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The map label for this gene is nuoCD

Identifier: 50083951

GI number: 50083951

Start: 715591

End: 717378

Strand: Direct

Name: nuoCD

Synonym: ACIAD0733

Alternate gene names: 50083951

Gene position: 715591-717378 (Clockwise)

Preceding gene: 50083950

Following gene: 50083952

Centisome position: 19.89

GC content: 45.64

Gene sequence:

>1788_bases
ATGGCTGAAACTGACATTGCTATGCCAGAATCAACCCCTGTTGATTCACGCCCAGCATTTGCAATTGTAGAAGAACTCAA
AACCAAATTCGGTGAGAACTTCTATGTGCAAACGACTTGCGAAGAGTTTCCAACGGTCTGGGTTGAGCGCTCACGCGTAC
AAGAAGTTTTGATGTTTCTACGTAAAGTAGACCGTCCTTATGTCATGTTATTTGACTTGTCTGCAATGGACGAGCGTTTA
CGTGTACATCGTGATGGTTTACCTGCTTCAGATTTCACTGTTTTCTATCATTTATTATCGTTAGAGCGCAATAGTGATAT
CCGTATCAAGGTTGCATTGAACGAGAGTGATTTAAACATTCCAACCGCGACCAATATTTGGCCAAACGCCAACTGGTACG
AACGTGAAGCCTACGATATGTTTGGAATCAATTTCGAAGGGCATCCGATGCTCCGTCGTATTTTGTTGCCAACCTATTGG
GAAGGTCATCCACTTCGTAAAGAGTATTCTGCGCGTGCGACCGAATATACGCCGTACATGCAGAATCAGGCGAAGCAGGA
TTTTGAACAGGAACATTTGCGTTTTGTGCCTGAAGACTGGGGTCTTAAGCGCGGTAACGCCGATGAAGACTTTATGTTCT
TGAACTTGGGTCCAAACCATCCATCTGCGCATGGTGCATTCCGTGTGGTCTTGCAGCTTGATGGTGAAGAAGTCAAAGAC
TGTGTGCCCGATATTGGTTATCACCACCGCGGTGTGGAAAAGATGGCTGAACGTCAAACATGGCATTCTTTCATTCCTTA
TACCGACCGTGTCGATTACTTGGGTGGTTGTGCGCAAAACATGCCGTATGTGATGGCAGTTGAGCAGCTAGCAGGCATTA
AAGTGCCTGAGCGTGCACAAGTGATTCGTGTCATGTTGAACGAATTGTTCCGTATCAATAACCACTTGTTGTTCTGCGGT
ACAGCGATTCAGGATGCGGGTGGTATGACACCTGTATTCTATATGTTTGCAGACCGTCAGAAAGTGTATGACATCGTAGA
AGCCATTACAGGTTACCGTATGCATCCAGCATGGTTCCGTATTGGTGGTACCGCTCACGATCTTCCAAATAACTGGCATA
AGCTGGTGAAGGAACTGCTCGAGTGGATGCCAAAACGTCTAAACGAATACCACACGGCAGCGCTGAAAAATTCGGTGTTT
ATTGGTCGTACCCGTAATGTTGCCCAGTATGATGCAAAATCGGCATTGGCTTGGGGTGTGACAGGAACTGGTTTACGTGC
AACAGGTATTGATTTTGACGTACGTAAATATCGTCCTTATAGCGGCTATGAAAACTTTGATTTTGATGTGCCGCTTGAGT
ATGAAGGCGATGCCTATGCACGTGTCATGGTGCATTTCCGTGAAATCACGGAGTCATTAAAAATTATTCAGCAATGTCTG
GATAACATGCCATCAGGCCCTTATAAAGCGGATCACCCATTGGCTGTTCCACCGCCAAAAGACAAGACATTACAAGATAT
TGAAACCTTGATCACACACTTCTTAAGTGTATCTTGGGGTCCAGTAATGCCTGCGGGTGAAGCATCATTCATGACTGAGG
TTGTAAAAGGTGCGAGCACGTATTACCTCACATCTGACAAGTCAACCATGAGCTATCGTACACGTATTCGTACGCCAACC
TTCACCCACTTGCAGCAAATGCCTTCGGTGATTAATGGTAGTCTGGTTTCGGACTTGATCATTTATTTGGCGACCATTGA
CGTGGTTATGGCTGACGTGGATCGCTAG

Upstream 100 bases:

>100_bases
TATGGATGAAATTAAATAATTTTTTTGATTTTCCATCTCTATGTTGAGCATGGTTGTCAAAAACCAAAAAAGAATTTGTA
TTAAATAGGAAGCCAAACCA

Downstream 100 bases:

>100_bases
GGGTAAACGATGATGATGATTTTGACTGATAAAAAACCTCGTGTGAATGTTGAAGGAATTTTGACTGCTGATGAAATTCA
TGAAATTGAACATCACATTC

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQTTCEEFPTVWVERSRVQEVLMFLRKVDRPYVMLFDLSAMDERL
RVHRDGLPASDFTVFYHLLSLERNSDIRIKVALNESDLNIPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYW
EGHPLRKEYSARATEYTPYMQNQAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVKD
CVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLFCG
TAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWHKLVKELLEWMPKRLNEYHTAALKNSVF
IGRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFDVPLEYEGDAYARVMVHFREITESLKIIQQCL
DNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKSTMSYRTRIRTPT
FTHLQQMPSVINGSLVSDLIIYLATIDVVMADVDR

Sequences:

>Translated_595_residues
MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQTTCEEFPTVWVERSRVQEVLMFLRKVDRPYVMLFDLSAMDERL
RVHRDGLPASDFTVFYHLLSLERNSDIRIKVALNESDLNIPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYW
EGHPLRKEYSARATEYTPYMQNQAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVKD
CVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLFCG
TAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWHKLVKELLEWMPKRLNEYHTAALKNSVF
IGRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFDVPLEYEGDAYARVMVHFREITESLKIIQQCL
DNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKSTMSYRTRIRTPT
FTHLQQMPSVINGSLVSDLIIYLATIDVVMADVDR
>Mature_594_residues
AETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQTTCEEFPTVWVERSRVQEVLMFLRKVDRPYVMLFDLSAMDERLR
VHRDGLPASDFTVFYHLLSLERNSDIRIKVALNESDLNIPTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWE
GHPLRKEYSARATEYTPYMQNQAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVKDC
VPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQVIRVMLNELFRINNHLLFCGT
AIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFRIGGTAHDLPNNWHKLVKELLEWMPKRLNEYHTAALKNSVFI
GRTRNVAQYDAKSALAWGVTGTGLRATGIDFDVRKYRPYSGYENFDFDVPLEYEGDAYARVMVHFREITESLKIIQQCLD
NMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGASTYYLTSDKSTMSYRTRIRTPTF
THLQQMPSVINGSLVSDLIIYLATIDVVMADVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=38.2198952879581, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=37.7659574468085, Blast_Score=276, Evalue=4e-74,
Organism=Homo sapiens, GI4758788, Length=174, Percent_Identity=36.7816091954023, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI145693162, Length=576, Percent_Identity=67.0138888888889, Blast_Score=853, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=507, Percent_Identity=28.2051282051282, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1788832, Length=507, Percent_Identity=27.4161735700197, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555284, Length=398, Percent_Identity=38.6934673366834, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17568379, Length=401, Percent_Identity=37.6558603491272, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI32563621, Length=120, Percent_Identity=37.5, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71990788, Length=120, Percent_Identity=37.5, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=37.8590078328982, Blast_Score=304, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=38.0208333333333, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24656494, Length=135, Percent_Identity=37.7777777777778, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_ACIAD (Q6FE69)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045461.1
- HSSP:   Q56220
- ProteinModelPortal:   Q6FE69
- STRING:   Q6FE69
- GeneID:   2879582
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0733
- NMPDR:   fig|62977.3.peg.540
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- PhylomeDB:   Q6FE69
- ProtClustDB:   PRK11742
- BioCyc:   ASP62977:ACIAD0733-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR020396
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 68470; Mature: 68339

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQTTCEEFPTVWVERSRVQEVLMFL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
RKVDRPYVMLFDLSAMDERLRVHRDGLPASDFTVFYHLLSLERNSDIRIKVALNESDLNI
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
PTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWEGHPLRKEYSARATEYTPYM
CCCCCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHH
QNQAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVKD
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHH
CVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQ
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCHHHHHHHHHCCCCCHHHH
VIRVMLNELFRINNHLLFCGTAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFR
HHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEE
IGGTAHDLPNNWHKLVKELLEWMPKRLNEYHTAALKNSVFIGRTRNVAQYDAKSALAWGV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCHHHEEECC
TGTGLRATGIDFDVRKYRPYSGYENFDFDVPLEYEGDAYARVMVHFREITESLKIIQQCL
CCCCCEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGAST
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCE
YYLTSDKSTMSYRTRIRTPTFTHLQQMPSVINGSLVSDLIIYLATIDVVMADVDR
EEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AETDIAMPESTPVDSRPAFAIVEELKTKFGENFYVQTTCEEFPTVWVERSRVQEVLMFL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHH
RKVDRPYVMLFDLSAMDERLRVHRDGLPASDFTVFYHLLSLERNSDIRIKVALNESDLNI
HHCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
PTATNIWPNANWYEREAYDMFGINFEGHPMLRRILLPTYWEGHPLRKEYSARATEYTPYM
CCCCCCCCCCCCCCCCHHHEEECCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCHHH
QNQAKQDFEQEHLRFVPEDWGLKRGNADEDFMFLNLGPNHPSAHGAFRVVLQLDGEEVKD
HHHHHHHHHHHHHHCCCHHCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHH
CVPDIGYHHRGVEKMAERQTWHSFIPYTDRVDYLGGCAQNMPYVMAVEQLAGIKVPERAQ
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCHHHHHHHHHCCCCCHHHH
VIRVMLNELFRINNHLLFCGTAIQDAGGMTPVFYMFADRQKVYDIVEAITGYRMHPAWFR
HHHHHHHHHHHHCCCEEEEECHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEE
IGGTAHDLPNNWHKLVKELLEWMPKRLNEYHTAALKNSVFIGRTRNVAQYDAKSALAWGV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHCCHHHEEECC
TGTGLRATGIDFDVRKYRPYSGYENFDFDVPLEYEGDAYARVMVHFREITESLKIIQQCL
CCCCCEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DNMPSGPYKADHPLAVPPPKDKTLQDIETLITHFLSVSWGPVMPAGEASFMTEVVKGAST
HCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCE
YYLTSDKSTMSYRTRIRTPTFTHLQQMPSVINGSLVSDLIIYLATIDVVMADVDR
EEEECCCCHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA