGCCATGGCACCT

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MTYQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQ
KMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDS
AKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN
AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASG
LYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAA
EGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAG
VQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFAH

Sequences:

>Translated_532_residues
MTYQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQ
KMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDS
AKVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN
AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASG
LYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAA
EGKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAG
VQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFAH
>Mature_531_residues
TYQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYDADNSSYTQSLGCWHGFIAQQK
MIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMHEKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSA
KVKDIESQIDNFETHVVPIIADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKINA
VRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQEDEILIKRDGKLHRPTRLASGL
YQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGIAGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAE
GKDVSAYDRAKLMSAEYDNTELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAGV
QRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFAH

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=499, Percent_Identity=27.6553106212425, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=29.0556900726392, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=29.0556900726392, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325263, Length=489, Percent_Identity=24.7443762781186, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320908, Length=172, Percent_Identity=31.9767441860465, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 58962; Mature: 58831

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYD
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
ADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMH
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHH
EKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
IADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN
EEECCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHH
AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQE
HHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
DEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGI
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHH
AGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDN
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
TELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHC
VQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFAH
CHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TYQSALEHVRAVKNKLGGTWDAIRPEDAARMIVQNRFHTGLDIAKYTAAIMRKDMAEYD
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHC
ADNSSYTQSLGCWHGFIAQQKMIANKKYFGTTNKRYIYLSGWMVAALRSEFGPLPDQSMH
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCHHH
EKTAVPKLIAEIYTFLRQADAKELNDLFRALQKAEAAGDSAKVKDIESQIDNFETHVVPI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEE
IADIDAGFGNEEATYLLTKQMIEAGACAIQIENQVSDAKQCGHQAGKVTVPHEDFLAKIN
EEECCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHCCCCEECCHHHHHHHHH
AVRYAFLELGVDEGVIVARTDSEGADLTQKIPVSKEKGDLASQYISYLDTQEIDIADAQE
HHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCC
DEILIKRDGKLHRPTRLASGLYQFREGTQHDRVVLDCVTSLQNGADMIWIETPTPDVAGI
CCEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHH
AGFVNDIKKQVPNAKLVYNNSPSFNWTLNFRQQAYDRWAAEGKDVSAYDRAKLMSAEYDN
HHHHHHHHHHCCCCEEEECCCCCEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
TELAADADEKIRTFQADAAREAGVFHHLITLPTYHTAALSTHELAKGYFGEEGMLAYVAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHC
VQRKEIRGGIACVKHQAMAGSDIGDDHKEIFAGEQALKAGDASKNTMNQFAH
CHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]