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The map label for this gene is nuoE [H]

Identifier: 50083952

GI number: 50083952

Start: 717388

End: 717900

Strand: Direct

Name: nuoE [H]

Synonym: ACIAD0734

Alternate gene names: 50083952

Gene position: 717388-717900 (Clockwise)

Preceding gene: 50083951

Following gene: 50083953

Centisome position: 19.94

GC content: 41.91

Gene sequence:

>513_bases
ATGATGATGATTTTGACTGATAAAAAACCTCGTGTGAATGTTGAAGGAATTTTGACTGCTGATGAAATTCATGAAATTGA
ACATCACATTCATCACTATCCTTATCCACGCGCTGCATCTTTAGATGCGTTGAAATGTGTTCAGCGTCGTAATGGCTGGG
TCGATGATGCGCAAATGAATGCGATTGCACAAATGCTCAGTATTAGTGTGGCTGATTTGGAAGGTGTAGCAACATTCTAT
AACCGTATTTACCGCCAGCCTGTAGGCCGTCATGTGATTTTACTCTGCGATTCGATCGCGTGTTTTCTCATGGGTGCTGA
AACGTTAGCAGAGGCATTCCAGCGTGAGCTTGGAATCCAGTATGGGCAAACGACAGCAGATGGTCGCTTCACATTATTGC
CAATTTGCTGTTTAGGAAATTGCGATAAAGGACCAACCTTAATGATTGATGAAGATACACATGGCTTAGTTGATGTATCT
TCGGTCAAACAGTTATTGGAGAAGTATGTATGA

Upstream 100 bases:

>100_bases
AATGCCTTCGGTGATTAATGGTAGTCTGGTTTCGGACTTGATCATTTATTTGGCGACCATTGACGTGGTTATGGCTGACG
TGGATCGCTAGGGGTAAACG

Downstream 100 bases:

>100_bases
ATACTGAACCAAAACCGATTTATGGCGACGGAAACCCTGAAACTCATCCGCTGACTTGGCGTTTGAGTAAGCAGGAGCAT
GTACGTAGTGCTGATGATTA

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MMMILTDKKPRVNVEGILTADEIHEIEHHIHHYPYPRAASLDALKCVQRRNGWVDDAQMNAIAQMLSISVADLEGVATFY
NRIYRQPVGRHVILLCDSIACFLMGAETLAEAFQRELGIQYGQTTADGRFTLLPICCLGNCDKGPTLMIDEDTHGLVDVS
SVKQLLEKYV

Sequences:

>Translated_170_residues
MMMILTDKKPRVNVEGILTADEIHEIEHHIHHYPYPRAASLDALKCVQRRNGWVDDAQMNAIAQMLSISVADLEGVATFY
NRIYRQPVGRHVILLCDSIACFLMGAETLAEAFQRELGIQYGQTTADGRFTLLPICCLGNCDKGPTLMIDEDTHGLVDVS
SVKQLLEKYV
>Mature_170_residues
MMMILTDKKPRVNVEGILTADEIHEIEHHIHHYPYPRAASLDALKCVQRRNGWVDDAQMNAIAQMLSISVADLEGVATFY
NRIYRQPVGRHVILLCDSIACFLMGAETLAEAFQRELGIQYGQTTADGRFTLLPICCLGNCDKGPTLMIDEDTHGLVDVS
SVKQLLEKYV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=153, Percent_Identity=32.6797385620915, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1788621, Length=152, Percent_Identity=57.2368421052632, Blast_Score=193, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17561328, Length=162, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI18859877, Length=144, Percent_Identity=31.9444444444444, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21355353, Length=151, Percent_Identity=29.1390728476821, Blast_Score=87, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 19047; Mature: 19047

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMILTDKKPRVNVEGILTADEIHEIEHHIHHYPYPRAASLDALKCVQRRNGWVDDAQMN
CEEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
AIAQMLSISVADLEGVATFYNRIYRQPVGRHVILLCDSIACFLMGAETLAEAFQRELGIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCHHHHHHHHHHHHCCC
YGQTTADGRFTLLPICCLGNCDKGPTLMIDEDTHGLVDVSSVKQLLEKYV
CCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MMMILTDKKPRVNVEGILTADEIHEIEHHIHHYPYPRAASLDALKCVQRRNGWVDDAQMN
CEEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
AIAQMLSISVADLEGVATFYNRIYRQPVGRHVILLCDSIACFLMGAETLAEAFQRELGIQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCHHHHHHHHHHHHCCC
YGQTTADGRFTLLPICCLGNCDKGPTLMIDEDTHGLVDVSSVKQLLEKYV
CCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]