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The map label for this gene is betA

Identifier: 50084211

GI number: 50084211

Start: 996846

End: 998507

Strand: Reverse

Name: betA

Synonym: ACIAD1008

Alternate gene names: 50084211

Gene position: 998507-996846 (Counterclockwise)

Preceding gene: 50084212

Following gene: 50084210

Centisome position: 27.75

GC content: 44.4

Gene sequence:

>1662_bases
ATGACGACTCAAACTTTTGATTATATTATTATTGGTGCAGGCTCAGCAGGTAATGTACTGGCTGCACGTTTAACTGAAGA
TGCCGATGTTTCGGTATTACTTTTAGAAGCAGGTGGCCCAGATTATCGTCTGGACTTTCGTACCCAGATGCCAGCCGCTT
TGGCCTACCCTTTACAAGGCCGCCGTTATAACTGGGCTTACCTGACCGAACCCGAACCGCATATGAATAACCGTCGTATG
GAATGTGGTCGCGGTAAAGGTCTGGGTGGCTCATCGCTGATTAATGGGATGTGTTATATCCGTGGTAATGCCATGGATCT
TGAAGGCTGGTCAAAGCTTAAAGGCCTGGAGAACTGGACCTATGCCGACTGCTTACCGTATTACAAGAAAGCAGAAACCC
GTGATATTGGAGGCAATGACTATCACGGTGATCATGGCCCTGTCAGTGTTGCAACGCCTAAAGATAACAATAATGTTTTG
TTTCATGCCATGGTTGAAGCAGGTGTACAGGCGGGTTATCCACGTACAGATGACTTGAACGGCTATCAACAAGAAGGTTT
TGGTCCAATGGATCGTACTGTCACCAAGAATGGGCGCCGTTCCAGTACAGCACGTGGTTATTTGGATATGGCAAAAGAAC
GGCCAAATTTAACCATTATCACCCATGCCATGACCAACAAAATTTTGTTTAATGGCAAGCAGGCCATTGGTGTTGAGTAT
ATACAAGGCGCCGATAAACGTGATTTAAAAAAGGTGATGGCCAATAAAGAAGTATTACTGTGTGCAGGAGCAATTGCTTC
TCCACAAATTTTACAACGTTCTGGTGTAGGTGAAAGTACCTTCCTAAAATCAATGGATATTGATGTCGTACATGATCTGC
CAGGTGTGGGTGAAAATCTGCAAGATCATTTGGAAATGTACCTACAATATAAATGTAAACAGCCTGTATCGTTATACCCT
GCCCTCAAATGGTATAACCAACCAGCGATTGGTGCTGAATGGCTATTTTTAGGTAAAGGTATTGGCGCAAGTAACCAATT
TGAAGCAGGCGGCTTTATTCGCTCTTCAGATGAATTTGAGTGGCCGAATATTCAATATCACTTTTTACCCGTTGCCATTA
ATTATAACGGCAGTAATGCAGTGAAAGAGCATGGCTTTCAAGCGCATGTTGGCTCTATGCGCTCGCCTTCACGTGGTCAT
ATCAAACTCAAATCGAAAGATCCGTTTGAACATCCAAGTATCCTGTTTAATTACATGTCAACTGAACAAGACTGGCAAGA
ATTTCGCGCAGCGATTCGGATTACCCGTGAGATTATGCATCAGCCAGCATTGGACCCGTATCGTGGTGAAGAAATTAGCC
CTGGCAAGCAACTGAGTACCGATACTCAACTTGATGATTTTGTTCGCAATCATGCTGAAACGGCTTACCATCCATCATGC
AGTTGTAAAATGGGCGAAGATGATATGGCTGTGGTCGATCATCAAGGACGTGTCCATGGCTTACAAGGTTTGCGCGTAGT
CGATGCGTCAATTATGCCACTGATCATTACAGGAAATCTAAATGCCACCACCATTATGATGGCAGAGAAAATTGCAGATC
AGATCCGTGAACGCGCGCCGTTGCCACGTTCTGATGCACCTTTTTATGTTGCATCAGCATAA

Upstream 100 bases:

>100_bases
AGCGTGTTTTAAGCATGCTCTGCCCACTTTAAAGTTTCCTCATAAATCTGATGTCACTGCTGTACACACAGCGTGACGCC
AACAATATTCAGGAATAGCA

Downstream 100 bases:

>100_bases
ATTTTAGTGATATTCGAACATGGTTTTTTACCGATCATCATGTTCGAATATCGAATTTCTTAGACAATTATCGAACATAT
TTTTATTTTGCTCTCATTTT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTTQTFDYIIIGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAYPLQGRRYNWAYLTEPEPHMNNRRM
ECGRGKGLGGSSLINGMCYIRGNAMDLEGWSKLKGLENWTYADCLPYYKKAETRDIGGNDYHGDHGPVSVATPKDNNNVL
FHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTKNGRRSSTARGYLDMAKERPNLTIITHAMTNKILFNGKQAIGVEY
IQGADKRDLKKVMANKEVLLCAGAIASPQILQRSGVGESTFLKSMDIDVVHDLPGVGENLQDHLEMYLQYKCKQPVSLYP
ALKWYNQPAIGAEWLFLGKGIGASNQFEAGGFIRSSDEFEWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGH
IKLKSKDPFEHPSILFNYMSTEQDWQEFRAAIRITREIMHQPALDPYRGEEISPGKQLSTDTQLDDFVRNHAETAYHPSC
SCKMGEDDMAVVDHQGRVHGLQGLRVVDASIMPLIITGNLNATTIMMAEKIADQIRERAPLPRSDAPFYVASA

Sequences:

>Translated_553_residues
MTTQTFDYIIIGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAYPLQGRRYNWAYLTEPEPHMNNRRM
ECGRGKGLGGSSLINGMCYIRGNAMDLEGWSKLKGLENWTYADCLPYYKKAETRDIGGNDYHGDHGPVSVATPKDNNNVL
FHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTKNGRRSSTARGYLDMAKERPNLTIITHAMTNKILFNGKQAIGVEY
IQGADKRDLKKVMANKEVLLCAGAIASPQILQRSGVGESTFLKSMDIDVVHDLPGVGENLQDHLEMYLQYKCKQPVSLYP
ALKWYNQPAIGAEWLFLGKGIGASNQFEAGGFIRSSDEFEWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGH
IKLKSKDPFEHPSILFNYMSTEQDWQEFRAAIRITREIMHQPALDPYRGEEISPGKQLSTDTQLDDFVRNHAETAYHPSC
SCKMGEDDMAVVDHQGRVHGLQGLRVVDASIMPLIITGNLNATTIMMAEKIADQIRERAPLPRSDAPFYVASA
>Mature_552_residues
TTQTFDYIIIGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAYPLQGRRYNWAYLTEPEPHMNNRRME
CGRGKGLGGSSLINGMCYIRGNAMDLEGWSKLKGLENWTYADCLPYYKKAETRDIGGNDYHGDHGPVSVATPKDNNNVLF
HAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTKNGRRSSTARGYLDMAKERPNLTIITHAMTNKILFNGKQAIGVEYI
QGADKRDLKKVMANKEVLLCAGAIASPQILQRSGVGESTFLKSMDIDVVHDLPGVGENLQDHLEMYLQYKCKQPVSLYPA
LKWYNQPAIGAEWLFLGKGIGASNQFEAGGFIRSSDEFEWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGHI
KLKSKDPFEHPSILFNYMSTEQDWQEFRAAIRITREIMHQPALDPYRGEEISPGKQLSTDTQLDDFVRNHAETAYHPSCS
CKMGEDDMAVVDHQGRVHGLQGLRVVDASIMPLIITGNLNATTIMMAEKIADQIRERAPLPRSDAPFYVASA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=551, Percent_Identity=47.7313974591652, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1786503, Length=548, Percent_Identity=78.2846715328467, Blast_Score=909, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=45.8928571428571, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24642059, Length=574, Percent_Identity=35.7142857142857, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24642048, Length=574, Percent_Identity=35.5400696864112, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=34.8432055749129, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24642055, Length=584, Percent_Identity=34.0753424657534, Blast_Score=268, Evalue=1e-71,
Organism=Drosophila melanogaster, GI45551458, Length=578, Percent_Identity=32.6989619377163, Blast_Score=268, Evalue=1e-71,
Organism=Drosophila melanogaster, GI45549471, Length=578, Percent_Identity=32.6989619377163, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17137792, Length=558, Percent_Identity=35.4838709677419, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642039, Length=571, Percent_Identity=34.1506129597198, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI18859995, Length=575, Percent_Identity=34.6086956521739, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24642051, Length=576, Percent_Identity=31.4236111111111, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24650267, Length=580, Percent_Identity=32.2413793103448, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24642035, Length=580, Percent_Identity=32.4137931034483, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI18859993, Length=576, Percent_Identity=33.5069444444444, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24642037, Length=311, Percent_Identity=38.9067524115756, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24645930, Length=580, Percent_Identity=27.0689655172414, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642057, Length=592, Percent_Identity=28.0405405405405, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_ACIAD (Q6FDF9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045721.1
- HSSP:   P13006
- ProteinModelPortal:   Q6FDF9
- SMR:   Q6FDF9
- STRING:   Q6FDF9
- GeneID:   2880313
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1008
- NMPDR:   fig|62977.3.peg.1059
- eggNOG:   COG2303
- HOGENOM:   HBG734713
- OMA:   RAAIRIT
- PhylomeDB:   Q6FDF9
- ProtClustDB:   PRK02106
- BioCyc:   ASP62977:ACIAD1008-MONOMER
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 61478; Mature: 61347

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 477-477

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQTFDYIIIGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAYPLQG
CCCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCHHEECCCCC
RRYNWAYLTEPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLEGWSKLKGLENWT
CEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCCCHHHHCCCCCCC
YADCLPYYKKAETRDIGGNDYHGDHGPVSVATPKDNNNVLFHAMVEAGVQAGYPRTDDLN
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEHHHHHCCCCCCCCCC
GYQQEGFGPMDRTVTKNGRRSSTARGYLDMAKERPNLTIITHAMTNKILFNGKQAIGVEY
CHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHCCHHH
IQGADKRDLKKVMANKEVLLCAGAIASPQILQRSGVGESTFLKSMDIDVVHDLPGVGENL
HCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHCCCCCEECCCCCCCCH
QDHLEMYLQYKCKQPVSLYPALKWYNQPAIGAEWLFLGKGIGASNQFEAGGFIRSSDEFE
HHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCC
WPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGHIKLKSKDPFEHPSILFNYMS
CCCEEEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHC
TEQDWQEFRAAIRITREIMHQPALDPYRGEEISPGKQLSTDTQLDDFVRNHAETAYHPSC
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
SCKMGEDDMAVVDHQGRVHGLQGLRVVDASIMPLIITGNLNATTIMMAEKIADQIRERAP
CCCCCCCCEEEEECCCCEECCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHCC
LPRSDAPFYVASA
CCCCCCCEEEECC
>Mature Secondary Structure 
TTQTFDYIIIGAGSAGNVLAARLTEDADVSVLLLEAGGPDYRLDFRTQMPAALAYPLQG
CCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCHHEECCCCC
RRYNWAYLTEPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLEGWSKLKGLENWT
CEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCEECCCCHHHHCCCCCCC
YADCLPYYKKAETRDIGGNDYHGDHGPVSVATPKDNNNVLFHAMVEAGVQAGYPRTDDLN
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEEHHHHHCCCCCCCCCC
GYQQEGFGPMDRTVTKNGRRSSTARGYLDMAKERPNLTIITHAMTNKILFNGKQAIGVEY
CHHHCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCHHCCHHH
IQGADKRDLKKVMANKEVLLCAGAIASPQILQRSGVGESTFLKSMDIDVVHDLPGVGENL
HCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHCCCCCEECCCCCCCCH
QDHLEMYLQYKCKQPVSLYPALKWYNQPAIGAEWLFLGKGIGASNQFEAGGFIRSSDEFE
HHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCC
WPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGHIKLKSKDPFEHPSILFNYMS
CCCEEEEEEEEEEEECCCCHHHHCCCHHHCCCCCCCCCCEEEECCCCCCCCHHHHHHHHC
TEQDWQEFRAAIRITREIMHQPALDPYRGEEISPGKQLSTDTQLDDFVRNHAETAYHPSC
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
SCKMGEDDMAVVDHQGRVHGLQGLRVVDASIMPLIITGNLNATTIMMAEKIADQIRERAP
CCCCCCCCEEEEECCCCEECCCCEEEECCCCEEEEEECCCCCEEHHHHHHHHHHHHHHCC
LPRSDAPFYVASA
CCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA